PF-3758309 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/25227462
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Genes

197 proteins with high or low expression in PF-3758309 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
ALPK3 alpha-kinase 3 4.53
TP53 tumor protein p53 3.24
JUN jun proto-oncogene 2.8
CREBZF CREB/ATF bZIP transcription factor 2.61
F10 coagulation factor X 1.94
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 1.73
TAZ tafazzin 1.68
PIP prolactin-induced protein 1.68
F5 coagulation factor V (proaccelerin, labile factor) 1.67
DEDD2 death effector domain containing 2 1.66
RAB40C RAB40C, member RAS oncogene family 1.6
TAGLN transgelin 1.58
SLC39A4 solute carrier family 39 (zinc transporter), member 4 1.54
PTPRD protein tyrosine phosphatase, receptor type, D 1.47
FN1 fibronectin 1 1.47
PTPRF protein tyrosine phosphatase, receptor type, F 1.46
MYO15B myosin XVB 1.45
CBR1 carbonyl reductase 1 1.44
QSOX1 quiescin Q6 sulfhydryl oxidase 1 1.43
TMBIM6 transmembrane BAX inhibitor motif containing 6 1.41
SYN2 synapsin II 1.41
CPN1 carboxypeptidase N, polypeptide 1 1.4
VTN vitronectin 1.39
CCDC66 coiled-coil domain containing 66 1.37
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 1.35
MERTK MER proto-oncogene, tyrosine kinase 1.34
COL14A1 collagen, type XIV, alpha 1 1.32
RNASE4 ribonuclease, RNase A family, 4 1.31
TIGD5 tigger transposable element derived 5 1.31
APOE apolipoprotein E 1.29
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 1.28
TMUB1 transmembrane and ubiquitin-like domain containing 1 1.27
PLEK pleckstrin 1.27
TPM2 tropomyosin 2 (beta) 1.26
HBA1 hemoglobin, alpha 1 1.26
PTPRS protein tyrosine phosphatase, receptor type, S 1.25
SRSF9 serine/arginine-rich splicing factor 9 1.24
DNLZ DNL-type zinc finger 1.24
C1QTNF3 C1q and tumor necrosis factor related protein 3 1.23
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B 1.18
TIMP3 TIMP metallopeptidase inhibitor 3 1.15
TSPAN3 tetraspanin 3 1.15
TTN titin 1.14
PLEC plectin 1.14
CCN2 cellular communication network factor 2 1.13
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 1.12
THBS2 thrombospondin 2 1.1
NDRG2 NDRG family member 2 1.08
NRXN3 neurexin 3 1.07
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial 1.05
CRLF1 cytokine receptor-like factor 1 1.05
PRG4 proteoglycan 4 1.03
AMPD1 adenosine monophosphate deaminase 1 1.02
C19ORF25 chromosome 19 open reading frame 25 0.99
GUK1 guanylate kinase 1 0.95
HLA-B major histocompatibility complex, class I, B 0.95
ZNF503 zinc finger protein 503 0.94
CKM creatine kinase, muscle 0.93
GALT galactose-1-phosphate uridylyltransferase 0.93
PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 0.92
SELENOK selenoprotein K 0.92
ARSB arylsulfatase B 0.91
HSP90AB4P heat shock protein 90kDa alpha (cytosolic), class B member 4, pseudogene 0.9
SH3TC2 SH3 domain and tetratricopeptide repeats 2 0.89
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 0.89
AXL AXL receptor tyrosine kinase 0.89
MZT2A mitotic spindle organizing protein 2A 0.88
ACTB actin, beta 0.88
PYGM phosphorylase, glycogen, muscle 0.88
CERCAM cerebral endothelial cell adhesion molecule 0.87
H1-0 H1.0 linker histone 0.87
ZYX zyxin 0.86
CCDC158 coiled-coil domain containing 158 0.86
KMT2B lysine (K)-specific methyltransferase 2B 0.86
MXRA7 matrix-remodelling associated 7 0.86
HRH1 histamine receptor H1 0.86
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 0.86
PCSK6 proprotein convertase subtilisin/kexin type 6 0.85
LRRC49 leucine rich repeat containing 49 0.85
ZNF692 zinc finger protein 692 0.85
PKN1 protein kinase N1 0.85
LAMB3 laminin, beta 3 0.85
ADCK1 aarF domain containing kinase 1 0.85
SRSF6 serine/arginine-rich splicing factor 6 0.84
TMEM64 transmembrane protein 64 0.84
SELENOW selenoprotein W 0.83
DPP7 dipeptidyl-peptidase 7 0.83
SCMH1 sex comb on midleg homolog 1 (Drosophila) 0.83
HLA-A major histocompatibility complex, class I, A 0.83
ZNF646 zinc finger protein 646 0.83
CARHSP1 calcium regulated heat stable protein 1, 24kDa 0.83
LAMA5 laminin, alpha 5 0.82
ZNF664 zinc finger protein 664 0.82
CNTNAP1 contactin associated protein 1 0.82
TMPO thymopoietin 0.82
TEX15 testis expressed 15 0.82
BUD23 BUD23 rRNA methyltransferase and ribosome maturation factor 0.81
ACSM3 acyl-CoA synthetase medium-chain family member 3 0.81

