| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/25114442 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in PF-04418948 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PIP | prolactin-induced protein | 1.15 |
| ZNF160 | zinc finger protein 160 | 0.97 |
| ATG2A | autophagy related 2A | 0.79 |
| BSN | bassoon presynaptic cytomatrix protein | 0.59 |
| ZNF3 | zinc finger protein 3 | 0.54 |
| RASSF5 | Ras association (RalGDS/AF-6) domain family member 5 | 0.52 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 0.52 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.49 |
| FBXW2 | F-box and WD repeat domain containing 2 | 0.46 |
| DUSP14 | dual specificity phosphatase 14 | 0.45 |
| XRCC2 | X-ray repair complementing defective repair in Chinese hamster cells 2 | 0.44 |
| ARHGEF26 | Rho guanine nucleotide exchange factor (GEF) 26 | 0.43 |
| MSLN | mesothelin | 0.4 |
| SOCS2 | suppressor of cytokine signaling 2 | 0.37 |
| CENPH | centromere protein H | 0.37 |
| AARS | alanyl-tRNA synthetase | 0.34 |
| HAPLN3 | hyaluronan and proteoglycan link protein 3 | 0.34 |
| ATP9B | ATPase, class II, type 9B | 0.34 |
| FBRSL1 | fibrosin-like 1 | 0.33 |
| PWWP2B | PWWP domain containing 2B | 0.32 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | 0.32 |
| SLC25A21 | solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 | 0.32 |
| NTAN1 | N-terminal asparagine amidase | 0.32 |
| TMC5 | transmembrane channel-like 5 | 0.32 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | 0.32 |
| DMTF1 | cyclin D binding myb-like transcription factor 1 | 0.32 |
| SNX21 | sorting nexin family member 21 | 0.31 |
| TMEM184C | transmembrane protein 184C | 0.31 |
| CEP70 | centrosomal protein 70kDa | 0.31 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | 0.3 |
| PTBP1 | polypyrimidine tract binding protein 1 | 0.3 |
| PRSS12 | protease, serine, 12 (neurotrypsin, motopsin) | 0.3 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.3 |
| PEX7 | peroxisomal biogenesis factor 7 | 0.3 |
| ZNF740 | zinc finger protein 740 | 0.3 |
| ZNF205 | zinc finger protein 205 | 0.3 |
| PLSCR3 | phospholipid scramblase 3 | 0.29 |
| LRRIQ1 | leucine-rich repeats and IQ motif containing 1 | 0.29 |
| ERCC6L2 | excision repair cross-complementation group 6-like 2 | 0.29 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | 0.29 |
| LRRC45 | leucine rich repeat containing 45 | 0.29 |
| ABCB4 | ATP-binding cassette, sub-family B (MDR/TAP), member 4 | 0.28 |
| SERAC1 | serine active site containing 1 | 0.28 |
| BPTF | bromodomain PHD finger transcription factor | 0.28 |
| ZHX1 | zinc fingers and homeoboxes 1 | 0.28 |
| B4GALT3 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 | 0.28 |
| FITM2 | fat storage-inducing transmembrane protein 2 | 0.28 |
| CBLC | Cbl proto-oncogene C, E3 ubiquitin protein ligase | 0.28 |
| GPN3 | GPN-loop GTPase 3 | 0.27 |
| ADGRL1 | adhesion G protein-coupled receptor L1 | 0.27 |
| PAXIP1 | PAX interacting (with transcription-activation domain) protein 1 | 0.27 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | 0.27 |
| ZNF746 | zinc finger protein 746 | 0.26 |
| FAM117A | family with sequence similarity 117, member A | 0.26 |
| ARHGEF40 | Rho guanine nucleotide exchange factor (GEF) 40 | 0.26 |
| ACTBL2 | actin, beta-like 2 | 0.26 |
| CACNB3 | calcium channel, voltage-dependent, beta 3 subunit | 0.26 |
| ANKEF1 | ankyrin repeat and EF-hand domain containing 1 | 0.26 |
| ANKLE1 | ankyrin repeat and LEM domain containing 1 | 0.25 |
| E2F2 | E2F transcription factor 2 | 0.25 |
| KRT222 | keratin 222, type II | 0.25 |
| EIF5A2 | eukaryotic translation initiation factor 5A2 | 0.25 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.25 |
| SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 | 0.25 |
| SPATA20 | spermatogenesis associated 20 | 0.25 |
| RMI2 | RecQ mediated genome instability 2 | 0.25 |
| ABHD17A | abhydrolase domain containing 17A | 0.25 |
| SPTA1 | spectrin, alpha, erythrocytic 1 | 0.24 |
| NCKAP5L | NCK-associated protein 5-like | 0.24 |
| PLK4 | polo-like kinase 4 | 0.24 |
| ABHD18 | abhydrolase domain containing 18 | 0.24 |
| VIM | vimentin | 0.24 |
| FAM20C | family with sequence similarity 20, member C | 0.24 |
| CST6 | cystatin E/M | 0.24 |
| NFKBIL1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 | 0.24 |
| GSTO2 | glutathione S-transferase omega 2 | 0.24 |
| TULP4 | tubby like protein 4 | 0.23 |
| RAB6B | RAB6B, member RAS oncogene family | 0.23 |
| PHLDB3 | pleckstrin homology-like domain, family B, member 3 | 0.23 |
| FOXM1 | forkhead box M1 | 0.23 |
| RAB36 | RAB36, member RAS oncogene family | 0.23 |
| ENO1 | enolase 1, (alpha) | 0.23 |
| VDR | vitamin D (1,25- dihydroxyvitamin D3) receptor | 0.23 |
| TNK2 | tyrosine kinase, non-receptor, 2 | 0.23 |
| ROR1 | receptor tyrosine kinase-like orphan receptor 1 | 0.23 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.23 |
| TECPR2 | tectonin beta-propeller repeat containing 2 | 0.23 |
| GPD1 | glycerol-3-phosphate dehydrogenase 1 (soluble) | 0.22 |
| RXRG | retinoid X receptor, gamma | 0.22 |
| PLPP6 | phospholipid phosphatase 6 | 0.22 |
| CYB5D2 | cytochrome b5 domain containing 2 | 0.22 |
| AMACR | alpha-methylacyl-CoA racemase | 0.22 |
| NR2C1 | nuclear receptor subfamily 2, group C, member 1 | 0.22 |
| TRIM7 | tripartite motif containing 7 | 0.22 |
| GCH1 | GTP cyclohydrolase 1 | 0.22 |
| TIGD5 | tigger transposable element derived 5 | 0.22 |
| ADAM22 | ADAM metallopeptidase domain 22 | 0.21 |
| CLCN2 | chloride channel, voltage-sensitive 2 | 0.21 |
| DHDDS | dehydrodolichyl diphosphate synthase | 0.21 |
| CRAT | carnitine O-acetyltransferase | 0.21 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MCF2L | MCF.2 cell line derived transforming sequence-like | -0.66 |
| FAM110C | family with sequence similarity 110, member C | -0.63 |
| INO80D | INO80 complex subunit D | -0.55 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | -0.54 |
| AHI1 | Abelson helper integration site 1 | -0.5 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.49 |
| PSEN2 | presenilin 2 | -0.47 |
| NFE2L3 | nuclear factor, erythroid 2-like 3 | -0.47 |
| FAM120C | family with sequence similarity 120C | -0.43 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.43 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.4 |
| AGAP2 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 | -0.4 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.39 |
| UBN1 | ubinuclein 1 | -0.39 |
| ZSCAN32 | zinc finger and SCAN domain containing 32 | -0.38 |
| C5 | complement component 5 | -0.38 |
| FASTK | Fas-activated serine/threonine kinase | -0.38 |
| TMPPE | transmembrane protein with metallophosphoesterase domain | -0.37 |
| RAC3 | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) | -0.37 |
| NHSL1 | NHS-like 1 | -0.37 |
| CELSR1 | cadherin, EGF LAG seven-pass G-type receptor 1 | -0.37 |
| ADCK5 | aarF domain containing kinase 5 | -0.37 |
| TSKU | tsukushi, small leucine rich proteoglycan | -0.36 |
| PUM2 | pumilio RNA-binding family member 2 | -0.35 |
| CILP2 | cartilage intermediate layer protein 2 | -0.35 |
| SERPING1 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | -0.35 |
| SYN2 | synapsin II | -0.35 |
| LYST | lysosomal trafficking regulator | -0.34 |
| ZNF264 | zinc finger protein 264 | -0.33 |
| MEGF8 | multiple EGF-like-domains 8 | -0.33 |
| NEBL | nebulette | -0.32 |
| STARD3 | StAR-related lipid transfer (START) domain containing 3 | -0.32 |
