PF-06260933_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description PF-06260933 perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the PF-06260933_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PSD3 pleckstrin and Sec7 domain containing 3 0.143992
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.10382
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0687497
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0651144
CAPRIN2 caprin family member 2 0.0528498
WWTR1 WW domain containing transcription regulator 1 0.0493876
MACF1 microtubule-actin crosslinking factor 1 0.0471797
TM4SF1 transmembrane 4 L six family member 1 0.0463981
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.040456
RUNX1 runt-related transcription factor 1 0.0402015
FMNL2 formin-like 2 0.040197
BCAR3 breast cancer anti-estrogen resistance 3 0.0395556
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.03948
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0390307
TSC22D1 TSC22 domain family, member 1 0.0389627
PDE10A phosphodiesterase 10A 0.0388945
PODXL podocalyxin-like 0.0375357
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0369491
KMT2E lysine (K)-specific methyltransferase 2E 0.0363063
CMIP c-Maf inducing protein 0.0337432
LOXL2 lysyl oxidase-like 2 0.0324272
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0323954
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0311456
BIRC3 baculoviral IAP repeat containing 3 0.0304702
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0297072
KDM4C lysine (K)-specific demethylase 4C 0.0287782
EHBP1 EH domain binding protein 1 0.0286382
ANGPTL4 angiopoietin-like 4 0.0274337
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0272437
TP63 tumor protein p63 0.0271492
SDK1 sidekick cell adhesion molecule 1 0.0268587
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.025564
DNER delta/notch-like EGF repeat containing 0.0254907
TNS3 tensin 3 0.0249961
TXNRD1 thioredoxin reductase 1 0.0247922
ZDHHC14 zinc finger, DHHC-type containing 14 0.0247636
VEGFA vascular endothelial growth factor A 0.0244018
USP34 ubiquitin specific peptidase 34 0.0241404
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0241383
DST dystonin 0.0240999
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0238959
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0238627
ARHGAP5 Rho GTPase activating protein 5 0.0228595
SMYD3 SET and MYND domain containing 3 0.0227263
RNF213 ring finger protein 213 0.0222906
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0219464
PYGL phosphorylase, glycogen, liver 0.0218577
NPAS2 neuronal PAS domain protein 2 0.021794
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0217854
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0215064
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0212393
DENND1A DENN/MADD domain containing 1A 0.0211839
SMAD3 SMAD family member 3 0.0202043
THSD4 thrombospondin, type I, domain containing 4 0.0193971
NEK10 NIMA-related kinase 10 0.0192942
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0192781
ZSWIM6 zinc finger, SWIM-type containing 6 0.0187874
TBC1D22A TBC1 domain family, member 22A 0.0186043
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0180049
KTN1 kinectin 1 (kinesin receptor) 0.0179662
ZBTB38 zinc finger and BTB domain containing 38 0.0178404
AGTPBP1 ATP/GTP binding protein 1 0.0175329
ZMIZ1 zinc finger, MIZ-type containing 1 0.0173983
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0173837
CAPN2 calpain 2, (m/II) large subunit 0.017367
DOCK1 dedicator of cytokinesis 1 0.0173639
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0173559
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0173141
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0173042
CSNK1A1 casein kinase 1, alpha 1 0.0171249
VMP1 vacuole membrane protein 1 0.0171118
LPIN1 lipin 1 0.0169895
YEATS2 YEATS domain containing 2 0.0169253
CXCL8 chemokine (C-X-C motif) ligand 8 0.0168955
GPATCH2L G patch domain containing 2-like 0.0168047
ANO6 anoctamin 6 0.0167651
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0167517
MCL1 myeloid cell leukemia 1 0.0165939
FLNB filamin B, beta 0.0164948
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0164045
ARFGEF3 ARFGEF family member 3 0.016345
JUN jun proto-oncogene 0.0162647
AMPD3 adenosine monophosphate deaminase 3 0.0162209
RIGI RNA sensor RIG-I 0.0156674
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0156579
CD44 CD44 molecule (Indian blood group) 0.0155862
MCTP1 multiple C2 domains, transmembrane 1 0.0155103
ANTXR2 anthrax toxin receptor 2 0.0152519
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0152514
RCOR1 REST corepressor 1 0.0152101
HOMER1 homer scaffolding protein 1 0.015121
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0151085
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0150746
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0150494
GSK3B glycogen synthase kinase 3 beta 0.0150282
