| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/46926360 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in PF-04620110 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAV2 | neuron navigator 2 | 2.29 |
| CACNA1E | calcium channel, voltage-dependent, R type, alpha 1E subunit | 0.72 |
| FAT4 | FAT atypical cadherin 4 | 0.65 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.58 |
| DSCAM | Down syndrome cell adhesion molecule | 0.55 |
| LYST | lysosomal trafficking regulator | 0.48 |
| BAK1 | BCL2-antagonist/killer 1 | 0.43 |
| OPHN1 | oligophrenin 1 | 0.42 |
| EXPH5 | exophilin 5 | 0.41 |
| FAM189B | family with sequence similarity 189, member B | 0.4 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.4 |
| ZNF35 | zinc finger protein 35 | 0.39 |
| CYBA | cytochrome b-245, alpha polypeptide | 0.39 |
| MGA | MGA, MAX dimerization protein | 0.39 |
| BOK | BCL2-related ovarian killer | 0.38 |
| UCHL5 | ubiquitin carboxyl-terminal hydrolase L5 | 0.38 |
| GPBP1L1 | GC-rich promoter binding protein 1-like 1 | 0.38 |
| GEMIN7 | gem (nuclear organelle) associated protein 7 | 0.37 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.37 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.36 |
| ZNF692 | zinc finger protein 692 | 0.35 |
| DENND5A | DENN/MADD domain containing 5A | 0.35 |
| FKTN | fukutin | 0.35 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | 0.35 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | 0.35 |
| CCDC167 | coiled-coil domain containing 167 | 0.34 |
| DMWD | dystrophia myotonica, WD repeat containing | 0.34 |
| ZNF799 | zinc finger protein 799 | 0.34 |
| UBE2G2 | ubiquitin-conjugating enzyme E2G 2 | 0.34 |
| PAH | phenylalanine hydroxylase | 0.34 |
| TRAPPC6A | trafficking protein particle complex 6A | 0.34 |
| INPP5K | inositol polyphosphate-5-phosphatase K | 0.33 |
| LGALSL | lectin, galactoside-binding-like | 0.33 |
| MYH15 | myosin, heavy chain 15 | 0.33 |
| C19ORF47 | chromosome 19 open reading frame 47 | 0.33 |
| RPS27A | ribosomal protein S27a | 0.33 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.33 |
| CCDC112 | coiled-coil domain containing 112 | 0.33 |
| RPL15 | ribosomal protein L15 | 0.32 |
| PBLD | phenazine biosynthesis-like protein domain containing | 0.32 |
| NEIL1 | nei endonuclease VIII-like 1 (E. coli) | 0.32 |
| HIPK1 | homeodomain interacting protein kinase 1 | 0.32 |
| EIF5A2 | eukaryotic translation initiation factor 5A2 | 0.32 |
| GNG5 | guanine nucleotide binding protein (G protein), gamma 5 | 0.32 |
| CKM | creatine kinase, muscle | 0.31 |
| RPL37 | ribosomal protein L37 | 0.31 |
| ABCF1 | ATP-binding cassette, sub-family F (GCN20), member 1 | 0.3 |
| ANKRD20A4 | ankyrin repeat domain 20 family, member A4 | 0.3 |
| MTMR8 | myotubularin related protein 8 | 0.3 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | 0.3 |
| DPY19L2 | dpy-19-like 2 (C. elegans) | 0.3 |
| ZNF7 | zinc finger protein 7 | 0.3 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.29 |
| TEX15 | testis expressed 15 | 0.29 |
| KIAA1586 | KIAA1586 | 0.29 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | 0.29 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 0.28 |
| MED8 | mediator complex subunit 8 | 0.28 |
| PET100 | PET100 homolog (S. cerevisiae) | 0.28 |
| PSMD4 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 | 0.28 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | 0.28 |
| TRO | trophinin | 0.27 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.27 |
