PF-00875133-00-5967 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the PF-00875133-00-5967 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADRBK1 adrenergic, beta, receptor kinase 1
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ARHGAP26 Rho GTPase activating protein 26
ARHGAP4 Rho GTPase activating protein 4
ARPIN actin-related protein 2/3 complex inhibitor
BCL2 B-cell CLL/lymphoma 2
BEGAIN brain-enriched guanylate kinase-associated
C14ORF1 chromosome 14 open reading frame 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD58 CD58 molecule
CD8A CD8a molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal)
CLCN1 chloride channel, voltage-sensitive 1
CNKSR2 connector enhancer of kinase suppressor of Ras 2
CNTD2 cyclin N-terminal domain containing 2
CNTFR ciliary neurotrophic factor receptor
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL7A1 collagen, type VII, alpha 1
CYLD cylindromatosis (turban tumor syndrome)
DAPK2 death-associated protein kinase 2
DENND5B DENN/MADD domain containing 5B
DMTN dematin actin binding protein
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
ETV5 ets variant 5
F2RL1 coagulation factor II (thrombin) receptor-like 1
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FGF5 fibroblast growth factor 5
FLJ11292
FPR1 formyl peptide receptor 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GAL galanin/GMAP prepropeptide
GMPR guanosine monophosphate reductase
GPC1 glypican 1
GPR182 G protein-coupled receptor 182
GPSM3 G-protein signaling modulator 3
GSK3A glycogen synthase kinase 3 alpha
HABP4 hyaluronan binding protein 4
HAND1 heart and neural crest derivatives expressed 1
HIPK2 homeodomain interacting protein kinase 2
HOXC8 homeobox C8
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ING1 inhibitor of growth family, member 1
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LARP6 La ribonucleoprotein domain family, member 6
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K7 mitogen-activated protein kinase kinase 7
MAPK7 mitogen-activated protein kinase 7
MAPK8 mitogen-activated protein kinase 8
MARCKS myristoylated alanine-rich protein kinase C substrate
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MNMIP1 manchette microtubule inner protein 1
MORC1 MORC family CW-type zinc finger 1
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYO15A myosin XVA
MYOZ3 myozenin 3
NR2E3 nuclear receptor subfamily 2, group E, member 3
PCNX pecanex homolog (Drosophila)
PDLIM4 PDZ and LIM domain 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLK3 polo-like kinase 3
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RGS5 regulator of G-protein signaling 5
RPL35A ribosomal protein L35a
RRP1B ribosomal RNA processing 1B
SAMD9 sterile alpha motif domain containing 9
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SFRP4 secreted frizzled-related protein 4
SLC38A4 solute carrier family 38, member 4
SPDEF SAM pointed domain containing ETS transcription factor
SPRY4 sprouty homolog 4 (Drosophila)
SRSF7 serine/arginine-rich splicing factor 7
STEAP4 STEAP family member 4
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCTN2 tectonic family member 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRDMT1 tRNA aspartic acid methyltransferase 1
TRIM36 tripartite motif containing 36
WDR62 WD repeat domain 62
YY1 YY1 transcription factor
ZBTB18 zinc finger and BTB domain containing 18
ZC4H2 zinc finger, C4H2 domain containing

decreased expression

Symbol Name
ADGRB2 adhesion G protein-coupled receptor B2
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
ALPK1 alpha-kinase 1
AMH anti-Mullerian hormone
ARID5A AT rich interactive domain 5A (MRF1-like)
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
AURKB aurora kinase B
BMP4 bone morphogenetic protein 4
BTF3P11 basic transcription factor 3 pseudogene 11
C5AR2 complement component 5a receptor 2
C8ORF44 chromosome 8 open reading frame 44
CA5BP1 carbonic anhydrase VB pseudogene 1
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCP110 centriolar coiled coil protein 110kDa
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CFAP45 cilia and flagella associated protein 45
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CNIH3 cornichon family AMPA receptor auxiliary protein 3
CNR2 cannabinoid receptor 2 (macrophage)
CRIP1 cysteine-rich protein 1 (intestinal)
CRMP1 collapsin response mediator protein 1
CRYBB2P1 crystallin, beta B2 pseudogene 1
CTRL chymotrypsin-like
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
EFNA3 ephrin-A3
ERCC2 excision repair cross-complementation group 2
FADS2 fatty acid desaturase 2
FAM131A family with sequence similarity 131, member A
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GPR143 G protein-coupled receptor 143
GPR19 G protein-coupled receptor 19
GUSBP3 glucuronidase, beta pseudogene 3
HDAC5 histone deacetylase 5
HIST1H2AI histone cluster 1, H2ai
HOXB2 homeobox B2
HOXC4 homeobox C4
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
IFI6 interferon, alpha-inducible protein 6
IFT54 intraflagellar transport 54
IRF2 interferon regulatory factor 2
KCNK5 potassium channel, two pore domain subfamily K, member 5
KDM8 lysine (K)-specific demethylase 8
KIAA0125 KIAA0125
KLHL28 kelch-like family member 28
LRRC6 leucine rich repeat containing 6
LRRC8E leucine rich repeat containing 8 family, member E
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MBTD1 mbt domain containing 1
MORN1 MORN repeat containing 1
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MRPS18C mitochondrial ribosomal protein S18C
NDRG4 NDRG family member 4
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NUPR1 nuclear protein, transcriptional regulator, 1
OPLAH 5-oxoprolinase (ATP-hydrolysing)
OSMR oncostatin M receptor
PADI1 peptidyl arginine deiminase, type I
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLSCR2 phospholipid scramblase 2
PRR4 proline rich 4 (lacrimal)
PVRL3 poliovirus receptor-related 3
RCN1 reticulocalbin 1, EF-hand calcium binding domain
SAYSD1 SAYSVFN motif domain containing 1
SCARA3 scavenger receptor class A, member 3
SCNN1B sodium channel, non voltage gated 1 beta subunit
SETD8 SET domain containing (lysine methyltransferase) 8
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC41A3 solute carrier family 41, member 3
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SSTR5 somatostatin receptor 5
STX5 syntaxin 5
SYCP2 synaptonemal complex protein 2
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TBC1D2 TBC1 domain family, member 2
TCHH trichohyalin
TESK1 testis-specific kinase 1
TMEM242 transmembrane protein 242
USP19 ubiquitin specific peptidase 19
WDR25 WD repeat domain 25
WNT16 wingless-type MMTV integration site family, member 16
ZFP69B ZFP69 zinc finger protein B
ZNF16 zinc finger protein 16
ZNF227 zinc finger protein 227
ZNF358 zinc finger protein 358
ZNF37BP zinc finger protein 37B, pseudogene
ZNF551 zinc finger protein 551