PEX12 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description peroxisomal biogenesis factor 12|This gene belongs to the peroxin-12 family. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of Zellweger syndrome (ZWS). [provided by RefSeq, Oct 2008] (NCBI Entrez Gene Database, 5193)
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Genes

315 genes differentially expressed following the PEX12 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TEKT2 tektin 2 (testicular) 2.109
SPACDR sperm acrosome developmental regulator 2.109
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 2.109
BHLHA9 basic helix-loop-helix family, member a9 2.109
PCDHA3 protocadherin alpha 3 2.109
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 2.109
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 2.109
PNMA5 paraneoplastic Ma antigen family member 5 2.109
RUNDC3B RUN domain containing 3B 2.109
PON1 paraoxonase 1 2.109
PRKCA protein kinase C, alpha 2.109
TPBGL trophoblast glycoprotein-like 2.109
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) 2.109
TLE6 transducin-like enhancer of split 6 2.109
IER5L immediate early response 5-like 2.109
NTSR1 neurotensin receptor 1 (high affinity) 2.109
SLC22A14 solute carrier family 22, member 14 2.109
GUCA1C guanylate cyclase activator 1C 2.109
APIP APAF1 interacting protein 2.06131
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 2.04284
NXPH4 neurexophilin 4 2.04284
CABP4 calcium binding protein 4 2.04284
HEATR9 HEAT repeat containing 9 2.04284
CPED1 cadherin-like and PC-esterase domain containing 1 2.04284
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 2.04284
KLRK1 killer cell lectin-like receptor subfamily K, member 1 2.04284
ENTHD1 ENTH domain containing 1 2.04284
SLC46A3 solute carrier family 46, member 3 2.04284
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 2.04284
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 2.04284
CFHR1 complement factor H-related 1 2.04284
FAM167B family with sequence similarity 167, member B 2.04284
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 2.04284
ADRB2 adrenoceptor beta 2, surface 2.04284
PCDHB7 protocadherin beta 7 2.04284
SLC23A3 solute carrier family 23, member 3 2.04284
TRIM74 tripartite motif containing 74 2.04284
C11ORF87 chromosome 11 open reading frame 87 2.04284
UBE2U ubiquitin-conjugating enzyme E2U (putative) 2.04284
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2.04284
TRPV2 transient receptor potential cation channel, subfamily V, member 2 2.04284
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.04284
TRPV5 transient receptor potential cation channel, subfamily V, member 5 2.04284
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.04284
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 2.04284
SSTR4 somatostatin receptor 4 2.04284
OPRL1 opiate receptor-like 1 2.04284
PAX7 paired box 7 2.04284
SSTR1 somatostatin receptor 1 2.04284
TBX15 T-box 15 2.04284
AADACL4 arylacetamide deacetylase-like 4 2.04284
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 2.04284
CEP295NL CEP295 N-terminal like 2.04284
LILRB5 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 2.04284
FOLR3 folate receptor 3 (gamma) 2.04284
UCN3 urocortin 3 2.04284
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2.04284
MS4A14 membrane-spanning 4-domains, subfamily A, member 14 2.04284
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10 2.04284
SPMAP2L sperm microtubule associated protein 2 like 2.04284
RTL5 retrotransposon Gag like 5 2.04284
FHIP1B FHF complex subunit HOOK interacting protein 1B 2.04284
GBP4 guanylate binding protein 4 2.04284
FAM13C family with sequence similarity 13, member C 2.04284
DUSP8 dual specificity phosphatase 8 2.04284
ELOVL3 ELOVL fatty acid elongase 3 2.04284
ASB11 ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase 2.04284
KRT80 keratin 80, type II 2.04284
SRGN serglycin 2.04284
