PF-06260933_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description PF-06260933 perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the PF-06260933_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.209012
EEF2 eukaryotic translation elongation factor 2 0.105334
KRT18 keratin 18, type I 0.0920578
FAT1 FAT atypical cadherin 1 0.0889261
FTL ferritin, light polypeptide 0.0852853
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0845818
RPS3 ribosomal protein S3 0.0844954
RPS8 ribosomal protein S8 0.0825185
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0806638
LDHA lactate dehydrogenase A 0.0798326
VEGFA vascular endothelial growth factor A 0.0786927
TMSB10 thymosin beta 10 0.07703
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0702151
HSPA8 heat shock 70kDa protein 8 0.0671288
ENO1 enolase 1, (alpha) 0.0624461
TPT1 tumor protein, translationally-controlled 1 0.058798
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0585688
MYH9 myosin, heavy chain 9, non-muscle 0.0579506
RPS6 ribosomal protein S6 0.0545795
PTMA prothymosin, alpha 0.0539738
RACK1 receptor for activated C kinase 1 0.0519596
MT2A metallothionein 2A 0.0517204
PRRC2C proline-rich coiled-coil 2C 0.0490749
MACF1 microtubule-actin crosslinking factor 1 0.0483765
PKM pyruvate kinase, muscle 0.047973
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0457415
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0453004
RPS12 ribosomal protein S12 0.0449391
HLA-B major histocompatibility complex, class I, B 0.0439864
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0433884
BRD2 bromodomain containing 2 0.0433767
RPS19 ribosomal protein S19 0.0418227
RPL26 ribosomal protein L26 0.0415495
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0394326
SRRM2 serine/arginine repetitive matrix 2 0.0394053
KTN1 kinectin 1 (kinesin receptor) 0.0392404
SET SET nuclear proto-oncogene 0.03831
TRIO trio Rho guanine nucleotide exchange factor 0.0378306
DST dystonin 0.0374249
ZMIZ1 zinc finger, MIZ-type containing 1 0.0373661
PLEC plectin 0.0372703
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0358595
RPL23 ribosomal protein L23 0.0356468
RPL36 ribosomal protein L36 0.0348459
ANXA2 annexin A2 0.0345999
NDRG1 N-myc downstream regulated 1 0.0338979
TPM3 tropomyosin 3 0.0333907
RPLP2 ribosomal protein, large, P2 0.0329293
MIDN midnolin 0.0324176
PTPRF protein tyrosine phosphatase, receptor type, F 0.0311588
GPC5 glypican 5 0.0311183
ARRDC3 arrestin domain containing 3 0.0306653
RPL18 ribosomal protein L18 0.0305605
MPRIP myosin phosphatase Rho interacting protein 0.0304863
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0303234
RPL37A ribosomal protein L37a 0.0302912
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0300394
RPS17 ribosomal protein S17 0.028943
JUN jun proto-oncogene 0.0285848
ACTG1 actin gamma 1 0.028366
AKAP12 A kinase (PRKA) anchor protein 12 0.0281165
SFTPA2 surfactant protein A2 0.0279189
TPI1 triosephosphate isomerase 1 0.0278765
EPHA2 EPH receptor A2 0.0278077
DDIT4 DNA-damage-inducible transcript 4 0.0273962
KLF12 Kruppel-like factor 12 0.0272905
RPLP1 ribosomal protein, large, P1 0.0267569
MYO5B myosin VB 0.0266097
EGR1 early growth response 1 0.0261371
FUS FUS RNA binding protein 0.0261274
EPCAM epithelial cell adhesion molecule 0.0260815
S100A10 S100 calcium binding protein A10 0.0258317
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0257716
RPS27A ribosomal protein S27a 0.0256513
FAM107B family with sequence similarity 107, member B 0.0255723
KMT2C lysine (K)-specific methyltransferase 2C 0.0255361
ZFYVE28 zinc finger, FYVE domain containing 28 0.0255157
TIMP2 TIMP metallopeptidase inhibitor 2 0.0253391
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 0.0252591
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0252495
RPL9 ribosomal protein L9 0.0251619
RPS10 ribosomal protein S10 0.0247707
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0246093
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0244848
NFE2L2 nuclear factor, erythroid 2-like 2 0.0244802
HMGA1 high mobility group AT-hook 1 0.0242574
CLU clusterin 0.0240898
PRDX2 peroxiredoxin 2 0.0240621
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.023957
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0238716
TUBB4B tubulin, beta 4B class IVb 0.0238141
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0237802
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0237704
KRT8 keratin 8, type II 0.0236069
LMNA lamin A/C 0.0235039
KLK10 kallikrein-related peptidase 10 0.0233625
RPLP0 ribosomal protein, large, P0 0.023209
BHLHE40 basic helix-loop-helix family, member e40 0.0231632
IFITM3 interferon induced transmembrane protein 3 0.0231584
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0231409

decreased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein -0.1237
MBD5 methyl-CpG binding domain protein 5 -0.0658746
