| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | PF-06260933 perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the PF-06260933_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.151997 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0988526 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0982336 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0925994 |
| IGF2 | insulin-like growth factor 2 | 0.0872794 |
| GPC6 | glypican 6 | 0.0731666 |
| FN1 | fibronectin 1 | 0.0596177 |
| FAT1 | FAT atypical cadherin 1 | 0.0577646 |
| C3 | complement component 3 | 0.0570376 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0535338 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0531507 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0510169 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0503893 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0499941 |
| MRTFA | myocardin related transcription factor A | 0.0492058 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0451051 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0429644 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0424358 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0405284 |
| SVIL | supervillin | 0.0405143 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0403093 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0389754 |
| FOXP1 | forkhead box P1 | 0.0384994 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0376181 |
| IQSEC1 | IQ motif and Sec7 domain 1 | 0.0359583 |
| RAD51B | RAD51 paralog B | 0.0354501 |
| YAP1 | Yes-associated protein 1 | 0.0352218 |
| JAG1 | jagged 1 | 0.0346971 |
| ASPH | aspartate beta-hydroxylase | 0.0339804 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0337523 |
| ITGB5 | integrin, beta 5 | 0.032584 |
| BCL2L1 | BCL2-like 1 | 0.0322493 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0320411 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0310834 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0306613 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0299648 |
| VCL | vinculin | 0.0296351 |
| TNS1 | tensin 1 | 0.0296326 |
| FILIP1L | filamin A interacting protein 1-like | 0.0291159 |
| MALRD1 | MAM and LDL receptor class A domain containing 1 | 0.0286434 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0278774 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0267264 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0259709 |
| FKTN | fukutin | 0.0255819 |
| GSE1 | Gse1 coiled-coil protein | 0.0254972 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0254003 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0250677 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0249705 |
| ANXA5 | annexin A5 | 0.0243714 |
| FRK | fyn-related Src family tyrosine kinase | 0.0240289 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0239453 |
| TRIM24 | tripartite motif containing 24 | 0.023764 |
| TNS3 | tensin 3 | 0.023608 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0232507 |
| FAM107B | family with sequence similarity 107, member B | 0.0231942 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0229629 |
| PLSCR1 | phospholipid scramblase 1 | 0.0229127 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.022701 |
| FOXO1 | forkhead box O1 | 0.0226503 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0225395 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0221478 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0217431 |
| RIGI | RNA sensor RIG-I | 0.0212869 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.020954 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.0208508 |
| FNIP1 | folliculin interacting protein 1 | 0.0204423 |
| FHIT | fragile histidine triad | 0.0203589 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0202442 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0202113 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0201882 |
| NABP1 | nucleic acid binding protein 1 | 0.020188 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | 0.0199891 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.0198819 |
| SMAD3 | SMAD family member 3 | 0.019809 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0196388 |
| MYO1E | myosin IE | 0.0195883 |
| N4BP1 | NEDD4 binding protein 1 | 0.0195817 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0194168 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0193885 |
| MTSS1 | metastasis suppressor 1 | 0.0192953 |
| CRLS1 | cardiolipin synthase 1 | 0.0192821 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0192641 |
| TBCK | TBC1 domain containing kinase | 0.0191484 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0191286 |
| DNAH17 | dynein, axonemal, heavy chain 17 | 0.0190604 |
| ALPK2 | alpha-kinase 2 | 0.0190126 |
| KIAA1217 | KIAA1217 | 0.0188885 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0182216 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0181408 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0180942 |
| SP3 | Sp3 transcription factor | 0.018045 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0179235 |
| KYNU | kynureninase | 0.0177646 |
| BRD2 | bromodomain containing 2 | 0.0177627 |
| BBX | bobby sox homolog (Drosophila) | 0.0177294 |
| ZNRF3 | zinc and ring finger 3 | 0.0176414 |
| FOXN3 | forkhead box N3 | 0.0175949 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0175754 |
