| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | PF-06260933 perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the PF-06260933_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.129856 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.127838 |
| NLGN1 | neuroligin 1 | 0.125498 |
| HMGA2 | high mobility group AT-hook 2 | 0.0961705 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0924472 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0767617 |
| DST | dystonin | 0.074239 |
| YAP1 | Yes-associated protein 1 | 0.0716058 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0705825 |
| PCDH7 | protocadherin 7 | 0.0675906 |
| NEBL | nebulette | 0.0640607 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.063731 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.059057 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0532773 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.053128 |
| RTN4 | reticulon 4 | 0.0529003 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0520503 |
| ACTG1 | actin gamma 1 | 0.0514006 |
| NHSL1 | NHS-like 1 | 0.0511773 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.0505851 |
| ASPH | aspartate beta-hydroxylase | 0.0499643 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0479555 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0466201 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.045408 |
| PDGFC | platelet derived growth factor C | 0.0446766 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.044621 |
| CELF2 | CUGBP, Elav-like family member 2 | 0.0444883 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0442175 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0436099 |
| RASAL2 | RAS protein activator like 2 | 0.0434504 |
| CMIP | c-Maf inducing protein | 0.0422051 |
| USP34 | ubiquitin specific peptidase 34 | 0.0417322 |
| LDHA | lactate dehydrogenase A | 0.0417017 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.041361 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0405952 |
| JMJD1C | jumonji domain containing 1C | 0.0391581 |
| BRD2 | bromodomain containing 2 | 0.0388276 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0386004 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0384344 |
| EHBP1 | EH domain binding protein 1 | 0.0383371 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0380049 |
| MKI67 | marker of proliferation Ki-67 | 0.0376487 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0374636 |
| TMEM41B | transmembrane protein 41B | 0.0366377 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0359486 |
| ANXA1 | annexin A1 | 0.0356657 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0350188 |
| DOCK1 | dedicator of cytokinesis 1 | 0.034927 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0347234 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0343296 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.033691 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0332689 |
| DTNA | dystrobrevin, alpha | 0.0331524 |
| SMYD3 | SET and MYND domain containing 3 | 0.0330567 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0326727 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0323626 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0323501 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0321028 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0318933 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0318792 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0318094 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.031762 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0317561 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0317158 |
| EGR1 | early growth response 1 | 0.0316276 |
| MSRB3 | methionine sulfoxide reductase B3 | 0.0311871 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0305403 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.0303263 |
| INTS6 | integrator complex subunit 6 | 0.0300681 |
| PRDX1 | peroxiredoxin 1 | 0.0299471 |
| NUP98 | nucleoporin 98kDa | 0.0296092 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0290486 |
| PCBP2 | poly(rC) binding protein 2 | 0.029029 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0287452 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0287039 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.028656 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0280665 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0279633 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0278387 |
| ADIPOR2 | adiponectin receptor 2 | 0.0277998 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0275643 |
| TENM3 | teneurin transmembrane protein 3 | 0.0275119 |
| XPOT | exportin, tRNA | 0.0274752 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | 0.0274531 |
| NRXN3 | neurexin 3 | 0.0272123 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0271512 |
| RPS3 | ribosomal protein S3 | 0.0265195 |
| PRKCE | protein kinase C, epsilon | 0.0264973 |
| NECTIN3 | nectin cell adhesion molecule 3 | 0.0259597 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.0257097 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0255672 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0254041 |
| R3HDM2 | R3H domain containing 2 | 0.0253698 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0252489 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.025202 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0249871 |
| EXOC6B | exocyst complex component 6B | 0.0249816 |
