PERK Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description eukaryotic translation initiation factor 2-alpha kinase 3|The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Jan 2010] (NCBI Entrez Gene Database, 9451)
Similar Terms
Downloads & Tools

Genes

100 substrates of the kinase PERK from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
TJP2 tight junction protein 2
TMF1 TATA element modulatory factor 1
SART1 squamous cell carcinoma antigen recognized by T cells
PDIA4 protein disulfide isomerase family A, member 4
TOR4A torsin family 4, member A
SACK1H scaffolding CK1 anchoring protein H
NFE2L2 nuclear factor, erythroid 2-like 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
MECP2 methyl CpG binding protein 2
RPS14 ribosomal protein S14
TUBA3E tubulin, alpha 3e
LMO7 LIM domain 7
AP1M1 adaptor-related protein complex 1, mu 1 subunit
PQBP1 polyglutamine binding protein 1
KAT7 K(lysine) acetyltransferase 7
KIF20A kinesin family member 20A
EPS8 epidermal growth factor receptor pathway substrate 8
TRAT1 T cell receptor associated transmembrane adaptor 1
RET ret proto-oncogene
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
VRK2 vaccinia related kinase 2
GIMAP8 GTPase, IMAP family member 8
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
TTN titin
TUBA3D tubulin, alpha 3d
AP2M1 adaptor-related protein complex 2, mu 1 subunit
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TNIK TRAF2 and NCK interacting kinase
RLIM ring finger protein, LIM domain interacting
SEC62 SEC62 homolog (S. cerevisiae)
MYH6 myosin, heavy chain 6, cardiac muscle, alpha
MYH7 myosin, heavy chain 7, cardiac muscle, beta
CEP170B centrosomal protein 170B
GORAB golgin, RAB6-interacting
YIPF5 Yip1 domain family, member 5
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae)
INSIG2 insulin induced gene 2
MYO18A myosin XVIIIA
SFPQ splicing factor proline/glutamine-rich
COL1A1 collagen, type I, alpha 1
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
GRB2 growth factor receptor-bound protein 2
PHKA1 phosphorylase kinase, alpha 1 (muscle)
MOB3A MOB kinase activator 3A
PHLDB2 pleckstrin homology-like domain, family B, member 2
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
CHEK2 checkpoint kinase 2
FRK fyn-related Src family tyrosine kinase
C3AR1 complement component 3a receptor 1
FKBP15 FK506 binding protein 15, 133kDa
TGFB1I1 transforming growth factor beta 1 induced transcript 1
DSP desmoplakin
FAM219A family with sequence similarity 219, member A
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
DOCK10 dedicator of cytokinesis 10
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
CDK11B cyclin-dependent kinase 11B
CASC5 cancer susceptibility candidate 5
SV2A synaptic vesicle glycoprotein 2A
SAP30BP SAP30 binding protein
INF2 inverted formin, FH2 and WH2 domain containing
ITGB5 integrin, beta 5
TICRR TOPBP1-interacting checkpoint and replication regulator
ATP7A ATPase, Cu++ transporting, alpha polypeptide
TUBA1C tubulin, alpha 1c
TUBA1B tubulin, alpha 1b
TUBA1A tubulin, alpha 1a
ANAPC5 anaphase promoting complex subunit 5
TMEM169 transmembrane protein 169
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
KLC2 kinesin light chain 2
ZNF513 zinc finger protein 513
INTS12 integrator complex subunit 12
PNP purine nucleoside phosphorylase
CNPY4 canopy FGF signaling regulator 4
KIF14 kinesin family member 14
MED1 mediator complex subunit 1
CTTN cortactin
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
TOP2B topoisomerase (DNA) II beta 180kDa
MINK1 misshapen-like kinase 1
CDK12 cyclin-dependent kinase 12
PTK2 protein tyrosine kinase 2
INSIG1 insulin induced gene 1
LATS2 large tumor suppressor kinase 2
ZNF407 zinc finger protein 407
BPTF bromodomain PHD finger transcription factor
TGM2 transglutaminase 2
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
ARHGAP24 Rho GTPase activating protein 24
STAB2 stabilin 2
LMNB1 lamin B1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
UBAP2L ubiquitin associated protein 2-like
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12
SMIM1 small integral membrane protein 1 (Vel blood group)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
LATS1 large tumor suppressor kinase 1