| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/53472153 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in PF 4800567 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABCA13 | ATP-binding cassette, sub-family A (ABC1), member 13 | 1.64 |
| ADCY10 | adenylate cyclase 10 (soluble) | 0.91 |
| GVINP1 | GTPase, very large interferon inducible pseudogene 1 | 0.82 |
| FAM89A | family with sequence similarity 89, member A | 0.76 |
| ZNF367 | zinc finger protein 367 | 0.76 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 0.74 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.73 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.7 |
| ALK | anaplastic lymphoma receptor tyrosine kinase | 0.66 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.65 |
| PAQR7 | progestin and adipoQ receptor family member VII | 0.6 |
| ANO8 | anoctamin 8 | 0.6 |
| MRC2 | mannose receptor, C type 2 | 0.58 |
| KIAA0556 | KIAA0556 | 0.55 |
| VPS37B | vacuolar protein sorting 37 homolog B (S. cerevisiae) | 0.52 |
| CSNK1D | casein kinase 1, delta | 0.51 |
| ASIC1 | acid sensing (proton gated) ion channel 1 | 0.51 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.5 |
| GAS2L1 | growth arrest-specific 2 like 1 | 0.49 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | 0.47 |
| RBL2 | retinoblastoma-like 2 | 0.47 |
| CEP57 | centrosomal protein 57kDa | 0.46 |
| INPP5J | inositol polyphosphate-5-phosphatase J | 0.45 |
| ZBTB45 | zinc finger and BTB domain containing 45 | 0.45 |
| AZIN1 | antizyme inhibitor 1 | 0.43 |
| FAM199X | family with sequence similarity 199, X-linked | 0.43 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.4 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.4 |
| MAP2K5 | mitogen-activated protein kinase kinase 5 | 0.4 |
| NCOR1 | nuclear receptor corepressor 1 | 0.4 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.4 |
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | 0.4 |
| SLC25A23 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 | 0.39 |
| CNNM1 | cyclin and CBS domain divalent metal cation transport mediator 1 | 0.39 |
| NUDT8 | nudix (nucleoside diphosphate linked moiety X)-type motif 8 | 0.39 |
| VDR | vitamin D (1,25- dihydroxyvitamin D3) receptor | 0.38 |
| TRIM2 | tripartite motif containing 2 | 0.38 |
| TNNC2 | troponin C type 2 (fast) | 0.38 |
| FAM53C | family with sequence similarity 53, member C | 0.37 |
| SLC66A2 | solute carrier family 66 member 2 | 0.37 |
| RCAN1 | regulator of calcineurin 1 | 0.37 |
| SNX29 | sorting nexin 29 | 0.37 |
| BTG3 | BTG family, member 3 | 0.37 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.36 |
| ZFYVE26 | zinc finger, FYVE domain containing 26 | 0.36 |
| CDK18 | cyclin-dependent kinase 18 | 0.36 |
| MCM9 | minichromosome maintenance complex component 9 | 0.35 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 0.35 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 0.35 |
| ZNF544 | zinc finger protein 544 | 0.34 |
| DHRS1 | dehydrogenase/reductase (SDR family) member 1 | 0.34 |
| ALPK1 | alpha-kinase 1 | 0.34 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.34 |
| ACAP3 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 | 0.33 |
| RUNX3 | runt-related transcription factor 3 | 0.33 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.33 |
| MON1A | MON1 secretory trafficking family member A | 0.33 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.33 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.33 |
| ZNF189 | zinc finger protein 189 | 0.33 |
| RNF145 | ring finger protein 145 | 0.33 |
| GPANK1 | G patch domain and ankyrin repeats 1 | 0.32 |
| DUSP6 | dual specificity phosphatase 6 | 0.32 |
