| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | PF-06260933 perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the PF-06260933_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.313449 |
| VEGFA | vascular endothelial growth factor A | 0.276468 |
| MT2A | metallothionein 2A | 0.0918506 |
| CD44 | CD44 molecule (Indian blood group) | 0.0894366 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.074886 |
| LOXL2 | lysyl oxidase-like 2 | 0.0533087 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0521631 |
| NDRG1 | N-myc downstream regulated 1 | 0.0502372 |
| STC1 | stanniocalcin 1 | 0.0453017 |
| LDHA | lactate dehydrogenase A | 0.0441811 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0435532 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0422008 |
| HLA-B | major histocompatibility complex, class I, B | 0.0409877 |
| NAV1 | neuron navigator 1 | 0.0398052 |
| FN1 | fibronectin 1 | 0.0365484 |
| EXT1 | exostosin glycosyltransferase 1 | 0.035696 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.0352834 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.03486 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.034536 |
| FTL | ferritin, light polypeptide | 0.0344531 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0338787 |
| CST3 | cystatin C | 0.0336566 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0311144 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0308601 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0302936 |
| IL6 | interleukin 6 | 0.0299452 |
| BRD2 | bromodomain containing 2 | 0.0291679 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.0273783 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0265179 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0262527 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0261335 |
| ACTG1 | actin gamma 1 | 0.0260798 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0253636 |
| HMGA2 | high mobility group AT-hook 2 | 0.0250258 |
| GOLGB1 | golgin B1 | 0.0248191 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0247637 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0246153 |
| PLEC | plectin | 0.02413 |
| HLA-A | major histocompatibility complex, class I, A | 0.023271 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0232192 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0232133 |
| EGFR | epidermal growth factor receptor | 0.0230163 |
| EFNA5 | ephrin-A5 | 0.0222791 |
| RPS12 | ribosomal protein S12 | 0.0218991 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0218977 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0218834 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0218112 |
| ECE1 | endothelin converting enzyme 1 | 0.021662 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0216092 |
| ITGA11 | integrin, alpha 11 | 0.0214304 |
| ATF4 | activating transcription factor 4 | 0.020964 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0205232 |
| RPS3 | ribosomal protein S3 | 0.0201469 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0201376 |
| CLMP | CXADR-like membrane protein | 0.0200224 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0196217 |
| RPS19 | ribosomal protein S19 | 0.0195275 |
| RPL37A | ribosomal protein L37a | 0.0191692 |
| CTSB | cathepsin B | 0.0188991 |
| MSN | moesin | 0.0188897 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0186295 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0183354 |
| CMIP | c-Maf inducing protein | 0.018167 |
| RPL36 | ribosomal protein L36 | 0.0180719 |
| ABLIM3 | actin binding LIM protein family, member 3 | 0.0177225 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0174559 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0172453 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0169986 |
| GLIS3 | GLIS family zinc finger 3 | 0.0168027 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0167358 |
| RPS17 | ribosomal protein S17 | 0.0166324 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.0166165 |
| PGM3 | phosphoglucomutase 3 | 0.0162819 |
| HDAC9 | histone deacetylase 9 | 0.0162784 |
| ANGPTL4 | angiopoietin-like 4 | 0.0161647 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | 0.0159656 |
| NRP1 | neuropilin 1 | 0.0159031 |
| AXL | AXL receptor tyrosine kinase | 0.0157892 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | 0.0154643 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0154455 |
| OSMR | oncostatin M receptor | 0.0154302 |
| KIAA1217 | KIAA1217 | 0.0151997 |
| ANKS1A | ankyrin repeat and sterile alpha motif domain containing 1A | 0.0151925 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0148756 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0147513 |
| ADAM12 | ADAM metallopeptidase domain 12 | 0.0146463 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0146039 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0145576 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0145136 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0142056 |
| NAV2 | neuron navigator 2 | 0.0141554 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0141257 |
| SARS1 | seryl-tRNA synthetase 1 | 0.0141203 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0141046 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0140106 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0140087 |
| SFTPA2 | surfactant protein A2 | 0.0139476 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.013934 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0139216 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | 0.0138867 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.446886 |
