PF-00875133-00-5923 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the PF-00875133-00-5923 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOE apolipoprotein E
ASIC1 acid sensing (proton gated) ion channel 1
BIRC3 baculoviral IAP repeat containing 3
BST2 bone marrow stromal cell antigen 2
C1R complement component 1, r subcomponent
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CLDN4 claudin 4
CREB1 cAMP responsive element binding protein 1
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DAPK2 death-associated protein kinase 2
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DOCK3 dedicator of cytokinesis 3
DST dystonin
DUSP13 dual specificity phosphatase 13
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ELOVL5 ELOVL fatty acid elongase 5
EPB41L1 erythrocyte membrane protein band 4.1-like 1
ERAP1 endoplasmic reticulum aminopeptidase 1
ETV5 ets variant 5
ETV6 ets variant 6
FBRS fibrosin
FGF23 fibroblast growth factor 23
FGFR4 fibroblast growth factor receptor 4
FRMD1 FERM domain containing 1
FSCN1 fascin actin-bundling protein 1
GID4 GID complex subunit 4
GMPR guanosine monophosphate reductase
GNG3 guanine nucleotide binding protein (G protein), gamma 3
HOXD1 homeobox D1
HYAL3 hyaluronoglucosaminidase 3
IRF2BP1 interferon regulatory factor 2 binding protein 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KLK8 kallikrein-related peptidase 8
LRP4 low density lipoprotein receptor-related protein 4
LRRC40 leucine rich repeat containing 40
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MAST2 microtubule associated serine/threonine kinase 2
MBOAT7 membrane bound O-acyltransferase domain containing 7
MEFV Mediterranean fever
MERTK MER proto-oncogene, tyrosine kinase
MRPS12 mitochondrial ribosomal protein S12
MT1H metallothionein 1H
NKX2-5 NK2 homeobox 5
P2RY11 purinergic receptor P2Y, G-protein coupled, 11
PBX2 pre-B-cell leukemia homeobox 2
PCNXL2 pecanex-like 2 (Drosophila)
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PLAA phospholipase A2-activating protein
PLCH1 phospholipase C, eta 1
PLEC plectin
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PRAMEF12 PRAME family member 12
PROSC proline synthetase co-transcribed homolog (bacterial)
PSG9 pregnancy specific beta-1-glycoprotein 9
PTBP3 polypyrimidine tract binding protein 3
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAB27B RAB27B, member RAS oncogene family
RABIF RAB interacting factor
RANBP1 RAN binding protein 1
RARA retinoic acid receptor, alpha
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RUSC2 RUN and SH3 domain containing 2
SAMD9 sterile alpha motif domain containing 9
SCYL2 SCY1-like 2 (S. cerevisiae)
SECTM1 secreted and transmembrane 1
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SLC39A9 solute carrier family 39, member 9
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SND1-IT1 SND1 intronic transcript 1
SOX9 SRY (sex determining region Y)-box 9
SPRY4 sprouty homolog 4 (Drosophila)
SRPR signal recognition particle receptor (docking protein)
TADA2A transcriptional adaptor 2A
TBX5 T-box 5
TEP1 telomerase-associated protein 1
TLR2 toll-like receptor 2
TMEM63A transmembrane protein 63A
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TOR1AIP1 torsin A interacting protein 1
TPP1 tripeptidyl peptidase I
TUBG2 tubulin, gamma 2
UBA6 ubiquitin-like modifier activating enzyme 6
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
WDR25 WD repeat domain 25
WDR62 WD repeat domain 62
ZNF365 zinc finger protein 365
ZNF384 zinc finger protein 384
ZNF552 zinc finger protein 552
ZNF639 zinc finger protein 639
ZNF821 zinc finger protein 821

decreased expression

Symbol Name
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ACTN4 actinin, alpha 4
ADM adrenomedullin