PKD2L1 polycystic kidney disease 2-like 1 2.04284
VXN vexin 2.04284
ELOA2 elongin A2 2.04284
GLYATL1B glycine-N-acyltransferase like 1B 2.04284
LOC114841035 uncharacterized LOC114841035 2.04284
SPATA31H1 SPATA31 subfamily H member 1 2.04284
TEX53 testis expressed 53 2.04284
SPDYE8 speedy/RINGO cell cycle regulator family member E8 2.04284
SPEM3 SPEM family member 3 2.04284
LRRC8C-DT LRRC8C divergent transcript 2.04284
C8ORF90 chromosome 8 open reading frame 90 2.04284
CFAP97D2 CFAP97 domain containing 2 2.04284
PVALEF parvalbumin like EF-hand containing 2.04284
H3C14 H3 clustered histone 14 2.04284
CATSPERQ catsper channel auxiliary subunit theta 2.04284
MYZAP myocardial zonula adherens protein 2.04284
MYH13 myosin, heavy chain 13, skeletal muscle 2.04284
TLR8 toll-like receptor 8 2.04284
NHLRC4 NHL repeat containing 4 2.04284
ZIC4 Zic family member 4 2.04284
CBLN3 cerebellin 3 precursor 2.04284
ANXA13 annexin A13 2.04284
CALCA calcitonin-related polypeptide alpha 2.04284
NXPE4 neurexophilin and PC-esterase domain family, member 4 2.04284
NXPE1 neurexophilin and PC-esterase domain family, member 1 2.04284
LGALS7B lectin, galactoside-binding, soluble, 7B 2.04284
PGC progastricsin (pepsinogen C) 2.04284
MRS2 MRS2 magnesium transporter 2.04284
SLC45A2 solute carrier family 45, member 2 2.04284
PROX2 prospero homeobox 2 2.04284
LY6K lymphocyte antigen 6 complex, locus K 2.04284
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 2.04284
UBE2QL1 ubiquitin-conjugating enzyme E2Q family-like 1 2.04284
TAS1R3 taste receptor, type 1, member 3 2.04284
VCX3A variable charge, X-linked 3A 2.04284
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 2.04284
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.04284
KCNT1 potassium channel, sodium activated subfamily T, member 1 2.04284
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 2.04284
PTPRH protein tyrosine phosphatase, receptor type, H 2.04284
EDDM3A epididymal protein 3A 2.04284
CPD carboxypeptidase D 2.04284
SV2C synaptic vesicle glycoprotein 2C 2.04284
RETNLB resistin like beta 2.04284
CLRN2 clarin 2 2.04284
ANKRD63 ankyrin repeat domain 63 2.04284
HSPA1L heat shock 70kDa protein 1-like 2.04284
BPIFB4 BPI fold containing family B, member 4 2.04284
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 2.04284
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 2.04284
TRADD TNFRSF1A-associated via death domain 2.04284
SPATA3 spermatogenesis associated 3 2.04284
CDH19 cadherin 19, type 2 2.04284
AMIGO1 adhesion molecule with Ig-like domain 1 2.04284
SYNC syncoilin, intermediate filament protein 2.04284
CPO carboxypeptidase O 2.04284
TIGIT T cell immunoreceptor with Ig and ITIM domains 2.04284
TMCC1 transmembrane and coiled-coil domain family 1 2.04284
LRRC46 leucine rich repeat containing 46 2.04284
CCL25 chemokine (C-C motif) ligand 25 2.04284
TMEM132E transmembrane protein 132E 2.04284
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 2.04284
ZNF132 zinc finger protein 132 2.04284
CH25H cholesterol 25-hydroxylase 2.04284
TCEA3 transcription elongation factor A (SII), 3 2.04284
DNAH12 dynein, axonemal, heavy chain 12 2.04284
PHF2 PHD finger protein 2 2.04284
KANSL1L KAT8 regulatory NSL complex subunit 1-like 2.04284
TSPYL4 TSPY-like 4 2.04284
CTSS cathepsin S 2.04284
CA5A carbonic anhydrase VA, mitochondrial 2.04284
HAND2 heart and neural crest derivatives expressed 2 2.04284
CD28 CD28 molecule 2.04284
LAMB3 laminin, beta 3 2.04284
GBX1 gastrulation brain homeobox 1 2.04284
LRRN4 leucine rich repeat neuronal 4 2.04284
NPY2R neuropeptide Y receptor Y2 2.04284
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 2.04284
GOLGA8R golgin A8 family, member R 2.04284
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 2.04284
NDE1 nudE neurodevelopment protein 1 2.04284
SH3GLB1 SH3-domain GRB2-like endophilin B1 2.04284
COL17A1 collagen, type XVII, alpha 1 2.04284
COL6A5 collagen, type VI, alpha 5 2.04284