| CFAP58 | cilia and flagella associated protein 58 | 0.27 |
| SULF2 | sulfatase 2 | 0.27 |
| RARA | retinoic acid receptor, alpha | 0.27 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | 0.27 |
| IER5L | immediate early response 5-like | 0.26 |
| TBC1D12 | TBC1 domain family, member 12 | 0.26 |
| NHP2 | NHP2 ribonucleoprotein | 0.25 |
| GCAT | glycine C-acetyltransferase | 0.25 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.25 |
| HSD11B2 | hydroxysteroid (11-beta) dehydrogenase 2 | 0.25 |
| AARS | alanyl-tRNA synthetase | 0.25 |
| PPT2 | palmitoyl-protein thioesterase 2 | 0.25 |
| DNPEP | aspartyl aminopeptidase | 0.25 |
| MTA1 | metastasis associated 1 | 0.25 |
| PRMT6 | protein arginine methyltransferase 6 | 0.25 |
| BTBD1 | BTB (POZ) domain containing 1 | 0.24 |
| POLR2L | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa | 0.24 |
| ATP13A2 | ATPase type 13A2 | 0.24 |
| MRM2 | mitochondrial rRNA methyltransferase 2 | 0.24 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | 0.24 |
| SEPTIN4 | septin 4 | 0.23 |
| PGRMC1 | progesterone receptor membrane component 1 | 0.23 |
| METTL8 | methyltransferase like 8 | 0.23 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.23 |
| HRH1 | histamine receptor H1 | 0.23 |
| ESAM | endothelial cell adhesion molecule | 0.23 |
| NEB | nebulin | 0.23 |
| H3C1 | H3 clustered histone 1 | 0.23 |
| RARG | retinoic acid receptor, gamma | 0.22 |
| NFYA | nuclear transcription factor Y, alpha | 0.22 |
| DPYSL5 | dihydropyrimidinase-like 5 | 0.22 |
| ELOC | elongin C | 0.22 |
| ELF4 | E74-like factor 4 (ets domain transcription factor) | 0.22 |
| RCAN1 | regulator of calcineurin 1 | 0.22 |
| AVEN | apoptosis, caspase activation inhibitor | 0.21 |
| CCDC158 | coiled-coil domain containing 158 | 0.21 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZSCAN32 | zinc finger and SCAN domain containing 32 | -2.82 |
| PEX7 | peroxisomal biogenesis factor 7 | -2.33 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -2.23 |
| PIP | prolactin-induced protein | -1.83 |
| VAV1 | vav 1 guanine nucleotide exchange factor | -1.64 |
| ECM1 | extracellular matrix protein 1 | -1.31 |
| SBSN | suprabasin | -1.19 |
| PDE7A | phosphodiesterase 7A | -1.06 |
| MT1X | metallothionein 1X | -0.79 |
| RPL35 | ribosomal protein L35 | -0.78 |
| SERF2 | small EDRK-rich factor 2 | -0.74 |
| ATP8B2 | ATPase, aminophospholipid transporter, class I, type 8B, member 2 | -0.62 |
| LRRK1 | leucine-rich repeat kinase 1 | -0.61 |
| CCAR2 | cell cycle and apoptosis regulator 2 | -0.6 |
| ZBTB17 | zinc finger and BTB domain containing 17 | -0.58 |
| LARP6 | La ribonucleoprotein domain family, member 6 | -0.56 |
| PLIN2 | perilipin 2 | -0.55 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.54 |
| MYH7B | myosin, heavy chain 7B, cardiac muscle, beta | -0.54 |
| TUBAL3 | tubulin, alpha-like 3 | -0.54 |
| CBR3 | carbonyl reductase 3 | -0.53 |
| FBXO44 | F-box protein 44 | -0.52 |
| KSR2 | kinase suppressor of ras 2 | -0.52 |
| PIM1 | Pim-1 proto-oncogene, serine/threonine kinase | -0.51 |
| PGGHG | protein-glucosylgalactosylhydroxylysine glucosidase | -0.51 |
| DUOX1 | dual oxidase 1 | -0.5 |
| ZNF337 | zinc finger protein 337 | -0.5 |
| OSBPL1A | oxysterol binding protein-like 1A | -0.49 |
| NOL12 | nucleolar protein 12 | -0.48 |
| ZNF524 | zinc finger protein 524 | -0.48 |
| PML | promyelocytic leukemia | -0.48 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.47 |
| RNFT2 | ring finger protein, transmembrane 2 | -0.46 |
