| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | PF-06260933 perturbation in KATO III cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the PF-06260933_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | 0.0724492 |
| TMSB10 | thymosin beta 10 | 0.0682033 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0624056 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0615976 |
| POTEF | POTE ankyrin domain family, member F | 0.0606136 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0526065 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0519345 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.050181 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0486875 |
| GOLGA4 | golgin A4 | 0.0479129 |
| CLDN7 | claudin 7 | 0.0471003 |
| EZR | ezrin | 0.0453573 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | 0.0450932 |
| CLDN4 | claudin 4 | 0.042733 |
| S100P | S100 calcium binding protein P | 0.0409742 |
| RPL35A | ribosomal protein L35a | 0.0398884 |
| S100A6 | S100 calcium binding protein A6 | 0.0397745 |
| LAMB3 | laminin, beta 3 | 0.0394404 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0394169 |
| WDR45B | WD repeat domain 45B | 0.039359 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.039141 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0386993 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0384211 |
| PGK1 | phosphoglycerate kinase 1 | 0.0371484 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0360784 |
| FAM13A | family with sequence similarity 13, member A | 0.0358354 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0358263 |
| AREG | amphiregulin | 0.0350737 |
| HLA-A | major histocompatibility complex, class I, A | 0.0338528 |
| B2M | beta-2-microglobulin | 0.0327896 |
| OXSR1 | oxidative stress responsive 1 | 0.0326689 |
| ITGA6 | integrin, alpha 6 | 0.0318182 |
| JUP | junction plakoglobin | 0.0313464 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0311449 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0307532 |
| S100A10 | S100 calcium binding protein A10 | 0.0306674 |
| TFRC | transferrin receptor | 0.0303656 |
| FLNB | filamin B, beta | 0.0297854 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0294764 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0291371 |
| EMP1 | epithelial membrane protein 1 | 0.029094 |
| ZNF292 | zinc finger protein 292 | 0.0281658 |
| S100A11 | S100 calcium binding protein A11 | 0.0275622 |
| PKM | pyruvate kinase, muscle | 0.0270121 |
| ITGB4 | integrin, beta 4 | 0.0269862 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | 0.0268897 |
| MUC17 | mucin 17, cell surface associated | 0.026047 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0260416 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0259717 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0258477 |
| LDHA | lactate dehydrogenase A | 0.0256116 |
| ANLN | anillin, actin binding protein | 0.0249469 |
| MYH14 | myosin, heavy chain 14, non-muscle | 0.0245875 |
| PERP | PERP, TP53 apoptosis effector | 0.0244884 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | 0.0238714 |
| TMBIM1 | transmembrane BAX inhibitor motif containing 1 | 0.0236862 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0236529 |
| CDK2AP2 | cyclin-dependent kinase 2 associated protein 2 | 0.0236504 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0234937 |
| CST3 | cystatin C | 0.0226635 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0224735 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0224156 |
| NUP58 | nucleoporin 58 | 0.022288 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0222744 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.0220924 |
| HMGA1 | high mobility group AT-hook 1 | 0.022047 |
| PPARG | peroxisome proliferator-activated receptor gamma | 0.0219173 |
| C1GALT1 | core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 | 0.0217996 |
| NCOR2 | nuclear receptor corepressor 2 | 0.021754 |
| S100A9 | S100 calcium binding protein A9 | 0.0217464 |
| PTMA | prothymosin, alpha | 0.0216003 |
| HYOU1 | hypoxia up-regulated 1 | 0.0211624 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.020706 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.020506 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.020027 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0199031 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0198284 |
| RBM39 | RNA binding motif protein 39 | 0.0197908 |
| FA2H | fatty acid 2-hydroxylase | 0.0194772 |
| SDCBP2 | syndecan binding protein (syntenin) 2 | 0.0194337 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0193214 |
| RLF | rearranged L-myc fusion | 0.0192497 |
| SRP54 | signal recognition particle 54kDa | 0.0192124 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0190882 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0188748 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0188189 |
| KLK10 | kallikrein-related peptidase 10 | 0.0187362 |
| PLS1 | plastin 1 | 0.01851 |
| TMF1 | TATA element modulatory factor 1 | 0.0184356 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0184023 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0183821 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | 0.0182721 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0180892 |
| PCBP2 | poly(rC) binding protein 2 | 0.0179318 |
| LMNA | lamin A/C | 0.0177684 |
| RSF1 | remodeling and spacing factor 1 | 0.017765 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0177521 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0177172 |