UGDH UDP-glucose 6-dehydrogenase 2.04284
KLK4 kallikrein-related peptidase 4 2.04284
KDM2A lysine (K)-specific demethylase 2A 2.04284
BEAN1 brain expressed, associated with NEDD4, 1 2.04284
CTXN3 cortexin 3 2.04284
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 2.04284
FCRLB Fc receptor-like B 2.04284
SIGLEC11 sialic acid binding Ig-like lectin 11 2.04284
LRRC24 leucine rich repeat containing 24 2.04284
COL11A2 collagen, type XI, alpha 2 2.04284
LCN15 lipocalin 15 2.04284
RNF39 ring finger protein 39 2.04284
LVRN laeverin 2.04284
GALK2 galactokinase 2 2.04284
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 2.04284
PSD2 pleckstrin and Sec7 domain containing 2 2.04284
MAGEC3 melanoma antigen family C3 2.04284
KIF12 kinesin family member 12 2.04284
GALNT9 polypeptide N-acetylgalactosaminyltransferase 9 2.04284
PRSS23 protease, serine, 23 2.04284
OR14A2 olfactory receptor, family 14, subfamily A, member 2 2.04284
SP6 Sp6 transcription factor 2.04284
ASGR2 asialoglycoprotein receptor 2 2.04284
MYO16 myosin XVI 2.04284
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 2.04284
CRX cone-rod homeobox 2.04284
RLN1 relaxin 1 2.04284
TTLL8 tubulin tyrosine ligase-like family member 8 2.04284
MCOLN3 mucolipin 3 2.04284
MEIKIN meiotic kinetochore factor 2.04284
S100A1 S100 calcium binding protein A1 2.04284
SLC44A1 solute carrier family 44 (choline transporter), member 1 2.04284
ATOH7 atonal homolog 7 (Drosophila) 2.04284
SLC39A11 solute carrier family 39, member 11 2.04284
SGMS1 sphingomyelin synthase 1 2.04284
FCN1 ficolin (collagen/fibrinogen domain containing) 1 2.04284
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 2.04284
CIB4 calcium and integrin binding family member 4 2.04284
MT1F metallothionein 1F 2.04284
AMER3 APC membrane recruitment protein 3 2.04284
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 2.04284
NUTM2D NUT family member 2D 2.04284
MC5R melanocortin 5 receptor 2.04284
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase 2.04284
AK4 adenylate kinase 4 2.04284
KIF4B kinesin family member 4B 2.04284
ARL16 ADP-ribosylation factor-like 16 2.04284
PRSS53 protease, serine, 53 2.04284
BPIFC BPI fold containing family C 2.04284
TGM1 transglutaminase 1 2.04284
ADAM28 ADAM metallopeptidase domain 28 2.04284
AHSG alpha-2-HS-glycoprotein 2.04284
SHISA3 shisa family member 3 2.04284
GREM1 gremlin 1, DAN family BMP antagonist 2.04284
RPRD2 regulation of nuclear pre-mRNA domain containing 2 2.04284
GRIK1 glutamate receptor, ionotropic, kainate 1 2.04284
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) 2.04284
KCNK15 potassium channel, two pore domain subfamily K, member 15 2.04284
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 2.04272
LTAP1 lipid transport auxiliary protein 1 2.04029
CHST13 carbohydrate (chondroitin 4) sulfotransferase 13 2.04029
GHRL ghrelin/obestatin prepropeptide 2.04029
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 2.01385
DMAP1 DNA methyltransferase 1 associated protein 1 2.00998
CENPS centromere protein S 2.00778
ANKRD35 ankyrin repeat domain 35 2.00441

decreased expression

Symbol Name Standardized Value
NR1D1 nuclear receptor subfamily 1, group D, member 1 -2.109
TANK TRAF family member-associated NFKB activator -2.109
LDHAL6A lactate dehydrogenase A-like 6A -2.109
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -2.109
DDX55 DEAD (Asp-Glu-Ala-Asp) box polypeptide 55 -2.109
GOLGB1 golgin B1 -2.109
VKORC1 vitamin K epoxide reductase complex, subunit 1 -2.109
ARC activity-regulated cytoskeleton-associated protein -2.109
BMP2 bone morphogenetic protein 2 -2.109
CISH cytokine inducible SH2-containing protein -2.109
NES nestin -2.109
ZNF652 zinc finger protein 652 -2.109
TMEM171 transmembrane protein 171 -2.109
TMEM100 transmembrane protein 100 -2.109
HRH4 histamine receptor H4 -2.04284
KIRREL2 kin of IRRE like 2 (Drosophila) -2.04284
P3H1 prolyl 3-hydroxylase 1 -2.04284