PRKCE protein kinase C, epsilon 0.0150281
SFPQ splicing factor proline/glutamine-rich 0.014941
SDCCAG8 serologically defined colon cancer antigen 8 0.0147859
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0146878
GYS1 glycogen synthase 1 (muscle) 0.0145751

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.256121
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.235719
VIM vimentin -0.193015
PTMA prothymosin, alpha -0.168493
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.16391
TMSB4X thymosin beta 4, X-linked -0.085254
TMSB10 thymosin beta 10 -0.0766
FTL ferritin, light polypeptide -0.0691335
GARS1 glycyl-tRNA synthetase 1 -0.0579431
CANX calnexin -0.055597
RPL35A ribosomal protein L35a -0.0553236
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0540926
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.051163
TPT1 tumor protein, translationally-controlled 1 -0.0439881
RPS8 ribosomal protein S8 -0.0429586
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0396322
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0380631
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0377322
RPS6 ribosomal protein S6 -0.0368932
RPLP0 ribosomal protein, large, P0 -0.0342699
CENPF centromere protein F, 350/400kDa -0.0328629
YBX1 Y box binding protein 1 -0.0321987
RPL12 ribosomal protein L12 -0.0319182
EIF1 eukaryotic translation initiation factor 1 -0.0315082
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0309354
MT2A metallothionein 2A -0.030646
TXNIP thioredoxin interacting protein -0.0298758
RPLP1 ribosomal protein, large, P1 -0.0290917
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0290363
TOP1 topoisomerase (DNA) I -0.0283587
TMEM123 transmembrane protein 123 -0.0281278
KLF6 Kruppel-like factor 6 -0.0277252
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0272784
RPS24 ribosomal protein S24 -0.026556
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0261058
DLG1 discs, large homolog 1 (Drosophila) -0.0259873
LOC112694756 uncharaterized LOC112694756 -0.0259728
ACTG1 actin gamma 1 -0.0259343
WDR45B WD repeat domain 45B -0.0257487
ZNF217 zinc finger protein 217 -0.0257384
GOLGA4 golgin A4 -0.0252331
RPL5 ribosomal protein L5 -0.0245934
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0242536
KDM3A lysine (K)-specific demethylase 3A -0.0237619
HMGA1 high mobility group AT-hook 1 -0.023682
TRA2A transformer 2 alpha homolog (Drosophila) -0.0235694
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0229833
SRGN serglycin -0.022944
RPS19 ribosomal protein S19 -0.0226575
CALR calreticulin -0.0223878
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0222406
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0222152
AHNAK AHNAK nucleoprotein -0.0221492
VDAC1 voltage-dependent anion channel 1 -0.0221136
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.02204
RPL34 ribosomal protein L34 -0.0219628
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0218804
RPL19 ribosomal protein L19 -0.0216663
MATR3 matrin 3 -0.0215884
PGK1 phosphoglycerate kinase 1 -0.0215683
GNAS GNAS complex locus -0.0213233
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0210807
RPS14 ribosomal protein S14 -0.0210631
SMC4 structural maintenance of chromosomes 4 -0.020893
H1-0 H1.0 linker histone -0.0208784
HMGB2 high mobility group box 2 -0.0208342
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0207572
ARID4B AT rich interactive domain 4B (RBP1-like) -0.020389
DEK DEK proto-oncogene -0.0203861
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.020207
NOP58 NOP58 ribonucleoprotein -0.0201116
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0200386
LMAN1 lectin, mannose-binding, 1 -0.0200266
SEPTIN7 septin 7 -0.0199946
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) -0.0194095
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0193246
OLA1 Obg-like ATPase 1 -0.0192409
RPL32 ribosomal protein L32 -0.0192346
RAB1A RAB1A, member RAS oncogene family -0.0191896
RPL26 ribosomal protein L26 -0.0190898
TUBB tubulin, beta class I -0.019063
ADGRG6 adhesion G protein-coupled receptor G6 -0.0190367
MT1E metallothionein 1E -0.0189797
RPS25 ribosomal protein S25 -0.0189068
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0188581
RPL8 ribosomal protein L8 -0.0187304
NAP1L1 nucleosome assembly protein 1-like 1 -0.0186019
ZNF292 zinc finger protein 292 -0.0185098
ANLN anillin, actin binding protein -0.0184542
MT1X metallothionein 1X -0.0183937
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0182399
MARCHF6 membrane associated ring-CH-type finger 6 -0.0181988
WASF2 WAS protein family, member 2 -0.0180752
RACK1 receptor for activated C kinase 1 -0.0179691
S100A9 S100 calcium binding protein A9 -0.0179269
NPEPPS aminopeptidase puromycin sensitive -0.017669
PDIA3 protein disulfide isomerase family A, member 3 -0.0176224
IARS1 isoleucyl-tRNA synthetase 1 -0.0175361
MYL12B myosin, light chain 12B, regulatory -0.0174787
NPR2 natriuretic peptide receptor 2 -0.0174301