| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | PF-06260933 perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the PF-06260933_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VEGFA | vascular endothelial growth factor A | 0.12001 |
| HLA-B | major histocompatibility complex, class I, B | 0.0953581 |
| CD44 | CD44 molecule (Indian blood group) | 0.0842193 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0604127 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0578351 |
| FTL | ferritin, light polypeptide | 0.0505505 |
| LDHA | lactate dehydrogenase A | 0.0488833 |
| MT2A | metallothionein 2A | 0.0485096 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0485034 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0478472 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0444249 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0444005 |
| HLA-A | major histocompatibility complex, class I, A | 0.0426261 |
| FN1 | fibronectin 1 | 0.0369185 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0362422 |
| SFTPA2 | surfactant protein A2 | 0.0348487 |
| HDAC9 | histone deacetylase 9 | 0.0335589 |
| SMAD3 | SMAD family member 3 | 0.0331779 |
| MKI67 | marker of proliferation Ki-67 | 0.032313 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0321818 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0320124 |
| KYNU | kynureninase | 0.0316514 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0309283 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.030362 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0292006 |
| C3 | complement component 3 | 0.0287601 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.02856 |
| CTSB | cathepsin B | 0.0280017 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0275457 |
| STC1 | stanniocalcin 1 | 0.0270769 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0266064 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0261398 |
| EGR1 | early growth response 1 | 0.026057 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0255682 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0253835 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0252556 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0245888 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0243813 |
| RPS6 | ribosomal protein S6 | 0.0236617 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0230395 |
| RPS3 | ribosomal protein S3 | 0.0228079 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0227336 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.022476 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0224444 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0223511 |
| B2M | beta-2-microglobulin | 0.0221285 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.021327 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0212307 |
| SP100 | SP100 nuclear antigen | 0.0209609 |
| PMP22 | peripheral myelin protein 22 | 0.0202764 |
| OSMR | oncostatin M receptor | 0.0200822 |
| CENPF | centromere protein F, 350/400kDa | 0.0198633 |
| PLIN2 | perilipin 2 | 0.0196117 |
| RPS10 | ribosomal protein S10 | 0.0191736 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0188978 |
| RND3 | Rho family GTPase 3 | 0.0188174 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.018759 |
| CDCP1 | CUB domain containing protein 1 | 0.0180963 |
| KIAA1217 | KIAA1217 | 0.0179446 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0179079 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0175277 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0171254 |
| RPL37A | ribosomal protein L37a | 0.0167984 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0167229 |
| RNF213 | ring finger protein 213 | 0.0166165 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0164591 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.015903 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0158145 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0157878 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0157665 |
| OPTN | optineurin | 0.0156575 |
| IL1RAP | interleukin 1 receptor accessory protein | 0.0154676 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0154579 |
| BICC1 | BicC family RNA binding protein 1 | 0.0152749 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.015172 |
| RPL9 | ribosomal protein L9 | 0.0150978 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0147806 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0145364 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0144563 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.014387 |
| MX1 | MX dynamin-like GTPase 1 | 0.014352 |
| DNTTIP1 | deoxynucleotidyltransferase, terminal, interacting protein 1 | 0.0140329 |
| TMSB4X | thymosin beta 4, X-linked | 0.0139815 |
| MAP1B | microtubule-associated protein 1B | 0.0138261 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0136 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0133374 |
| RPL7A | ribosomal protein L7a | 0.0133133 |
| INHBA | inhibin, beta A | 0.0132556 |
| RIGI | RNA sensor RIG-I | 0.0131374 |
| CUL4B | cullin 4B | 0.0130694 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0130225 |
| SYNJ2 | synaptojanin 2 | 0.013014 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0127652 |
| RPL36 | ribosomal protein L36 | 0.0127596 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0126108 |
| ARRDC3 | arrestin domain containing 3 | 0.0125759 |
| CST3 | cystatin C | 0.0124467 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.012341 |
| CD68 | CD68 molecule | 0.0121713 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0121512 |