| ZNF518A | zinc finger protein 518A | 0.0175113 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.0174478 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.192892 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.159232 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.152652 |
| ENO1 | enolase 1, (alpha) | -0.123083 |
| GPC3 | glypican 3 | -0.122385 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.111309 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.10089 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.10048 |
| APOB | apolipoprotein B | -0.097374 |
| FTL | ferritin, light polypeptide | -0.0953702 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0947745 |
| APOA2 | apolipoprotein A-II | -0.09043 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0864403 |
| RPS6 | ribosomal protein S6 | -0.08502 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0771318 |
| RPLP0 | ribosomal protein, large, P0 | -0.0762316 |
| TRIM26 | tripartite motif containing 26 | -0.0732943 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0729467 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0728356 |
| TMEM123 | transmembrane protein 123 | -0.0710195 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0689779 |
| PEG3 | paternally expressed 3 | -0.0686978 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0670561 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0638118 |
| RPL12 | ribosomal protein L12 | -0.0625896 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0594121 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0592487 |
| RPS24 | ribosomal protein S24 | -0.0590022 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0587723 |
| H1-0 | H1.0 linker histone | -0.0564764 |
| RPS8 | ribosomal protein S8 | -0.054529 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0543455 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0539239 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.0539167 |
| LYZ | lysozyme | -0.0524342 |
| CP | ceruloplasmin (ferroxidase) | -0.0517374 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0514793 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0511733 |
| RPLP1 | ribosomal protein, large, P1 | -0.0492268 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0484226 |
| A2M | alpha-2-macroglobulin | -0.0472858 |
| FMNL2 | formin-like 2 | -0.0465228 |
| AHSG | alpha-2-HS-glycoprotein | -0.0464798 |
| DSPP | dentin sialophosphoprotein | -0.0456812 |
| RPS27A | ribosomal protein S27a | -0.0449843 |
| RPL32 | ribosomal protein L32 | -0.0448088 |
| PERP | PERP, TP53 apoptosis effector | -0.0432922 |
| WDR45B | WD repeat domain 45B | -0.0425227 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0405736 |
| RPL11 | ribosomal protein L11 | -0.0404333 |
| RPL34 | ribosomal protein L34 | -0.038778 |
| RPL35A | ribosomal protein L35a | -0.0387554 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0385992 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0384149 |
| GNAS | GNAS complex locus | -0.0384091 |
| SDC4 | syndecan 4 | -0.0378937 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0375159 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0369536 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0367063 |
| APOE | apolipoprotein E | -0.0365896 |
| NPR2 | natriuretic peptide receptor 2 | -0.0358706 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0356582 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0355176 |
| GDF15 | growth differentiation factor 15 | -0.0353836 |
| LDHA | lactate dehydrogenase A | -0.03525 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0351221 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0349199 |
| IER3 | immediate early response 3 | -0.0346051 |
| RPS19 | ribosomal protein S19 | -0.0341519 |
| HDLBP | high density lipoprotein binding protein | -0.0337221 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0336548 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0336413 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0334245 |
| SELENOP | selenoprotein P | -0.0331696 |
| KIF5B | kinesin family member 5B | -0.032964 |
| PGK1 | phosphoglycerate kinase 1 | -0.0319944 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0318511 |
| CANX | calnexin | -0.0317491 |
| RRBP1 | ribosome binding protein 1 | -0.0317381 |
| RPS23 | ribosomal protein S23 | -0.031603 |
| KRT18 | keratin 18, type I | -0.0315554 |
| CALR | calreticulin | -0.0312138 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0310789 |
| MATR3 | matrin 3 | -0.0307136 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.030395 |
| ARHGAP21 | Rho GTPase activating protein 21 | -0.0301312 |
| FAM162A | family with sequence similarity 162, member A | -0.0298929 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0294344 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0292633 |
| QKI | QKI, KH domain containing, RNA binding | -0.0292517 |
| TF | transferrin | -0.0290821 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.028982 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0288079 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0285348 |
| APOC1 | apolipoprotein C-I | -0.0285264 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0282514 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0279846 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | -0.0279667 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | -0.0278449 |
| WAC | WW domain containing adaptor with coiled-coil | -0.027783 |
