| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | PF-06260933 perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the PF-06260933_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.104563 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0741522 |
| FBN1 | fibrillin 1 | 0.0710531 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0655763 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0482567 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0438379 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0433889 |
| LOXL2 | lysyl oxidase-like 2 | 0.040611 |
| ATP13A3 | ATPase type 13A3 | 0.0396838 |
| GPC6 | glypican 6 | 0.0384706 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0382154 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0366342 |
| FLNB | filamin B, beta | 0.0357504 |
| COL1A2 | collagen, type I, alpha 2 | 0.0351851 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0347081 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0342761 |
| SBF2 | SET binding factor 2 | 0.0341611 |
| STC1 | stanniocalcin 1 | 0.0331819 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0317607 |
| OGA | O-GlcNAcase | 0.0306733 |
| CD44 | CD44 molecule (Indian blood group) | 0.030456 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0302174 |
| C1D | C1D nuclear receptor corepressor | 0.0294059 |
| OPTN | optineurin | 0.0291018 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0286995 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0283612 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0282409 |
| MT2A | metallothionein 2A | 0.0281461 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0280488 |
| NDRG1 | N-myc downstream regulated 1 | 0.0268878 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0264039 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0254314 |
| RNF145 | ring finger protein 145 | 0.0253706 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0252788 |
| SETD5 | SET domain containing 5 | 0.0252304 |
| GOLGA4 | golgin A4 | 0.0248696 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0248469 |
| C1GALT1 | core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 | 0.0243156 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0242811 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0242322 |
| VEGFA | vascular endothelial growth factor A | 0.0236229 |
| UBC | ubiquitin C | 0.0233008 |
| ARRDC3 | arrestin domain containing 3 | 0.0230678 |
| SQSTM1 | sequestosome 1 | 0.0229 |
| WDFY1 | WD repeat and FYVE domain containing 1 | 0.022442 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0224342 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0223487 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0215677 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0215577 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0212923 |
| CD109 | CD109 molecule | 0.0209085 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0208552 |
| HELZ | helicase with zinc finger | 0.0208487 |
| RTN4 | reticulon 4 | 0.0207487 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0203124 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0202185 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0199013 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0196385 |
| NAV2 | neuron navigator 2 | 0.019547 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.019069 |
| YEATS2 | YEATS domain containing 2 | 0.0189947 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0189679 |
| PRKD3 | protein kinase D3 | 0.0188951 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0188098 |
| ZNF292 | zinc finger protein 292 | 0.0187774 |
| KIAA1217 | KIAA1217 | 0.0187059 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0187045 |
| RUNX1 | runt-related transcription factor 1 | 0.0186565 |
| TMOD1 | tropomodulin 1 | 0.0183882 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0183853 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0180741 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | 0.017904 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.017666 |
| ATXN1 | ataxin 1 | 0.0176379 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0175924 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0174582 |
| NGLY1 | N-glycanase 1 | 0.0174459 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0174302 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0173969 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0169235 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0168436 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0167863 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0167799 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0167587 |
| B2M | beta-2-microglobulin | 0.0166781 |
| RNF24 | ring finger protein 24 | 0.0166521 |
| FNIP1 | folliculin interacting protein 1 | 0.0165592 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0165214 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0163936 |
| CLU | clusterin | 0.0163126 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0162879 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0162803 |
| FMNL2 | formin-like 2 | 0.0161036 |
| WTAP | Wilms tumor 1 associated protein | 0.0158886 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0158733 |
| KIFAP3 | kinesin-associated protein 3 | 0.0158405 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0158396 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0155266 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0153837 |