| CDC26 | cell division cycle 26 | 0.32 |
| SLC35A5 | solute carrier family 35, member A5 | 0.32 |
| ZNF768 | zinc finger protein 768 | 0.32 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.32 |
| SCAP | SREBF chaperone | 0.32 |
| TPGS1 | tubulin polyglutamylase complex subunit 1 | 0.31 |
| TATDN2 | TatD DNase domain containing 2 | 0.31 |
| PTPRU | protein tyrosine phosphatase, receptor type, U | 0.31 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.31 |
| BOLA1 | bolA family member 1 | 0.31 |
| IQCE | IQ motif containing E | 0.31 |
| RREB1 | ras responsive element binding protein 1 | 0.31 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.3 |
| C12ORF73 | chromosome 12 open reading frame 73 | 0.3 |
| MYADM | myeloid-associated differentiation marker | 0.3 |
| MNX1 | motor neuron and pancreas homeobox 1 | 0.3 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.3 |
| CTHRC1 | collagen triple helix repeat containing 1 | 0.3 |
| ZNF76 | zinc finger protein 76 | 0.29 |
| HGH1 | HGH1 homolog (S. cerevisiae) | 0.29 |
| S100A14 | S100 calcium binding protein A14 | 0.29 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.29 |
| MFSD6 | major facilitator superfamily domain containing 6 | 0.29 |
| MSMO1 | methylsterol monooxygenase 1 | 0.29 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.29 |
| TMEM200A | transmembrane protein 200A | 0.29 |
| TMEM87B | transmembrane protein 87B | 0.29 |
| BMERB1 | bMERB domain containing 1 | 0.28 |
| CSNK1E | casein kinase 1, epsilon | 0.28 |
| ATG4A | autophagy related 4A, cysteine peptidase | 0.28 |
| ABCD4 | ATP-binding cassette, sub-family D (ALD), member 4 | 0.28 |
| EGR1 | early growth response 1 | 0.28 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.28 |
| ABHD17B | abhydrolase domain containing 17B | 0.28 |
| CCDC28A | coiled-coil domain containing 28A | 0.28 |
| GAB1 | GRB2-associated binding protein 1 | 0.28 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.28 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.87 |
| MALRD1 | MAM and LDL receptor class A domain containing 1 | -0.82 |
| VGF | VGF nerve growth factor inducible | -0.65 |
| C1QTNF3 | C1q and tumor necrosis factor related protein 3 | -0.65 |
| MCPH1 | microcephalin 1 | -0.6 |
| GALNT13 | polypeptide N-acetylgalactosaminyltransferase 13 | -0.59 |
| TBX3 | T-box 3 | -0.55 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | -0.55 |
| PIGL | phosphatidylinositol glycan anchor biosynthesis, class L | -0.53 |
| C1ORF52 | chromosome 1 open reading frame 52 | -0.52 |
| BDNF | brain-derived neurotrophic factor | -0.5 |
| GGT1 | gamma-glutamyltransferase 1 | -0.5 |
| KIAA0825 | KIAA0825 | -0.48 |
| PEX7 | peroxisomal biogenesis factor 7 | -0.48 |
| TRIM7 | tripartite motif containing 7 | -0.48 |
| ABCC9 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | -0.47 |
| GSTO1 | glutathione S-transferase omega 1 | -0.46 |
| DUSP5 | dual specificity phosphatase 5 | -0.45 |
| C12ORF45 | chromosome 12 open reading frame 45 | -0.45 |
| DISP2 | dispatched homolog 2 (Drosophila) | -0.45 |
| CECR2 | cat eye syndrome chromosome region, candidate 2 | -0.45 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.43 |
| LRRC28 | leucine rich repeat containing 28 | -0.43 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | -0.42 |
| RAB36 | RAB36, member RAS oncogene family | -0.42 |
| ZFHX2 | zinc finger homeobox 2 | -0.42 |
| S100PBP | S100P binding protein | -0.41 |
| MAX | MYC associated factor X | -0.41 |
| ZNF197 | zinc finger protein 197 | -0.41 |
| PDE4DIP | phosphodiesterase 4D interacting protein | -0.4 |
| CCNG1 | cyclin G1 | -0.37 |
| TACC3 | transforming, acidic coiled-coil containing protein 3 | -0.37 |
| RHBDF1 | rhomboid 5 homolog 1 (Drosophila) | -0.37 |
| CCDC158 | coiled-coil domain containing 158 | -0.37 |
| MPHOSPH9 | M-phase phosphoprotein 9 | -0.37 |
| SLC44A2 | solute carrier family 44 (choline transporter), member 2 | -0.36 |
| TTC13 | tetratricopeptide repeat domain 13 | -0.36 |
| KLK7 | kallikrein-related peptidase 7 | -0.36 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.36 |
| TEPSIN | TEPSIN adaptor related protein complex 4 accessory protein | -0.36 |
| DPY30 | dpy-30 homolog (C. elegans) | -0.35 |
| CAPN6 | calpain 6 | -0.35 |
| MEST | mesoderm specific transcript | -0.35 |
| LYST | lysosomal trafficking regulator | -0.34 |
| CPA4 | carboxypeptidase A4 | -0.34 |
| IFT57 | intraflagellar transport 57 | -0.34 |
| ORC3 | origin recognition complex, subunit 3 | -0.34 |
| ADAM22 | ADAM metallopeptidase domain 22 | -0.33 |
| ICAM5 | intercellular adhesion molecule 5, telencephalin | -0.33 |
| INO80D | INO80 complex subunit D | -0.33 |
| CCNE1 | cyclin E1 | -0.32 |
| EMC10 | ER membrane protein complex subunit 10 | -0.32 |
| THBS1 | thrombospondin 1 | -0.31 |
| JMJD4 | jumonji domain containing 4 | -0.31 |
| PCBD2 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 | -0.31 |
| BTBD3 | BTB (POZ) domain containing 3 | -0.3 |
| RETREG3 | reticulophagy regulator family member 3 | -0.3 |
| ZNF548 | zinc finger protein 548 | -0.3 |
| NDUFAB1 | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa | -0.3 |
| ELFN1 | extracellular leucine-rich repeat and fibronectin type III domain containing 1 | -0.3 |
| SYBU | syntabulin (syntaxin-interacting) | -0.3 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.3 |
| CCDC85C | coiled-coil domain containing 85C | -0.29 |
| ATP13A2 | ATPase type 13A2 | -0.29 |
| DNMT3B | DNA (cytosine-5-)-methyltransferase 3 beta | -0.29 |
| TGFB1 | transforming growth factor, beta 1 | -0.29 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.29 |
| FHIT | fragile histidine triad | -0.29 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | -0.29 |
| HGFAC | HGF activator | -0.29 |
| P2RX4 | purinergic receptor P2X, ligand gated ion channel, 4 | -0.29 |
| LRP6 | low density lipoprotein receptor-related protein 6 | -0.28 |
| SLC7A6OS | solute carrier family 7, member 6 opposite strand | -0.28 |
| CCDC14 | coiled-coil domain containing 14 | -0.27 |
| CERK | ceramide kinase | -0.27 |
| ARG2 | arginase 2 | -0.27 |
| RNF4 | ring finger protein 4 | -0.27 |
| UBXN1 | UBX domain protein 1 | -0.27 |
| NUDT14 | nudix (nucleoside diphosphate linked moiety X)-type motif 14 | -0.27 |
| ATP6V1F | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | -0.27 |
| FBRSL1 | fibrosin-like 1 | -0.27 |
| PRKX | protein kinase, X-linked | -0.26 |
| KLHL18 | kelch-like family member 18 | -0.26 |
| JPT2 | Jupiter microtubule associated homolog 2 | -0.26 |
| CCDC9B | coiled-coil domain containing 9B | -0.26 |
| AXIN2 | axin 2 | -0.26 |
| ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) | -0.26 |
| FOSL1 | FOS-like antigen 1 | -0.26 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.26 |
| MSANTD4 | Myb/SANT-like DNA-binding domain containing 4 with coiled-coils | -0.26 |
| SYDE1 | synapse defective 1, Rho GTPase, homolog 1 (C. elegans) | -0.26 |
| DEF8 | differentially expressed in FDCP 8 homolog (mouse) | -0.25 |
| BMPR1A | bone morphogenetic protein receptor, type IA | -0.25 |
| NBEAL1 | neurobeachin-like 1 | -0.25 |
| PLD6 | phospholipase D family, member 6 | -0.25 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.25 |
| RUSC2 | RUN and SH3 domain containing 2 | -0.25 |
| PDLIM1 | PDZ and LIM domain 1 | -0.25 |
| ALDOA | aldolase A, fructose-bisphosphate | -0.25 |
