PEX26 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description peroxisomal biogenesis factor 26|This gene belongs to the peroxin-26 gene family. It is probably required for protein import into peroxisomes. It anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Defects in this gene are the cause of peroxisome biogenesis disorder complementation group 8 (PBD-CG8). PBD refers to a group of peroxisomal disorders arising from a failure of protein import into the peroxisomal membrane or matrix. The PBD group is comprised of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Dec 2010] (NCBI Entrez Gene Database, 55670)
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Genes

275 genes differentially expressed following the PEX26 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TUBB8 tubulin, beta 8 class VIII 2.63376
NUTM2F NUT family member 2F 2.63376
PRSS54 protease, serine, 54 2.63376
CDKN2A cyclin-dependent kinase inhibitor 2A 2.63376
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 2.63376
HCRTR2 hypocretin (orexin) receptor 2 2.63376
SPRR1B small proline-rich protein 1B 2.63376
VWA7 von Willebrand factor A domain containing 7 2.63376
CD1C CD1c molecule 2.63376
NANOS3 nanos homolog 3 (Drosophila) 2.63376
CLEC4D C-type lectin domain family 4, member D 2.63376
PTGFR prostaglandin F receptor (FP) 2.63376
RP1 retinitis pigmentosa 1 (autosomal dominant) 2.63376
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 2.63376
MT3 metallothionein 3 2.63376
DEFB135 defensin, beta 135 2.63376
CNR2 cannabinoid receptor 2 (macrophage) 2.63376
GRAPL GRB2-related adaptor protein-like 2.63376
TMEM270 transmembrane protein 270 2.63376
OTOP2 otopetrin 2 2.63376
AVPR1B arginine vasopressin receptor 1B 2.63376
IL2RG interleukin 2 receptor, gamma 2.5127
SNTN sentan, cilia apical structure protein 2.5127
MMP20 matrix metallopeptidase 20 2.5127
TREML1 triggering receptor expressed on myeloid cells-like 1 2.5127
MUC20 mucin 20, cell surface associated 2.5127
SPDYE11 speedy/RINGO cell cycle regulator family member E11 2.5127
CD22 CD22 molecule 2.5127
BSX brain-specific homeobox 2.5127
SCARA5 scavenger receptor class A, member 5 2.5127
PLA2G1B phospholipase A2, group IB (pancreas) 2.5127
LGALS4 lectin, galactoside-binding, soluble, 4 2.5127
TGM6 transglutaminase 6 2.5127
STOML3 stomatin (EPB72)-like 3 2.5127
FOXG1 forkhead box G1 2.5127
MROH2A maestro heat-like repeat family member 2A 2.5127
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 2.5127
NNMT nicotinamide N-methyltransferase 2.5127
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 2.5127
TTF1 transcription termination factor, RNA polymerase I 2.5127
TPH1 tryptophan hydroxylase 1 2.5127
CCDC83 coiled-coil domain containing 83 2.5127
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 2.5127
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.5127
RTP3 receptor (chemosensory) transporter protein 3 2.5127
GALR2 galanin receptor 2 2.5127
CRX cone-rod homeobox 2.5127
SLC23A3 solute carrier family 23, member 3 2.5127
BHLHA9 basic helix-loop-helix family, member a9 2.5127
C9 complement component 9 2.5127
SPMAP2 sperm microtubule associated protein 2 2.5127
ACE2 angiotensin I converting enzyme 2 2.5127
LRRN4CL LRRN4 C-terminal like 2.5127
C15ORF62 chromosome 15 open reading frame 62 2.5127
MYL10 myosin, light chain 10, regulatory 2.5127
MYPN myopalladin 2.5127
PLEKHA3 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 2.5127
SLC7A13 solute carrier family 7 (anionic amino acid transporter), member 13 2.5127
