PEX19 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description peroxisomal biogenesis factor 19|This gene is necessary for early peroxisomal biogenesis. It acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. These disorders have at least 14 complementation groups, with more than one phenotype being observed for some complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of Zellweger syndrome (ZWS), as well as peroxisome biogenesis disorder complementation group 14 (PBD-CG14), which is also known as PBD-CGJ. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010] (NCBI Entrez Gene Database, 5824)
External Link http://www.ncbi.nlm.nih.gov/gene/5824
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Genes

149 interacting proteins for PEX19 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
AGPS alkylglycerone phosphate synthase
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATAD1 ATPase family, AAA domain containing 1
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATXN10 ataxin 10
BCAR1 breast cancer anti-estrogen resistance 1
BCAR3 breast cancer anti-estrogen resistance 3
BZW2 basic leucine zipper and W2 domains 2
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CCT4 chaperonin containing TCP1, subunit 4 (delta)
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)
CCT7 chaperonin containing TCP1, subunit 7 (eta)
CCT8 chaperonin containing TCP1, subunit 8 (theta)
CDC25A cell division cycle 25A
CDCP1 CUB domain containing protein 1
CDK1 cyclin-dependent kinase 1
CKAP4 cytoskeleton-associated protein 4
CNOT1 CCR4-NOT transcription complex, subunit 1
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNND1 catenin (cadherin-associated protein), delta 1
DCTN1 dynactin 1
DHRS4 dehydrogenase/reductase (SDR family) member 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNM1L dynamin 1-like
DNM2 dynamin 2
DSTN destrin (actin depolymerizing factor)
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EFNB1 ephrin-B1
EGFR epidermal growth factor receptor
EIF1B eukaryotic translation initiation factor 1B
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
ELAVL1 ELAV like RNA binding protein 1
EPHA2 EPH receptor A2
EPHB4 EPH receptor B4
ERBB2 erb-b2 receptor tyrosine kinase 2
F11R F11 receptor
FANCI Fanconi anemia, complementation group I
FAR1 fatty acyl CoA reductase 1
FHL2 four and a half LIM domains 2
GNPAT glyceronephosphate O-acyltransferase
GRB2 growth factor receptor-bound protein 2
GSKIP GSK3B interacting protein
HACD3 3-hydroxyacyl-CoA dehydratase 3
HIST1H1E histone cluster 1, H1e
HIST1H2BF histone cluster 1, H2bf
HNRNPF heterogeneous nuclear ribonucleoprotein F
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HNRNPK heterogeneous nuclear ribonucleoprotein K
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1B heat shock 70kDa protein 1B
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IQGAP1 IQ motif containing GTPase activating protein 1
IQGAP2 IQ motif containing GTPase activating protein 2
IRF3 interferon regulatory factor 3
KIF11 kinesin family member 11
KIFAP3 kinesin-associated protein 3
KPNB1 karyopherin (importin) beta 1
KRT1 keratin 1, type II
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LRPPRC leucine-rich pentatricopeptide repeat containing
LRRC59 leucine rich repeat containing 59
MAP2K2 mitogen-activated protein kinase kinase 2
MFSD5 major facilitator superfamily domain containing 5
NUBP2 nucleotide binding protein 2
NUDCD2 NudC domain containing 2
OIP5 Opa interacting protein 5
PEX1 peroxisomal biogenesis factor 1
PEX10 peroxisomal biogenesis factor 10
PEX11A peroxisomal biogenesis factor 11 alpha
PEX11B peroxisomal biogenesis factor 11 beta
PEX12 peroxisomal biogenesis factor 12
PEX13 peroxisomal biogenesis factor 13
PEX14 peroxisomal biogenesis factor 14
PEX16 peroxisomal biogenesis factor 16
PEX2 peroxisomal biogenesis factor 2
PEX26 peroxisomal biogenesis factor 26
PEX3 peroxisomal biogenesis factor 3
PEX5 peroxisomal biogenesis factor 5
PKP2 plakophilin 2
PMP22 peripheral myelin protein 22
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PXMP2 peroxisomal membrane protein 2, 22kDa
PXMP4 peroxisomal membrane protein 4, 24kDa
PXN paxillin
S100A11 S100 calcium binding protein A11
SFN stratifin
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SMAD2 SMAD family member 2
SRPK1 SRSF protein kinase 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK3 serine/threonine kinase 3
TBRG4 transforming growth factor beta regulator 4
TCP1 t-complex 1
TCP11L1 t-complex 11, testis-specific-like 1
TMEM54 transmembrane protein 54
TNK2 tyrosine kinase, non-receptor, 2
TRIM29 tripartite motif containing 29
TTC1 tetratricopeptide repeat domain 1
TUBA1A tubulin, alpha 1a
TUBA1B tubulin, alpha 1b
TUBA4A tubulin, alpha 4a
TUBB tubulin, beta class I
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUBB3 tubulin, beta 3 class III
TUBB4A tubulin, beta 4A class IVa
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
TUBB8 tubulin, beta 8 class VIII
TUBG2 tubulin, gamma 2
TXN thioredoxin
UBB ubiquitin B
UBC ubiquitin C
VCP valosin containing protein
XPOT exportin, tRNA
YES1 YES proto-oncogene 1, Src family tyrosine kinase
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta