| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | PF-06260933 perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the PF-06260933_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VEGFA | vascular endothelial growth factor A | 0.117608 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.110732 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.095717 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0768173 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0747858 |
| FAT1 | FAT atypical cadherin 1 | 0.0738681 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0701232 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0692506 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0678388 |
| STC2 | stanniocalcin 2 | 0.0648583 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0583323 |
| ASPH | aspartate beta-hydroxylase | 0.0540154 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0473263 |
| LOXL2 | lysyl oxidase-like 2 | 0.046758 |
| HMGA2 | high mobility group AT-hook 2 | 0.0443319 |
| EGFR | epidermal growth factor receptor | 0.0421082 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0411678 |
| MAP1B | microtubule-associated protein 1B | 0.0411642 |
| FN1 | fibronectin 1 | 0.0397683 |
| ENO1 | enolase 1, (alpha) | 0.0376469 |
| PLEC | plectin | 0.0371889 |
| INTS6 | integrator complex subunit 6 | 0.0370771 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0356598 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0353048 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0350156 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0348351 |
| SFTPA2 | surfactant protein A2 | 0.0344057 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0338983 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0328151 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0319418 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0306309 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0303568 |
| AEBP2 | AE binding protein 2 | 0.0300753 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0298667 |
| PTK2 | protein tyrosine kinase 2 | 0.0277984 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0272247 |
| LDHA | lactate dehydrogenase A | 0.0269606 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0268695 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0268445 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0268429 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0265148 |
| MLPH | melanophilin | 0.0259024 |
| ACTG1 | actin gamma 1 | 0.0253022 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0252601 |
| TPM3 | tropomyosin 3 | 0.0246525 |
| NDRG1 | N-myc downstream regulated 1 | 0.0240816 |
| CADM1 | cell adhesion molecule 1 | 0.0239462 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.023797 |
| SEPTIN9 | septin 9 | 0.0237412 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.023618 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0234889 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0234214 |
| CCND1 | cyclin D1 | 0.0226847 |
| UBC | ubiquitin C | 0.0225276 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0222206 |
| PRKCA | protein kinase C, alpha | 0.0219794 |
| FLNB | filamin B, beta | 0.021923 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.021783 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0217301 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.0216168 |
| MTSS1 | metastasis suppressor 1 | 0.0214738 |
| FOSL1 | FOS-like antigen 1 | 0.0214576 |
| ATXN1 | ataxin 1 | 0.0214159 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0213868 |
| TBC1D22A | TBC1 domain family, member 22A | 0.021208 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | 0.0211389 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.021133 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.021076 |
| AREG | amphiregulin | 0.0205403 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0204957 |
| POU2F2 | POU class 2 homeobox 2 | 0.0203891 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0203164 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0202378 |
| ATN1 | atrophin 1 | 0.0201046 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0198507 |
| ABR | active BCR-related | 0.0198281 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.019785 |
| RASAL2 | RAS protein activator like 2 | 0.0195497 |
| GPATCH2L | G patch domain containing 2-like | 0.0194819 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0194592 |
| FLNA | filamin A, alpha | 0.0193392 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.019321 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0191033 |
| ANO6 | anoctamin 6 | 0.0190259 |
| POTEF | POTE ankyrin domain family, member F | 0.0188035 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0186131 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0185584 |
| SMAD3 | SMAD family member 3 | 0.0183972 |
| TFRC | transferrin receptor | 0.0183216 |
| CCDC138 | coiled-coil domain containing 138 | 0.0182381 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0181808 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0179831 |
| CST3 | cystatin C | 0.0176875 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0176864 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0176307 |
| BRD2 | bromodomain containing 2 | 0.0174416 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0173204 |
| DUSP6 | dual specificity phosphatase 6 | 0.0172497 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.01724 |
