PF-00539758-00-6416 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the PF-00539758-00-6416 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRB2 adhesion G protein-coupled receptor B2
ALDOB aldolase B, fructose-bisphosphate
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ASB1 ankyrin repeat and SOCS box containing 1
ATAT1 alpha tubulin acetyltransferase 1
AVPR1A arginine vasopressin receptor 1A
BCL2L10 BCL2-like 10 (apoptosis facilitator)
C11ORF21 chromosome 11 open reading frame 21
C3 complement component 3
CC2D1A coiled-coil and C2 domain containing 1A
CCDC177 coiled-coil domain containing 177
CCDC57 coiled-coil domain containing 57
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CELF3 CUGBP, Elav-like family member 3
CLEC3B C-type lectin domain family 3, member B
COL1A1 collagen, type I, alpha 1
CPM carboxypeptidase M
CRMP1 collapsin response mediator protein 1
DAO D-amino-acid oxidase
DBP D site of albumin promoter (albumin D-box) binding protein
DUSP6 dual specificity phosphatase 6
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EPHB2 EPH receptor B2
ERN2 endoplasmic reticulum to nucleus signaling 2
FBXO21 F-box protein 21
FFAR2 free fatty acid receptor 2
FH fumarate hydratase
GARNL3 GTPase activating Rap/RanGAP domain-like 3
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2
GSTTP1 glutathione S-transferase theta pseudogene 1
HEMK1 HemK methyltransferase family member 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HIST1H1B histone cluster 1, H1b
HIST1H2BM histone cluster 1, H2bm
HOXA9 homeobox A9
IL1B interleukin 1, beta
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KDM8 lysine (K)-specific demethylase 8
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LIMD2 LIM domain containing 2
LOC157562 uncharacterized LOC157562
MAGEA6 melanoma antigen family A6
MAPK14 mitogen-activated protein kinase 14
MORN1 MORN repeat containing 1
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NIPAL3 NIPA-like domain containing 3
NOP14-AS1 NOP14 antisense RNA 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR6A1 nuclear receptor subfamily 6, group A, member 1
NTM neurotrimin
NUP88 nucleoporin 88kDa
OLFML2A olfactomedin-like 2A
PAOX polyamine oxidase (exo-N4-amino)
PAPOLG poly(A) polymerase gamma
PAX8 paired box 8
PDE9A phosphodiesterase 9A
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PKNOX2 PBX/knotted 1 homeobox 2
PLA2G1B phospholipase A2, group IB (pancreas)
PLCD1 phospholipase C, delta 1
PLSCR2 phospholipid scramblase 2
POLL polymerase (DNA directed), lambda
RBFA ribosome binding factor A (putative)
RIF1 replication timing regulatory factor 1
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RPL10 ribosomal protein L10
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SAFB scaffold attachment factor B
SAPCD1 suppressor APC domain containing 1
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SH2D3A SH2 domain containing 3A
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOAT2 sterol O-acyltransferase 2
SPEG SPEG complex locus
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRRM2 serine/arginine repetitive matrix 2
SSPN sarcospan
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TFR2 transferrin receptor 2
TLDC1 TBC/LysM-associated domain containing 1
TRIO trio Rho guanine nucleotide exchange factor
TSHR thyroid stimulating hormone receptor
TTLL1 tubulin tyrosine ligase-like family member 1
TTLL4 tubulin tyrosine ligase-like family member 4
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
VPS9D1 VPS9 domain containing 1
WDR78 WD repeat domain 78
WNT10B wingless-type MMTV integration site family, member 10B
XIST X inactive specific transcript (non-protein coding)
