PEX5 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description peroxisomal biogenesis factor 5|The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008] (NCBI Entrez Gene Database, 5830)
External Link http://www.ncbi.nlm.nih.gov/gene/5830
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Genes

186 interacting proteins for PEX5 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ACAD11 acyl-CoA dehydrogenase family, member 11
ACD adrenocortical dysplasia homolog (mouse)
ACOT2 acyl-CoA thioesterase 2
ACOT4 acyl-CoA thioesterase 4
ACOT8 acyl-CoA thioesterase 8
ACOX1 acyl-CoA oxidase 1, palmitoyl
ACOX2 acyl-CoA oxidase 2, branched chain
ACOX3 acyl-CoA oxidase 3, pristanoyl
AGPS alkylglycerone phosphate synthase
AGXT alanine-glyoxylate aminotransferase
AHCYL2 adenosylhomocysteinase-like 2
AKAP11 A kinase (PRKA) anchor protein 11
ALKBH2 alkB, alkylation repair homolog 2 (E. coli)
AMACR alpha-methylacyl-CoA racemase
ANKRD17 ankyrin repeat domain 17
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATAD1 ATPase family, AAA domain containing 1
ATG7 autophagy related 7
ATM ATM serine/threonine kinase
BAAT bile acid CoA:amino acid N-acyltransferase
BRCA1 breast cancer 1, early onset
C11ORF58 chromosome 11 open reading frame 58
CAT catalase
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CCT4 chaperonin containing TCP1, subunit 4 (delta)
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)
CCT7 chaperonin containing TCP1, subunit 7 (eta)
CCT8 chaperonin containing TCP1, subunit 8 (theta)
CHEK1 checkpoint kinase 1
CNN3 calponin 3, acidic
CNOT1 CCR4-NOT transcription complex, subunit 1
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CRAT carnitine O-acetyltransferase
CROT carnitine O-octanoyltransferase
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2B casein kinase 2, beta polypeptide
CTTN cortactin
CWC15 CWC15 spliceosome-associated protein
DAO D-amino-acid oxidase
DCTN1 dynactin 1
DDO D-aspartate oxidase
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DEPDC7 DEP domain containing 7
DHRS4 dehydrogenase/reductase (SDR family) member 4
DMWD dystrophia myotonica, WD repeat containing
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DNM1L dynamin 1-like
DNM2 dynamin 2
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
ECH1 enoyl CoA hydratase 1, peroxisomal
ECI2 enoyl-CoA delta isomerase 2
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPHX2 epoxide hydrolase 2, cytoplasmic
FAM192A family with sequence similarity 192, member A
FAR1 fatty acyl CoA reductase 1
FARSB phenylalanyl-tRNA synthetase, beta subunit
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FTO fat mass and obesity associated
GFM1 G elongation factor, mitochondrial 1
GFM2 G elongation factor, mitochondrial 2
GNPAT glyceronephosphate O-acyltransferase
GPATCH4 G patch domain containing 4
GPHN gephyrin
GPN3 GPN-loop GTPase 3
GSTK1 glutathione S-transferase kappa 1
GYS1 glycogen synthase 1 (muscle)
HACL1 2-hydroxyacyl-CoA lyase 1
HAO1 hydroxyacid oxidase (glycolate oxidase) 1
HAO2 hydroxyacid oxidase 2 (long chain)
HCFC1 host cell factor C1
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase
HOXA7 homeobox A7
HOXB9 homeobox B9
HOXC9 homeobox C9
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
HSDL2 hydroxysteroid dehydrogenase like 2
HSPA1B heat shock 70kDa protein 1B
ICT1 immature colon carcinoma transcript 1
IDE insulin-degrading enzyme
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IQGAP1 IQ motif containing GTPase activating protein 1
IQGAP2 IQ motif containing GTPase activating protein 2