| ANK2 | ankyrin 2, neuronal | 0.015336 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CDH13 | cadherin 13 | -0.14773 |
| VIM | vimentin | -0.146764 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.134958 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.134253 |
| AHNAK | AHNAK nucleoprotein | -0.0976459 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0909889 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0869726 |
| COL5A1 | collagen, type V, alpha 1 | -0.0844657 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0780871 |
| FN1 | fibronectin 1 | -0.0774586 |
| PODXL | podocalyxin-like | -0.0750034 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0728265 |
| TMSB10 | thymosin beta 10 | -0.0687343 |
| MAP1B | microtubule-associated protein 1B | -0.0658529 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0655951 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0587717 |
| SUCNR1 | succinate receptor 1 | -0.0494442 |
| CANX | calnexin | -0.0489673 |
| S100A10 | S100 calcium binding protein A10 | -0.0489369 |
| NAV1 | neuron navigator 1 | -0.0487379 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0485255 |
| PLAT | plasminogen activator, tissue | -0.0462202 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0461875 |
| RIGI | RNA sensor RIG-I | -0.0456184 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0453089 |
| EFNA5 | ephrin-A5 | -0.0438415 |
| FSTL1 | follistatin-like 1 | -0.0433384 |
| S100A6 | S100 calcium binding protein A6 | -0.0419224 |
| PRSS23 | protease, serine, 23 | -0.0402085 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0389124 |
| DGKG | diacylglycerol kinase, gamma 90kDa | -0.0376316 |
| EGFR | epidermal growth factor receptor | -0.0373973 |
| LMNA | lamin A/C | -0.0366237 |
| ASPH | aspartate beta-hydroxylase | -0.0361768 |
| CCND1 | cyclin D1 | -0.0358128 |
| CYTH3 | cytohesin 3 | -0.0356852 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.035408 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.035238 |
| CUX1 | cut-like homeobox 1 | -0.0345779 |
| CALR | calreticulin | -0.0339938 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.03318 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0328738 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0319443 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0315138 |
| TPM4 | tropomyosin 4 | -0.0314381 |
| TMSB4X | thymosin beta 4, X-linked | -0.0297965 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0296832 |
| PLXNA2 | plexin A2 | -0.0293903 |
| LRRC17 | leucine rich repeat containing 17 | -0.02922 |
| THBS2 | thrombospondin 2 | -0.0284622 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0283855 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0280614 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0279729 |
| CSTB | cystatin B (stefin B) | -0.0274228 |
| CAVIN1 | caveolae associated protein 1 | -0.0262464 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0260489 |
| IL7R | interleukin 7 receptor | -0.0256174 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.0253405 |
| FRMD4A | FERM domain containing 4A | -0.0249618 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | -0.02438 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0236122 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0234282 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | -0.0233403 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | -0.0232391 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0231289 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0230715 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0227605 |
| CENPF | centromere protein F, 350/400kDa | -0.0219287 |
| KRT81 | keratin 81, type II | -0.021793 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.021454 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0212872 |
| SP100 | SP100 nuclear antigen | -0.0212651 |
| FMN2 | formin 2 | -0.0211683 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0209648 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0205882 |
| RASAL2 | RAS protein activator like 2 | -0.0205106 |
| TNS3 | tensin 3 | -0.0203693 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0203192 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.020186 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0200962 |
| INTS6 | integrator complex subunit 6 | -0.0196521 |
| PCDH7 | protocadherin 7 | -0.0196369 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0194574 |
| LOX | lysyl oxidase | -0.0192329 |
| TPM1 | tropomyosin 1 (alpha) | -0.0192214 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | -0.018972 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | -0.0188798 |
| S100A4 | S100 calcium binding protein A4 | -0.0186394 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0186211 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0186203 |
| ENO1 | enolase 1, (alpha) | -0.0185189 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0182916 |
| KIAA1549L | KIAA1549-like | -0.0181964 |
| ZNF217 | zinc finger protein 217 | -0.0181753 |
| SASH1 | SAM and SH3 domain containing 1 | -0.0180361 |
| TAGLN2 | transgelin 2 | -0.0177391 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0174672 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0170387 |
| C12ORF75 | chromosome 12 open reading frame 75 | -0.0168765 |
| ACTG1 | actin gamma 1 | -0.0167078 |