| AGR3 | anterior gradient 3 | 0.0176152 |
| NBEAL1 | neurobeachin-like 1 | 0.0176009 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FGFR2 | fibroblast growth factor receptor 2 | -0.230679 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.106609 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.096859 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0709336 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0646593 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0645272 |
| TMC5 | transmembrane channel-like 5 | -0.0589857 |
| LMO7 | LIM domain 7 | -0.057603 |
| ASPH | aspartate beta-hydroxylase | -0.057474 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0571943 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0556558 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.054546 |
| RUNX1 | runt-related transcription factor 1 | -0.053736 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.053503 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0526066 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0520789 |
| EHBP1 | EH domain binding protein 1 | -0.0520407 |
| AHR | aryl hydrocarbon receptor | -0.0519227 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0518233 |
| EXOC4 | exocyst complex component 4 | -0.0509311 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0502479 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0500785 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0477296 |
| RAD51B | RAD51 paralog B | -0.0439943 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0439019 |
| ATF7IP2 | activating transcription factor 7 interacting protein 2 | -0.0434873 |
| POF1B | premature ovarian failure, 1B | -0.0427737 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0426177 |
| VCL | vinculin | -0.0416496 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0414722 |
| SEPTIN9 | septin 9 | -0.0411741 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0402746 |
| SP100 | SP100 nuclear antigen | -0.0402337 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0399942 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0399458 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0395835 |
| CDK6 | cyclin-dependent kinase 6 | -0.0375393 |
| WWOX | WW domain containing oxidoreductase | -0.0370634 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0370465 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0363749 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0357016 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.035334 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0352655 |
| CANX | calnexin | -0.0351499 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0351161 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0350925 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0350767 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0348882 |
| ZC3H12B | zinc finger CCCH-type containing 12B | -0.0348012 |
| BCL2L1 | BCL2-like 1 | -0.03411 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0340928 |
| TMEM123 | transmembrane protein 123 | -0.0339968 |
| ATXN1 | ataxin 1 | -0.033738 |
| GOLGB1 | golgin B1 | -0.0330063 |
| MYO1D | myosin ID | -0.0328288 |
| MECOM | MDS1 and EVI1 complex locus | -0.0327835 |
| INTS6 | integrator complex subunit 6 | -0.0326769 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0324258 |
| MYOF | myoferlin | -0.0323793 |
| MCU | mitochondrial calcium uniporter | -0.0320936 |
| PDLIM5 | PDZ and LIM domain 5 | -0.032088 |
| ACTN4 | actinin, alpha 4 | -0.0317416 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0315963 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0313368 |
| SH3RF1 | SH3 domain containing ring finger 1 | -0.0309726 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0308154 |
| H1-0 | H1.0 linker histone | -0.0307767 |
| FNDC3B | fibronectin type III domain containing 3B | -0.029714 |
| GPHN | gephyrin | -0.0297072 |
| NFIB | nuclear factor I/B | -0.0290733 |
| APP | amyloid beta (A4) precursor protein | -0.028928 |
| DIAPH2 | diaphanous-related formin 2 | -0.0286554 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.028629 |
| LCN2 | lipocalin 2 | -0.0286087 |
| MTAP | methylthioadenosine phosphorylase | -0.0284329 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0279648 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0277081 |
| ETV6 | ets variant 6 | -0.0275452 |
| SKAP1 | src kinase associated phosphoprotein 1 | -0.0274496 |
| RPL26 | ribosomal protein L26 | -0.0272984 |
| RNF213 | ring finger protein 213 | -0.0271366 |
| XAF1 | XIAP associated factor 1 | -0.0265711 |
| PLSCR1 | phospholipid scramblase 1 | -0.0262922 |
| PCDH7 | protocadherin 7 | -0.0261933 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0261409 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | -0.0260107 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0258371 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0258078 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0257567 |
| RPS2 | ribosomal protein S2 | -0.0257429 |
| AGR2 | anterior gradient 2 | -0.0256998 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0256272 |
| CLDN1 | claudin 1 | -0.0255729 |
| PRELID2 | PRELI domain containing 2 | -0.0255646 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0253277 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0252058 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0251215 |
| XKR6 | XK, Kell blood group complex subunit-related family, member 6 | -0.0248269 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.024767 |
| FHIT | fragile histidine triad | -0.0245635 |
