PEX6 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description peroxisomal biogenesis factor 6|This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) family of ATPases. This member is a predominantly cytoplasmic protein, which plays a direct role in peroxisomal protein import and is required for PTS1 (peroxisomal targeting signal 1, a C-terminal tripeptide of the sequence ser-lys-leu) receptor activity. Mutations in this gene cause peroxisome biogenesis disorders of complementation group 4 and complementation group 6. [provided by RefSeq, Oct 2008] (NCBI Entrez Gene Database, 5190)
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Genes

319 genes differentially expressed following the PEX6 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
GGT5 gamma-glutamyltransferase 5 2.50668
NPPC natriuretic peptide C 2.50668
XAF1 XIAP associated factor 1 2.50668
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 2.50668
MUC1 mucin 1, cell surface associated 2.50668
EPPIN epididymal peptidase inhibitor 2.50668
TNNI1 troponin I type 1 (skeletal, slow) 2.50668
SOX18 SRY (sex determining region Y)-box 18 2.50668
KRT20 keratin 20, type I 2.50668
NRAP nebulin-related anchoring protein 2.50668
BYSL bystin-like 2.50668
UCN urocortin 2.50668
CEMP1 cementum protein 1 2.50668
PCDHA2 protocadherin alpha 2 2.50668
FOXD1 forkhead box D1 2.50668
SECTM1 secreted and transmembrane 1 2.50668
LOC390937 Ets2 repressor factor-like 2.50668
CPNE6 copine VI (neuronal) 2.50668
TBX20 T-box 20 2.50668
AKAP8 A kinase (PRKA) anchor protein 8 2.50668
HRH1 histamine receptor H1 2.50668
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 2.50668
GJB3 gap junction protein, beta 3, 31kDa 2.50668
MUC5B mucin 5B, oligomeric mucus/gel-forming 2.50668
DSG3 desmoglein 3 2.50668
BIRC7 baculoviral IAP repeat containing 7 2.50668
NRROS negative regulator of reactive oxygen species 2.50668
CA7 carbonic anhydrase VII 2.50668
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 2.50668
C1ORF141 chromosome 1 open reading frame 141 2.50668
LRRC10B leucine rich repeat containing 10B 2.50668
LCN12 lipocalin 12 2.50668
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 2.50668
PSCA prostate stem cell antigen 2.50668
RFPL3 ret finger protein-like 3 2.50668
HCRTR2 hypocretin (orexin) receptor 2 2.50668
PECAM1 platelet/endothelial cell adhesion molecule 1 2.50668
PAX7 paired box 7 2.50668
GFAP glial fibrillary acidic protein 2.50668
ASB17 ankyrin repeat and SOCS box containing 17 2.50668
OLFM4 olfactomedin 4 2.50668
RSPO1 R-spondin 1 2.50668
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 2.50668
SSTR5 somatostatin receptor 5 2.50668
GYPA glycophorin A (MNS blood group) 2.50668
GPR21 G protein-coupled receptor 21 2.50668
CLEC5A C-type lectin domain family 5, member A 2.50668
TBC1D3I TBC1 domain family member 3I 2.50668
HAO2 hydroxyacid oxidase 2 (long chain) 2.50668
C3AR1 complement component 3a receptor 1 2.50668
UNC93A unc-93 homolog A (C. elegans) 2.50668
YIPF7 Yip1 domain family, member 7 2.50668
ROPN1B rhophilin associated tail protein 1B 2.50668
CXCL13 chemokine (C-X-C motif) ligand 13 2.50668
SIM1 single-minded family bHLH transcription factor 1 2.50668
AHNAK2 AHNAK nucleoprotein 2 2.50668
DUSP5 dual specificity phosphatase 5 2.50668
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 2.50668
RIOX2 ribosomal oxygenase 2 2.50668
ANGPTL8 angiopoietin like 8 2.50668
TMT1B thiol methyltransferase 1B 2.50668
LOC124904411 uncharacterized LOC124904411 2.50668
CTXND1 cortexin domain containing 1 2.50668
MYMK myomaker, myoblast fusion factor 2.50668
CIBAR2 CBY1 interacting BAR domain containing 2 2.50668
GSG1L2 GSG1 like 2 2.50668
ELOA2 elongin A2 2.50668
CIROP ciliated left-right organizer metallopeptidase 2.50668
PTGR3 prostaglandin reductase 3 2.50668
FAIM Fas apoptotic inhibitory molecule 2.50668
KRT86 keratin 86, type II 2.50668
PDF peptide deformylase (mitochondrial) 2.50668
S100B S100 calcium binding protein B 2.50668
