| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | PF-06260933 perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the PF-06260933_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HLA-B | major histocompatibility complex, class I, B | 0.169815 |
| VEGFA | vascular endothelial growth factor A | 0.14695 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0832533 |
| IL6 | interleukin 6 | 0.077406 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0733657 |
| B2M | beta-2-microglobulin | 0.066924 |
| CD44 | CD44 molecule (Indian blood group) | 0.0630707 |
| MT2A | metallothionein 2A | 0.0625434 |
| EGFR | epidermal growth factor receptor | 0.0617116 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0564386 |
| COL5A1 | collagen, type V, alpha 1 | 0.0534091 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0529865 |
| PRELID2 | PRELI domain containing 2 | 0.0495092 |
| CALR | calreticulin | 0.0479267 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0475183 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0469921 |
| GOLGB1 | golgin B1 | 0.04602 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0432835 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0425962 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0374282 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0366885 |
| FLNA | filamin A, alpha | 0.0366274 |
| INTS6 | integrator complex subunit 6 | 0.0354638 |
| LDHA | lactate dehydrogenase A | 0.0347296 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.033723 |
| LOXL2 | lysyl oxidase-like 2 | 0.0324883 |
| OPTN | optineurin | 0.0320056 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0319017 |
| ACTG1 | actin gamma 1 | 0.0317767 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0315346 |
| CST3 | cystatin C | 0.0310165 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0305338 |
| FTL | ferritin, light polypeptide | 0.0300747 |
| KYNU | kynureninase | 0.0294289 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0288863 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.027728 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0277213 |
| FHIT | fragile histidine triad | 0.0271777 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0269439 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0266516 |
| BPTF | bromodomain PHD finger transcription factor | 0.0265527 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0265475 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0261067 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.025839 |
| GSE1 | Gse1 coiled-coil protein | 0.025701 |
| ENO1 | enolase 1, (alpha) | 0.0256924 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0254646 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0251541 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.0250989 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0250145 |
| CALD1 | caldesmon 1 | 0.0249555 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0247322 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0246584 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 0.0245674 |
| MYO10 | myosin X | 0.0245254 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.024477 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0242901 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0242231 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0237683 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0237662 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0237267 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0235069 |
| ANO6 | anoctamin 6 | 0.0232286 |
| FTO | fat mass and obesity associated | 0.0231934 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0229155 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0224922 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0223927 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0219125 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0217524 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0217467 |
| SEC62 | SEC62 homolog (S. cerevisiae) | 0.0217126 |
| FAM53C | family with sequence similarity 53, member C | 0.0216849 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | 0.0216802 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.0216497 |
| MTERF1 | mitochondrial transcription termination factor 1 | 0.0216298 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0214334 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0212557 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0212042 |
| NUCB2 | nucleobindin 2 | 0.0211843 |
| LYSMD3 | LysM, putative peptidoglycan-binding, domain containing 3 | 0.0211765 |
| VEGFC | vascular endothelial growth factor C | 0.0211235 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0210724 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0210357 |
| UMAD1 | UBAP1-MVB12-associated (UMA) domain containing 1 | 0.0209085 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0207301 |
| PLEC | plectin | 0.0206174 |
| FRMD4A | FERM domain containing 4A | 0.0205077 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.0203733 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0203513 |
| ALK | anaplastic lymphoma receptor tyrosine kinase | 0.0203019 |
| IL6ST | interleukin 6 signal transducer | 0.0202895 |
| RPS8 | ribosomal protein S8 | 0.0202656 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0201005 |
| USO1 | USO1 vesicle transport factor | 0.0200239 |
| PGM3 | phosphoglucomutase 3 | 0.0199891 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0198423 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0198334 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0197927 |
