PEX5 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description peroxisomal biogenesis factor 5|The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008] (NCBI Entrez Gene Database, 5830)
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Genes

305 genes differentially expressed following the PEX5 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
THTPA thiamine triphosphatase 2.75298
FSCN3 fascin actin-bundling protein 3, testicular 2.75298
ALPK2 alpha-kinase 2 2.75298
DOK7 docking protein 7 2.75298
MYOM2 myomesin 2 2.75298
ANKRD33 ankyrin repeat domain 33 2.75298
SPEF1 sperm flagellar 1 2.75298
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 2.75298
BATF2 basic leucine zipper transcription factor, ATF-like 2 2.75298
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 2.75298
TTC16 tetratricopeptide repeat domain 16 2.75298
CCR4 chemokine (C-C motif) receptor 4 2.75298
VWA3B von Willebrand factor A domain containing 3B 2.75298
SPINK9 serine peptidase inhibitor, Kazal type 9 2.75298
IL17REL interleukin 17 receptor E-like 2.75298
AKR1B15 aldo-keto reductase family 1, member B15 2.75298
TCEA3 transcription elongation factor A (SII), 3 2.75298
SLC7A4 solute carrier family 7, member 4 2.75298
IRF2-DT IRF2 divergent transcript 2.75298
ASGR2 asialoglycoprotein receptor 2 2.75298
NMUR1 neuromedin U receptor 1 2.75298
HES2 hes family bHLH transcription factor 2 2.75298
KRTAP13-4 keratin associated protein 13-4 2.75298
GFY golgi-associated, olfactory signaling regulator 2.75298
PADI4 peptidyl arginine deiminase, type IV 2.75298
ERICH6B glutamate-rich 6B 2.75298
WNT16 wingless-type MMTV integration site family, member 16 2.75298
CRYGN crystallin, gamma N 2.75298
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.68712
SPINK7 serine peptidase inhibitor, Kazal type 7 (putative) 2.60337
RNF17 ring finger protein 17 2.60337
FGF21 fibroblast growth factor 21 2.60337
SMCO1 single-pass membrane protein with coiled-coil domains 1 2.60337
CD3E CD3e molecule, epsilon (CD3-TCR complex) 2.60337
NANOS3 nanos homolog 3 (Drosophila) 2.60337
OR52A5 olfactory receptor, family 52, subfamily A, member 5 2.60337
GLYAT glycine-N-acyltransferase 2.60337
SLC25A41 solute carrier family 25, member 41 2.60337
DUSP14 dual specificity phosphatase 14 2.60337
WNT8B wingless-type MMTV integration site family, member 8B 2.60337
TREML1 triggering receptor expressed on myeloid cells-like 1 2.60337
TDRD9 tudor domain containing 9 2.60337
GNAT3 guanine nucleotide binding protein, alpha transducing 3 2.60337
SLC39A5 solute carrier family 39 (zinc transporter), member 5 2.60337
IL2RA interleukin 2 receptor, alpha 2.60337
ATOH1 atonal homolog 1 (Drosophila) 2.60337
GPR25 G protein-coupled receptor 25 2.60337
MYO16 myosin XVI 2.60337
PAX8 paired box 8 2.60337
MRC1 mannose receptor, C type 1 2.60337
CCL5 chemokine (C-C motif) ligand 5 2.60337
SMIM5 small integral membrane protein 5 2.60337
TMPRSS11E transmembrane protease, serine 11E 2.60337
FPR2 formyl peptide receptor 2 2.60337
LOC124906892 uncharacterized LOC124906892 2.60337
AANAT aralkylamine N-acetyltransferase 2.60337
STMN4 stathmin-like 4 2.60337
SPRR2D small proline-rich protein 2D 2.60337
PDF peptide deformylase (mitochondrial) 2.60337
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 2.60337
TMPRSS3 transmembrane protease, serine 3 2.60337
TMEM40 transmembrane protein 40 2.60337
MIOX myo-inositol oxygenase 2.60337
GRAMD1B GRAM domain containing 1B 2.60337
ARX aristaless related homeobox 2.60337
CCDC187 coiled-coil domain containing 187 2.60337
ACKR5 atypical chemokine receptor 5 2.60337
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 2.60337
SPMIP1 sperm microtubule inner protein 1 2.60337
HSFX3 heat shock transcription factor family, X-linked member 3 2.60337
PNMA6F PNMA family member 6F 2.60337
SMIM45 small integral membrane protein 45 2.60337