H1-6 H1.6 linker histone, cluster member 2.5127
CZIB CXXC motif containing zinc binding protein 2.5127
SLURP2 secreted LY6/PLAUR domain containing 2 2.5127
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 2.5127
TLR8 toll-like receptor 8 2.5127
DNASE2B deoxyribonuclease II beta 2.5127
LZTFL1 leucine zipper transcription factor-like 1 2.5127
HBA1 hemoglobin, alpha 1 2.5127
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 2.5127
CXORF65 chromosome X open reading frame 65 2.5127
RAX retina and anterior neural fold homeobox 2.5127
OR1A1 olfactory receptor, family 1, subfamily A, member 1 2.5127
PGAM4 phosphoglycerate mutase family member 4 2.5127
CAMP cathelicidin antimicrobial peptide 2.5127
SCG2 secretogranin II 2.5127
GJA3 gap junction protein, alpha 3, 46kDa 2.5127
SECTM1 secreted and transmembrane 1 2.5127
RAB44 RAB44, member RAS oncogene family 2.5127
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 2.5127
CLEC3A C-type lectin domain family 3, member A 2.5127
SPDYE9 speedy/RINGO cell cycle regulator family member E9 2.5127
PTCRA pre T-cell antigen receptor alpha 2.5127
OR52N5 olfactory receptor, family 52, subfamily N, member 5 2.5127
TEKT2 tektin 2 (testicular) 2.5127
COX7B2 cytochrome c oxidase subunit VIIb2 2.5127
PCDHGA3 protocadherin gamma subfamily A, 3 2.5127
POU2AF1 POU class 2 associating factor 1 2.5127
TCP11X2 t-complex 11 family, X-linked 2 2.5127
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.5127
PKDREJ polycystin (PKD) family receptor for egg jelly 2.5127
TRADD TNFRSF1A-associated via death domain 2.5127
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 2.5127
CALHM3 calcium homeostasis modulator 3 2.5127
MKRN3 makorin ring finger protein 3 2.5127
LCN8 lipocalin 8 2.5127
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 2.5127
CYSLTR1 cysteinyl leukotriene receptor 1 2.5127
CPSF4L cleavage and polyadenylation specific factor 4-like 2.5127
FBXO40 F-box protein 40 2.5127
EPGN epithelial mitogen 2.5127
KLK5 kallikrein-related peptidase 5 2.5127
VMO1 vitelline membrane outer layer 1 homolog (chicken) 2.5127
IL26 interleukin 26 2.5127
PCDHAC2 protocadherin alpha subfamily C, 2 2.5127
DAOA D-amino acid oxidase activator 2.5127
NKX6-1 NK6 homeobox 1 2.5127
LGALS12 lectin, galactoside-binding, soluble, 12 2.5127
CLEC1A C-type lectin domain family 1, member A 2.5127
CYTH4 cytohesin 4 2.5127
MOS v-mos Moloney murine sarcoma viral oncogene homolog 2.5127
PLCD4 phospholipase C, delta 4 2.5127
PGR progesterone receptor 2.5127
IBSP integrin-binding sialoprotein 2.5127
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 2.5127
CALHM1 calcium homeostasis modulator 1 2.5127
ZC3H11D zinc finger CCCH-type containing 11D 2.5127
CXCR2 chemokine (C-X-C motif) receptor 2 2.5127
PRSS50 protease, serine, 50 2.5127
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 2.5127
FITM1 fat storage-inducing transmembrane protein 1 2.5127
SLITRK6 SLIT and NTRK-like family, member 6 2.5127
GMNC geminin coiled-coil domain containing 2.5127
SP100 SP100 nuclear antigen 2.5127
ACBD3 acyl-CoA binding domain containing 3 2.5127
C10ORF120 chromosome 10 open reading frame 120 2.5127
CLEC7A C-type lectin domain family 7, member A 2.5127
TSPAN32 tetraspanin 32 2.5127
KIF4B kinesin family member 4B 2.5127
RFX4 regulatory factor X, 4 (influences HLA class II expression) 2.5127
CLCA2 chloride channel accessory 2 2.5127
FGF17 fibroblast growth factor 17 2.5127
GLT6D1 glycosyltransferase 6 domain containing 1 2.5127
APOL3 apolipoprotein L, 3 2.5127
NPAS4 neuronal PAS domain protein 4 2.5127