| Symbol | Name | Standardized Value |
|---|---|---|
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.143393 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.130115 |
| FRMD4A | FERM domain containing 4A | -0.091564 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0661017 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0653864 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0650816 |
| CANX | calnexin | -0.062524 |
| PDE10A | phosphodiesterase 10A | -0.0603478 |
| FRMPD4 | FERM and PDZ domain containing 4 | -0.0580158 |
| AHNAK | AHNAK nucleoprotein | -0.0543327 |
| CADM1 | cell adhesion molecule 1 | -0.0541162 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0536986 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0491526 |
| PCBP2 | poly(rC) binding protein 2 | -0.0476139 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0475452 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0465492 |
| CDH13 | cadherin 13 | -0.0453312 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0431919 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0389353 |
| OGA | O-GlcNAcase | -0.0386107 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0379125 |
| TSC22D2 | TSC22 domain family, member 2 | -0.037876 |
| QKI | QKI, KH domain containing, RNA binding | -0.03736 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0368275 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.036696 |
| SPAG9 | sperm associated antigen 9 | -0.0354076 |
| FNDC3B | fibronectin type III domain containing 3B | -0.035057 |
| HELZ | helicase with zinc finger | -0.0334345 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0320779 |
| UBC | ubiquitin C | -0.0319111 |
| ZNF292 | zinc finger protein 292 | -0.0316663 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0311712 |
| GOLGA4 | golgin A4 | -0.0310904 |
| RPS27A | ribosomal protein S27a | -0.0307345 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | -0.0302664 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0302453 |
| VIM | vimentin | -0.0293722 |
| DIAPH2 | diaphanous-related formin 2 | -0.0289652 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0285453 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0280796 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0279058 |
| DST | dystonin | -0.0278166 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0264263 |
| COL5A1 | collagen, type V, alpha 1 | -0.0263236 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0262779 |
| INTS6 | integrator complex subunit 6 | -0.0259738 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0258647 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0257742 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0255942 |
| HMGA2 | high mobility group AT-hook 2 | -0.0255363 |
| FLNA | filamin A, alpha | -0.0253843 |
| ZNF207 | zinc finger protein 207 | -0.0251678 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0250502 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0250041 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0247474 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0245796 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0241933 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0232714 |
| MORF4L2 | mortality factor 4 like 2 | -0.0227502 |
| ERBIN | erbb2 interacting protein | -0.0227201 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0224823 |
| PTMA | prothymosin, alpha | -0.0218463 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0216843 |
| MYOF | myoferlin | -0.021551 |
| RYBP | RING1 and YY1 binding protein | -0.0215399 |
| FOXO3 | forkhead box O3 | -0.0215136 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0213794 |
| RBM39 | RNA binding motif protein 39 | -0.0213435 |
| MMP12 | matrix metallopeptidase 12 | -0.021158 |
| TMSB10 | thymosin beta 10 | -0.0210958 |
| ARF4 | ADP-ribosylation factor 4 | -0.0207086 |
| FAM20C | family with sequence similarity 20, member C | -0.0205861 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0204165 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0201675 |
| CNNM2 | cyclin and CBS domain divalent metal cation transport mediator 2 | -0.0201226 |
| RPS24 | ribosomal protein S24 | -0.0197223 |
| FBXO11 | F-box protein 11 | -0.0196592 |
| KIF13A | kinesin family member 13A | -0.0195211 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.019455 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0193997 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0193872 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | -0.0193691 |
| STAG2 | stromal antigen 2 | -0.0192768 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -0.0190617 |
| MED13 | mediator complex subunit 13 | -0.0190264 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.018986 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | -0.0188157 |
| TAOK1 | TAO kinase 1 | -0.0185605 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0185364 |
| GNAS | GNAS complex locus | -0.018331 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.018303 |
| PTEN | phosphatase and tensin homolog | -0.0182785 |
| USP34 | ubiquitin specific peptidase 34 | -0.018267 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0181651 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | -0.0179979 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0179161 |
| PRR16 | proline rich 16 | -0.0178708 |
| CCBE1 | collagen and calcium binding EGF domains 1 | -0.017859 |
| IER3 | immediate early response 3 | -0.0178032 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.017736 |
