PES1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description pescadillo ribosomal biogenesis factor 1|This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 23481)
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Genes

343 genes differentially expressed following the PES1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ADGRE3 adhesion G protein-coupled receptor E3 3.30078
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 3.30078
SP7 Sp7 transcription factor 3.30078
SLC39A5 solute carrier family 39 (zinc transporter), member 5 3.30078
C16ORF89 chromosome 16 open reading frame 89 3.30078
ADAMTSL5 ADAMTS-like 5 3.30078
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 3.30078
SNPH syntaphilin 3.30078
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 3.30078
OR13C3 olfactory receptor, family 13, subfamily C, member 3 3.30078
WDR5B WD repeat domain 5B 3.30078
NPSR1 neuropeptide S receptor 1 3.30078
PAX6 paired box 6 3.30078
DUXB double homeobox B 3.30078
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 3.30078
KLRK1 killer cell lectin-like receptor subfamily K, member 1 3.30078
CELF6 CUGBP, Elav-like family member 6 3.30078
CABP4 calcium binding protein 4 3.30078
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 3.30078
PCDHB7 protocadherin beta 7 3.30078
TM4SF1 transmembrane 4 L six family member 1 3.30078
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 3.30078
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 3.30078
LCN12 lipocalin 12 3.30078
GLRA3 glycine receptor, alpha 3 3.30078
RGPD6 RANBP2-like and GRIP domain containing 6 3.30078
LVRN laeverin 3.30078
CFAP54 cilia and flagella associated 54 3.30078
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 3.30078
NR4A3 nuclear receptor subfamily 4, group A, member 3 3.30078
PCDHGA11 protocadherin gamma subfamily A, 11 3.30078
PRSS21 protease, serine, 21 (testisin) 3.30078
CYSRT1 cysteine-rich tail protein 1 3.30078
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 3.30078
SOST sclerostin 3.30078
MEIG1 meiosis/spermiogenesis associated 1 3.30078
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 3.30078
LGALS9 lectin, galactoside-binding, soluble, 9 3.30078
MOGAT3 monoacylglycerol O-acyltransferase 3 3.30078
MOGAT2 monoacylglycerol O-acyltransferase 2 3.30078
FABP12 fatty acid binding protein 12 3.30078
DLL4 delta-like 4 (Drosophila) 3.30078
IDUA iduronidase, alpha-L- 3.30078
HBZ hemoglobin, zeta 3.30078
OXT oxytocin/neurophysin I prepropeptide 3.30078
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 3.30078
LRG1 leucine-rich alpha-2-glycoprotein 1 3.30078
TRPC5OS TRPC5 opposite strand 3.30078
WFDC13 WAP four-disulfide core domain 13 3.30078
SAXO5 stabilizer of axonemal microtubules 5 3.30078
KRT86 keratin 86, type II 3.30078
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 3.30078
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 3.30078
ANO3 anoctamin 3 3.30078
BDKRB2 bradykinin receptor B2 3.30078
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 3.30078
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) 3.30078
HNF1B HNF1 homeobox B 3.30078
LGSN lengsin, lens protein with glutamine synthetase domain 3.30078
PNPLA1 patatin-like phospholipase domain containing 1 3.30078
GOLGA6L10 golgin A6 family-like 10 3.30078
ADGRG3 adhesion G protein-coupled receptor G3 3.30078
SLC67A1 solute carrier family 67 member 1 3.30078
PNMA6F PNMA family member 6F 3.30078
IRF2-DT IRF2 divergent transcript 3.30078
TMEM238L transmembrane protein 238 like 3.30078
TMEM272 transmembrane protein 272 3.30078
ARMH2 armadillo like helical domain containing 2 3.30078
GARIN1A golgi associated RAB2 interactor 1A 3.30078
CFAP119 cilia and flagella associated protein 119 3.30078
PLAAT2 phospholipase A and acyltransferase 2 3.30078
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 3.30078
SHC4 SHC (Src homology 2 domain containing) family, member 4 3.30078
ARMC12 armadillo repeat containing 12 3.30078
GLIPR1L2 GLI pathogenesis-related 1 like 2 3.30078
RNASE4 ribonuclease, RNase A family, 4 3.30078
EFHB EF-hand domain family, member B 3.30078
OR2A25 olfactory receptor, family 2, subfamily A, member 25 3.30078
HBA2 hemoglobin, alpha 2 3.30078
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 3.30078
PARP3 poly (ADP-ribose) polymerase family, member 3 3.30078