OR56A3 olfactory receptor, family 56, subfamily A, member 3 2.5127
IL17REL interleukin 17 receptor E-like 2.5127
BTNL9 butyrophilin-like 9 2.5127
ZDHHC18 zinc finger, DHHC-type containing 18 2.51023
CCT4 chaperonin containing TCP1, subunit 4 (delta) 2.51023
SHF Src homology 2 domain containing F 2.51023
ZNF664 zinc finger protein 664 2.44765
EFCAB12 EF-hand calcium binding domain 12 2.43183
C16ORF78 chromosome 16 open reading frame 78 2.43183
PGF placental growth factor 2.42989
TSPAN9 tetraspanin 9 2.39432
ARL9 ADP-ribosylation factor-like 9 2.39432
TMEM223 transmembrane protein 223 2.39239
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 2.35565
CCDC138 coiled-coil domain containing 138 2.28112
EPHB3 EPH receptor B3 2.27523
CHIT1 chitinase 1 (chitotriosidase) 2.27523
APH1B APH1B gamma secretase subunit 2.27352
FCRLB Fc receptor-like B 2.26052
CAPSL calcyphosine-like 2.26052
BAIAP2L2 BAI1-associated protein 2-like 2 2.23301
SF3A1 splicing factor 3a, subunit 1, 120kDa 2.2262
B9D2 B9 protein domain 2 2.21907
ZAR1 zygote arrest 1 2.21907
VCX3A variable charge, X-linked 3A 2.21907
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11 2.21907
SLC22A14 solute carrier family 22, member 14 2.21907
WEE1 WEE1 G2 checkpoint kinase 2.21907
CXCR5 chemokine (C-X-C motif) receptor 5 2.21907
ITGAV integrin, alpha V 2.21907
DTNB dystrobrevin, beta 2.21734
PPP1R35 protein phosphatase 1, regulatory subunit 35 2.21628
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.14458
ILK integrin-linked kinase 2.12823
PARD6A par-6 family cell polarity regulator alpha 2.12614
ZNF44 zinc finger protein 44 2.12614
MTMR8 myotubularin related protein 8 2.11499
PRR19 proline rich 19 2.11157
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) 2.10051
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 2.07988
ALG9 ALG9, alpha-1,2-mannosyltransferase 2.06331
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 2.06176
ZNF274 zinc finger protein 274 2.05993
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) 2.0464
VPS29 vacuolar protein sorting 29 homolog (S. cerevisiae) 2.04192
DHRS7B dehydrogenase/reductase (SDR family) member 7B 2.0402
ZNF487 zinc finger protein 487 2.02136
GCNA germ cell nuclear acidic peptidase 2.02136
NPTX2 neuronal pentraxin II 2.02136
CEP120 centrosomal protein 120kDa 2.02115
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 2.01831

decreased expression

Symbol Name Standardized Value
TIGD3 tigger transposable element derived 3 -2.63376
AGA-DT AGA divergent transcript -2.63376
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -2.63376
RAB27B RAB27B, member RAS oncogene family -2.63376
ABLIM3 actin binding LIM protein family, member 3 -2.63376
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -2.5127
LOC390937 Ets2 repressor factor-like -2.5127
TTC36 tetratricopeptide repeat domain 36 -2.5127
AMDHD1 amidohydrolase domain containing 1 -2.5127
CHRNG cholinergic receptor, nicotinic, gamma (muscle) -2.5127
OXER1 oxoeicosanoid (OXE) receptor 1 -2.5127
HIGD1B HIG1 hypoxia inducible domain family, member 1B -2.5127
PRSS21 protease, serine, 21 (testisin) -2.5127
CCDC87 coiled-coil domain containing 87 -2.5127
FGF8 fibroblast growth factor 8 (androgen-induced) -2.5127
ASPA aspartoacylase -2.5127
DPPA3 developmental pluripotency associated 3 -2.5127
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 -2.5127
EEFSEC eukaryotic elongation factor, selenocysteine-tRNA-specific -2.5127
CNTNAP4 contactin associated protein-like 4 -2.5127
TMEM176B transmembrane protein 176B -2.5127
