PF-06260933_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description PF-06260933 perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the PF-06260933_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TSC22D1 TSC22 domain family, member 1 0.152822
LCN2 lipocalin 2 0.143226
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.109112
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0848238
SMAD3 SMAD family member 3 0.0713944
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.060717
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0505026
SHB Src homology 2 domain containing adaptor protein B 0.048508
FTL ferritin, light polypeptide 0.0468517
HLA-B major histocompatibility complex, class I, B 0.044137
EXT1 exostosin glycosyltransferase 1 0.0430072
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0421582
GCLC glutamate-cysteine ligase, catalytic subunit 0.0405374
EFNB2 ephrin-B2 0.0404115
PDZD8 PDZ domain containing 8 0.0403841
FAT1 FAT atypical cadherin 1 0.0397459
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0392839
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0361966
HSPH1 heat shock 105kDa/110kDa protein 1 0.0358793
AKAP13 A kinase (PRKA) anchor protein 13 0.0350478
HKDC1 hexokinase domain containing 1 0.0326853
PRRC2C proline-rich coiled-coil 2C 0.0326172
KLF5 Kruppel-like factor 5 (intestinal) 0.030349
VEGFA vascular endothelial growth factor A 0.0282308
CST3 cystatin C 0.0265153
RPL12 ribosomal protein L12 0.0263639
RRBP1 ribosome binding protein 1 0.0259497
HSPA8 heat shock 70kDa protein 8 0.0258629
MATR3 matrin 3 0.0257899
AFF1 AF4/FMR2 family, member 1 0.0255392
CTSB cathepsin B 0.025498
ETV6 ets variant 6 0.0251958
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0250685
DST dystonin 0.024718
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0245416
SEPTIN9 septin 9 0.0243334
PARP4 poly (ADP-ribose) polymerase family, member 4 0.024275
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0241122
DPP4 dipeptidyl-peptidase 4 0.0239832
PHF3 PHD finger protein 3 0.0238652
ASPH aspartate beta-hydroxylase 0.0236837
KLF6 Kruppel-like factor 6 0.023245
ZC3H13 zinc finger CCCH-type containing 13 0.0230595
YAP1 Yes-associated protein 1 0.023014
LURAP1L leucine rich adaptor protein 1-like 0.0229708
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0228767
SOX9 SRY (sex determining region Y)-box 9 0.0228496
APP amyloid beta (A4) precursor protein 0.022789
B2M beta-2-microglobulin 0.0225441
RAD23B RAD23 homolog B (S. cerevisiae) 0.0225315
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0224966
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0224425
DUSP10 dual specificity phosphatase 10 0.0223591
LMO7 LIM domain 7 0.0223005
IRS2 insulin receptor substrate 2 0.0219448
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0217898
DSCAM Down syndrome cell adhesion molecule 0.0217496
FNIP2 folliculin interacting protein 2 0.021334
MLPH melanophilin 0.0209975
RPL18 ribosomal protein L18 0.0206043
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0203101
TMEM65 transmembrane protein 65 0.0200183
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.019866
TJP1 tight junction protein 1 0.0197589
TRERF1 transcriptional regulating factor 1 0.0195561
ERN1 endoplasmic reticulum to nucleus signaling 1 0.019462
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0194517
EPCAM epithelial cell adhesion molecule 0.0190288
SRRM2 serine/arginine repetitive matrix 2 0.0190088
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 0.0189001
KYNU kynureninase 0.0188426
SFTPA2 surfactant protein A2 0.0187541
CXCL8 chemokine (C-X-C motif) ligand 8 0.0185817
TRIB1 tribbles pseudokinase 1 0.018242
MCU mitochondrial calcium uniporter 0.0182177
HOMER2 homer scaffolding protein 2 0.0181999
SLTM SAFB-like, transcription modulator 0.0181653
MYO5B myosin VB 0.0179935
ANXA1 annexin A1 0.0178883
PLPP3 phospholipid phosphatase 3 0.0177982
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0176832
IFI6 interferon, alpha-inducible protein 6 0.0175544
RPL26 ribosomal protein L26 0.017447
SET SET nuclear proto-oncogene 0.0173093
FHIT fragile histidine triad 0.0172165
MYH9 myosin, heavy chain 9, non-muscle 0.0170596
SIK3 SIK family kinase 3 0.0170457
MUC13 mucin 13, cell surface associated 0.0167198
FHL2 four and a half LIM domains 2 0.016671
TMED2 transmembrane emp24 domain trafficking protein 2 0.0166438
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0163638
TBK1 TANK-binding kinase 1 0.0163375
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0161808
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0161705
MEIS2 Meis homeobox 2 0.0160817
RND3 Rho family GTPase 3 0.0160522
CLDN4 claudin 4 0.0159728
CDHR2 cadherin-related family member 2 0.0159684
IFNGR1 interferon gamma receptor 1 0.0158437
DUSP16 dual specificity phosphatase 16 0.015827

decreased expression

Symbol Name Standardized Value
LYZ lysozyme -0.131568
NDRG1 N-myc downstream regulated 1 -0.0898625
FNDC3B fibronectin type III domain containing 3B -0.0884038
