| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/137699113 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in PF 04447943 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE9A | phosphodiesterase 9A | 1.32 |
| CCDC34 | coiled-coil domain containing 34 | 1.21 |
| MCRIP2 | MAPK regulated corepressor interacting protein 2 | 0.78 |
| HIPK1 | homeodomain interacting protein kinase 1 | 0.58 |
| ZBTB45 | zinc finger and BTB domain containing 45 | 0.54 |
| FSIP2 | fibrous sheath interacting protein 2 | 0.49 |
| HECW1 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 | 0.49 |
| BCL2L12 | BCL2-like 12 (proline rich) | 0.46 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.44 |
| APOLTP | apolipoprotein lipid transfer particle homolog | 0.42 |
| FRMD6 | FERM domain containing 6 | 0.42 |
| ANKRD46 | ankyrin repeat domain 46 | 0.41 |
| TATDN2 | TatD DNase domain containing 2 | 0.4 |
| ZMYND19 | zinc finger, MYND-type containing 19 | 0.39 |
| METTL22 | methyltransferase like 22 | 0.38 |
| PITX2 | paired-like homeodomain 2 | 0.38 |
| NEU3 | sialidase 3 (membrane sialidase) | 0.37 |
| ASB8 | ankyrin repeat and SOCS box containing 8 | 0.37 |
| ZNF304 | zinc finger protein 304 | 0.35 |
| NSUN3 | NOP2/Sun domain family, member 3 | 0.35 |
| LSM11 | LSM11, U7 small nuclear RNA associated | 0.35 |
| UPRT | uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) | 0.35 |
| ZNF749 | zinc finger protein 749 | 0.35 |
| SNTA1 | syntrophin, alpha 1 | 0.35 |
| COL17A1 | collagen, type XVII, alpha 1 | 0.34 |
| SNX19 | sorting nexin 19 | 0.33 |
| AZIN1 | antizyme inhibitor 1 | 0.33 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | 0.32 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B | 0.32 |
| ZGRF1 | zinc finger, GRF-type containing 1 | 0.31 |
| COA5 | cytochrome c oxidase assembly factor 5 | 0.31 |
| FUT1 | fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) | 0.3 |
| MRPL35 | mitochondrial ribosomal protein L35 | 0.3 |
| NRM | nurim (nuclear envelope membrane protein) | 0.3 |
| EHF | ets homologous factor | 0.3 |
| DEDD | death effector domain containing | 0.28 |
| DNAJC6 | DnaJ (Hsp40) homolog, subfamily C, member 6 | 0.28 |
| SLC10A4 | solute carrier family 10, member 4 | 0.28 |
| FAU | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed | 0.28 |
| MED8 | mediator complex subunit 8 | 0.28 |
| ZNF729 | zinc finger protein 729 | 0.28 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.27 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.27 |
| FASTK | Fas-activated serine/threonine kinase | 0.27 |
| CR2 | complement component (3d/Epstein Barr virus) receptor 2 | 0.27 |
| GLB1L2 | galactosidase, beta 1-like 2 | 0.27 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.27 |
| ZNF267 | zinc finger protein 267 | 0.26 |
| RAD52 | RAD52 homolog (S. cerevisiae) | 0.26 |
| RIPK4 | receptor-interacting serine-threonine kinase 4 | 0.26 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.26 |
| HAUS7 | HAUS augmin-like complex, subunit 7 | 0.26 |
| TSLIG1 | tRNA splicing ligase complex subunit 1 | 0.26 |
| ZNF608 | zinc finger protein 608 | 0.26 |
| NOP16 | NOP16 nucleolar protein | 0.26 |
| LYST | lysosomal trafficking regulator | 0.26 |
| NEBL | nebulette | 0.25 |
| TMCO4 | transmembrane and coiled-coil domains 4 | 0.25 |
| YAP1 | Yes-associated protein 1 | 0.25 |
| TCOF1 | Treacher Collins-Franceschetti syndrome 1 | 0.25 |
| BRF2 | BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit | 0.25 |
| VPS37B | vacuolar protein sorting 37 homolog B (S. cerevisiae) | 0.25 |
| WASHC3 | WASH complex subunit 3 | 0.24 |
