| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/11316919 |
| Similar Terms | |
| Downloads & Tools |
197 proteins with high or low expression in PF-514273 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DOCK11 | dedicator of cytokinesis 11 | 1.22 |
| ADIPOR1 | adiponectin receptor 1 | 0.79 |
| MCL1 | myeloid cell leukemia 1 | 0.68 |
| MIDN | midnolin | 0.59 |
| C15ORF61 | chromosome 15 open reading frame 61 | 0.57 |
| STARD7 | StAR-related lipid transfer (START) domain containing 7 | 0.54 |
| SLC25A33 | solute carrier family 25 (pyrimidine nucleotide carrier), member 33 | 0.53 |
| ELOVL6 | ELOVL fatty acid elongase 6 | 0.47 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.47 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.47 |
| TTLL5 | tubulin tyrosine ligase-like family member 5 | 0.47 |
| PRELID3B | PRELI domain containing 3B | 0.47 |
| SIGIRR | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain | 0.46 |
| GRID1 | glutamate receptor, ionotropic, delta 1 | 0.45 |
| JAK2 | Janus kinase 2 | 0.45 |
| MLPH | melanophilin | 0.45 |
| RNF6 | ring finger protein (C3H2C3 type) 6 | 0.44 |
| LIPA | lipase A, lysosomal acid, cholesterol esterase | 0.43 |
| METRN | meteorin, glial cell differentiation regulator | 0.43 |
| TCP11L1 | t-complex 11, testis-specific-like 1 | 0.42 |
| PITX1 | paired-like homeodomain 1 | 0.42 |
| ADAMTS7 | ADAM metallopeptidase with thrombospondin type 1 motif, 7 | 0.42 |
| OTX1 | orthodenticle homeobox 1 | 0.42 |
| FRMPD3 | FERM and PDZ domain containing 3 | 0.42 |
| NIBAN1 | niban apoptosis regulator 1 | 0.41 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.41 |
| CNTRL | centriolin | 0.4 |
| BBS1 | Bardet-Biedl syndrome 1 | 0.4 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 0.4 |
| JUN | jun proto-oncogene | 0.39 |
| CABLES2 | Cdk5 and Abl enzyme substrate 2 | 0.39 |
| HOXB9 | homeobox B9 | 0.39 |
| GK5 | glycerol kinase 5 (putative) | 0.39 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.38 |
| KLF3 | Kruppel-like factor 3 (basic) | 0.38 |
| MKS1 | Meckel syndrome, type 1 | 0.38 |
| MZT2B | mitotic spindle organizing protein 2B | 0.37 |
| ESCO2 | establishment of sister chromatid cohesion N-acetyltransferase 2 | 0.37 |
| GPR179 | G protein-coupled receptor 179 | 0.37 |
| ZNF768 | zinc finger protein 768 | 0.37 |
| AKT1S1 | AKT1 substrate 1 (proline-rich) | 0.36 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.36 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.36 |
| GGT2 | gamma-glutamyltransferase 2 | 0.36 |
| MT2A | metallothionein 2A | 0.36 |
| SYTL3 | synaptotagmin-like 3 | 0.36 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | 0.35 |
| XBP1 | X-box binding protein 1 | 0.35 |
| SEMA4G | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G | 0.35 |
| HIST2H2AA3 | histone cluster 2, H2aa3 | 0.35 |
| FAM117B | family with sequence similarity 117, member B | 0.35 |
| NAPEPLD | N-acyl phosphatidylethanolamine phospholipase D | 0.34 |
| MEGF8 | multiple EGF-like-domains 8 | 0.34 |
| ZNF696 | zinc finger protein 696 | 0.34 |
| ABCC9 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | 0.33 |
| PLXNB1 | plexin B1 | 0.33 |
| ZNF106 | zinc finger protein 106 | 0.33 |
| VGF | VGF nerve growth factor inducible | 0.33 |
| KIF27 | kinesin family member 27 | 0.33 |
| COMMD9 | COMM domain containing 9 | 0.33 |
| DNAH12 | dynein, axonemal, heavy chain 12 | 0.33 |
| ATL1 | atlastin GTPase 1 | 0.33 |
| CELSR1 | cadherin, EGF LAG seven-pass G-type receptor 1 | 0.33 |
| ZNF395 | zinc finger protein 395 | 0.33 |
| RANBP17 | RAN binding protein 17 | 0.33 |
| ZNHIT1 | zinc finger, HIT-type containing 1 | 0.33 |