| SOX12 | SRY (sex determining region Y)-box 12 | -0.46 |
| PTK6 | protein tyrosine kinase 6 | -0.43 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -0.42 |
| DCBLD1 | discoidin, CUB and LCCL domain containing 1 | -0.41 |
| TMEM64 | transmembrane protein 64 | -0.4 |
| SMPD1 | sphingomyelin phosphodiesterase 1, acid lysosomal | -0.4 |
| ALG6 | ALG6, alpha-1,3-glucosyltransferase | -0.4 |
| FITM2 | fat storage-inducing transmembrane protein 2 | -0.39 |
| BMP1 | bone morphogenetic protein 1 | -0.38 |
| TMEM97 | transmembrane protein 97 | -0.38 |
| FGF2 | fibroblast growth factor 2 (basic) | -0.38 |
| CYP2U1 | cytochrome P450, family 2, subfamily U, polypeptide 1 | -0.37 |
| POF1B | premature ovarian failure, 1B | -0.37 |
| ABAT | 4-aminobutyrate aminotransferase | -0.37 |
| MATR3 | matrin 3 | -0.37 |
| HSPA8 | heat shock 70kDa protein 8 | -0.36 |
| PRMT2IP | PRMT2 interacting protein | -0.36 |
| ZNF367 | zinc finger protein 367 | -0.36 |
| SLC22A18 | solute carrier family 22, member 18 | -0.35 |
| YOD1 | YOD1 deubiquitinase | -0.35 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.35 |
| CHST3 | carbohydrate (chondroitin 6) sulfotransferase 3 | -0.35 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.35 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.35 |
| CENPJ | centromere protein J | -0.35 |
| TFAP4 | transcription factor AP-4 (activating enhancer binding protein 4) | -0.34 |
| USP46 | ubiquitin specific peptidase 46 | -0.34 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.34 |
| MIGA2 | mitoguardin 2 | -0.34 |
| TMEM51 | transmembrane protein 51 | -0.34 |
| CENPT | centromere protein T | -0.34 |
| ETNK2 | ethanolamine kinase 2 | -0.34 |
| REX1BD | required for excision 1-B domain containing | -0.33 |
| FN1 | fibronectin 1 | -0.33 |
| PPP1R2B | PPP1R2 family member B | -0.33 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | -0.32 |
| SLC45A4 | solute carrier family 45, member 4 | -0.32 |
| ATXN1L | ataxin 1-like | -0.32 |
| FRK | fyn-related Src family tyrosine kinase | -0.32 |
| OTUD5 | OTU deubiquitinase 5 | -0.32 |
| MED12L | mediator complex subunit 12-like | -0.32 |
| CCDC66 | coiled-coil domain containing 66 | -0.32 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.32 |
| SPATA2L | spermatogenesis associated 2-like | -0.31 |
| FAM102B | family with sequence similarity 102, member B | -0.31 |
| INPP5E | inositol polyphosphate-5-phosphatase, 72 kDa | -0.31 |
| TMEM134 | transmembrane protein 134 | -0.31 |
| RPGR | retinitis pigmentosa GTPase regulator | -0.31 |
| S100A14 | S100 calcium binding protein A14 | -0.31 |
| TMEM120A | transmembrane protein 120A | -0.31 |
| DMD | dystrophin | -0.31 |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | -0.3 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.3 |
| INPP5B | inositol polyphosphate-5-phosphatase, 75kDa | -0.3 |
| SPHK2 | sphingosine kinase 2 | -0.3 |
| ASTE1 | asteroid homolog 1 (Drosophila) | -0.3 |
| HAL | histidine ammonia-lyase | -0.3 |
| MTUS2 | microtubule associated tumor suppressor candidate 2 | -0.3 |
| CBX7 | chromobox homolog 7 | -0.3 |
| ZNF320 | zinc finger protein 320 | -0.29 |
| MRPL57 | mitochondrial ribosomal protein L57 | -0.29 |
| PGK2 | phosphoglycerate kinase 2 | -0.29 |
| TOB2 | transducer of ERBB2, 2 | -0.29 |
| SDHAF4 | succinate dehydrogenase complex assembly factor 4 | -0.29 |
| TMEM41A | transmembrane protein 41A | -0.29 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | -0.28 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.28 |
