PF-01378883-00-6368 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the PF-01378883-00-6368 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ACTN2 actinin, alpha 2
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
AIM1L absent in melanoma 1-like
ANKRD6 ankyrin repeat domain 6
APC adenomatous polyposis coli
APOE apolipoprotein E
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATAT1 alpha tubulin acetyltransferase 1
ATN1 atrophin 1
BBC3 BCL2 binding component 3
BCAP29 B-cell receptor-associated protein 29
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C21ORF2 chromosome 21 open reading frame 2
CA9 carbonic anhydrase IX
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CCDC71 coiled-coil domain containing 71
CCDC85B coiled-coil domain containing 85B
CEP41 centrosomal protein 41kDa
CISH cytokine inducible SH2-containing protein
CLCN6 chloride channel, voltage-sensitive 6
CLPS colipase, pancreatic
COL6A1 collagen, type VI, alpha 1
DCN decorin
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EFNB3 ephrin-B3
EGFL7 EGF-like-domain, multiple 7
ELL elongation factor RNA polymerase II
FGFR2 fibroblast growth factor receptor 2
FKBP10 FK506 binding protein 10, 65 kDa
FOXO4 forkhead box O4
FYB FYN binding protein
GEMIN7 gem (nuclear organelle) associated protein 7
GIMAP5 GTPase, IMAP family member 5
GPC3 glypican 3
GPNMB glycoprotein (transmembrane) nmb
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HEMK1 HemK methyltransferase family member 1
HLA-DOB major histocompatibility complex, class II, DO beta
HOXB2 homeobox B2
HPS1 Hermansky-Pudlak syndrome 1
INHBA inhibin, beta A
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12
LAMP1 lysosomal-associated membrane protein 1
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
LRP1 low density lipoprotein receptor-related protein 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIIP migration and invasion inhibitory protein
NF1 neurofibromin 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NOX1 NADPH oxidase 1
NPPA natriuretic peptide A
NRG2 neuregulin 2
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OASL 2'-5'-oligoadenylate synthetase-like
PADI1 peptidyl arginine deiminase, type I
PDE4B phosphodiesterase 4B, cAMP-specific
PDE4D phosphodiesterase 4D, cAMP-specific
PID1 phosphotyrosine interaction domain containing 1
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PODNL1 podocan-like 1
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
RABIF RAB interacting factor
RAD51 RAD51 recombinase
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RNF126P1 ring finger protein 126 pseudogene 1
RPLP2 ribosomal protein, large, P2
RUNX1 runt-related transcription factor 1
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SLAMF7 SLAM family member 7
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SRRT serrate, RNA effector molecule
SSX3 synovial sarcoma, X breakpoint 3
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYT1 synaptotagmin I
TACC1 transforming, acidic coiled-coil containing protein 1
TAGLN3 transgelin 3
TBX1 T-box 1
TCP10 t-complex 10
TGFBI transforming growth factor, beta-induced, 68kDa
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TRPC1 transient receptor potential cation channel, subfamily C, member 1
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UST uronyl-2-sulfotransferase
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
WNT16 wingless-type MMTV integration site family, member 16
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZIC3 Zic family member 3
ZNF3 zinc finger protein 3
ZNF444 zinc finger protein 444
ZNF460 zinc finger protein 460
ZNF76 zinc finger protein 76
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMT aminomethyltransferase
AOC2 amine oxidase, copper containing 2 (retina-specific)
ASPHD1 aspartate beta-hydroxylase domain containing 1
BICC1 BicC family RNA binding protein 1
BIRC7 baculoviral IAP repeat containing 7
BMPR1B bone morphogenetic protein receptor, type IB
C1ORF95 chromosome 1 open reading frame 95
C4ORF29 chromosome 4 open reading frame 29
CCDC9 coiled-coil domain containing 9
CCNK cyclin K
CD300C CD300c molecule
CFAP70 cilia and flagella associated protein 70
CGA glycoprotein hormones, alpha polypeptide
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
CLEC4E C-type lectin domain family 4, member E
CLUL1 clusterin-like 1 (retinal)
COPZ2 coatomer protein complex, subunit zeta 2
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPNE7 copine VII
CST4 cystatin S
CT62 cancer/testis antigen 62
CYBA cytochrome b-245, alpha polypeptide
CYTH3 cytohesin 3
DDR2 discoidin domain receptor tyrosine kinase 2
DES desmin
DKFZP434C153 DKFZP434C153 protein
DOK5 docking protein 5
DPY19L1P1 DPY19L1 pseudogene 1
EDAR ectodysplasin A receptor
EIF5A2 eukaryotic translation initiation factor 5A2
EVI2A ecotropic viral integration site 2A
EYA4 EYA transcriptional coactivator and phosphatase 4
FBXO22 F-box protein 22
FBXO31 F-box protein 31
FGL1 fibrinogen-like 1
FLJ22184
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FOXC1 forkhead box C1
FRMD1 FERM domain containing 1
GJA8 gap junction protein, alpha 8, 50kDa
GSTTP1 glutathione S-transferase theta pseudogene 1
HIRA histone cell cycle regulator
HIST1H1D histone cluster 1, H1d
HIST1H2BO histone cluster 1, H2bo
IPO8 importin 8
IRX4 iroquois homeobox 4
ITK IL2-inducible T-cell kinase
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2
KCNIP1 Kv channel interacting protein 1
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KLHL29 kelch-like family member 29
KRT85 keratin 85, type II
LEFTY1 left-right determination factor 1
LMNB1 lamin B1
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAGEA6 melanoma antigen family A6
MAOB monoamine oxidase B
MFSD6 major facilitator superfamily domain containing 6
MRPL41 mitochondrial ribosomal protein L41
MRPS18C mitochondrial ribosomal protein S18C
MTA2 metastasis associated 1 family, member 2
MXRA8 matrix-remodelling associated 8
NPFFR1 neuropeptide FF receptor 1
NRIP3 nuclear receptor interacting protein 3
OR10H1 olfactory receptor, family 10, subfamily H, member 1
OSMR oncostatin M receptor
P2RY11 purinergic receptor P2Y, G-protein coupled, 11
PDCD1 programmed cell death 1
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDE9A phosphodiesterase 9A
PGK2 phosphoglycerate kinase 2
PGM5 phosphoglucomutase 5
PMP2 peripheral myelin protein 2
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PSG4 pregnancy specific beta-1-glycoprotein 4
RAB3D RAB3D, member RAS oncogene family
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RHBDD3 rhomboid domain containing 3
RIMS1 regulating synaptic membrane exocytosis 1
SCARF1 scavenger receptor class F, member 1
SCG2 secretogranin II
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SLC46A3 solute carrier family 46, member 3
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
STEAP4 STEAP family member 4
STK16 serine/threonine kinase 16
STMN4 stathmin-like 4
TAOK1 TAO kinase 1
TAS2R10 taste receptor, type 2, member 10
TMEM19 transmembrane protein 19
TMEM53 transmembrane protein 53
TTN titin
WDR78 WD repeat domain 78
ZNF446 zinc finger protein 446