H2BC12L H2B clustered histone 12 like 2.60337
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 2.60337
LOC124905976 uncharacterized LOC124905976 2.60337
LY6H lymphocyte antigen 6 complex, locus H 2.60337
PTP4A3 protein tyrosine phosphatase type IVA, member 3 2.60337
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 2.60337
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase 2.60337
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.60337
MUCL3 mucin like 3 2.60337
SYNJ1 synaptojanin 1 2.60337
PPP2R5D protein phosphatase 2, regulatory subunit B', delta 2.60337
RAB41 RAB41, member RAS oncogene family 2.60337
CXCL16 chemokine (C-X-C motif) ligand 16 2.60337
SCRT2 scratch family zinc finger 2 2.60337
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G 2.60337
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 2.60337
MOV10L1 Mov10 RISC complex RNA helicase like 1 2.60337
PNPLA1 patatin-like phospholipase domain containing 1 2.60337
ALG10B ALG10B, alpha-1,2-glucosyltransferase 2.60337
GTSF1 gametocyte specific factor 1 2.60337
SASH3 SAM and SH3 domain containing 3 2.60337
ARMS2 age-related maculopathy susceptibility 2 2.60337
INSRR insulin receptor-related receptor 2.60337
SPDYE6 speedy/RINGO cell cycle regulator family member E6 2.60337
GOLGA8T golgin A8 family, member T 2.60337
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 2.60337
HK3 hexokinase 3 (white cell) 2.60337
CDCA7 cell division cycle associated 7 2.60337
FAM135B family with sequence similarity 135, member B 2.60337
COL6A5 collagen, type VI, alpha 5 2.60337
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 2.60337
CCDC27 coiled-coil domain containing 27 2.60337
MAB21L2 mab-21-like 2 (C. elegans) 2.60337
WFDC1 WAP four-disulfide core domain 1 2.60337
KLHL41 kelch-like family member 41 2.60337
REST RE1-silencing transcription factor 2.60337
ANKRD60 ankyrin repeat domain 60 2.60337
GCOM1 GRINL1A complex locus 1 2.60337
CST4 cystatin S 2.60337
HAMP hepcidin antimicrobial peptide 2.60337
APLNR apelin receptor 2.60337
CLIC5 chloride intracellular channel 5 2.60337
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 2.60337
TRIM31 tripartite motif containing 31 2.60337
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 2.60337
CNGB1 cyclic nucleotide gated channel beta 1 2.60337
ETV3L ets variant 3-like 2.60337
TM4SF19 transmembrane 4 L six family member 19 2.60337
LAMB4 laminin, beta 4 2.60337
ARHGAP40 Rho GTPase activating protein 40 2.60337
NKX6-1 NK6 homeobox 1 2.60337
LY6G6D lymphocyte antigen 6 complex, locus G6D 2.60337
LGALS12 lectin, galactoside-binding, soluble, 12 2.60337
DCT dopachrome tautomerase 2.60337
SH2D1B SH2 domain containing 1B 2.60337
CTSE cathepsin E 2.60337
PENK proenkephalin 2.60337
NT5C1B 5'-nucleotidase, cytosolic IB 2.60337
DLX1 distal-less homeobox 1 2.60337
SLC36A3 solute carrier family 36, member 3 2.60337
CRHBP corticotropin releasing hormone binding protein 2.60337
APOB apolipoprotein B 2.60337
PLGLB2 plasminogen-like B2 2.60337
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 2.60337
IL17B interleukin 17B 2.60337
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 2.60337
STOML3 stomatin (EPB72)-like 3 2.60337
OR51I2 olfactory receptor, family 51, subfamily I, member 2 2.60337
FOXP3 forkhead box P3 2.60337
GPRC5A G protein-coupled receptor, class C, group 5, member A 2.60337
NXF3 nuclear RNA export factor 3 2.60337
ZPLD1 zona pellucida-like domain containing 1 2.60337
GREM1 gremlin 1, DAN family BMP antagonist 2.60337
EPX eosinophil peroxidase 2.60337
TRIM29 tripartite motif containing 29 2.60337
MORC1 MORC family CW-type zinc finger 1 2.60337
HP haptoglobin 2.60337
SMIM22 small integral membrane protein 22 2.60337
PRR15L proline rich 15-like 2.60337
TBC1D26 TBC1 domain family, member 26 2.60337
POTEJ POTE ankyrin domain family, member J 2.60337
PAGE2B P antigen family, member 2B 2.60337