| GSE1 | Gse1 coiled-coil protein | 0.0248169 |
| MYPN | myopalladin | 0.0244649 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0243291 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0542914 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.052712 |
| H1-0 | H1.0 linker histone | -0.0488389 |
| MYL12B | myosin, light chain 12B, regulatory | -0.047958 |
| VIM | vimentin | -0.0442226 |
| RPLP1 | ribosomal protein, large, P1 | -0.0398802 |
| RPS27A | ribosomal protein S27a | -0.0397095 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0376505 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0372934 |
| HMGA1 | high mobility group AT-hook 1 | -0.0372202 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0370271 |
| RPL12 | ribosomal protein L12 | -0.0353344 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0333822 |
| RPS6 | ribosomal protein S6 | -0.0315947 |
| AREG | amphiregulin | -0.0313829 |
| CLDN1 | claudin 1 | -0.0311419 |
| FTL | ferritin, light polypeptide | -0.0311289 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0302947 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0296294 |
| RPS24 | ribosomal protein S24 | -0.0287296 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0283046 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0275912 |
| RPL35A | ribosomal protein L35a | -0.0274772 |
| YBX1 | Y box binding protein 1 | -0.0271701 |
| RPS16 | ribosomal protein S16 | -0.0271348 |
| RPL19 | ribosomal protein L19 | -0.0261 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.0257262 |
| ZNF217 | zinc finger protein 217 | -0.0255983 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0251616 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0247776 |
| RPL34 | ribosomal protein L34 | -0.0246576 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0241023 |
| RPL32 | ribosomal protein L32 | -0.0239414 |
| OGA | O-GlcNAcase | -0.0238492 |
| HMGB1 | high mobility group box 1 | -0.0238366 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0236457 |
| S100A6 | S100 calcium binding protein A6 | -0.0235394 |
| AHNAK | AHNAK nucleoprotein | -0.0234413 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0233089 |
| RPLP0 | ribosomal protein, large, P0 | -0.0229778 |
| CANX | calnexin | -0.022946 |
| RPL38 | ribosomal protein L38 | -0.0226443 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | -0.0225899 |
| TMEM123 | transmembrane protein 123 | -0.0221931 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0208312 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.02068 |
| TMSB10 | thymosin beta 10 | -0.0202333 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0194632 |
| NIPSNAP2 | nipsnap homolog 2 | -0.0194412 |
| SPTSSA | serine palmitoyltransferase, small subunit A | -0.0186471 |
| FBXO11 | F-box protein 11 | -0.0184962 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0184658 |
| RPL36A | ribosomal protein L36a | -0.0183908 |
| SLC38A1 | solute carrier family 38, member 1 | -0.018304 |
| MGAT4C | MGAT4 family, member C | -0.0182476 |
| CD2AP | CD2-associated protein | -0.0181233 |
| RPL27A | ribosomal protein L27a | -0.0180575 |
| LMO7 | LIM domain 7 | -0.0179333 |
| STAG2 | stromal antigen 2 | -0.0175743 |
| RPL6 | ribosomal protein L6 | -0.0175658 |
| RPL8 | ribosomal protein L8 | -0.0175057 |
| PTMA | prothymosin, alpha | -0.0174391 |
| RPS19 | ribosomal protein S19 | -0.0173066 |
| KLHL24 | kelch-like family member 24 | -0.0172268 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0169352 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0169019 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.016884 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0167601 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0166035 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0163776 |
| RPS5 | ribosomal protein S5 | -0.016267 |
| SPAG9 | sperm associated antigen 9 | -0.0161771 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0161221 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0160822 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0160734 |
| NEMF | nuclear export mediator factor | -0.0159977 |
| HMGB2 | high mobility group box 2 | -0.0158434 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0157674 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0155997 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit | -0.015549 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0151944 |
| THOC1 | THO complex 1 | -0.015161 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.0149254 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0148832 |
| PARK7 | parkinson protein 7 | -0.0146453 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0146442 |
| SRP72 | signal recognition particle 72kDa | -0.0146262 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0143634 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0143184 |
| NEK7 | NIMA-related kinase 7 | -0.0142458 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0141667 |
| RPL37 | ribosomal protein L37 | -0.0141273 |
| SETD5 | SET domain containing 5 | -0.0141064 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0141029 |
| DNM1L | dynamin 1-like | -0.0140093 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0139669 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0138867 |
| HBP1 | HMG-box transcription factor 1 | -0.0138653 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | -0.0138426 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0137888 |