NPFF neuropeptide FF-amide peptide precursor 2.50668
RASAL3 RAS protein activator like 3 2.50668
ZNF257 zinc finger protein 257 2.50668
CFAP45 cilia and flagella associated protein 45 2.50668
SIM2 single-minded family bHLH transcription factor 2 2.50668
SPEGNB SPEG neighbor 2.50668
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase 2.50668
TUBA3E tubulin, alpha 3e 2.50668
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 2.50668
TACR2 tachykinin receptor 2 2.50668
UTS2 urotensin 2 2.50668
SMLR1 small leucine-rich protein 1 2.50668
ASB4 ankyrin repeat and SOCS box containing 4 2.50668
DOK2 docking protein 2, 56kDa 2.50668
TSPAN8 tetraspanin 8 2.50668
SPATA25 spermatogenesis associated 25 2.50668
CFC1 cripto, FRL-1, cryptic family 1 2.50668
CSF3 colony stimulating factor 3 (granulocyte) 2.50668
METTL3 methyltransferase like 3 2.50668
OOSP1 oocyte secreted protein 1, pseudogene 2.50668
LTBP2 latent transforming growth factor beta binding protein 2 2.50668
RIMBP3C RIMS binding protein 3C 2.50668
PKDREJ polycystin (PKD) family receptor for egg jelly 2.50668
TBPL1 TBP-like 1 2.50668
CPO carboxypeptidase O 2.50668
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 2.50668
GNG4 guanine nucleotide binding protein (G protein), gamma 4 2.50668
PRSS55 protease, serine, 55 2.50668
ZCCHC12 zinc finger, CCHC domain containing 12 2.50668
TEX12 testis expressed 12 2.50668
ZNF596 zinc finger protein 596 2.50668
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 2.50668
PTGDR prostaglandin D2 receptor (DP) 2.50668
MC5R melanocortin 5 receptor 2.50668
SUN5 Sad1 and UNC84 domain containing 5 2.50668
POU3F3 POU class 3 homeobox 3 2.50668
ZNF843 zinc finger protein 843 2.50668
FSHR follicle stimulating hormone receptor 2.50668
RGCC regulator of cell cycle 2.50668
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 2.50668
IL1B interleukin 1, beta 2.50668
FAM177B family with sequence similarity 177, member B 2.50668
CPA2 carboxypeptidase A2 (pancreatic) 2.50668
ANKRD61 ankyrin repeat domain 61 2.50668
CTAGE4 CTAGE family, member 4 2.50668
AQP7 aquaporin 7 2.50668
FCHO2 FCH domain only 2 2.50668
AGXT2 alanine--glyoxylate aminotransferase 2 2.50668
BTNL9 butyrophilin-like 9 2.50668
EVPLL envoplakin-like 2.50668
TTLL10 tubulin tyrosine ligase-like family member 10 2.50668
RAB40A RAB40A, member RAS oncogene family 2.50668
MUC13 mucin 13, cell surface associated 2.50668
VWA3A von Willebrand factor A domain containing 3A 2.50668
VWA3B von Willebrand factor A domain containing 3B 2.50668
CLIC5 chloride intracellular channel 5 2.50668
MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B 2.50668
SLITRK1 SLIT and NTRK-like family, member 1 2.50668
GPR68 G protein-coupled receptor 68 2.50668
GPR62 G protein-coupled receptor 62 2.50668
RGS8 regulator of G-protein signaling 8 2.50668
NMBR neuromedin B receptor 2.50668
C2ORF78 chromosome 2 open reading frame 78 2.50668
WNT10B wingless-type MMTV integration site family, member 10B 2.50668
SLC39A10 solute carrier family 39 (zinc transporter), member 10 2.50668
TAS2R13 taste receptor, type 2, member 13 2.50668
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 2.50668
DRC7 dynein regulatory complex subunit 7 2.50668
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 2.50668
GOLGA8K golgin A8 family, member K 2.50668
MISP mitotic spindle positioning 2.50668
NPIPA3 nuclear pore complex interacting protein family, member A3 2.50668
LONRF3 LON peptidase N-terminal domain and ring finger 3 2.50668
BSDC1 BSD domain containing 1 2.50668
FGF6 fibroblast growth factor 6 2.50668
SMCO1 single-pass membrane protein with coiled-coil domains 1 2.50668
REV1 REV1, polymerase (DNA directed) 2.50668
CETP cholesteryl ester transfer protein, plasma 2.50668
CD8B CD8b molecule 2.50668
NNMT nicotinamide N-methyltransferase 2.50668
HK3 hexokinase 3 (white cell) 2.50668
CHIT1 chitinase 1 (chitotriosidase) 2.50668
TGM6 transglutaminase 6 2.50668
ANXA8 annexin A8 2.50668