FAM167B family with sequence similarity 167, member B 3.30078
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 3.30078
WDR87 WD repeat domain 87 3.30078
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) 3.30078
KLHL31 kelch-like family member 31 3.30078
C1ORF87 chromosome 1 open reading frame 87 3.30078
CCR8 chemokine (C-C motif) receptor 8 3.30078
C1QL2 complement component 1, q subcomponent-like 2 3.30078
ESR1 estrogen receptor 1 3.30078
MSX1 msh homeobox 1 3.30078
TMEM235 transmembrane protein 235 3.30078
FAM178B family with sequence similarity 178, member B 3.30078
CBLN1 cerebellin 1 precursor 3.30078
DAO D-amino-acid oxidase 3.30078
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 3.30078
CCDC17 coiled-coil domain containing 17 3.30078
COLEC10 collectin sub-family member 10 (C-type lectin) 3.30078
KANK4 KN motif and ankyrin repeat domains 4 3.30078
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) 3.30078
FBP1 fructose-1,6-bisphosphatase 1 3.30078
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 3.30078
TRADD TNFRSF1A-associated via death domain 3.30078
SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), member 2 3.30078
APOC4 apolipoprotein C-IV 3.30078
PEBP4 phosphatidylethanolamine-binding protein 4 3.30078
EMP1 epithelial membrane protein 1 3.30078
TBXA2R thromboxane A2 receptor 3.30078
TSLP thymic stromal lymphopoietin 3.30078
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 3.30078
GAB3 GRB2-associated binding protein 3 3.30078
IHH indian hedgehog 3.30078
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta 3.30078
CPO carboxypeptidase O 3.30078
MAGEA11 melanoma antigen family A11 3.30078
ERMN ermin, ERM-like protein 3.30078
SMIM22 small integral membrane protein 22 3.30078
PCDHGB2 protocadherin gamma subfamily B, 2 3.30078
INSR insulin receptor 3.30078
PLSCR2 phospholipid scramblase 2 3.30078
NUPR1 nuclear protein, transcriptional regulator, 1 3.30078
C17ORF99 chromosome 17 open reading frame 99 3.30078
LY6G6D lymphocyte antigen 6 complex, locus G6D 3.30078
GPR150 G protein-coupled receptor 150 3.30078
GPR149 G protein-coupled receptor 149 3.30078
KLHDC1 kelch domain containing 1 3.30078
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 3.30078
GPRC6A G protein-coupled receptor, class C, group 6, member A 3.30078
SP140L SP140 nuclear body protein-like 3.30078
WNT4 wingless-type MMTV integration site family, member 4 3.30078
SLC17A2 solute carrier family 17, member 2 3.30078
ANAPC2 anaphase promoting complex subunit 2 3.30078
TMPPE transmembrane protein with metallophosphoesterase domain 3.30078
LHX2 LIM homeobox 2 3.30078
GTF2A1L general transcription factor IIA, 1-like 3.30078
KLK5 kallikrein-related peptidase 5 3.30078
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) 3.30078
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 3.30078
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 3.30078
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 3.30078
AMH anti-Mullerian hormone 3.30078
ANKRD53 ankyrin repeat domain 53 3.30078
IBSP integrin-binding sialoprotein 3.30078
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 3.30078
GRAP2 GRB2-related adaptor protein 2 3.30078
MAGEB17 melanoma antigen family B17 3.30078
GPRC5D G protein-coupled receptor, class C, group 5, member D 3.30078
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 3.30078
KCTD4 potassium channel tetramerization domain containing 4 3.30078
MMP3 matrix metallopeptidase 3 3.30078
PPP1R3G protein phosphatase 1, regulatory subunit 3G 3.30078
XCR1 chemokine (C motif) receptor 1 3.30078
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 3.30078
TGM5 transglutaminase 5 3.30078
AQP1 aquaporin 1 (Colton blood group) 3.30078
CD8B CD8b molecule 3.30078
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 3.30078
BPIFC BPI fold containing family C 3.30078
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 3.30078
SHISA3 shisa family member 3 3.30078
PSORS1C1 psoriasis susceptibility 1 candidate 1 3.30078
OR6B3 olfactory receptor, family 6, subfamily B, member 3 3.30078
APOA1 apolipoprotein A-I 3.30078
ALOX15B arachidonate 15-lipoxygenase, type B 3.30078
BANF2 barrier to autointegration factor 2 3.30078
POU3F4 POU class 3 homeobox 4 3.30078
CLNK cytokine-dependent hematopoietic cell linker 3.30078
AZU1 azurocidin 1 3.30078
CDCP2 CUB domain containing protein 2 3.30078