| ZNF354B | zinc finger protein 354B | 0.33 |
| AMOT | angiomotin | 0.32 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.32 |
| PIGX | phosphatidylinositol glycan anchor biosynthesis, class X | 0.32 |
| CHPF | chondroitin polymerizing factor | 0.32 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.32 |
| ZNF362 | zinc finger protein 362 | 0.32 |
| PDP2 | pyruvate dehyrogenase phosphatase catalytic subunit 2 | 0.32 |
| ZNF324 | zinc finger protein 324 | 0.32 |
| DCLK2 | doublecortin-like kinase 2 | 0.32 |
| LIPT1 | lipoyltransferase 1 | 0.32 |
| ATAD5 | ATPase family, AAA domain containing 5 | 0.31 |
| SRD5A3 | steroid 5 alpha-reductase 3 | 0.31 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | 0.31 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | 0.31 |
| FOXP4 | forkhead box P4 | 0.31 |
| NOVA2 | neuro-oncological ventral antigen 2 | 0.31 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.3 |
| DISP2 | dispatched homolog 2 (Drosophila) | 0.3 |
| ANKRD26 | ankyrin repeat domain 26 | 0.3 |
| DNAH2 | dynein, axonemal, heavy chain 2 | 0.3 |
| SPEG | SPEG complex locus | 0.3 |
| ADAM11 | ADAM metallopeptidase domain 11 | 0.3 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.3 |
| ATF6B | activating transcription factor 6 beta | 0.29 |
| RNF185 | ring finger protein 185 | 0.29 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | 0.29 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.29 |
| SEC11C | SEC11 homolog C (S. cerevisiae) | 0.28 |
| KATNBL1 | katanin p80 subunit B-like 1 | 0.28 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.28 |
| SREBF1 | sterol regulatory element binding transcription factor 1 | 0.28 |
| ATXN7L3 | ataxin 7-like 3 | 0.28 |
| SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 | 0.28 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SPTA1 | spectrin, alpha, erythrocytic 1 | -1.72 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -1.48 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | -1.3 |
| RNF145 | ring finger protein 145 | -1.21 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -1.13 |
| MYH13 | myosin, heavy chain 13, skeletal muscle | -1.01 |
| RIOX1 | ribosomal oxygenase 1 | -0.71 |
| SNRPC | small nuclear ribonucleoprotein polypeptide C | -0.69 |
| ATP13A2 | ATPase type 13A2 | -0.63 |
| C1ORF52 | chromosome 1 open reading frame 52 | -0.62 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | -0.56 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -0.56 |
| PPIE | peptidylprolyl isomerase E (cyclophilin E) | -0.55 |
| SF1 | splicing factor 1 | -0.51 |
| SLC4A11 | solute carrier family 4, sodium borate transporter, member 11 | -0.5 |
| TTC39A | tetratricopeptide repeat domain 39A | -0.48 |
| CKS1B | CDC28 protein kinase regulatory subunit 1B | -0.48 |
| COX19 | COX19 cytochrome c oxidase assembly factor | -0.48 |
| PRR14L | proline rich 14-like | -0.44 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.44 |
| ZNF707 | zinc finger protein 707 | -0.44 |
| CCDC158 | coiled-coil domain containing 158 | -0.42 |
| FUNDC1 | FUN14 domain containing 1 | -0.42 |
| ZXDC | ZXD family zinc finger C | -0.42 |
| PLEKHF1 | pleckstrin homology domain containing, family F (with FYVE domain) member 1 | -0.42 |
| SASH1 | SAM and SH3 domain containing 1 | -0.41 |
| TRIAP1 | TP53 regulated inhibitor of apoptosis 1 | -0.41 |
| MT-ND5 | NADH dehydrogenase, subunit 5 (complex I) | -0.41 |
| PPTC7 | PTC7 protein phosphatase homolog (S. cerevisiae) | -0.4 |
| E2F1 | E2F transcription factor 1 | -0.4 |
| MSMO1 | methylsterol monooxygenase 1 | -0.4 |
