PF-00562151-00-5954 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the PF-00562151-00-5954 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABI2 abl-interactor 2
ADCK2 aarF domain containing kinase 2
ADCY7 adenylate cyclase 7
ADGRG1 adhesion G protein-coupled receptor G1
AQP3 aquaporin 3 (Gill blood group)
BAIAP3 BAI1-associated protein 3
BDKRB2 bradykinin receptor B2
BGN biglycan
C10ORF12 chromosome 10 open reading frame 12
C14ORF79 chromosome 14 open reading frame 79
CA4 carbonic anhydrase IV
CCDC68 coiled-coil domain containing 68
CDC14A cell division cycle 14A
CFAP69 cilia and flagella associated protein 69
CHRM3 cholinergic receptor, muscarinic 3
CLCF1 cardiotrophin-like cytokine factor 1
COMT catechol-O-methyltransferase
CYB5R2 cytochrome b5 reductase 2
CYHR1 cysteine/histidine-rich 1
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DAAM2 dishevelled associated activator of morphogenesis 2
DRD1 dopamine receptor D1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDA2R ectodysplasin A2 receptor
EGR1 early growth response 1
EGR3 early growth response 3
EHD2 EH-domain containing 2
ETV5 ets variant 5
FAM105A family with sequence similarity 105, member A
FOSL1 FOS-like antigen 1
FRMD1 FERM domain containing 1
GK glycerol kinase
HIST1H2AJ histone cluster 1, H2aj
HIST1H3E histone cluster 1, H3e
HOXA10 homeobox A10
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
IRF5 interferon regulatory factor 5
ITGA6 integrin, alpha 6
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KRT17 keratin 17, type I
LAMP1 lysosomal-associated membrane protein 1
LAT2 linker for activation of T cells family, member 2
LIF leukemia inhibitory factor
LIME1 Lck interacting transmembrane adaptor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MAX MYC associated factor X
MLX MLX, MAX dimerization protein
MLXIPL MLX interacting protein-like
MYO1F myosin IF
NBL1 neuroblastoma 1, DAN family BMP antagonist
NCAPH2 non-SMC condensin II complex, subunit H2
NF1 neurofibromin 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NGDN neuroguidin, EIF4E binding protein
NOX1 NADPH oxidase 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUMA1 nuclear mitotic apparatus protein 1
OASL 2'-5'-oligoadenylate synthetase-like
PAOX polyamine oxidase (exo-N4-amino)
PCDHB13 protocadherin beta 13
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PICK1 protein interacting with PRKCA 1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PRSS53 protease, serine, 53
PSG9 pregnancy specific beta-1-glycoprotein 9
PTCRA pre T-cell antigen receptor alpha
RAB28 RAB28, member RAS oncogene family
RAD51 RAD51 recombinase
RANBP1 RAN binding protein 1
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RHOBTB2 Rho-related BTB domain containing 2
RPL23AP32 ribosomal protein L23a pseudogene 32
RPL7 ribosomal protein L7
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
RUSC2 RUN and SH3 domain containing 2
SH2B1 SH2B adaptor protein 1
SLC25A40 solute carrier family 25, member 40
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPRY4 sprouty homolog 4 (Drosophila)
STX2 syntaxin 2
SZT2 seizure threshold 2 homolog (mouse)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TUBBP5 tubulin, beta pseudogene 5
U2AF2 U2 small nuclear RNA auxiliary factor 2
VEGFB vascular endothelial growth factor B
ZCCHC14 zinc finger, CCHC domain containing 14
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF137P zinc finger protein 137, pseudogene
ZNF365 zinc finger protein 365
ZNF37BP zinc finger protein 37B, pseudogene
ZNF701 zinc finger protein 701

decreased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
ACSL4 acyl-CoA synthetase long-chain family member 4
ADAMTSL4 ADAMTS-like 4
ADM adrenomedullin
ALS2CL ALS2 C-terminal like
AMH anti-Mullerian hormone
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
ARMC4 armadillo repeat containing 4
ART1 ADP-ribosyltransferase 1
ASIC2 acid sensing (proton gated) ion channel 2
ATAT1 alpha tubulin acetyltransferase 1
ATP10D ATPase, class V, type 10D
AUTS2 autism susceptibility candidate 2
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
C9ORF9 chromosome 9 open reading frame 9
CA5BP1 carbonic anhydrase VB pseudogene 1
CARD9 caspase recruitment domain family, member 9
CCL22 chemokine (C-C motif) ligand 22
CD53 CD53 molecule
CDH18 cadherin 18, type 2
CDK3 cyclin-dependent kinase 3
CFAP45 cilia and flagella associated protein 45
COLEC11 collectin sub-family member 11
DNAH17 dynein, axonemal, heavy chain 17
ECEL1 endothelin converting enzyme-like 1
EPX eosinophil peroxidase
ERN2 endoplasmic reticulum to nucleus signaling 2
EXD3 exonuclease 3'-5' domain containing 3
FAM189A1 family with sequence similarity 189, member A1
FOXN2 forkhead box N2
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
GDAP1 ganglioside induced differentiation associated protein 1
GPATCH2L G patch domain containing 2-like
GPRC5D G protein-coupled receptor, class C, group 5, member D
GRM2 glutamate receptor, metabotropic 2
GSTCD glutathione S-transferase, C-terminal domain containing
HCAR3 hydroxycarboxylic acid receptor 3
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
IFI6 interferon, alpha-inducible protein 6
IGSF6 immunoglobulin superfamily, member 6
IL12RB1 interleukin 12 receptor, beta 1
INSL5 insulin-like 5
IQSEC2 IQ motif and Sec7 domain 2
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KLF3 Kruppel-like factor 3 (basic)
KLRF1 killer cell lectin-like receptor subfamily F, member 1
LHX3 LIM homeobox 3
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LINC00339 long intergenic non-protein coding RNA 339
LOC157562 uncharacterized LOC157562
LPAR3 lysophosphatidic acid receptor 3
LSP1 lymphocyte-specific protein 1
MAPK10 mitogen-activated protein kinase 10
MATK megakaryocyte-associated tyrosine kinase
MC3R melanocortin 3 receptor
MRPL41 mitochondrial ribosomal protein L41
MUC3B mucin 3B, cell surface associated
MX1 MX dynamin-like GTPase 1
MXD3 MAX dimerization protein 3
NECAB2 N-terminal EF-hand calcium binding protein 2
NME5 NME/NM23 family member 5
NNAT neuronatin
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NSUN6 NOP2/Sun domain family, member 6
NT5M 5',3'-nucleotidase, mitochondrial
NTF3 neurotrophin 3
OR1D2 olfactory receptor, family 1, subfamily D, member 2
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PCDHGA8 protocadherin gamma subfamily A, 8
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PROL1 proline rich, lacrimal 1
RNF122 ring finger protein 122
RORC RAR-related orphan receptor C
RUNDC3B RUN domain containing 3B
SCD5 stearoyl-CoA desaturase 5
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SNTA1 syntrophin, alpha 1
TBC1D19 TBC1 domain family, member 19
TMCC2 transmembrane and coiled-coil domain family 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPSG1 tryptase gamma 1
TRABD TraB domain containing
TRAIP TRAF interacting protein
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
UPK2 uroplakin 2
VEZT vezatin, adherens junctions transmembrane protein
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
ZNF10 zinc finger protein 10
ZNF304 zinc finger protein 304
ZNF747 zinc finger protein 747