EPX eosinophil peroxidase 3.30078
MTNR1A melatonin receptor 1A 3.25073
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 3.24324
DOC2B double C2-like domains, beta 3.16941
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 3.16941
SLIT2 slit homolog 2 (Drosophila) 3.10637
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa 3.06441
COG7 component of oligomeric golgi complex 7 3.02674
THAP7 THAP domain containing 7 2.97413
PCDHGA6 protocadherin gamma subfamily A, 6 2.95546
CDC73 cell division cycle 73 2.94853
MROH7 maestro heat-like repeat family member 7 2.90457
GABRR3 gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene) 2.90457
NAP1L1 nucleosome assembly protein 1-like 1 2.76013
GYPE glycophorin E (MNS blood group) 2.74867
RNF144A ring finger protein 144A 2.71312
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) 2.69003
ZNF577 zinc finger protein 577 2.64134
CD101 CD101 molecule 2.63265
LACTB2 lactamase, beta 2 2.62619
TOX4 TOX high mobility group box family member 4 2.55448
ANKRD29 ankyrin repeat domain 29 2.53549
CEMIP2 cell migration inducing hyaluronidase 2 2.48985
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.48985
EXOSC1 exosome component 1 2.48985
FSCN1 fascin actin-bundling protein 1 2.44158
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 2.40338
CEP70 centrosomal protein 70kDa 2.38598
TSKS testis-specific serine kinase substrate 2.35784
CD53 CD53 molecule 2.356
CLEC2D C-type lectin domain family 2, member D 2.35089
RAE1 ribonucleic acid export 1 2.34146
F13A1 coagulation factor XIII, A1 polypeptide 2.32611
SLCO1B1 solute carrier organic anion transporter family, member 1B1 2.32611
ART3 ADP-ribosyltransferase 3 2.32611
SRGAP2C SLIT-ROBO Rho GTPase activating protein 2C 2.32289
SNX15 sorting nexin 15 2.30505
GALC galactosylceramidase 2.2486
EIF4H eukaryotic translation initiation factor 4H 2.23465
HPSE2 heparanase 2 (inactive) 2.23465
R3HCC1 R3H domain and coiled-coil containing 1 2.18971
FITM2 fat storage-inducing transmembrane protein 2 2.1843
C6ORF47 chromosome 6 open reading frame 47 2.1843
XRRA1 X-ray radiation resistance associated 1 2.16911
RHOXF1 Rhox homeobox family, member 1 2.1635
SHISA2 shisa family member 2 2.1635
NSUN3 NOP2/Sun domain family, member 3 2.15923
NUP107 nucleoporin 107kDa 2.15627
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 2.15447
ERC2 ELKS/RAB6-interacting/CAST family member 2 2.1479
PRKCD protein kinase C, delta 2.14509
PALM2AKAP2 PALM2 and AKAP2 fusion 2.13243
ATF6 activating transcription factor 6 2.12244
ZNF174 zinc finger protein 174 2.11606
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa 2.11271
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 2.10237
SLU7 SLU7 splicing factor homolog (S. cerevisiae) 2.08516
MYH10 myosin, heavy chain 10, non-muscle 2.07953
CMC2 C-x(9)-C motif containing 2 2.07063
TRMT61B tRNA methyltransferase 61B 2.06613
RNF41 ring finger protein 41, E3 ubiquitin protein ligase 2.05126
KIF14 kinesin family member 14 2.05068
FGFR1 fibroblast growth factor receptor 1 2.03447
TCF25 transcription factor 25 (basic helix-loop-helix) 2.00037

decreased expression

Symbol Name Standardized Value
SPMIP8 sperm microtubule inner protein 8 -3.30078
COL16A1 collagen, type XVI, alpha 1 -3.30078
OLFM3 olfactomedin 3 -3.30078
PPP1R42 protein phosphatase 1, regulatory subunit 42 -3.30078
ARHGAP9 Rho GTPase activating protein 9 -3.30078
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4 -3.30078
RABEP2 rabaptin, RAB GTPase binding effector protein 2 -3.30078
DSEL dermatan sulfate epimerase-like -3.30078
BAIAP2L2 BAI1-associated protein 2-like 2 -3.30078
SHLD3 shieldin complex subunit 3 -3.30078
ZNF776 zinc finger protein 776 -3.30078
RUMY2 RUMY family member 2 -3.30078
CDH18 cadherin 18, type 2 -3.26444
TTC26 tetratricopeptide repeat domain 26 -3.24523
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) -3.2015
ZSCAN22 zinc finger and SCAN domain containing 22 -3.10637
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 -3.10637
VSTM2L V-set and transmembrane domain containing 2 like -3.10637
SPX spexin hormone -3.10637
MANSC4 MANSC domain containing 4 -3.10637
ASB16 ankyrin repeat and SOCS box containing 16 -3.10637
LPIN3 lipin 3 -3.10637
RGL4 ral guanine nucleotide dissociation stimulator-like 4 -3.10637
BTBD19 BTB (POZ) domain containing 19 -3.10637
CACNB3 calcium channel, voltage-dependent, beta 3 subunit -3.10637