AGR2 anterior gradient 2 2.60337
APOE apolipoprotein E 2.55568
POGK pogo transposable element with KRAB domain 2.54709
SLX4 SLX4 structure-specific endonuclease subunit 2.53359
LRRC56 leucine rich repeat containing 56 2.51056
FAM120AOS family with sequence similarity 120A opposite strand 2.49108
RBMX2 RNA binding motif protein, X-linked 2 2.46221
B4GALNT4 beta-1,4-N-acetyl-galactosaminyl transferase 4 2.45663
ZNF98 zinc finger protein 98 2.41654
ZC3H6 zinc finger CCCH-type containing 6 2.39757
LIMD2 LIM domain containing 2 2.3825
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12 2.38208
ANKRD36C ankyrin repeat domain 36C 2.28383
GPR22 G protein-coupled receptor 22 2.27921
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 2.27086
GPLD1 glycosylphosphatidylinositol specific phospholipase D1 2.27086
TLR3 toll-like receptor 3 2.26105
CHAD chondroadherin 2.25682
ASB9 ankyrin repeat and SOCS box containing 9 2.25682
CCDC169 coiled-coil domain containing 169 2.24929
RALGDS ral guanine nucleotide dissociation stimulator 2.24163
MIMS1 mitochondrial inner membrane scaffold 1 2.24069
CEP85L centrosomal protein 85kDa-like 2.23372
IRAK1BP1 interleukin-1 receptor-associated kinase 1 binding protein 1 2.23153
FAM131C family with sequence similarity 131, member C 2.23009
CLDN34 claudin 34 2.23009
IL22RA1 interleukin 22 receptor, alpha 1 2.23009
RIN1 Ras and Rab interactor 1 2.22369
ZNF513 zinc finger protein 513 2.21949
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.20193
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 2.19228
JAKMIP3 Janus kinase and microtubule interacting protein 3 2.19228
STEAP1 six transmembrane epithelial antigen of the prostate 1 2.18401
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa 2.13553
EGFR epidermal growth factor receptor 2.1337
KLKB1 kallikrein B, plasma (Fletcher factor) 1 2.12775
CDX4 caudal type homeobox 4 2.12775
THRA thyroid hormone receptor, alpha 2.12775
HIRA histone cell cycle regulator 2.12775
HIBADH 3-hydroxyisobutyrate dehydrogenase 2.12521
DERL3 derlin 3 2.11918
ZNF714 zinc finger protein 714 2.11052
CNOT6 CCR4-NOT transcription complex, subunit 6 2.11052
OLFM3 olfactomedin 3 2.10549
LIPT2-AS1 LIPT2 antisense RNA 1 2.09305
SCARF1 scavenger receptor class F, member 1 2.06144
RBSN rabenosyn, RAB effector 2.05706
RSKR ribosomal protein S6 kinase related 2.05325
CALHM6 calcium homeostasis modulator family member 6 2.05169
TYW1B tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae) 2.05169
NRIP1 nuclear receptor interacting protein 1 2.05169
TCF7 transcription factor 7 (T-cell specific, HMG-box) 2.05169
HCN3 hyperpolarization activated cyclic nucleotide gated potassium channel 3 2.05169
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4 2.04238
BRWD1 bromodomain and WD repeat domain containing 1 2.00969

decreased expression

Symbol Name Standardized Value
LRRC55 leucine rich repeat containing 55 -2.75298
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 -2.75298
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) -2.60337
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2 -2.60337
TIGIT T cell immunoreceptor with Ig and ITIM domains -2.60337
CFAP70 cilia and flagella associated protein 70 -2.60337
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 -2.60337
MR1 major histocompatibility complex, class I-related -2.60337
CST1 cystatin SN -2.60337
TMEM74B transmembrane protein 74B -2.60337
GJA4 gap junction protein, alpha 4, 37kDa -2.60337
PABPC4L poly(A) binding protein, cytoplasmic 4-like -2.60337
RBPMS2 RNA binding protein with multiple splicing 2 -2.60337
SGPP2 sphingosine-1-phosphate phosphatase 2 -2.60337
GRM6 glutamate receptor, metabotropic 6 -2.60337
KLHL20 kelch-like family member 20 -2.60337
MYL7 myosin, light chain 7, regulatory -2.60337
NFE2 nuclear factor, erythroid 2 -2.60337
MYO1H myosin IH -2.60337