| KDELR3 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 | 0.24 |
| ARL16 | ADP-ribosylation factor-like 16 | 0.24 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.24 |
| TMEM131L | transmembrane 131 like | 0.24 |
| RFWD3 | ring finger and WD repeat domain 3 | 0.23 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.23 |
| TOX2 | TOX high mobility group box family member 2 | 0.23 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.23 |
| RNF4 | ring finger protein 4 | 0.23 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | 0.23 |
| ZNF655 | zinc finger protein 655 | 0.23 |
| NADK | NAD kinase | 0.22 |
| SPATA33 | spermatogenesis associated 33 | 0.22 |
| HOXA9 | homeobox A9 | 0.22 |
| LRRC58 | leucine rich repeat containing 58 | 0.22 |
| PRKCQ | protein kinase C, theta | 0.22 |
| CRYBG2 | crystallin beta-gamma domain containing 2 | 0.22 |
| TIMM23 | translocase of inner mitochondrial membrane 23 homolog (yeast) | 0.22 |
| DCLRE1A | DNA cross-link repair 1A | 0.22 |
| PTPRU | protein tyrosine phosphatase, receptor type, U | 0.22 |
| TADA2A | transcriptional adaptor 2A | 0.22 |
| TRIM35 | tripartite motif containing 35 | 0.21 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.21 |
| CST6 | cystatin E/M | 0.21 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | 0.21 |
| AURKAIP1 | aurora kinase A interacting protein 1 | 0.21 |
| GATC | glutamyl-tRNA(Gln) amidotransferase, subunit C | 0.21 |
| SLX4 | SLX4 structure-specific endonuclease subunit | 0.21 |
| FBRSL1 | fibrosin-like 1 | 0.2 |
| GATD1 | glutamine amidotransferase class 1 domain containing 1 | 0.2 |
| SCNM1 | sodium channel modifier 1 | 0.2 |
| FUNDC1 | FUN14 domain containing 1 | 0.2 |
| ENTPD4 | ectonucleoside triphosphate diphosphohydrolase 4 | 0.2 |
| ERICH1 | glutamate-rich 1 | 0.2 |
| CNTLN | centlein, centrosomal protein | 0.2 |
| BORA | bora, aurora kinase A activator | 0.19 |
| C16ORF72 | chromosome 16 open reading frame 72 | 0.19 |
| Symbol | Name | Standardized Value |
|---|---|---|
| KIF26A | kinesin family member 26A | -2.31 |
| LMOD1 | leiomodin 1 (smooth muscle) | -2.22 |
| KLHL23 | kelch-like family member 23 | -1.82 |
| SPTBN5 | spectrin, beta, non-erythrocytic 5 | -1.57 |
| PLEKHH2 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 | -1.5 |
| PIP | prolactin-induced protein | -1.49 |
| ZNF654 | zinc finger protein 654 | -0.95 |
| CCDC102A | coiled-coil domain containing 102A | -0.77 |
| CES2 | carboxylesterase 2 | -0.71 |
| ZNF524 | zinc finger protein 524 | -0.68 |
| KSR1 | kinase suppressor of ras 1 | -0.68 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.65 |
| PON3 | paraoxonase 3 | -0.61 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -0.6 |
| ACTBL2 | actin, beta-like 2 | -0.59 |
| HIST2H2AA3 | histone cluster 2, H2aa3 | -0.58 |
| SEZ6L2 | seizure related 6 homolog (mouse)-like 2 | -0.58 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.58 |
| CLASP1 | cytoplasmic linker associated protein 1 | -0.56 |
| EVA1C | eva-1 homolog C (C. elegans) | -0.53 |
| LRFN3 | leucine rich repeat and fibronectin type III domain containing 3 | -0.53 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.52 |
| ATF6B | activating transcription factor 6 beta | -0.52 |
| TMOD1 | tropomodulin 1 | -0.48 |
| DPP8 | dipeptidyl-peptidase 8 | -0.48 |
| TLL2 | tolloid-like 2 | -0.47 |
| PDE5A | phosphodiesterase 5A, cGMP-specific | -0.45 |
| PCSK6 | proprotein convertase subtilisin/kexin type 6 | -0.44 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.44 |
| CEP70 | centrosomal protein 70kDa | -0.44 |
| C9ORF72 | chromosome 9 open reading frame 72 | -0.4 |
| FHIT | fragile histidine triad | -0.4 |