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALOX15 arachidonate 15-lipoxygenase
AMT aminomethyltransferase
ATAT1 alpha tubulin acetyltransferase 1
AVPR1B arginine vasopressin receptor 1B
CALML5 calmodulin-like 5
CAPN5 calpain 5
CCL22 chemokine (C-C motif) ligand 22
CDON cell adhesion associated, oncogene regulated
CEP85 centrosomal protein 85kDa
CES3 carboxylesterase 3
CFD complement factor D (adipsin)
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric)
COL16A1 collagen, type XVI, alpha 1
CPED1 cadherin-like and PC-esterase domain containing 1
CRYBB2P1 crystallin, beta B2 pseudogene 1
CSF1R colony stimulating factor 1 receptor
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8
DLK1 delta-like 1 homolog (Drosophila)
DNALI1 dynein, axonemal, light intermediate chain 1
DNASE1L3 deoxyribonuclease I-like 3
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DYSF dysferlin
ELSPBP1 epididymal sperm binding protein 1
EN2 engrailed homeobox 2
F11 coagulation factor XI
FAM212B family with sequence similarity 212, member B
FBXL7 F-box and leucine-rich repeat protein 7
FGF4 fibroblast growth factor 4
FHIT fragile histidine triad
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLJ11710 uncharacterized protein FLJ11710
FRMPD1 FERM and PDZ domain containing 1
GADD45G growth arrest and DNA-damage-inducible, gamma
GAL3ST4 galactose-3-O-sulfotransferase 4
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
GIF gastric intrinsic factor (vitamin B synthesis)
GNG7 guanine nucleotide binding protein (G protein), gamma 7
HDAC11 histone deacetylase 11
HOXA10 homeobox A10
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
IGSF6 immunoglobulin superfamily, member 6
INCENP inner centromere protein antigens 135/155kDa
IRS4 insulin receptor substrate 4
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
KCNK12 potassium channel, two pore domain subfamily K, member 12
KLK5 kallikrein-related peptidase 5
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LOC157562 uncharacterized LOC157562
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MFGE8 milk fat globule-EGF factor 8 protein
MLLT4-AS1 MLLT4 antisense RNA 1 (head to head)
MORN1 MORN repeat containing 1
MPDU1 mannose-P-dolichol utilization defect 1
MSI1 musashi RNA-binding protein 1
MYF5 myogenic factor 5
NDOR1 NADPH dependent diflavin oxidoreductase 1
NIPAL2 NIPA-like domain containing 2
NPFFR1 neuropeptide FF receptor 1
NPIPB3 nuclear pore complex interacting protein family, member B3
ONECUT2 one cut homeobox 2
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
OVGP1 oviductal glycoprotein 1, 120kDa
PACS1 phosphofurin acidic cluster sorting protein 1
PADI1 peptidyl arginine deiminase, type I
PARPBP PARP1 binding protein
PCDHB12 protocadherin beta 12
PCDHGA8 protocadherin gamma subfamily A, 8
PCDHGB5 protocadherin gamma subfamily B, 5
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PNPLA3 patatin-like phospholipase domain containing 3
PRAMEF10 PRAME family member 10
PRF1 perforin 1 (pore forming protein)
PRKCE protein kinase C, epsilon
PROL1 proline rich, lacrimal 1
PSG4 pregnancy specific beta-1-glycoprotein 4
RAB30 RAB30, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RNF126P1 ring finger protein 126 pseudogene 1
S100A12 S100 calcium binding protein A12
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SP1 Sp1 transcription factor
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STON1 stonin 1
TAS2R3 taste receptor, type 2, member 3
TCTN2 tectonic family member 2
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TMEM254 transmembrane protein 254
TPK1 thiamin pyrophosphokinase 1
WNT1 wingless-type MMTV integration site family, member 1
YIPF5 Yip1 domain family, member 5
YPEL1 yippee-like 1 (Drosophila)
ZBTB22 zinc finger and BTB domain containing 22