| SEC14L1 | SEC14-like 1 (S. cerevisiae) | -0.4 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.39 |
| NDUFAB1 | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa | -0.39 |
| DERPC | DERPC proline and glycine rich nuclear protein | -0.38 |
| MTCH2 | mitochondrial carrier 2 | -0.38 |
| ENO1 | enolase 1, (alpha) | -0.38 |
| FAM124A | family with sequence similarity 124A | -0.38 |
| ALG10B | ALG10B, alpha-1,2-glucosyltransferase | -0.38 |
| ZNF440 | zinc finger protein 440 | -0.37 |
| JPT2 | Jupiter microtubule associated homolog 2 | -0.37 |
| C5 | complement component 5 | -0.37 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.36 |
| PLSCR1 | phospholipid scramblase 1 | -0.35 |
| IQCG | IQ motif containing G | -0.35 |
| ZNF564 | zinc finger protein 564 | -0.35 |
| TMEM39B | transmembrane protein 39B | -0.34 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | -0.34 |
| NUCB1 | nucleobindin 1 | -0.33 |
| TMEM104 | transmembrane protein 104 | -0.33 |
| B2M | beta-2-microglobulin | -0.33 |
| ZNRD1 | zinc ribbon domain containing 1 | -0.33 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.33 |
| UQCRH | ubiquinol-cytochrome c reductase hinge protein | -0.33 |
| WLS | wntless Wnt ligand secretion mediator | -0.32 |
| BRD7 | bromodomain containing 7 | -0.32 |
| EIF4EBP2 | eukaryotic translation initiation factor 4E binding protein 2 | -0.32 |
| SDHAF4 | succinate dehydrogenase complex assembly factor 4 | -0.31 |
| COL6A3 | collagen, type VI, alpha 3 | -0.31 |
| TDRKH | tudor and KH domain containing | -0.31 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.31 |
| MTPN | myotrophin | -0.31 |
| HGH1 | HGH1 homolog (S. cerevisiae) | -0.31 |
| PEBP1 | phosphatidylethanolamine binding protein 1 | -0.3 |
| PYGO2 | pygopus family PHD finger 2 | -0.3 |
| SF3B5 | splicing factor 3b, subunit 5, 10kDa | -0.3 |
| MTUS2 | microtubule associated tumor suppressor candidate 2 | -0.3 |
| ZNF276 | zinc finger protein 276 | -0.29 |
| PLPP3 | phospholipid phosphatase 3 | -0.29 |
| MFSD14B | major facilitator superfamily domain containing 14B | -0.29 |
| TAMM41 | TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae) | -0.29 |
| VMP1 | vacuole membrane protein 1 | -0.29 |
| STMN2 | stathmin 2 | -0.29 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.29 |
| TBCA | tubulin folding cofactor A | -0.29 |
| SRSF9 | serine/arginine-rich splicing factor 9 | -0.29 |
| COX16 | COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) | -0.29 |
| FTL | ferritin, light polypeptide | -0.28 |
| RNF139 | ring finger protein 139 | -0.28 |
| MAX | MYC associated factor X | -0.28 |
| FKBP1A | FK506 binding protein 1A, 12kDa | -0.28 |
| DPYD | dihydropyrimidine dehydrogenase | -0.28 |
| C19ORF25 | chromosome 19 open reading frame 25 | -0.28 |
| MSANTD2 | Myb/SANT-like DNA-binding domain containing 2 | -0.28 |
| GON7 | GON7 subunit of KEOPS complex | -0.28 |
| C16ORF70 | chromosome 16 open reading frame 70 | -0.28 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.28 |
| TACC3 | transforming, acidic coiled-coil containing protein 3 | -0.28 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | -0.27 |
| MFSD5 | major facilitator superfamily domain containing 5 | -0.27 |
| FRK | fyn-related Src family tyrosine kinase | -0.27 |
| LANCL3 | LanC lantibiotic synthetase component C-like 3 (bacterial) | -0.27 |
| NENF | neudesin neurotrophic factor | -0.27 |
| BAG3 | BCL2-associated athanogene 3 | -0.27 |
| BCS1L | BC1 (ubiquinol-cytochrome c reductase) synthesis-like | -0.26 |
| ARHGDIA | Rho GDP dissociation inhibitor (GDI) alpha | -0.26 |
| DBI | diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) | -0.26 |