| JPH2 | junctophilin 2 | 0.0196849 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0196441 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.126842 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0818618 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0779292 |
| COL1A1 | collagen, type I, alpha 1 | -0.0757772 |
| COL1A2 | collagen, type I, alpha 2 | -0.071276 |
| LOC112694756 | uncharaterized LOC112694756 | -0.067923 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0676417 |
| POTEF | POTE ankyrin domain family, member F | -0.0666697 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0585548 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0579475 |
| MAP1B | microtubule-associated protein 1B | -0.0546221 |
| FN1 | fibronectin 1 | -0.0531306 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0518936 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0511798 |
| NDRG1 | N-myc downstream regulated 1 | -0.0502132 |
| VIM | vimentin | -0.0497086 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0484988 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0478549 |
| HIP1 | huntingtin interacting protein 1 | -0.0474094 |
| LOX | lysyl oxidase | -0.0464247 |
| PGK1 | phosphoglycerate kinase 1 | -0.0450631 |
| ASPH | aspartate beta-hydroxylase | -0.0446153 |
| PKM | pyruvate kinase, muscle | -0.0415855 |
| AHNAK | AHNAK nucleoprotein | -0.040686 |
| PTMA | prothymosin, alpha | -0.0402498 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0393153 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0389363 |
| ANLN | anillin, actin binding protein | -0.0371444 |
| ZNF292 | zinc finger protein 292 | -0.0364637 |
| SEPTIN7 | septin 7 | -0.0354312 |
| ANXA2 | annexin A2 | -0.0349776 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0345232 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0337638 |
| MEF2A | myocyte enhancer factor 2A | -0.0335583 |
| RYBP | RING1 and YY1 binding protein | -0.0330808 |
| PFN1 | profilin 1 | -0.0327709 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.032766 |
| MED13L | mediator complex subunit 13-like | -0.0327219 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | -0.0324397 |
| RBM39 | RNA binding motif protein 39 | -0.0316673 |
| SPAG9 | sperm associated antigen 9 | -0.0316667 |
| ATP13A3 | ATPase type 13A3 | -0.0310529 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0302378 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0302278 |
| RNF145 | ring finger protein 145 | -0.0291352 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0290976 |
| ITM2B | integral membrane protein 2B | -0.0289674 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0289155 |
| S100A10 | S100 calcium binding protein A10 | -0.0288523 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0288037 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.028498 |
| RLF | rearranged L-myc fusion | -0.0282963 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0280121 |
| NUP58 | nucleoporin 58 | -0.027998 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0279648 |
| TPM1 | tropomyosin 1 (alpha) | -0.0279293 |
| CENPF | centromere protein F, 350/400kDa | -0.027734 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0274398 |
| PRSS23 | protease, serine, 23 | -0.0271629 |
| RTN4 | reticulon 4 | -0.0269123 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0268834 |
| WDR45B | WD repeat domain 45B | -0.0265829 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0264866 |
| ANXA5 | annexin A5 | -0.0258972 |
| JMJD1C | jumonji domain containing 1C | -0.0253551 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0251863 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0241225 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0240398 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0239 |
| TMEM123 | transmembrane protein 123 | -0.0237984 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0237811 |
| CD109 | CD109 molecule | -0.0234557 |
| PTBP2 | polypyrimidine tract binding protein 2 | -0.0226409 |
| ANKRD37 | ankyrin repeat domain 37 | -0.0222555 |
| XPO1 | exportin 1 | -0.0222365 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | -0.022221 |
| GLG1 | golgi glycoprotein 1 | -0.0222087 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0219953 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0219225 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0218166 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0217095 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0217049 |
| PRRC1 | proline-rich coiled-coil 1 | -0.021481 |
| CDC27 | cell division cycle 27 | -0.021376 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0213492 |
| WDFY2 | WD repeat and FYVE domain containing 2 | -0.0212692 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.021042 |
| ZNF395 | zinc finger protein 395 | -0.0208476 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0207127 |
| PRKCA | protein kinase C, alpha | -0.0206565 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0205437 |
| GNAS | GNAS complex locus | -0.0203503 |
| TFG | TRK-fused gene | -0.0202328 |
| TAGLN2 | transgelin 2 | -0.0200989 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0200954 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.020023 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0199901 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0199709 |
| PHIP | pleckstrin homology domain interacting protein | -0.0198869 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0197214 |
