| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/11598628 |
| Similar Terms | |
| Downloads & Tools |
197 proteins with high or low expression in PF-431396 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TP53 | tumor protein p53 | 4.11 |
| ATF3 | activating transcription factor 3 | 3.41 |
| JUN | jun proto-oncogene | 3.27 |
| F5 | coagulation factor V (proaccelerin, labile factor) | 2.52 |
| ZNF503 | zinc finger protein 503 | 2.33 |
| JPT1 | Jupiter microtubule associated homolog 1 | 2.29 |
| ATAD3B | ATPase family, AAA domain containing 3B | 2.27 |
| RIPK4 | receptor-interacting serine-threonine kinase 4 | 1.94 |
| ENO1 | enolase 1, (alpha) | 1.86 |
| ICAM5 | intercellular adhesion molecule 5, telencephalin | 1.85 |
| PCLO | piccolo presynaptic cytomatrix protein | 1.8 |
| HMGA2 | high mobility group AT-hook 2 | 1.79 |
| F2 | coagulation factor II (thrombin) | 1.74 |
| DAP | death-associated protein | 1.65 |
| HMGB3 | high mobility group box 3 | 1.64 |
| HMGN1 | high mobility group nucleosome binding domain 1 | 1.56 |
| IMMT | inner membrane protein, mitochondrial | 1.52 |
| PRDX2 | peroxiredoxin 2 | 1.52 |
| COL17A1 | collagen, type XVII, alpha 1 | 1.48 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 1.47 |
| UNC80 | unc-80 homolog (C. elegans) | 1.45 |
| GEM | GTP binding protein overexpressed in skeletal muscle | 1.44 |
| HSD17B10 | hydroxysteroid (17-beta) dehydrogenase 10 | 1.43 |
| CCN1 | cellular communication network factor 1 | 1.41 |
| TMUB1 | transmembrane and ubiquitin-like domain containing 1 | 1.41 |
| SMTN | smoothelin | 1.39 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 1.38 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 1.36 |
| CHKB | choline kinase beta | 1.35 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 1.34 |
| CD2BP2 | CD2 (cytoplasmic tail) binding protein 2 | 1.32 |
| SMN1 | survival of motor neuron 1, telomeric | 1.3 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 1.3 |
| MGST1 | microsomal glutathione S-transferase 1 | 1.3 |
| ITGB8 | integrin, beta 8 | 1.29 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 1.26 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 1.24 |
| SEPTIN2 | septin 2 | 1.23 |
| EEF2 | eukaryotic translation elongation factor 2 | 1.23 |
| RHOB | ras homolog family member B | 1.22 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | 1.21 |
| CPN1 | carboxypeptidase N, polypeptide 1 | 1.21 |
| ANKRD36C | ankyrin repeat domain 36C | 1.2 |
| PLK2 | polo-like kinase 2 | 1.19 |
| H1-4 | H1.4 linker histone, cluster member | 1.19 |
| CRYM | crystallin, mu | 1.19 |
| GPATCH2L | G patch domain containing 2-like | 1.17 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 1.17 |
| PER1 | period circadian clock 1 | 1.16 |
| VTN | vitronectin | 1.16 |
| AXL | AXL receptor tyrosine kinase | 1.16 |
| MDH1 | malate dehydrogenase 1, NAD (soluble) | 1.16 |
| METRN | meteorin, glial cell differentiation regulator | 1.15 |
| EGR1 | early growth response 1 | 1.15 |
| CCDC158 | coiled-coil domain containing 158 | 1.14 |
| ARMT1 | acidic residue methyltransferase 1 | 1.14 |
| LIMK2 | LIM domain kinase 2 | 1.14 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 1.13 |
| SRSF6 | serine/arginine-rich splicing factor 6 | 1.12 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 1.12 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 1.12 |
| IDH3B | isocitrate dehydrogenase 3 (NAD+) beta | 1.11 |
| PEX7 | peroxisomal biogenesis factor 7 | 1.1 |
| UBTF | upstream binding transcription factor, RNA polymerase I | 1.1 |