RPL39 ribosomal protein L39 -2.04284
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.04284
NME8 NME/NM23 family member 8 -2.04284
WDR82 WD repeat domain 82 -2.04284
HCRTR1 hypocretin (orexin) receptor 1 -2.04284
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) -2.04284
MTERF4 mitochondrial transcription termination factor 4 -2.04284
ADAM32 ADAM metallopeptidase domain 32 -2.04284
TMEM176A transmembrane protein 176A -2.04284
GUCA1B guanylate cyclase activator 1B (retina) -2.04284
TBX22 T-box 22 -2.04284
TMEM229B transmembrane protein 229B -2.04284
PNPLA1 patatin-like phospholipase domain containing 1 -2.04284
BEST2 bestrophin 2 -2.04284
ZNF527 zinc finger protein 527 -2.04284
RIPOR1 RHO family interacting cell polarization regulator 1 -2.04284
JPT2 Jupiter microtubule associated homolog 2 -2.04284
RIPOR2 RHO family interacting cell polarization regulator 2 -2.04284
DYNLT2B dynein light chain Tctex-type 2B -2.04284
H4C5 H4 clustered histone 5 -2.04284
C7ORF57 chromosome 7 open reading frame 57 -2.04284
MIA melanoma inhibitory activity -2.04284
TMIE transmembrane inner ear -2.04284
MBD4 methyl-CpG binding domain protein 4 -2.04284
TELO2 telomere maintenance 2 -2.04284
FAM43B family with sequence similarity 43, member B -2.04284
THPO thrombopoietin -2.04284
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 -2.04284
CDK6 cyclin-dependent kinase 6 -2.04284
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 -2.04284
STMP1 short transmembrane mitochondrial protein 1 -2.04284
PLAG1 pleiomorphic adenoma gene 1 -2.04284
RIN1 Ras and Rab interactor 1 -2.04284
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A -2.04284
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) -2.04284
ARG1 arginase 1 -2.04284
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -2.04284
PTRH2 peptidyl-tRNA hydrolase 2 -2.04284
PLBD1 phospholipase B domain containing 1 -2.04284
IGFBP4 insulin-like growth factor binding protein 4 -2.04284
SKAP2 src kinase associated phosphoprotein 2 -2.04284
C12ORF56 chromosome 12 open reading frame 56 -2.04284
SPEF2 sperm flagellar 2 -2.04284
DHRS12 dehydrogenase/reductase (SDR family) member 12 -2.04284
PFN4 profilin family, member 4 -2.04284
MRPS9 mitochondrial ribosomal protein S9 -2.04284
INSM1 insulinoma-associated 1 -2.04284
RBM24 RNA binding motif protein 24 -2.04284
DENND2D DENN/MADD domain containing 2D -2.04284
CRYBA1 crystallin, beta A1 -2.04284
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 -2.04284
FCN3 ficolin (collagen/fibrinogen domain containing) 3 -2.04284
PLEKHM3 pleckstrin homology domain containing, family M, member 3 -2.04284
FOXJ1 forkhead box J1 -2.04284
CCDC39 coiled-coil domain containing 39 -2.04284
ZNF613 zinc finger protein 613 -2.04284
PRSS27 protease, serine 27 -2.04284
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) -2.04284
CEP72 centrosomal protein 72kDa -2.04284
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 -2.04284
IL1RAP interleukin 1 receptor accessory protein -2.04284
DNAJC25 DnaJ (Hsp40) homolog, subfamily C , member 25 -2.04284
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase -2.04284
ACTR10 actin-related protein 10 homolog (S. cerevisiae) -2.04284
R3HDM1 R3H domain containing 1 -2.04284
STXBP6 syntaxin binding protein 6 (amisyn) -2.04274
TATDN3 TatD DNase domain containing 3 -2.04029
THEMIS2 thymocyte selection associated family member 2 -2.03794
ADD3 adducin 3 (gamma) -2.02171
NRG4 neuregulin 4 -2.02034
SIK1 salt-inducible kinase 1 -2.01853
PEX11A peroxisomal biogenesis factor 11 alpha -2.01853
DIRAS1 DIRAS family, GTP-binding RAS-like 1 -2.01198
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa -2.0097
TMEM269 transmembrane protein 269 -2.0097
OBI1 ORC ubiquitin ligase 1 -2.0097
KRTDAP keratinocyte differentiation-associated protein -2.0097
CCSAP centriole, cilia and spindle-associated protein -2.00237
MBTPS1 membrane-bound transcription factor peptidase, site 1 -2.00178