PF-00562151-00-5959 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the PF-00562151-00-5959 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRB2 adhesion G protein-coupled receptor B2
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ALDOB aldolase B, fructose-bisphosphate
APOM apolipoprotein M
ARHGAP26 Rho GTPase activating protein 26
ARHGAP35 Rho GTPase activating protein 35
ASPN asporin
ATF7IP activating transcription factor 7 interacting protein
BICD1 bicaudal D homolog 1 (Drosophila)
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1
CALHM2 calcium homeostasis modulator 2
CCDC7 coiled-coil domain containing 7
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLMN calmin (calponin-like, transmembrane)
COL6A1 collagen, type VI, alpha 1
CTNND2 catenin (cadherin-associated protein), delta 2
DAPK3 death-associated protein kinase 3
DHRS12 dehydrogenase/reductase (SDR family) member 12
DHRS9 dehydrogenase/reductase (SDR family) member 9
DIAPH1 diaphanous-related formin 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DVL2 dishevelled segment polarity protein 2
EPS8L1 EPS8-like 1
ERN2 endoplasmic reticulum to nucleus signaling 2
EXPH5 exophilin 5
FAM134B family with sequence similarity 134, member B
FAT2 FAT atypical cadherin 2
FBXL7 F-box and leucine-rich repeat protein 7
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
FYB FYN binding protein
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GRIK5 glutamate receptor, ionotropic, kainate 5
HCG4B HLA complex group 4B (non-protein coding)
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HOXB2 homeobox B2
HOXC5 homeobox C5
ICA1 islet cell autoantigen 1, 69kDa
IDUA iduronidase, alpha-L-
IFNB1 interferon, beta 1, fibroblast
IGL immunoglobulin lambda locus
IL11RA interleukin 11 receptor, alpha
IL36G interleukin 36, gamma
ITGB6 integrin, beta 6
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCTD14 potassium channel tetramerization domain containing 14
KDM4C lysine (K)-specific demethylase 4C
KDM8 lysine (K)-specific demethylase 8
LOC390998 ribosomal protein L10 pseudogene
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRRK1 leucine-rich repeat kinase 1
MAPK7 mitogen-activated protein kinase 7
MPPE1 metallophosphoesterase 1
MSL3 male-specific lethal 3 homolog (Drosophila)
MST1 macrophage stimulating 1
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NEK9 NIMA-related kinase 9
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NPFF neuropeptide FF-amide peptide precursor
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PBX1 pre-B-cell leukemia homeobox 1
PDE12 phosphodiesterase 12
PDE4DIP phosphodiesterase 4D interacting protein
PLXNA3 plexin A3
PODXL2 podocalyxin-like 2
POM121 POM121 transmembrane nucleoporin
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PTAFR platelet-activating factor receptor
PTCRA pre T-cell antigen receptor alpha
PTGES prostaglandin E synthase
RAP1GAP RAP1 GTPase activating protein
RGS12 regulator of G-protein signaling 12
RNF208 ring finger protein 208
ROM1 retinal outer segment membrane protein 1
RPL35A ribosomal protein L35a
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SGSM3 small G protein signaling modulator 3
SIRT4 sirtuin 4
SIX3 SIX homeobox 3
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
SPINK5 serine peptidase inhibitor, Kazal type 5
STX7 syntaxin 7
TAOK1 TAO kinase 1
TAPBP TAP binding protein (tapasin)
TBC1D22A TBC1 domain family, member 22A
TLN2 talin 2
TLR2 toll-like receptor 2
TMPRSS4 transmembrane protease, serine 4
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNK2 tyrosine kinase, non-receptor, 2
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TTC38 tetratricopeptide repeat domain 38
TUBA3C tubulin, alpha 3c
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VNN1 vanin 1
ZBTB20 zinc finger and BTB domain containing 20
ZER1 zyg-11 related, cell cycle regulator
ZNF614 zinc finger protein 614

decreased expression

Symbol Name
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ADAM23 ADAM metallopeptidase domain 23
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AIRE autoimmune regulator
ALG12 ALG12, alpha-1,6-mannosyltransferase
ANKFY1 ankyrin repeat and FYVE domain containing 1
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARRB2 arrestin, beta 2
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BMP4 bone morphogenetic protein 4
C14ORF105 chromosome 14 open reading frame 105
C1ORF105 chromosome 1 open reading frame 105
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CARD8 caspase recruitment domain family, member 8
CBX8 chromobox homolog 8
CLIP4 CAP-GLY domain containing linker protein family, member 4
CNKSR2 connector enhancer of kinase suppressor of Ras 2
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
COBL cordon-bleu WH2 repeat protein
CSF1R colony stimulating factor 1 receptor
CUZD1 CUB and zona pellucida-like domains 1
DCAF13 DDB1 and CUL4 associated factor 13
DCLRE1B DNA cross-link repair 1B
DLL3 delta-like 3 (Drosophila)
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPN1 epsin 1
FGF22 fibroblast growth factor 22
GID4 GID complex subunit 4
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
HIST1H1E histone cluster 1, H1e
HIST1H1T histone cluster 1, H1t
HIST1H2AJ histone cluster 1, H2aj
HIST1H4D histone cluster 1, H4d
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXB9 homeobox B9
HOXC8 homeobox C8
HSPA1L heat shock 70kDa protein 1-like
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IL32 interleukin 32
IL7 interleukin 7
INO80D INO80 complex subunit D
IREB2 iron-responsive element binding protein 2
KIFC3 kinesin family member C3
KLK7 kallikrein-related peptidase 7
LMAN1 lectin, mannose-binding, 1
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LYRM9 LYR motif containing 9
MANEA mannosidase, endo-alpha
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MCC mutated in colorectal cancers
MEGF6 multiple EGF-like-domains 6
METTL16 methyltransferase like 16
MFSD6 major facilitator superfamily domain containing 6
MICALL2 MICAL-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NHEJ1 nonhomologous end-joining factor 1
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
ORC1 origin recognition complex, subunit 1
OSBP2 oxysterol binding protein 2
OSMR oncostatin M receptor
PICK1 protein interacting with PRKCA 1
PTPRH protein tyrosine phosphatase, receptor type, H
PWAR5 Prader Willi/Angelman region RNA 5
RAB40AL RAB40A, member RAS oncogene family-like
RABL6 RAB, member RAS oncogene family-like 6
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RGCC regulator of cell cycle
RNF126P1 ring finger protein 126 pseudogene 1
RUNDC3B RUN domain containing 3B
SAYSD1 SAYSVFN motif domain containing 1
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SENP7 SUMO1/sentrin specific peptidase 7
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SH3GL2 SH3-domain GRB2-like 2
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
TAGLN transgelin
TCEAL2 transcription elongation factor A (SII)-like 2
THOP1 thimet oligopeptidase 1
TLX3 T-cell leukemia homeobox 3
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM156 transmembrane protein 156
TMEM8A transmembrane protein 8A
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TNS2 tensin 2
TRDMT1 tRNA aspartic acid methyltransferase 1
UGT8 UDP glycosyltransferase 8
WDR25 WD repeat domain 25
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
ZBTB3 zinc finger and BTB domain containing 3
ZNF268 zinc finger protein 268
ZNF484 zinc finger protein 484
ZNF675 zinc finger protein 675
ZNF711 zinc finger protein 711
ZNF76 zinc finger protein 76
ZW10 zw10 kinetochore protein