PDCD1LG2 programmed cell death 1 ligand 2 2.50668
LPO lactoperoxidase 2.50668
OR6B1 olfactory receptor, family 6, subfamily B, member 1 2.50668
NPR3 natriuretic peptide receptor 3 2.50668
DMRT3 doublesex and mab-3 related transcription factor 3 2.50668
OR5A2 olfactory receptor, family 5, subfamily A, member 2 2.50668
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 2.50668
TGM3 transglutaminase 3 2.50668
SLC39A9 solute carrier family 39, member 9 2.49489
FZD7 frizzled class receptor 7 2.49392
TMEM42 transmembrane protein 42 2.48751
PRPF4 pre-mRNA processing factor 4 2.48751
PLCG1 phospholipase C, gamma 1 2.47497
CTSO cathepsin O 2.40202
MEIS1 Meis homeobox 1 2.40202
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 2.37293
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit 2.35662
HDX highly divergent homeobox 2.35662
LLGL2 lethal giant larvae homolog 2 (Drosophila) 2.33382
PEDS1 plasmanylethanolamine desaturase 1 2.31515
ANKRD17 ankyrin repeat domain 17 2.30692
RNF7 ring finger protein 7 2.30287
MLEC malectin 2.29624
BBS7 Bardet-Biedl syndrome 7 2.29065
TTC16 tetratricopeptide repeat domain 16 2.26855
NCOA6 nuclear receptor coactivator 6 2.26855
TLE6 transducin-like enhancer of split 6 2.26855
CCNO cyclin O 2.26855
ANKRD63 ankyrin repeat domain 63 2.26855
SPRR2F small proline-rich protein 2F 2.26702
NDE1 nudE neurodevelopment protein 1 2.26331
C9ORF85 chromosome 9 open reading frame 85 2.22104
DYDC2 DPY30 domain containing 2 2.21193
TP53I3 tumor protein p53 inducible protein 3 2.16834
WDR55 WD repeat domain 55 2.1394
NKAIN4 Na+/K+ transporting ATPase interacting 4 2.13094
POLR2J3 polymerase (RNA) II (DNA directed) polypeptide J3 2.1247
HMGN2 high mobility group nucleosomal binding domain 2 2.08347
IKZF5 IKAROS family zinc finger 5 (Pegasus) 2.07746
NRBP2 nuclear receptor binding protein 2 2.06378
SSR4 signal sequence receptor, delta 2.05533
M6PR mannose-6-phosphate receptor (cation dependent) 2.04961
USP12 ubiquitin specific peptidase 12 2.04798
CTH cystathionine gamma-lyase 2.04119
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.03283
ERICH2 glutamate-rich 2 2.03102
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha 2.02993
VLDLR very low density lipoprotein receptor 2.00555
NFE2L3 nuclear factor, erythroid 2-like 3 2.00555
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 2.00432

decreased expression

Symbol Name Standardized Value
IFI6 interferon, alpha-inducible protein 6 -2.50668
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 -2.50668
NR2E3 nuclear receptor subfamily 2, group E, member 3 -2.50668
NRBP1 nuclear receptor binding protein 1 -2.50668
MAEL maelstrom spermatogenic transposon silencer -2.50668
ZNF492 zinc finger protein 492 -2.50668
FOXJ3 forkhead box J3 -2.50668
LPAR6 lysophosphatidic acid receptor 6 -2.50668
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha -2.50668
FZD8 frizzled class receptor 8 -2.50668
TMPRSS11D transmembrane protease, serine 11D -2.50668
LOX lysyl oxidase -2.50668
FPR1 formyl peptide receptor 1 -2.50668
TAS2R31 taste receptor, type 2, member 31 -2.50668
ACTL8 actin-like 8 -2.50668
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 -2.50668
FOXO6 forkhead box O6 -2.50668
RLN1 relaxin 1 -2.50668
HIPK4 homeodomain interacting protein kinase 4 -2.50668
METTL23 methyltransferase like 23 -2.50668
CRYGN crystallin, gamma N -2.50668
TDRD6 tudor domain containing 6 -2.50668
CCDC85A coiled-coil domain containing 85A -2.50668
DGKD diacylglycerol kinase, delta 130kDa -2.50668
SH3BGRL2 SH3 domain binding glutamate-rich protein like 2 -2.50668
ZBBX zinc finger, B-box domain containing -2.50668
KIF19 kinesin family member 19 -2.50668
PPP1R18 protein phosphatase 1, regulatory subunit 18 -2.50668
WNT3A wingless-type MMTV integration site family, member 3A -2.50668
GEMIN2 gem (nuclear organelle) associated protein 2 -2.50668
PM20D1 peptidase M20 domain containing 1 -2.50668
BOLL boule-like RNA-binding protein -2.50668