THEM4 thioesterase superfamily member 4 -2.60337
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) -2.60337
CD8B CD8b molecule -2.60337
SAAL1 serum amyloid A-like 1 -2.60337
S100Z S100 calcium binding protein Z -2.60337
KLHDC8A kelch domain containing 8A -2.60337
ADGRD1 adhesion G protein-coupled receptor D1 -2.60337
TPPP3 tubulin polymerization-promoting protein family member 3 -2.60337
H2BC26 H2B clustered histone 26 -2.60337
C11ORF42 chromosome 11 open reading frame 42 -2.60337
OLAH oleoyl-ACP hydrolase -2.60337
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -2.60337
TESC tescalcin -2.60337
NPM2 nucleophosmin/nucleoplasmin 2 -2.60337
ZNF146 zinc finger protein 146 -2.60337
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide -2.60337
PEX5 peroxisomal biogenesis factor 5 -2.60337
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) -2.60337
NDRG1 N-myc downstream regulated 1 -2.60337
PDE2A phosphodiesterase 2A, cGMP-stimulated -2.60337
ATP5MGL ATP synthase membrane subunit g like -2.60337
AP3M2 adaptor-related protein complex 3, mu 2 subunit -2.59676
DNA2 DNA replication helicase/nuclease 2 -2.57872
PLXNA4 plexin A4 -2.57519
RGS11 regulator of G-protein signaling 11 -2.55634
PPP1R10 protein phosphatase 1, regulatory subunit 10 -2.51056
ANPEP alanyl (membrane) aminopeptidase -2.51056
RAB15 RAB15, member RAS oncogene family -2.50344
TMEM237 transmembrane protein 237 -2.48757
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 -2.47185
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2 -2.4496
ALKBH2 alkB, alkylation repair homolog 2 (E. coli) -2.43856
FKBP1B FK506 binding protein 1B, 12.6 kDa -2.43856
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) -2.38977
MAGEA4 melanoma antigen family A4 -2.38977
TRIP13 thyroid hormone receptor interactor 13 -2.38208
MKKS McKusick-Kaufman syndrome -2.34953
ADPRH ADP-ribosylarginine hydrolase -2.34844
POLE polymerase (DNA directed), epsilon, catalytic subunit -2.3256
DEPDC1B DEP domain containing 1B -2.29992
HDHD5 haloacid dehalogenase like hydrolase domain containing 5 -2.29819
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin -2.29536
VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae) -2.29536
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha -2.27416
ATP10B ATPase, class V, type 10B -2.27086
LIME1 Lck interacting transmembrane adaptor 1 -2.27086
SERF1A small EDRK-rich factor 1A (telomeric) -2.25724
NUTM2G NUT family member 2G -2.25724
TDRD12 tudor domain containing 12 -2.25682
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.25604
C1ORF53 chromosome 1 open reading frame 53 -2.24929
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a -2.24633
ANGEL1 angel homolog 1 (Drosophila) -2.23372
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 -2.23193
BRI3 brain protein I3 -2.22661
ZNF418 zinc finger protein 418 -2.19228
FXYD3 FXYD domain containing ion transport regulator 3 -2.19228
PRTG protogenin -2.17604
PLAG1 pleiomorphic adenoma gene 1 -2.17604
HAX1 HCLS1 associated protein X-1 -2.15706
DMGDH dimethylglycine dehydrogenase -2.13495
LRP4 low density lipoprotein receptor-related protein 4 -2.12775
GUCA1A guanylate cyclase activator 1A (retina) -2.12775
OMG oligodendrocyte myelin glycoprotein -2.12521
MDH1B malate dehydrogenase 1B, NAD (soluble) -2.12521
CTC1 CTS telomere maintenance complex component 1 -2.10549
ZNF483 zinc finger protein 483 -2.08342
CKLF chemokine-like factor -2.0677
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) -2.06338
NRP2 neuropilin 2 -2.06144
TTYH3 tweety family member 3 -2.06144
ARHGAP23 Rho GTPase activating protein 23 -2.05706
ECD ecdysoneless homolog (Drosophila) -2.05169
RNF220 ring finger protein 220 -2.04644
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -2.03426
LOC124904942 uncharacterized LOC124904942 -2.02725
C8ORF82 chromosome 8 open reading frame 82 -2.0088