GMDS GDP-mannose 4,6-dehydratase -0.0874861
ZMYND8 zinc finger, MYND-type containing 8 -0.0787959
NPSR1 neuropeptide S receptor 1 -0.0773747
PTMA prothymosin, alpha -0.0748378
EPSTI1 epithelial stromal interaction 1 (breast) -0.0709118
ERBIN erbb2 interacting protein -0.0706441
IGFBP3 insulin-like growth factor binding protein 3 -0.066289
PRKCA protein kinase C, alpha -0.0606396
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0596321
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0539566
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0532528
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0506379
SSH2 slingshot protein phosphatase 2 -0.0497483
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0489191
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0470087
EGR1 early growth response 1 -0.0463932
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0462144
P4HB prolyl 4-hydroxylase, beta polypeptide -0.045578
PDIA3 protein disulfide isomerase family A, member 3 -0.0450453
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0428661
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.042861
TXNIP thioredoxin interacting protein -0.0423468
PLSCR1 phospholipid scramblase 1 -0.042085
MX1 MX dynamin-like GTPase 1 -0.0419566
RABGAP1L RAB GTPase activating protein 1-like -0.0413091
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0409921
VMP1 vacuole membrane protein 1 -0.0407311
EZR ezrin -0.0401461
IFI27 interferon, alpha-inducible protein 27 -0.0398337
ZCCHC7 zinc finger, CCHC domain containing 7 -0.039651
LOC102724023 ES1 protein homolog, mitochondrial -0.0396086
MAML2 mastermind-like 2 (Drosophila) -0.0395334
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0394161
CCNL1 cyclin L1 -0.0392479
SEC31A SEC31 homolog A (S. cerevisiae) -0.0388716
PERP PERP, TP53 apoptosis effector -0.0388564
MXD1 MAX dimerization protein 1 -0.0382675
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0379005
S100A6 S100 calcium binding protein A6 -0.0372948
ANXA2 annexin A2 -0.0369929
RAB7A RAB7A, member RAS oncogene family -0.0364281
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0359355
PATJ PATJ crumbs cell polarity complex component -0.0357229
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0355049
C6ORF132 chromosome 6 open reading frame 132 -0.0345207
TTC3 tetratricopeptide repeat domain 3 -0.0344273
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0339605
COG6 component of oligomeric golgi complex 6 -0.0338923
AREG amphiregulin -0.0330983
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0326738
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -0.0319781
RIGI RNA sensor RIG-I -0.0319378
NPEPPS aminopeptidase puromycin sensitive -0.031904
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.031388
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0310915
FNDC3A fibronectin type III domain containing 3A -0.030914
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0308785
ITGA6 integrin, alpha 6 -0.030678
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0305851
ZBTB20 zinc finger and BTB domain containing 20 -0.0305712
TNS4 tensin 4 -0.0297156
TRIO trio Rho guanine nucleotide exchange factor -0.0296836
COPA coatomer protein complex, subunit alpha -0.0292379
MAGT1 magnesium transporter 1 -0.0291266
HM13 histocompatibility (minor) 13 -0.0288948
PARD3 par-3 family cell polarity regulator -0.0288251
KIF16B kinesin family member 16B -0.0286911
SLC44A1 solute carrier family 44 (choline transporter), member 1 -0.0286214
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0284712
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.028316
DDIT3 DNA-damage-inducible transcript 3 -0.0282788
ARHGAP26 Rho GTPase activating protein 26 -0.0282481
TPM4 tropomyosin 4 -0.0282353
TMSB10 thymosin beta 10 -0.0275057
CMIP c-Maf inducing protein -0.0274068
RBM39 RNA binding motif protein 39 -0.0273409
SPDYA speedy/RINGO cell cycle regulator family member A -0.0271572
SCFD1 sec1 family domain containing 1 -0.027113
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0269392
SCARB1 scavenger receptor class B, member 1 -0.0269294
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0268306
VIM vimentin -0.026827
OXSR1 oxidative stress responsive 1 -0.0267915
RAB6A RAB6A, member RAS oncogene family -0.0267401
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0266808
STS steroid sulfatase (microsomal), isozyme S -0.0262424
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0261678
HLA-E major histocompatibility complex, class I, E -0.0259579
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) -0.0259494
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0259107
GNAS GNAS complex locus -0.0257968
WASF2 WAS protein family, member 2 -0.0257864
ARF4 ADP-ribosylation factor 4 -0.0257435
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0257145
TSHZ2 teashirt zinc finger homeobox 2 -0.0256997
WDR45B WD repeat domain 45B -0.0256134
SREBF2 sterol regulatory element binding transcription factor 2 -0.0253248