LGALS7B lectin, galactoside-binding, soluble, 7B -2.50668
ARG1 arginase 1 -2.50668
SCN10A sodium channel, voltage gated, type X alpha subunit -2.50668
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough -2.50668
COL17A1 collagen, type XVII, alpha 1 -2.50668
PCDH17 protocadherin 17 -2.50668
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) -2.50668
BEND5 BEN domain containing 5 -2.50668
SPMIP8 sperm microtubule inner protein 8 -2.50668
PLCL2 phospholipase C-like 2 -2.50668
SCNN1D sodium channel, non voltage gated 1 delta subunit -2.50668
TP63 tumor protein p63 -2.50668
SOS2 son of sevenless homolog 2 (Drosophila) -2.50668
WNT4 wingless-type MMTV integration site family, member 4 -2.50668
ABHD15 abhydrolase domain containing 15 -2.50668
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 -2.50668
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -2.50668
PLSCR2 phospholipid scramblase 2 -2.50668
RABEPK Rab9 effector protein with kelch motifs -2.50668
DYDC1 DPY30 domain containing 1 -2.50668
OR8D4 olfactory receptor, family 8, subfamily D, member 4 -2.50668
GANC glucosidase, alpha; neutral C -2.50668
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18 -2.50668
CRYBB3 crystallin, beta B3 -2.50668
CRTAC1 cartilage acidic protein 1 -2.50668
GJD3 gap junction protein, delta 3, 31.9kDa -2.50668
DCLK3 doublecortin-like kinase 3 -2.50668
CLK4 CDC-like kinase 4 -2.50668
ATP13A1 ATPase type 13A1 -2.49489
KIAA1217 KIAA1217 -2.48751
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 -2.48751
STYK1 serine/threonine/tyrosine kinase 1 -2.47497
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -2.4738
SYCP3 synaptonemal complex protein 3 -2.4376
SART1 squamous cell carcinoma antigen recognized by T cells -2.4376
SLX4IP SLX4 interacting protein -2.42274
DCHS1 dachsous cadherin-related 1 -2.39908
TPH2 tryptophan hydroxylase 2 -2.3702
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 -2.3702
MAN2B2 mannosidase, alpha, class 2B, member 2 -2.3702
GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 -2.34874
POU5F1B POU class 5 homeobox 1B -2.30829
ACSM6 acyl-CoA synthetase medium-chain family member 6 -2.26855
PHC1 polyhomeotic homolog 1 (Drosophila) -2.26677
BAG4 BCL2-associated athanogene 4 -2.26677
ARHGEF37 Rho guanine nucleotide exchange factor (GEF) 37 -2.26331
ZBTB8B zinc finger and BTB domain containing 8B -2.2571
ADAM9 ADAM metallopeptidase domain 9 -2.21428
PABIR3 PABIR family member 3 -2.21193
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 -2.20735
CCDC110 coiled-coil domain containing 110 -2.20735
AFP alpha-fetoprotein -2.2043
RGN regucalcin -2.2043
CASS4 Cas scaffolding protein family member 4 -2.2043
CDK6 cyclin-dependent kinase 6 -2.19562
LMTK1 lemur tail kinase 1 -2.18855
PEAK1 pseudopodium-enriched atypical kinase 1 -2.18855
SMYD2 SET and MYND domain containing 2 -2.16834
AK8 adenylate kinase 8 -2.15079
PGAM2 phosphoglycerate mutase 2 (muscle) -2.14661
TXNDC16 thioredoxin domain containing 16 -2.14661
CEACAM19 carcinoembryonic antigen-related cell adhesion molecule 19 -2.1338
MAPK6 mitogen-activated protein kinase 6 -2.13364
EBF3 early B-cell factor 3 -2.1173
NXF1 nuclear RNA export factor 1 -2.11065
DPYSL4 dihydropyrimidinase-like 4 -2.10549
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 -2.10549
RABL6 RAB, member RAS oncogene family-like 6 -2.10075
CEBPD CCAAT/enhancer binding protein (C/EBP), delta -2.08509
CCDC73 coiled-coil domain containing 73 -2.08194
SOX10 SRY (sex determining region Y)-box 10 -2.08194
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase -2.08194
PYGM phosphorylase, glycogen, muscle -2.08194
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -2.0805
F2R coagulation factor II (thrombin) receptor -2.05533
DRC2 dynein regulatory complex subunit 2 -2.05533
MOB1B MOB kinase activator 1B -2.04154
PIGB phosphatidylinositol glycan anchor biosynthesis, class B -2.02845
MCTP1 multiple C2 domains, transmembrane 1 -2.01928
ACKR4 atypical chemokine receptor 4 -2.01174