| ROR1 | receptor tyrosine kinase-like orphan receptor 1 | -0.4 |
| KIAA1191 | KIAA1191 | -0.4 |
| GPATCH3 | G patch domain containing 3 | -0.4 |
| SEPTIN7 | septin 7 | -0.4 |
| PCGF3 | polycomb group ring finger 3 | -0.4 |
| OTX1 | orthodenticle homeobox 1 | -0.39 |
| KLF4 | Kruppel-like factor 4 (gut) | -0.39 |
| MBP | myelin basic protein | -0.39 |
| R3HDM2 | R3H domain containing 2 | -0.39 |
| SASH1 | SAM and SH3 domain containing 1 | -0.39 |
| HDAC8 | histone deacetylase 8 | -0.39 |
| FBXL15 | F-box and leucine-rich repeat protein 15 | -0.38 |
| CD82 | CD82 molecule | -0.38 |
| OLFM2 | olfactomedin 2 | -0.38 |
| MCFD2 | multiple coagulation factor deficiency 2 | -0.37 |
| VIM | vimentin | -0.37 |
| TUFT1 | tuftelin 1 | -0.37 |
| BMP1 | bone morphogenetic protein 1 | -0.37 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | -0.37 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.37 |
| METTL25 | methyltransferase like 25 | -0.35 |
| ZNF440 | zinc finger protein 440 | -0.35 |
| FIZ1 | FLT3-interacting zinc finger 1 | -0.35 |
| NRP1 | neuropilin 1 | -0.34 |
| ITGB8 | integrin, beta 8 | -0.34 |
| ZNF888 | zinc finger protein 888 | -0.33 |
| MLX | MLX, MAX dimerization protein | -0.33 |
| RPP25 | ribonuclease P/MRP 25kDa subunit | -0.33 |
| CSNK1G2 | casein kinase 1, gamma 2 | -0.33 |
| FBXO31 | F-box protein 31 | -0.33 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | -0.32 |
| ADCY9 | adenylate cyclase 9 | -0.32 |
| C1ORF52 | chromosome 1 open reading frame 52 | -0.31 |
| PPM1L | protein phosphatase, Mg2+/Mn2+ dependent, 1L | -0.31 |
| ATP6V0A1 | ATPase, H+ transporting, lysosomal V0 subunit a1 | -0.31 |
| FTL | ferritin, light polypeptide | -0.31 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.31 |
| HSP90AA4P | heat shock protein 90kDa alpha (cytosolic), class A member 4, pseudogene | -0.31 |
| SDHAF4 | succinate dehydrogenase complex assembly factor 4 | -0.3 |
| ZNF490 | zinc finger protein 490 | -0.3 |
| PLD1 | phospholipase D1, phosphatidylcholine-specific | -0.3 |
| RBL2 | retinoblastoma-like 2 | -0.3 |
| PLCL2 | phospholipase C-like 2 | -0.29 |
| TSPAN3 | tetraspanin 3 | -0.29 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.29 |
| C1QTNF3 | C1q and tumor necrosis factor related protein 3 | -0.29 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | -0.29 |
| ZSWIM7 | zinc finger, SWIM-type containing 7 | -0.29 |
| MFSD6 | major facilitator superfamily domain containing 6 | -0.29 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | -0.29 |
| CDC42EP2 | CDC42 effector protein (Rho GTPase binding) 2 | -0.28 |
| ANKRD16 | ankyrin repeat domain 16 | -0.28 |
| PBLD | phenazine biosynthesis-like protein domain containing | -0.28 |
| ARL4A | ADP-ribosylation factor-like 4A | -0.28 |
| B4GALT3 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 | -0.28 |
| HSH2D | hematopoietic SH2 domain containing | -0.28 |
| CMTM4 | CKLF-like MARVEL transmembrane domain containing 4 | -0.28 |
| HGFAC | HGF activator | -0.28 |
| CCDC97 | coiled-coil domain containing 97 | -0.28 |
| KCNAB2 | potassium channel, voltage gated subfamily A regulatory beta subunit 2 | -0.27 |
| FKBP1A | FK506 binding protein 1A, 12kDa | -0.27 |
| B3GNTL1 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 | -0.27 |
| PLEKHA3 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 | -0.27 |
| RNASEL | ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) | -0.27 |
| GTF2A1 | general transcription factor IIA, 1, 19/37kDa | -0.27 |
| IMMT | inner membrane protein, mitochondrial | -0.27 |
| BLOC1S6 | biogenesis of lysosomal organelles complex-1, subunit 6, pallidin | -0.27 |