| CNEP1R1 | CTD nuclear envelope phosphatase 1 regulatory subunit 1 | -0.32 |
| IL6ST | interleukin 6 signal transducer | -0.31 |
| ZNF518A | zinc finger protein 518A | -0.31 |
| MICB | MHC class I polypeptide-related sequence B | -0.31 |
| RAB19 | RAB19, member RAS oncogene family | -0.31 |
| TBC1D12 | TBC1 domain family, member 12 | -0.31 |
| ZNF276 | zinc finger protein 276 | -0.31 |
| SLC27A3 | solute carrier family 27 (fatty acid transporter), member 3 | -0.31 |
| ERCC1 | excision repair cross-complementation group 1 | -0.3 |
| CPN1 | carboxypeptidase N, polypeptide 1 | -0.3 |
| ZFP1 | ZFP1 zinc finger protein | -0.3 |
| ZNF175 | zinc finger protein 175 | -0.3 |
| ABCC10 | ATP-binding cassette, sub-family C (CFTR/MRP), member 10 | -0.3 |
| ATXN7L3B | ataxin 7-like 3B | -0.29 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -0.29 |
| VSIR | V-set immunoregulatory receptor | -0.28 |
| APOB | apolipoprotein B | -0.28 |
| PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma | -0.28 |
| S100PBP | S100P binding protein | -0.27 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | -0.27 |
| SHC4 | SHC (Src homology 2 domain containing) family, member 4 | -0.27 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.27 |
| FCHO1 | FCH domain only 1 | -0.26 |
| ALG14 | ALG14, UDP-N-acetylglucosaminyltransferase subunit | -0.26 |
| CROCC2 | ciliary rootlet coiled-coil, rootletin family member 2 | -0.26 |
| MAN2A2 | mannosidase, alpha, class 2A, member 2 | -0.26 |
| TMEM179B | transmembrane protein 179B | -0.26 |
| CRAMP1 | cramped chromatin regulator homolog 1 | -0.26 |
| COMMD5 | COMM domain containing 5 | -0.26 |
| AKIRIN2 | akirin 2 | -0.26 |
| ZNF250 | zinc finger protein 250 | -0.26 |
| ZNF552 | zinc finger protein 552 | -0.26 |
| RASGRP2 | RAS guanyl releasing protein 2 (calcium and DAG-regulated) | -0.25 |
| HPX | hemopexin | -0.25 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | -0.25 |
| ZFP37 | ZFP37 zinc finger protein | -0.25 |
| GSTA1 | glutathione S-transferase alpha 1 | -0.25 |
| ZNF410 | zinc finger protein 410 | -0.25 |
| TMEM219 | transmembrane protein 219 | -0.25 |
| ADAT2 | adenosine deaminase, tRNA-specific 2 | -0.25 |
| ZNF444 | zinc finger protein 444 | -0.25 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.25 |
| MRPS18C | mitochondrial ribosomal protein S18C | -0.25 |
| KLK6 | kallikrein-related peptidase 6 | -0.24 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.24 |
| PPP2R5B | protein phosphatase 2, regulatory subunit B', beta | -0.24 |
| RPP14 | ribonuclease P/MRP 14kDa subunit | -0.24 |
| HECA | headcase homolog (Drosophila) | -0.24 |
| POLQ | polymerase (DNA directed), theta | -0.23 |
| BICRA | BRD4 interacting chromatin remodeling complex associated protein | -0.23 |
| SIAH1 | siah E3 ubiquitin protein ligase 1 | -0.23 |
| BIRC5 | baculoviral IAP repeat containing 5 | -0.23 |
| CYLD | cylindromatosis (turban tumor syndrome) | -0.23 |
| LSM11 | LSM11, U7 small nuclear RNA associated | -0.23 |
| ABCC9 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | -0.23 |
| FGG | fibrinogen gamma chain | -0.23 |
| SP140L | SP140 nuclear body protein-like | -0.23 |
| SLC49A4 | solute carrier family 49 member 4 | -0.22 |
| CCDC82 | coiled-coil domain containing 82 | -0.22 |
| MAPK12 | mitogen-activated protein kinase 12 | -0.22 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | -0.22 |
| MAST2 | microtubule associated serine/threonine kinase 2 | -0.22 |
| ZNF771 | zinc finger protein 771 | -0.22 |
| ZSWIM7 | zinc finger, SWIM-type containing 7 | -0.22 |
| BICRAL | BICRA like chromatin remodeling complex associated protein | -0.22 |
| C9ORF40 | chromosome 9 open reading frame 40 | -0.21 |
| ANKRD36C | ankyrin repeat domain 36C | -0.21 |
