| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | PF-06260933 perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the PF-06260933_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.184281 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.146246 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.123578 |
| TNS4 | tensin 4 | 0.102829 |
| VEGFA | vascular endothelial growth factor A | 0.0947929 |
| NDRG1 | N-myc downstream regulated 1 | 0.079709 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | 0.0729095 |
| EREG | epiregulin | 0.0686977 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0659761 |
| ABHD2 | abhydrolase domain containing 2 | 0.062483 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0618819 |
| KLF3 | Kruppel-like factor 3 (basic) | 0.0609715 |
| LDHA | lactate dehydrogenase A | 0.0597284 |
| AREG | amphiregulin | 0.0589876 |
| FAM13A | family with sequence similarity 13, member A | 0.0554583 |
| TXNIP | thioredoxin interacting protein | 0.0542405 |
| FAT1 | FAT atypical cadherin 1 | 0.0516659 |
| TPM4 | tropomyosin 4 | 0.0505839 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0497316 |
| RPS12 | ribosomal protein S12 | 0.0473909 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0468864 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0441864 |
| B2M | beta-2-microglobulin | 0.0398429 |
| RPS6 | ribosomal protein S6 | 0.038673 |
| FOSL1 | FOS-like antigen 1 | 0.0386368 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0378549 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0376445 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0364394 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0360836 |
| VDR | vitamin D (1,25- dihydroxyvitamin D3) receptor | 0.0345228 |
| PPARG | peroxisome proliferator-activated receptor gamma | 0.0343455 |
| RPL9 | ribosomal protein L9 | 0.0338653 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0337453 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0335359 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0335065 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0330971 |
| ABHD17C | abhydrolase domain containing 17C | 0.0326313 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0321209 |
| CDH17 | cadherin 17, LI cadherin (liver-intestine) | 0.0314352 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0314322 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | 0.0308664 |
| RNF43 | ring finger protein 43 | 0.0303662 |
| RIGI | RNA sensor RIG-I | 0.0299503 |
| CDCP1 | CUB domain containing protein 1 | 0.0296524 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0294554 |
| PRSS3 | protease, serine, 3 | 0.0293801 |
| ONECUT3 | one cut homeobox 3 | 0.0290511 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0286283 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0285112 |
| PTEN | phosphatase and tensin homolog | 0.0284452 |
| CALB1 | calbindin 1, 28kDa | 0.0278778 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0265837 |
| TMF1 | TATA element modulatory factor 1 | 0.026159 |
| ATXN1 | ataxin 1 | 0.0253753 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0253322 |
| RPL37A | ribosomal protein L37a | 0.0253213 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0250039 |
| NEBL | nebulette | 0.0247939 |
| ADD3 | adducin 3 (gamma) | 0.0247138 |
| B3GNT5 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 | 0.024707 |
| RPS17 | ribosomal protein S17 | 0.0246162 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0245465 |
| RPS3 | ribosomal protein S3 | 0.0243422 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0242333 |
| RHOA | ras homolog family member A | 0.0242006 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0241682 |
| KIF5B | kinesin family member 5B | 0.0241529 |
| TMEM165 | transmembrane protein 165 | 0.0240243 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0239098 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.023353 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0233515 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.023171 |
| PERP | PERP, TP53 apoptosis effector | 0.0228615 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0228492 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | 0.0224475 |
| SSR1 | signal sequence receptor, alpha | 0.0222994 |
| TMEM45B | transmembrane protein 45B | 0.022288 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0221689 |
| SCFD1 | sec1 family domain containing 1 | 0.0219098 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0216927 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.021409 |
| ITGAV | integrin, alpha V | 0.0210872 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0210434 |
| BMP4 | bone morphogenetic protein 4 | 0.0210383 |
| ZNF292 | zinc finger protein 292 | 0.0209322 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0204839 |
| SNX13 | sorting nexin 13 | 0.0203724 |
| CAB39 | calcium binding protein 39 | 0.0203469 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.0203274 |
| PLS1 | plastin 1 | 0.0202653 |
| GOLGA4 | golgin A4 | 0.020251 |
| FHL2 | four and a half LIM domains 2 | 0.0201607 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0200967 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0200831 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | 0.0199004 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0198233 |
| SLK | STE20-like kinase | 0.0198083 |
| CDK19 | cyclin-dependent kinase 19 | 0.0195943 |
| UBXN4 | UBX domain protein 4 | 0.019583 |