HMX3 H6 family homeobox 3 -2.5127
TANGO2 transport and golgi organization 2 homolog (Drosophila) -2.5127
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 -2.5127
GOLGA4 golgin A4 -2.5127
GLIPR1 GLI pathogenesis-related 1 -2.5127
TAS1R1 taste receptor, type 1, member 1 -2.5127
DNA2 DNA replication helicase/nuclease 2 -2.5127
PEX26 peroxisomal biogenesis factor 26 -2.5127
GSG1L GSG1-like -2.5127
FAM177B family with sequence similarity 177, member B -2.5127
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 -2.5127
LTB4R2 leukotriene B4 receptor 2 -2.5127
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -2.5127
STYXL2 serine/threonine/tyrosine interacting like 2 -2.5127
ATOSA atos homolog A -2.5127
F10 coagulation factor X -2.5127
TCEA3 transcription elongation factor A (SII), 3 -2.5127
MIA melanoma inhibitory activity -2.5127
PHOSPHO1 phosphatase, orphan 1 -2.5127
HAPLN2 hyaluronan and proteoglycan link protein 2 -2.5127
C3ORF80 chromosome 3 open reading frame 80 -2.5127
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 -2.5127
MORC2 MORC family CW-type zinc finger 2 -2.5127
FNDC8 fibronectin type III domain containing 8 -2.5127
OR2A7 olfactory receptor, family 2, subfamily A, member 7 -2.48453
WDR25 WD repeat domain 25 -2.47701
ATP5ME ATP synthase membrane subunit e -2.46106
AKAP10 A kinase (PRKA) anchor protein 10 -2.46062
CHRM3 cholinergic receptor, muscarinic 3 -2.44765
UNC119B unc-119 homolog B (C. elegans) -2.44585
GBE1 glucan (1,4-alpha-), branching enzyme 1 -2.40947
MED14 mediator complex subunit 14 -2.39575
IGFBP3 insulin-like growth factor binding protein 3 -2.39392
RPP14 ribonuclease P/MRP 14kDa subunit -2.36244
IVD isovaleryl-CoA dehydrogenase -2.35565
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -2.34526
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) -2.33641
RANBP3L RAN binding protein 3-like -2.29612
ANKRD11 ankyrin repeat domain 11 -2.29215
BCAP29 B-cell receptor-associated protein 29 -2.28142
ZNF264 zinc finger protein 264 -2.28128
ZNF668 zinc finger protein 668 -2.27352
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -2.26096
DLG2 discs, large homolog 2 (Drosophila) -2.26052
NEK5 NIMA-related kinase 5 -2.24921
UNC13B unc-13 homolog B (C. elegans) -2.23502
MOSMO modulator of smoothened -2.22938
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 -2.21907
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha -2.21907
SLC22A31 solute carrier family 22, member 31 -2.21907
CSNK1G2 casein kinase 1, gamma 2 -2.21458
KIF2A kinesin heavy chain member 2A -2.20282
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) -2.19383
MAIP1 matrix AAA peptidase interacting protein 1 -2.18039
PUDP pseudouridine 5'-phosphatase -2.17991
CHIC1 cysteine-rich hydrophobic domain 1 -2.14458
IPCEF1 interaction protein for cytohesin exchange factors 1 -2.1383
MEST mesoderm specific transcript -2.13814
PDE4B phosphodiesterase 4B, cAMP-specific -2.12885
PHETA1 PH domain containing endocytic trafficking adaptor 1 -2.12614
PEX12 peroxisomal biogenesis factor 12 -2.11157
TBX10 T-box 10 -2.10543
PDGFA platelet-derived growth factor alpha polypeptide -2.09974
SIDT2 SID1 transmembrane family, member 2 -2.09974
CA1 carbonic anhydrase I -2.08616
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -2.03663
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3 -2.03082
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 -2.02182
ARL10 ADP-ribosylation factor-like 10 -2.02136
CLEC16A C-type lectin domain family 16, member A -2.02136
JAK2 Janus kinase 2 -2.02063