| CCDC91 | coiled-coil domain containing 91 | 1.1 |
| LBR | lamin B receptor | 1.1 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 1.09 |
| FHIT | fragile histidine triad | 1.09 |
| JMJD8 | jumonji domain containing 8 | 1.09 |
| RAB1B | RAB1B, member RAS oncogene family | 1.08 |
| GLUL | glutamate-ammonia ligase | 1.06 |
| RNASE4 | ribonuclease, RNase A family, 4 | 1.06 |
| TAGLN | transgelin | 1.06 |
| DDX4 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 | 1.06 |
| DCTD | dCMP deaminase | 1.06 |
| PTBP1 | polypyrimidine tract binding protein 1 | 1.05 |
| GDF15 | growth differentiation factor 15 | 1.04 |
| PRMT5 | protein arginine methyltransferase 5 | 1.04 |
| LASP1 | LIM and SH3 protein 1 | 1.03 |
| ACTB | actin, beta | 1.02 |
| DDB1 | damage-specific DNA binding protein 1, 127kDa | 1.02 |
| ADCK5 | aarF domain containing kinase 5 | 1.02 |
| VTA1 | vesicle (multivesicular body) trafficking 1 | 1.02 |
| ADIRF | adipogenesis regulatory factor | 1.01 |
| ZNF746 | zinc finger protein 746 | 1.0 |
| SARNP | SAP domain containing ribonucleoprotein | 1.0 |
| ARSB | arylsulfatase B | 1.0 |
| SUPT4H1 | suppressor of Ty 4 homolog 1 (S. cerevisiae) | 1.0 |
| FN1 | fibronectin 1 | 0.99 |
| MT-ND5 | NADH dehydrogenase, subunit 5 (complex I) | 0.97 |
| JUNB | jun B proto-oncogene | 0.97 |
| CARHSP1 | calcium regulated heat stable protein 1, 24kDa | 0.97 |
| ASNA1 | arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) | 0.97 |
| TOMM7 | translocase of outer mitochondrial membrane 7 homolog (yeast) | 0.97 |
| ACO2 | aconitase 2, mitochondrial | 0.96 |
| C1QTNF3 | C1q and tumor necrosis factor related protein 3 | 0.96 |
| EIF4A3 | eukaryotic translation initiation factor 4A3 | 0.96 |
| Symbol | Name | Standardized Value |
|---|---|---|
| JARID2 | jumonji, AT rich interactive domain 2 | -12.05 |
| FNIP1 | folliculin interacting protein 1 | -8.21 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -7.53 |
| CCDC137 | coiled-coil domain containing 137 | -7.2 |
| NOP16 | NOP16 nucleolar protein | -5.32 |
| HSF2 | heat shock transcription factor 2 | -5.18 |
| FYTTD1 | forty-two-three domain containing 1 | -4.96 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -4.81 |
| DUSP4 | dual specificity phosphatase 4 | -4.77 |
| AMD1 | adenosylmethionine decarboxylase 1 | -4.69 |
| CCNA1 | cyclin A1 | -4.59 |
| PRELID3B | PRELI domain containing 3B | -4.53 |
| ESCO2 | establishment of sister chromatid cohesion N-acetyltransferase 2 | -4.36 |
| TCEANC2 | transcription elongation factor A (SII) N-terminal and central domain containing 2 | -4.31 |
| DUSP6 | dual specificity phosphatase 6 | -4.29 |
| SURF6 | surfeit 6 | -4.29 |
| SOX4 | SRY (sex determining region Y)-box 4 | -4.28 |
| DDX56 | DEAD (Asp-Glu-Ala-Asp) box helicase 56 | -4.27 |
| NSA2 | NSA2 ribosome biogenesis homolog (S. cerevisiae) | -4.23 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | -4.22 |
| ZBED2 | zinc finger, BED-type containing 2 | -4.17 |
| CCNA2 | cyclin A2 | -4.16 |
| TNS4 | tensin 4 | -4.15 |
| SMAD1 | SMAD family member 1 | -4.13 |
| ZNF696 | zinc finger protein 696 | -4.1 |
| NOP53 | NOP53 ribosome biogenesis factor | -4.02 |
| RBM23 | RNA binding motif protein 23 | -3.98 |
| TGIF1 | TGFB-induced factor homeobox 1 | -3.93 |
| ZIC2 | Zic family member 2 | -3.83 |
| RBIS | ribosomal biogenesis factor | -3.76 |
| UBE2J2 | ubiquitin-conjugating enzyme E2, J2 | -3.74 |
| FAM207A | family with sequence similarity 207, member A | -3.74 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -3.74 |
| DERPC | DERPC proline and glycine rich nuclear protein | -3.71 |