KIF11 kinesin family member 11
LARP7 La ribonucleoprotein domain family, member 7
LONP2 lon peptidase 2, peroxisomal
LRPPRC leucine-rich pentatricopeptide repeat containing
LRRC1 leucine rich repeat containing 1
MAP2K2 mitogen-activated protein kinase kinase 2
MEPCE methylphosphate capping enzyme
MICU1 mitochondrial calcium uptake 1
MLYCD malonyl-CoA decarboxylase
MPV17 MpV17 mitochondrial inner membrane protein
MRPL15 mitochondrial ribosomal protein L15
MRPL41 mitochondrial ribosomal protein L41
MRPL44 mitochondrial ribosomal protein L44
MRPL9 mitochondrial ribosomal protein L9
MRPS11 mitochondrial ribosomal protein S11
MRPS16 mitochondrial ribosomal protein S16
MRPS21 mitochondrial ribosomal protein S21
MRPS31 mitochondrial ribosomal protein S31
NOS2 nitric oxide synthase 2, inducible
NRD1 nardilysin (N-arginine dibasic convertase)
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3
NUDT7 nudix (nucleoside diphosphate linked moiety X)-type motif 7
NUP188 nucleoporin 188kDa
NUP93 nucleoporin 93kDa
PAOX polyamine oxidase (exo-N4-amino)
PARK7 parkinson protein 7
PARP1 poly (ADP-ribose) polymerase 1
PDCD2L programmed cell death 2-like
PDZK1 PDZ domain containing 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PEX1 peroxisomal biogenesis factor 1
PEX10 peroxisomal biogenesis factor 10
PEX12 peroxisomal biogenesis factor 12
PEX13 peroxisomal biogenesis factor 13
PEX14 peroxisomal biogenesis factor 14
PEX16 peroxisomal biogenesis factor 16
PEX19 peroxisomal biogenesis factor 19
PEX2 peroxisomal biogenesis factor 2
PEX3 peroxisomal biogenesis factor 3
PEX7 peroxisomal biogenesis factor 7
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PIPOX pipecolic acid oxidase
PLS3 plastin 3
POLR2G polymerase (RNA) II (DNA directed) polypeptide G
POT1 protection of telomeres 1
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma
PPP2R2D protein phosphatase 2, regulatory subunit B, delta
PRDX5 peroxiredoxin 5
PRPF31 pre-mRNA processing factor 31
RAD54L2 RAD54-like 2 (S. cerevisiae)
RANBP6 RAN binding protein 6
RANGAP1 Ran GTPase activating protein 1
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
RNH1 ribonuclease/angiogenin inhibitor 1
RRBP1 ribosome binding protein 1
SART1 squamous cell carcinoma antigen recognized by T cells
SCARB1 scavenger receptor class B, member 1
SCP2 sterol carrier protein 2
SCRIB scribbled planar cell polarity protein
SDE2 SDE2 telomere maintenance homolog (S. pombe)
SIRT3 sirtuin 3
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
SLX4 SLX4 structure-specific endonuclease subunit
SNUPN snurportin 1
SSTR5 somatostatin receptor 5
TBC1D4 TBC1 domain family, member 4
TCOF1 Treacher Collins-Franceschetti syndrome 1
TCP1 t-complex 1
TCP11L1 t-complex 11, testis-specific-like 1
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TK1 thymidine kinase 1, soluble
TTC1 tetratricopeptide repeat domain 1
TTLL12 tubulin tyrosine ligase-like family member 12
TUBA1A tubulin, alpha 1a
TUBA1B tubulin, alpha 1b
TUBA4A tubulin, alpha 4a
TUBB tubulin, beta class I
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUBB3 tubulin, beta 3 class III
TUBB4A tubulin, beta 4A class IVa
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
TUBB8 tubulin, beta 8 class VIII
TUBG2 tubulin, gamma 2
TYSND1 trypsin domain containing 1
UBA5 ubiquitin-like modifier activating enzyme 5
UBC ubiquitin C
UBE2O ubiquitin-conjugating enzyme E2O
UBR5 ubiquitin protein ligase E3 component n-recognin 5
USP9X ubiquitin specific peptidase 9, X-linked
ZADH2 zinc binding alcohol dehydrogenase domain containing 2
ZNF282 zinc finger protein 282