| IGF2 | insulin-like growth factor 2 | 0.0171913 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.278699 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.132143 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.130871 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.124829 |
| TXNIP | thioredoxin interacting protein | -0.102298 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0981919 |
| PTMA | prothymosin, alpha | -0.0897719 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0893022 |
| MT2A | metallothionein 2A | -0.088956 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0837946 |
| CANX | calnexin | -0.0833929 |
| ITGA1 | integrin, alpha 1 | -0.0676388 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0650133 |
| TMSB10 | thymosin beta 10 | -0.0605852 |
| S100A6 | S100 calcium binding protein A6 | -0.0599363 |
| AHR | aryl hydrocarbon receptor | -0.0593964 |
| RPL35A | ribosomal protein L35a | -0.0590336 |
| RPS24 | ribosomal protein S24 | -0.0540916 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0539475 |
| RPS6 | ribosomal protein S6 | -0.0527234 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0525228 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0476895 |
| RPLP1 | ribosomal protein, large, P1 | -0.0475793 |
| CD109 | CD109 molecule | -0.0473738 |
| KLHL5 | kelch-like family member 5 | -0.0465131 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0451769 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0447859 |
| RPS25 | ribosomal protein S25 | -0.0427109 |
| FTL | ferritin, light polypeptide | -0.0424073 |
| SMOX | spermine oxidase | -0.0409005 |
| RPS20 | ribosomal protein S20 | -0.0391496 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0390753 |
| B2M | beta-2-microglobulin | -0.0381335 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0380004 |
| OGA | O-GlcNAcase | -0.0376419 |
| RPL34 | ribosomal protein L34 | -0.0374762 |
| RBM39 | RNA binding motif protein 39 | -0.0369052 |
| RPL11 | ribosomal protein L11 | -0.0366052 |
| RPL26 | ribosomal protein L26 | -0.0361715 |
| ETNK1 | ethanolamine kinase 1 | -0.0352676 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0351546 |
| RPS19 | ribosomal protein S19 | -0.0346471 |
| DENND5B | DENN/MADD domain containing 5B | -0.0344988 |
| RPS16 | ribosomal protein S16 | -0.0340978 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0339906 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0339456 |
| RPS21 | ribosomal protein S21 | -0.0338962 |
| TENT2 | terminal nucleotidyltransferase 2 | -0.0338114 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0337462 |
| CENPF | centromere protein F, 350/400kDa | -0.0335221 |
| NEK7 | NIMA-related kinase 7 | -0.0335021 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0333876 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.033291 |
| TMEM165 | transmembrane protein 165 | -0.0332197 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0327382 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0327051 |
| FOXP1 | forkhead box P1 | -0.0326747 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0324864 |
| GNAS | GNAS complex locus | -0.0323387 |
| RPL37 | ribosomal protein L37 | -0.0321672 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0319839 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0316729 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0314001 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0313847 |
| ETV1 | ets variant 1 | -0.0313788 |
| CDC27 | cell division cycle 27 | -0.0311779 |
| RPS27 | ribosomal protein S27 | -0.0311398 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0308148 |
| RNF145 | ring finger protein 145 | -0.0307423 |
| ZFR | zinc finger RNA binding protein | -0.0305018 |
| RPS23 | ribosomal protein S23 | -0.030328 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0302414 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0300992 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0299755 |
| SYT1 | synaptotagmin I | -0.0295315 |
| RPS29 | ribosomal protein S29 | -0.0295046 |
| IER3 | immediate early response 3 | -0.0294672 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0293816 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0292201 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0291609 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0290714 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0290388 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0282035 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0280034 |
| FAF2 | Fas associated factor family member 2 | -0.0278284 |
| RPL12 | ribosomal protein L12 | -0.0273699 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0273576 |
| OSMR | oncostatin M receptor | -0.0271435 |
| RPS28 | ribosomal protein S28 | -0.027057 |
| AKAP10 | A kinase (PRKA) anchor protein 10 | -0.0269721 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0264634 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0263814 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0260321 |
| TMEM156 | transmembrane protein 156 | -0.0259871 |
| RPL32 | ribosomal protein L32 | -0.0259032 |
| RPL19 | ribosomal protein L19 | -0.0258402 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0256282 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0255994 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0255581 |
| FNBP1 | formin binding protein 1 | -0.0253563 |