| PRSS8 | protease, serine, 8 | -3.69 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -3.67 |
| ZFAND5 | zinc finger, AN1-type domain 5 | -3.65 |
| ZCCHC9 | zinc finger, CCHC domain containing 9 | -3.64 |
| CHTOP | chromatin target of PRMT1 | -3.58 |
| ZBTB8A | zinc finger and BTB domain containing 8A | -3.57 |
| MCM10 | minichromosome maintenance complex component 10 | -3.56 |
| YY1AP1 | YY1 associated protein 1 | -3.53 |
| STK17A | serine/threonine kinase 17a | -3.53 |
| CCNF | cyclin F | -3.51 |
| CDC20 | cell division cycle 20 | -3.51 |
| CDC25B | cell division cycle 25B | -3.47 |
| ARHGAP11A | Rho GTPase activating protein 11A | -3.45 |
| SGO2 | shugoshin 2 | -3.43 |
| ATMIN | ATM interactor | -3.4 |
| KIF18B | kinesin family member 18B | -3.38 |
| FAM20C | family with sequence similarity 20, member C | -3.38 |
| PPRC1 | peroxisome proliferator-activated receptor gamma, coactivator-related 1 | -3.34 |
| SYTL3 | synaptotagmin-like 3 | -3.32 |
| ZNF445 | zinc finger protein 445 | -3.32 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -3.32 |
| OBI1 | ORC ubiquitin ligase 1 | -3.3 |
| DEPDC1 | DEP domain containing 1 | -3.29 |
| HOXB4 | homeobox B4 | -3.27 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -3.26 |
| CBX6 | chromobox homolog 6 | -3.25 |
| TPGS1 | tubulin polyglutamylase complex subunit 1 | -3.23 |
| PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1 | -3.21 |
| UTP14A | UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) | -3.2 |
| PIAS4 | protein inhibitor of activated STAT, 4 | -3.19 |
| FBXO5 | F-box protein 5 | -3.19 |
| TIGD5 | tigger transposable element derived 5 | -3.18 |
| ZNF91 | zinc finger protein 91 | -3.18 |
| EHF | ets homologous factor | -3.18 |
| CDC6 | cell division cycle 6 | -3.13 |
| C6ORF62 | chromosome 6 open reading frame 62 | -3.12 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | -3.11 |
| SPATA2L | spermatogenesis associated 2-like | -3.1 |
| GMNN | geminin, DNA replication inhibitor | -3.09 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -3.08 |
| RPF1 | ribosome production factor 1 homolog (S. cerevisiae) | -3.06 |
| SOX13 | SRY (sex determining region Y)-box 13 | -3.05 |
| APPBP2 | amyloid beta precursor protein (cytoplasmic tail) binding protein 2 | -3.04 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | -3.04 |
| RNF115 | ring finger protein 115 | -3.04 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -3.03 |
| TRAIP | TRAF interacting protein | -3.03 |
| ZC3H3 | zinc finger CCCH-type containing 3 | -3.03 |
| FRMD6 | FERM domain containing 6 | -3.02 |
| CCDC59 | coiled-coil domain containing 59 | -3.02 |
| POLDIP3 | polymerase (DNA-directed), delta interacting protein 3 | -3.02 |
| NCKAP5L | NCK-associated protein 5-like | -3.02 |
| MAGEF1 | melanoma antigen family F1 | -3.0 |
| C1ORF131 | chromosome 1 open reading frame 131 | -3.0 |
| TFAP4 | transcription factor AP-4 (activating enhancer binding protein 4) | -2.99 |
| KMT5A | lysine methyltransferase 5A | -2.96 |
| DUSP5 | dual specificity phosphatase 5 | -2.95 |
| PCMTD2 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 | -2.95 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | -2.93 |
| C5ORF30 | chromosome 5 open reading frame 30 | -2.93 |
| KIF18A | kinesin family member 18A | -2.92 |
| MLPH | melanophilin | -2.91 |
| TMEM200A | transmembrane protein 200A | -2.9 |
| RFWD3 | ring finger and WD repeat domain 3 | -2.89 |
| ANKEF1 | ankyrin repeat and EF-hand domain containing 1 | -2.86 |
| ZNF770 | zinc finger protein 770 | -2.86 |