PRELID2 PRELI domain containing 2 -0.0616761
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0549395
RAD51B RAD51 paralog B -0.0522062
SEC31A SEC31 homolog A (S. cerevisiae) -0.0497045
CANX calnexin -0.0493334
ARF4 ADP-ribosylation factor 4 -0.0466217
VCL vinculin -0.0461845
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0440604
NF1 neurofibromin 1 -0.0427783
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0422173
ZNF292 zinc finger protein 292 -0.0420415
SERINC5 serine incorporator 5 -0.0405193
MON2 MON2 homolog (S. cerevisiae) -0.0402255
TBC1D22A TBC1 domain family, member 22A -0.0399644
RAB1A RAB1A, member RAS oncogene family -0.0391748
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0383163
EXOC4 exocyst complex component 4 -0.0374716
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0369483
COPB1 coatomer protein complex, subunit beta 1 -0.0364579
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0359938
DLG1 discs, large homolog 1 (Drosophila) -0.0353804
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0337919
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0330695
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0330305
SBF2 SET binding factor 2 -0.0329686
TRA2A transformer 2 alpha homolog (Drosophila) -0.0326813
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0323277
SLC38A2 solute carrier family 38, member 2 -0.0318709
ZNF207 zinc finger protein 207 -0.0317653
ZNF638 zinc finger protein 638 -0.0310408
ARL5B ADP-ribosylation factor-like 5B -0.0308857
LCORL ligand dependent nuclear receptor corepressor-like -0.0307668
ZNF654 zinc finger protein 654 -0.0304799
N4BP2L2 NEDD4 binding protein 2-like 2 -0.030306
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0301047
CDK19 cyclin-dependent kinase 19 -0.0298213
ATM ATM serine/threonine kinase -0.0296777
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0292985
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0290939
JMJD1C jumonji domain containing 1C -0.02903
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0290161
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0288723
SRP54 signal recognition particle 54kDa -0.028817
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0284609
TTC3 tetratricopeptide repeat domain 3 -0.0284021
TPM4 tropomyosin 4 -0.0283529
FDPS farnesyl diphosphate synthase -0.0281631
HM13 histocompatibility (minor) 13 -0.0281235
NBAS neuroblastoma amplified sequence -0.0278023
CD2AP CD2-associated protein -0.0277541
NKTR natural killer cell triggering receptor -0.0276377
RTN3 reticulon 3 -0.0275328
MARCHF6 membrane associated ring-CH-type finger 6 -0.0274706
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0273535
COPA coatomer protein complex, subunit alpha -0.0271566
GOLGA4 golgin A4 -0.0270726
HDAC8 histone deacetylase 8 -0.0270565
CSNK1A1 casein kinase 1, alpha 1 -0.0269479
IARS1 isoleucyl-tRNA synthetase 1 -0.0268875
SUCO SUN domain containing ossification factor -0.0265041
TBC1D4 TBC1 domain family, member 4 -0.0262033
RCOR1 REST corepressor 1 -0.0259707
TMEM41B transmembrane protein 41B -0.0259362
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0257428
KDM4C lysine (K)-specific demethylase 4C -0.0256465
AFF4 AF4/FMR2 family, member 4 -0.0256054
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0255092
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0253511
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0253387
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0252379
HMBOX1 homeobox containing 1 -0.0251506
GLG1 golgi glycoprotein 1 -0.0249238
DSCAM Down syndrome cell adhesion molecule -0.0244922
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0244487
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0244249
SETD5 SET domain containing 5 -0.0242977
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0240205
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0239025
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0238736
RAD21 RAD21 homolog (S. pombe) -0.0237163
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0237068
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0236814
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0236022
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0233967
ERBIN erbb2 interacting protein -0.0232192
FOXO3 forkhead box O3 -0.0231271
CLTC clathrin, heavy chain (Hc) -0.0230867
BIRC6 baculoviral IAP repeat containing 6 -0.0230048
TAS2R14 taste receptor, type 2, member 14 -0.0228618
WSB1 WD repeat and SOCS box containing 1 -0.0225323
LMO7 LIM domain 7 -0.0223991
APOLD1 apolipoprotein L domain containing 1 -0.0222288
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0221642
FNDC3B fibronectin type III domain containing 3B -0.0221321
YME1L1 YME1-like 1 ATPase -0.0220507
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0220308
PNISR PNN-interacting serine/arginine-rich protein -0.0219757
PTBP3 polypyrimidine tract binding protein 3 -0.0219293