| CADM1 | cell adhesion molecule 1 | -0.122066 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.112837 |
| COL1A1 | collagen, type I, alpha 1 | -0.102994 |
| CANX | calnexin | -0.0895004 |
| VIM | vimentin | -0.085561 |
| IER3 | immediate early response 3 | -0.071839 |
| AHNAK | AHNAK nucleoprotein | -0.0708556 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0636561 |
| PTMA | prothymosin, alpha | -0.0626581 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0584446 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0584091 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0573964 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0555191 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0539627 |
| QKI | QKI, KH domain containing, RNA binding | -0.0511186 |
| SPAG9 | sperm associated antigen 9 | -0.050267 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0488325 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0463608 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0440568 |
| ATP13A3 | ATPase type 13A3 | -0.043013 |
| UBC | ubiquitin C | -0.042738 |
| RHEB | Ras homolog enriched in brain | -0.0422341 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0419541 |
| USP3 | ubiquitin specific peptidase 3 | -0.0412726 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0409448 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0398965 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0395882 |
| FBN1 | fibrillin 1 | -0.0389738 |
| ZNF292 | zinc finger protein 292 | -0.0388332 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0370534 |
| ANXA2 | annexin A2 | -0.0365992 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0358567 |
| IL6ST | interleukin 6 signal transducer | -0.0346521 |
| POSTN | periostin, osteoblast specific factor | -0.0342093 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0332945 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0327916 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0319254 |
| CALU | calumenin | -0.0315875 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0314791 |
| RLF | rearranged L-myc fusion | -0.0312575 |
| MAP4 | microtubule-associated protein 4 | -0.030829 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0307779 |
| TRAM1 | translocation associated membrane protein 1 | -0.0307057 |
| SEPTIN7 | septin 7 | -0.0305297 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0292883 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0290711 |
| HDLBP | high density lipoprotein binding protein | -0.0289555 |
| CLIC4 | chloride intracellular channel 4 | -0.0287194 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0284926 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0284775 |
| PGK1 | phosphoglycerate kinase 1 | -0.0282434 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0282234 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0281305 |
| OGA | O-GlcNAcase | -0.0279652 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0278295 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0271427 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0271403 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.027026 |
| RYBP | RING1 and YY1 binding protein | -0.026817 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0261356 |
| HMGB2 | high mobility group box 2 | -0.0261053 |
| RBM39 | RNA binding motif protein 39 | -0.0260413 |
| TFG | TRK-fused gene | -0.0259603 |
| CLINT1 | clathrin interactor 1 | -0.025737 |
| SDCBP | syndecan binding protein (syntenin) | -0.025384 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0253795 |
| TPM4 | tropomyosin 4 | -0.025227 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0252268 |
| JAK1 | Janus kinase 1 | -0.0250781 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0246677 |
| ANKRD10 | ankyrin repeat domain 10 | -0.02458 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0245245 |
| YBX1 | Y box binding protein 1 | -0.0244249 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.024067 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0237287 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.023708 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0234185 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0231522 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0231044 |
| TMSB4X | thymosin beta 4, X-linked | -0.0228808 |
| CALD1 | caldesmon 1 | -0.02282 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0223513 |
| ANLN | anillin, actin binding protein | -0.0223325 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0220579 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0219352 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0218929 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0217669 |
| RPS24 | ribosomal protein S24 | -0.0216479 |
| TKT | transketolase | -0.0216413 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0215638 |
| BBX | bobby sox homolog (Drosophila) | -0.0209909 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.020941 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.020814 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | -0.0205424 |
| CDC73 | cell division cycle 73 | -0.0204964 |
| FSTL1 | follistatin-like 1 | -0.0204806 |
| AZIN1 | antizyme inhibitor 1 | -0.0204173 |
| COL4A1 | collagen, type IV, alpha 1 | -0.020317 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | -0.0201619 |
