| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | PF-06260933 perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the PF-06260933_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.212954 |
| GRAMD1B | GRAM domain containing 1B | 0.162206 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.140107 |
| YBX3 | Y box binding protein 3 | 0.121496 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0626533 |
| ATP11A | ATPase, class VI, type 11A | 0.0619458 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0587596 |
| RAD51B | RAD51 paralog B | 0.0547606 |
| EGR1 | early growth response 1 | 0.0542742 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0506334 |
| SMYD3 | SET and MYND domain containing 3 | 0.0505943 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0499833 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0481781 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0478934 |
| MT2A | metallothionein 2A | 0.0472017 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0469231 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0465041 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0445681 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0442986 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0442047 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0441181 |
| RPL26 | ribosomal protein L26 | 0.0382496 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0381902 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0366405 |
| CAVIN1 | caveolae associated protein 1 | 0.0363762 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0359868 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0348821 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0347534 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0346616 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.034063 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0337125 |
| RPS4X | ribosomal protein S4, X-linked | 0.0333862 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0331956 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0325607 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.032406 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0320968 |
| RPS3 | ribosomal protein S3 | 0.0315509 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0313612 |
| R3HDM2 | R3H domain containing 2 | 0.0311164 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0311154 |
| GATAD2B | GATA zinc finger domain containing 2B | 0.0303006 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0302022 |
| IGF1R | insulin-like growth factor 1 receptor | 0.029994 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0296569 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0295321 |
| WWOX | WW domain containing oxidoreductase | 0.0295133 |
| YAP1 | Yes-associated protein 1 | 0.0294228 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0293914 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0293855 |
| TPI1 | triosephosphate isomerase 1 | 0.0289535 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0289156 |
| AGO2 | argonaute RISC catalytic component 2 | 0.028744 |
| RPS10 | ribosomal protein S10 | 0.0286406 |
| PRKCE | protein kinase C, epsilon | 0.0282356 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0281685 |
| BRD2 | bromodomain containing 2 | 0.0279705 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0275432 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 0.0270702 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0265893 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0265475 |
| RRM2 | ribonucleotide reductase M2 | 0.0264824 |
| RPL31 | ribosomal protein L31 | 0.026434 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0261687 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0256443 |
| RPLP2 | ribosomal protein, large, P2 | 0.0252822 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0249767 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0245528 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0241894 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0241089 |
| MED13 | mediator complex subunit 13 | 0.023972 |
| RPS12 | ribosomal protein S12 | 0.023926 |
| CMIP | c-Maf inducing protein | 0.0237638 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0234724 |
| HLA-B | major histocompatibility complex, class I, B | 0.0233184 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0232946 |
| ZNF638 | zinc finger protein 638 | 0.0232617 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0225596 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0224977 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.0224786 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0223826 |
| EGFR | epidermal growth factor receptor | 0.0223109 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.022308 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0221546 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.0219129 |
| DENND1A | DENN/MADD domain containing 1A | 0.0217781 |
| EXOC4 | exocyst complex component 4 | 0.0216498 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0215084 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0214985 |
| PFKP | phosphofructokinase, platelet | 0.0214832 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0212166 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0211981 |
| RPL9 | ribosomal protein L9 | 0.0210569 |
| FARS2 | phenylalanyl-tRNA synthetase 2, mitochondrial | 0.0208959 |
| ACAP2 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 | 0.0208397 |
| TLN1 | talin 1 | 0.0208183 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0207872 |
| INTS6 | integrator complex subunit 6 | 0.0206243 |
| RPLP1 | ribosomal protein, large, P1 | 0.0204516 |
| ZSWIM5 | zinc finger, SWIM-type containing 5 | 0.0203939 |
| RPL35A | ribosomal protein L35a | 0.0203486 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.228222 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.111676 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0640023 |
| PTMA | prothymosin, alpha | -0.0565509 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0553504 |
| VIM | vimentin | -0.0485634 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.047267 |
| GNAS | GNAS complex locus | -0.0454903 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0446943 |
| H1-0 | H1.0 linker histone | -0.0438069 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0418822 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0402701 |
| CCND2 | cyclin D2 | -0.0400865 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0398961 |
| COPA | coatomer protein complex, subunit alpha | -0.0398777 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0386219 |
| CANX | calnexin | -0.0374408 |
| RSF1 | remodeling and spacing factor 1 | -0.0359692 |
| RBM39 | RNA binding motif protein 39 | -0.0319297 |
| ZNF292 | zinc finger protein 292 | -0.0316497 |
| AHNAK | AHNAK nucleoprotein | -0.0310966 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0306239 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.030183 |
| MORF4L2 | mortality factor 4 like 2 | -0.0301025 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0285299 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0283027 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0282232 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0276477 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0274624 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0273492 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0265453 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0260168 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0257542 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.025538 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0255259 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.025369 |
| ENO1 | enolase 1, (alpha) | -0.0251717 |
| TFG | TRK-fused gene | -0.0251482 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0250119 |
| RLF | rearranged L-myc fusion | -0.0248193 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0246396 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0244703 |
| SEPTIN2 | septin 2 | -0.0244529 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0242847 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | -0.0240973 |
| HMGA1 | high mobility group AT-hook 1 | -0.0240955 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | -0.0237279 |
| RNMT | RNA (guanine-7-) methyltransferase | -0.0235706 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.023402 |
| SPAG9 | sperm associated antigen 9 | -0.0231396 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | -0.0230348 |
| USP34 | ubiquitin specific peptidase 34 | -0.0229882 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.022941 |
| CD2AP | CD2-associated protein | -0.0227058 |
| SRP54 | signal recognition particle 54kDa | -0.0224804 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0222801 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | -0.0220955 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0218505 |
| RPL12 | ribosomal protein L12 | -0.0216401 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0216379 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0215789 |
| WRN | Werner syndrome, RecQ helicase-like | -0.021477 |
| XPO1 | exportin 1 | -0.0213373 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.021195 |
| DARS1 | aspartyl-tRNA synthetase 1 | -0.0211669 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | -0.0211441 |
| ANXA2 | annexin A2 | -0.0210562 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0207859 |
| SSR2 | signal sequence receptor, beta (translocon-associated protein beta) | -0.0206171 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.0205948 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0205071 |
| OGA | O-GlcNAcase | -0.0203455 |
| PREPL | prolyl endopeptidase-like | -0.0202045 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0201278 |
| UBC | ubiquitin C | -0.0200966 |
| ARF4 | ADP-ribosylation factor 4 | -0.0199678 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0199094 |
| WASF2 | WAS protein family, member 2 | -0.0197662 |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | -0.0196336 |
| CDYL | chromodomain protein, Y-like | -0.019627 |
| PYGL | phosphorylase, glycogen, liver | -0.0196082 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0193775 |
| SUCO | SUN domain containing ossification factor | -0.0193276 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0192906 |
| MYSM1 | Myb-like, SWIRM and MPN domains 1 | -0.0192832 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0192548 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0191854 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0191423 |
| NOP58 | NOP58 ribonucleoprotein | -0.0191325 |
| ANLN | anillin, actin binding protein | -0.0190863 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.018985 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0189158 |
| S100A10 | S100 calcium binding protein A10 | -0.0187365 |
| CALR | calreticulin | -0.0186863 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -0.0185307 |
| ZFR | zinc finger RNA binding protein | -0.0184444 |
| VCL | vinculin | -0.0183714 |
| ZBTB35 | zinc finger and BTB domain containing 35 | -0.0183689 |
| SEC22B | SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) | -0.0182326 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0181845 |