low expression

Symbol Name Standardized Value
ABTB1 ankyrin repeat and BTB (POZ) domain containing 1 -6.09
KCTD2 potassium channel tetramerization domain containing 2 -5.82
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor -5.32
CLIC6 chloride intracellular channel 6 -5.26
C5ORF34 chromosome 5 open reading frame 34 -5.05
PSRC1 proline/serine-rich coiled-coil 1 -4.93
RGS3 regulator of G-protein signaling 3 -4.78
MT2A metallothionein 2A -4.39
STARD5 StAR-related lipid transfer (START) domain containing 5 -4.34
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -4.22
LGALSL lectin, galactoside-binding-like -4.08
GGNBP2 gametogenetin binding protein 2 -4.07
ZNF317 zinc finger protein 317 -4.04
ANKEF1 ankyrin repeat and EF-hand domain containing 1 -3.94
ZFAND5 zinc finger, AN1-type domain 5 -3.93
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -3.92
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -3.84
ZFP36L2 ZFP36 ring finger protein-like 2 -3.78
USP37 ubiquitin specific peptidase 37 -3.78
WEE1 WEE1 G2 checkpoint kinase -3.74
AREG amphiregulin -3.64
EWSR1 EWS RNA-binding protein 1 -3.61
AMD1 adenosylmethionine decarboxylase 1 -3.59
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.59
SOX4 SRY (sex determining region Y)-box 4 -3.59
HLA-F major histocompatibility complex, class I, F -3.57
DEPDC7 DEP domain containing 7 -3.54
IP6K2 inositol hexakisphosphate kinase 2 -3.52
ZNF460 zinc finger protein 460 -3.47
PEX2 peroxisomal biogenesis factor 2 -3.43
PEG10 paternally expressed 10 -3.39
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -3.38
TGIF1 TGFB-induced factor homeobox 1 -3.37
ATXN7L3B ataxin 7-like 3B -3.37
AURKA aurora kinase A -3.37
FAM86B2 family with sequence similarity 86, member B2 -3.36
MLPH melanophilin -3.31
SESN1 sestrin 1 -3.29
PRSS23 protease, serine, 23 -3.28
GTF3A general transcription factor IIIA -3.27
ZNF57 zinc finger protein 57 -3.27
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase -3.26
CSNK1G3 casein kinase 1, gamma 3 -3.26
AZIN1 antizyme inhibitor 1 -3.21
COBL cordon-bleu WH2 repeat protein -3.21
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase -3.18
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A -3.18
ARMC7 armadillo repeat containing 7 -3.16
RBAK RB-associated KRAB zinc finger -3.16
COQ10B coenzyme Q10 homolog B (S. cerevisiae) -3.15
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -3.12
CCDC112 coiled-coil domain containing 112 -3.11
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria -3.11
MT1L metallothionein 1L (gene/pseudogene) -3.1
ZFAND3 zinc finger, AN1-type domain 3 -3.1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -3.09
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) -3.09
BBS10 Bardet-Biedl syndrome 10 -3.09
STK17A serine/threonine kinase 17a -3.08
TRIM8 tripartite motif containing 8 -3.06
RAD51 RAD51 recombinase -3.06
IGFBP5 insulin-like growth factor binding protein 5 -3.05
MTMR4 myotubularin related protein 4 -3.01
DUSP4 dual specificity phosphatase 4 -3.01
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -2.98
ZNF638 zinc finger protein 638 -2.97
CCDC102A coiled-coil domain containing 102A -2.97
SNX10 sorting nexin 10 -2.95
DZIP3 DAZ interacting zinc finger protein 3 -2.93
TSPAN15 tetraspanin 15 -2.92
KLF3 Kruppel-like factor 3 (basic) -2.9
KLHL21 kelch-like family member 21 -2.9
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -2.87
TMCO4 transmembrane and coiled-coil domains 4 -2.87
PER2 period circadian clock 2 -2.84
TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast) -2.84
MYH4 myosin, heavy chain 4, skeletal muscle -2.83
RHPN2 rhophilin, Rho GTPase binding protein 2 -2.82
KLHL7 kelch-like family member 7 -2.78
LUC7L LUC7-like (S. cerevisiae) -2.78
RNF13 ring finger protein 13 -2.75
SYTL3 synaptotagmin-like 3 -2.74
ZNF436 zinc finger protein 436 -2.7
SREBF1 sterol regulatory element binding transcription factor 1 -2.68
CEBPB CCAAT/enhancer binding protein (C/EBP), beta -2.68
ZNF417 zinc finger protein 417 -2.66
MIER3 mesoderm induction early response 1, family member 3 -2.65
CNTLN centlein, centrosomal protein -2.62
MT1E metallothionein 1E -2.62
ODC1 ornithine decarboxylase 1 -2.61
MICOS10 mitochondrial contact site and cristae organizing system subunit 10 -2.6
ZNF749 zinc finger protein 749 -2.6
SMIM26 small integral membrane protein 26 -2.57
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor -2.55
MIIP migration and invasion inhibitory protein -2.55
CARD10 caspase recruitment domain family, member 10 -2.55
ZIC2 Zic family member 2 -2.51
PDE4B phosphodiesterase 4B, cAMP-specific -2.51
NES nestin -2.51