PF-00562151-00-5917 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the PF-00562151-00-5917 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM22 ADAM metallopeptidase domain 22
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADORA1 adenosine A1 receptor
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
ATRNL1 attractin-like 1
BARX2 BARX homeobox 2
BCAP29 B-cell receptor-associated protein 29
BEGAIN brain-enriched guanylate kinase-associated
BMP1 bone morphogenetic protein 1
C1ORF95 chromosome 1 open reading frame 95
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CALML5 calmodulin-like 5
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCNK cyclin K
CLCF1 cardiotrophin-like cytokine factor 1
DCAF4 DDB1 and CUL4 associated factor 4
DLG5 discs, large homolog 5 (Drosophila)
DOK4 docking protein 4
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EDRF1 erythroid differentiation regulatory factor 1
EFNA3 ephrin-A3
EGR1 early growth response 1
EHD2 EH-domain containing 2
EMC1 ER membrane protein complex subunit 1
EPYC epiphycan
ETV5 ets variant 5
EXTL3 exostosin-like glycosyltransferase 3
EZR ezrin
FAM110B family with sequence similarity 110, member B
FBXO21 F-box protein 21
FCMR Fc fragment of IgM receptor
FYN FYN proto-oncogene, Src family tyrosine kinase
GMPR guanosine monophosphate reductase
GPR143 G protein-coupled receptor 143
GRM1 glutamate receptor, metabotropic 1
GRM3 glutamate receptor, metabotropic 3
HCRP1 hepatocellular carcinoma-related HCRP1
HDLBP high density lipoprotein binding protein
HIPK2 homeodomain interacting protein kinase 2
HIST1H1D histone cluster 1, H1d
IDS iduronate 2-sulfatase
LATS1 large tumor suppressor kinase 1
LEFTY2 left-right determination factor 2
LIF leukemia inhibitory factor
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LYST lysosomal trafficking regulator
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MAP1B microtubule-associated protein 1B
MARK4 MAP/microtubule affinity-regulating kinase 4
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MST1 macrophage stimulating 1
NAT6 N-acetyltransferase 6 (GCN5-related)
NAV2 neuron navigator 2
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
OSBP2 oxysterol binding protein 2
PARP3 poly (ADP-ribose) polymerase family, member 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKD2L2 polycystic kidney disease 2-like 2
PLCB2 phospholipase C, beta 2
PLD1 phospholipase D1, phosphatidylcholine-specific
POM121L2 POM121 transmembrane nucleoporin-like 2
PRX periaxin
REST RE1-silencing transcription factor
RGS9 regulator of G-protein signaling 9
RHBG Rh family, B glycoprotein (gene/pseudogene)
RNF39 ring finger protein 39
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RUSC2 RUN and SH3 domain containing 2
RYR1 ryanodine receptor 1 (skeletal)
SFRP4 secreted frizzled-related protein 4
SIM2 single-minded family bHLH transcription factor 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMAD3 SMAD family member 3
SNAP23 synaptosomal-associated protein, 23kDa
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SPN sialophorin
SPRY4 sprouty homolog 4 (Drosophila)
SRRT serrate, RNA effector molecule
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TCTN2 tectonic family member 2
TJAP1 tight junction associated protein 1 (peripheral)
TMCC2 transmembrane and coiled-coil domain family 2
TMEM40 transmembrane protein 40
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNPO2 transportin 2
TRA2A transformer 2 alpha homolog (Drosophila)
TRIM10 tripartite motif containing 10
UBE3B ubiquitin protein ligase E3B
VIM vimentin
VWA5A von Willebrand factor A domain containing 5A
ZBTB1 zinc finger and BTB domain containing 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF202 zinc finger protein 202

decreased expression

Symbol Name
ADRA2B adrenoceptor alpha 2B
AFAP1 actin filament associated protein 1
ANXA2P3 annexin A2 pseudogene 3
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
BCO1 beta-carotene oxygenase 1
BTF3P12 basic transcription factor 3 pseudogene 12
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1
C11ORF63 chromosome 11 open reading frame 63
C1QTNF3 C1q and tumor necrosis factor related protein 3
C2ORF27A chromosome 2 open reading frame 27A
C9ORF9 chromosome 9 open reading frame 9
CAMK1D calcium/calmodulin-dependent protein kinase ID
CDH18 cadherin 18, type 2
CORT cortistatin
CRYAB crystallin, alpha B
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DEPDC5 DEP domain containing 5
DGCR5 DiGeorge syndrome critical region gene 5 (non-protein coding)
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DUX1 double homeobox 1
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
ELAVL3 ELAV like neuron-specific RNA binding protein 3
FAM120C family with sequence similarity 120C
FAM188A family with sequence similarity 188, member A
FGF22 fibroblast growth factor 22
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FRS3 fibroblast growth factor receptor substrate 3
FSHB follicle stimulating hormone, beta polypeptide
GATA4 GATA binding protein 4
GDAP1 ganglioside induced differentiation associated protein 1
GEMIN8 gem (nuclear organelle) associated protein 8
GPR68 G protein-coupled receptor 68
GSTTP1 glutathione S-transferase theta pseudogene 1
HCAR3 hydroxycarboxylic acid receptor 3
HDAC11 histone deacetylase 11
HIRA histone cell cycle regulator
HIST1H2BO histone cluster 1, H2bo
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HSF2BP heat shock transcription factor 2 binding protein
IGSF6 immunoglobulin superfamily, member 6
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIAA0125 KIAA0125
KIAA0319L KIAA0319-like
KIAA1456 KIAA1456
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LINC00597 long intergenic non-protein coding RNA 597
LOC100286895 cell division cycle 27 homolog pseudogene
LOC390998 ribosomal protein L10 pseudogene
LOXL3 lysyl oxidase-like 3
MEGF8 multiple EGF-like-domains 8
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MSC musculin
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
MTL5 metallothionein-like 5, testis-specific (tesmin)
MYH2 myosin, heavy chain 2, skeletal muscle, adult
NME5 NME/NM23 family member 5
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PALM paralemmin
PCDHA5 protocadherin alpha 5
PCDHA9 protocadherin alpha 9
PDE9A phosphodiesterase 9A
PER3 period circadian clock 3
PGR progesterone receptor
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLD3 phospholipase D family, member 3
POLH polymerase (DNA directed), eta
PQLC2 PQ loop repeat containing 2
PRAMEF11 PRAME family member 11
PRR34 proline rich 34
RAB33A RAB33A, member RAS oncogene family
RAB3D RAB3D, member RAS oncogene family
RAB40C RAB40C, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RHBDD3 rhomboid domain containing 3
RPGRIP1L RPGRIP1-like
S100A9 S100 calcium binding protein A9
SCG2 secretogranin II
SIPA1 signal-induced proliferation-associated 1
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SOX12 SRY (sex determining region Y)-box 12
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SREK1IP1 SREK1-interacting protein 1
SRPK3 SRSF protein kinase 3
STAG3 stromal antigen 3
TAOK1 TAO kinase 1
TFF2 trefoil factor 2
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TM4SF5 transmembrane 4 L six family member 5
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TSGA10 testis specific, 10
VNN2 vanin 2
WFDC2 WAP four-disulfide core domain 2
ZNF446 zinc finger protein 446
ZNF747 zinc finger protein 747
ZSCAN2 zinc finger and SCAN domain containing 2