ZFHX4 zinc finger homeobox 4
ZIM2 zinc finger, imprinted 2
ZNF442 zinc finger protein 442

decreased expression

Symbol Name
ACTL8 actin-like 8
ADAM2 ADAM metallopeptidase domain 2
ADCK4 aarF domain containing kinase 4
ALDOAP2 aldolase A, fructose-bisphosphate pseudogene 2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AOC3 amine oxidase, copper containing 3
ARHGAP4 Rho GTPase activating protein 4
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BCAS1 breast carcinoma amplified sequence 1
BDKRB1 bradykinin receptor B1
BDKRB2 bradykinin receptor B2
BEST2 bestrophin 2
BET1L Bet1 golgi vesicular membrane trafficking protein-like
CA9 carbonic anhydrase IX
CAMKV CaM kinase-like vesicle-associated
CCDC121 coiled-coil domain containing 121
CCDC134 coiled-coil domain containing 134
CD14 CD14 molecule
CD248 CD248 molecule, endosialin
CDHR2 cadherin-related family member 2
CHRM3 cholinergic receptor, muscarinic 3
CLCN6 chloride channel, voltage-sensitive 6
CLEC4E C-type lectin domain family 4, member E
CPA4 carboxypeptidase A4
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
EDAR ectodysplasin A receptor
ESM1 endothelial cell-specific molecule 1
FAT4 FAT atypical cadherin 4
GDF5 growth differentiation factor 5
GPC5 glypican 5
GPR27 G protein-coupled receptor 27
HEXA-AS1 HEXA antisense RNA 1
HIST1H3A histone cluster 1, H3a
HIST1H4C histone cluster 1, H4c
HOXB2 homeobox B2
HOXB3 homeobox B3
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3
IL12RB1 interleukin 12 receptor, beta 1
IRF2BP1 interferon regulatory factor 2 binding protein 1
JAM3 junctional adhesion molecule 3
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KIAA1456 KIAA1456
KLF8 Kruppel-like factor 8
LDB2 LIM domain binding 2
LMTK1 lemur tail kinase 1
LOC729164 hCG1732469
LPA lipoprotein, Lp(a)
LPAR4 lysophosphatidic acid receptor 4
LSP1 lymphocyte-specific protein 1
LTBP2 latent transforming growth factor beta binding protein 2
LYZL6 lysozyme-like 6
MAK male germ cell-associated kinase
MAP2 microtubule-associated protein 2
MARK1 MAP/microtubule affinity-regulating kinase 1
MIR600HG MIR600 host gene
MS4A5 membrane-spanning 4-domains, subfamily A, member 5
MUC3A mucin 3A, cell surface associated
MX2 MX dynamin-like GTPase 2
NLRX1 NLR family member X1
NUPR1 nuclear protein, transcriptional regulator, 1
OR1D2 olfactory receptor, family 1, subfamily D, member 2
OR2S2 olfactory receptor, family 2, subfamily S, member 2 (gene/pseudogene)
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PCBP3 poly(rC) binding protein 3
PCDHGA8 protocadherin gamma subfamily A, 8
PCDHGA9 protocadherin gamma subfamily A, 9
PDE12 phosphodiesterase 12
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
POM121L2 POM121 transmembrane nucleoporin-like 2
PRDM12 PR domain containing 12
PRR4 proline rich 4 (lacrimal)
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RETN resistin
RPS2P45 ribosomal protein S2 pseudogene 45
SCG5 secretogranin V
SEC14L2 SEC14-like 2 (S. cerevisiae)
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SENP7 SUMO1/sentrin specific peptidase 7
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SNAI2 snail family zinc finger 2
SNX29 sorting nexin 29
SP4 Sp4 transcription factor
SPRR1B small proline-rich protein 1B
SPTBN2 spectrin, beta, non-erythrocytic 2
SPTBN5 spectrin, beta, non-erythrocytic 5
SULT4A1 sulfotransferase family 4A, member 1
TEX13A testis expressed 13A
TFF2 trefoil factor 2
TSPAN12 tetraspanin 12
TTPA tocopherol (alpha) transfer protein
TUBB1 tubulin, beta 1 class VI
UGT8 UDP glycosyltransferase 8
ZNF343 zinc finger protein 343
ZNF41 zinc finger protein 41
ZNF613 zinc finger protein 613