| CLDN4 | claudin 4 | 0.0195828 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.369444 |
| NPSR1 | neuropeptide S receptor 1 | -0.167 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.14766 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.105901 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0987217 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.09176 |
| AHNAK | AHNAK nucleoprotein | -0.0844565 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0643111 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.064172 |
| VCL | vinculin | -0.0612874 |
| TMSB10 | thymosin beta 10 | -0.0550395 |
| LAMA4 | laminin, alpha 4 | -0.0520812 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0502201 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0496466 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0481692 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0466191 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0462511 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0457248 |
| H1-0 | H1.0 linker histone | -0.0454207 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0448368 |
| EHBP1 | EH domain binding protein 1 | -0.0429238 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0428122 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0425671 |
| FHIT | fragile histidine triad | -0.042409 |
| GDF15 | growth differentiation factor 15 | -0.0420475 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0417023 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0394733 |
| GPHN | gephyrin | -0.0392035 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0391444 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.03828 |
| SBF2 | SET binding factor 2 | -0.0378591 |
| POF1B | premature ovarian failure, 1B | -0.0378384 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0377867 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0375922 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0367031 |
| HDLBP | high density lipoprotein binding protein | -0.036657 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0365195 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | -0.0360647 |
| CANX | calnexin | -0.0355808 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0354561 |
| ACTG1 | actin gamma 1 | -0.035389 |
| RRBP1 | ribosome binding protein 1 | -0.0350033 |
| RPLP1 | ribosomal protein, large, P1 | -0.0349416 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | -0.0343445 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0342094 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0339901 |
| EXOC4 | exocyst complex component 4 | -0.0339136 |
| DIAPH3 | diaphanous-related formin 3 | -0.0334745 |
| HMGB1 | high mobility group box 1 | -0.0329972 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0326751 |
| ARF1 | ADP-ribosylation factor 1 | -0.0319785 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.031866 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | -0.0316145 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0315492 |
| RIN2 | Ras and Rab interactor 2 | -0.0315151 |
| AGR2 | anterior gradient 2 | -0.0314814 |
| DENND1A | DENN/MADD domain containing 1A | -0.0312581 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0304667 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0298686 |
| YBX1 | Y box binding protein 1 | -0.0291641 |
| ECT2 | epithelial cell transforming 2 | -0.0290633 |
| RAD51B | RAD51 paralog B | -0.0289289 |
| NOP58 | NOP58 ribonucleoprotein | -0.0286274 |
| UBAP2 | ubiquitin associated protein 2 | -0.0285829 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.028453 |
| ZNF207 | zinc finger protein 207 | -0.0283815 |
| SVIL | supervillin | -0.0282517 |
| LSAMP | limbic system-associated membrane protein | -0.0282189 |
| MSI2 | musashi RNA-binding protein 2 | -0.0279553 |
| SERINC5 | serine incorporator 5 | -0.0278835 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.027774 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0277643 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0277474 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0277304 |
| CLTC | clathrin, heavy chain (Hc) | -0.0274781 |
| FBXO11 | F-box protein 11 | -0.0273725 |
| HMGB2 | high mobility group box 2 | -0.0272944 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0272679 |
| HMGA1 | high mobility group AT-hook 1 | -0.0272023 |
| FUS | FUS RNA binding protein | -0.027039 |
| CTBP2 | C-terminal binding protein 2 | -0.0268737 |
| HDAC2 | histone deacetylase 2 | -0.0268118 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0264101 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0263439 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.0262381 |
| FMNL2 | formin-like 2 | -0.0261489 |
| PKP4 | plakophilin 4 | -0.0260584 |
| RAB10 | RAB10, member RAS oncogene family | -0.0260508 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0257498 |
| ANKRD10 | ankyrin repeat domain 10 | -0.025653 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0256231 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0253029 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0252742 |
| B4GALNT3 | beta-1,4-N-acetyl-galactosaminyl transferase 3 | -0.025086 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0250069 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0248973 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0248366 |
| VWA8 | von Willebrand factor A domain containing 8 | -0.024727 |
| LMNA | lamin A/C | -0.0247078 |
| PPP4R3A | protein phosphatase 4 regulatory subunit 3A | -0.0246552 |