SAXO2 stabilizer of axonemal microtubules 2 -3.10637
KLRD1 killer cell lectin-like receptor subfamily D, member 1 -3.10637
INSYN2A inhibitory synaptic factor 2A -3.10637
MINAR1 membrane integral NOTCH2 associated receptor 1 -3.10637
PP2D1 protein phosphatase 2C-like domain containing 1 -3.10637
C2 complement component 2 -3.10637
LENG9 leukocyte receptor cluster (LRC) member 9 -3.10637
DNAAF8 dynein axonemal assembly factor 8 -3.10637
CATSPER4 cation channel, sperm associated 4 -3.10637
PRB2 proline-rich protein BstNI subfamily 2 -3.10637
TM6SF1 transmembrane 6 superfamily member 1 -3.10637
CPED1 cadherin-like and PC-esterase domain containing 1 -3.10637
MAP3K6 mitogen-activated protein kinase kinase kinase 6 -3.10637
SMOC1 SPARC related modular calcium binding 1 -3.10637
COLEC11 collectin sub-family member 11 -3.10637
SCN2A sodium channel, voltage gated, type II alpha subunit -3.10637
PCDHB3 protocadherin beta 3 -3.10637
TEKTIP1 tektin bundle interacting protein 1 -3.10637
NRGN neurogranin (protein kinase C substrate, RC3) -3.10637
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) -3.10637
PCDHGA1 protocadherin gamma subfamily A, 1 -3.10637
PCDH17 protocadherin 17 -3.10637
MOB3C MOB kinase activator 3C -3.10637
LSMEM2 leucine-rich single-pass membrane protein 2 -3.10637
EPHA5 EPH receptor A5 -3.10637
KIFC2 kinesin family member C2 -3.10637
TP63 tumor protein p63 -3.10637
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like -3.10637
GSDMA gasdermin A -3.10637
PIH1D2 PIH1 domain containing 2 -3.10637
CSPG4 chondroitin sulfate proteoglycan 4 -3.10637
ZNF703 zinc finger protein 703 -3.10637
EPN3 epsin 3 -3.10637
TMEM187 transmembrane protein 187 -3.10637
NTSR1 neurotensin receptor 1 (high affinity) -3.10637
RIPPLY3 ripply transcriptional repressor 3 -3.05606
FAM114A2 family with sequence similarity 114, member A2 -2.96599
CARF calcium responsive transcription factor -2.94354
ZNF341 zinc finger protein 341 -2.94354
CFAP418 cilia and flagella associated protein 418 -2.942
ADORA1 adenosine A1 receptor -2.942
CDK8 cyclin-dependent kinase 8 -2.92883
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -2.84986
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta -2.8122
CIPC CLOCK-interacting pacemaker -2.77739
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase -2.76327
ATRN attractin -2.76033
SPIN2A spindlin family, member 2A -2.75324
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.55448
KHSRP KH-type splicing regulatory protein -2.54534
CRY1 cryptochrome circadian clock 1 -2.50998
RFESD Rieske (Fe-S) domain containing -2.47674
MAP6D1 MAP6 domain containing 1 -2.47674
RTN1 reticulon 1 -2.44231
ERAP1 endoplasmic reticulum aminopeptidase 1 -2.4247
MRPL44 mitochondrial ribosomal protein L44 -2.39761
BVES blood vessel epicardial substance -2.38875
PIERCE2 piercer of microtubule wall 2 -2.38875
RABAC1 Rab acceptor 1 (prenylated) -2.32611
CREBRF CREB3 regulatory factor -2.29984
THAP1 THAP domain containing, apoptosis associated protein 1 -2.29396
PTGR1 prostaglandin reductase 1 -2.29396
DYNLT1 dynein, light chain, Tctex-type 1 -2.28029
SF3B5 splicing factor 3b, subunit 5, 10kDa -2.26563
NAT14 N-acetyltransferase 14 (GCN5-related, putative) -2.26345
SH3BP5 SH3-domain binding protein 5 (BTK-associated) -2.24631
INTS11 integrator complex subunit 11 -2.24134
SLC33A2 solute carrier family 33 member 2 -2.22914
WIPF2 WAS/WASL interacting protein family, member 2 -2.21627
TRIM39 tripartite motif containing 39 -2.18013
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 -2.18013
TGFBI transforming growth factor, beta-induced, 68kDa -2.16906
P4HA3 prolyl 4-hydroxylase, alpha polypeptide III -2.16906
PLEKHD1 pleckstrin homology domain containing, family D (with coiled-coil domains) member 1 -2.16906
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 -2.13243
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 -2.11271
ZNF518B zinc finger protein 518B -2.11271
HSPA1B heat shock 70kDa protein 1B -2.11271
FZD2 frizzled class receptor 2 -2.1084
SYT17 synaptotagmin XVII -2.10055
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor -2.06951
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -2.05167
RNF121 ring finger protein 121 -2.04581
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) -2.04079
UBA5 ubiquitin-like modifier activating enzyme 5 -2.00037