| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/66577038 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in PF-543 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 1.8 |
| APOB | apolipoprotein B | 1.57 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 1.56 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 1.35 |
| SQLE | squalene epoxidase | 1.34 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 1.3 |
| MSMO1 | methylsterol monooxygenase 1 | 1.21 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 1.13 |
| HSD17B7 | hydroxysteroid (17-beta) dehydrogenase 7 | 1.05 |
| NKD2 | naked cuticle homolog 2 (Drosophila) | 1.01 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.97 |
| ACAT2 | acetyl-CoA acetyltransferase 2 | 0.91 |
| TSPAN3 | tetraspanin 3 | 0.91 |
| DHCR7 | 7-dehydrocholesterol reductase | 0.88 |
| SC5D | sterol-C5-desaturase | 0.85 |
| DHCR24 | 24-dehydrocholesterol reductase | 0.83 |
| LSS | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 0.83 |
| CDC37L1 | cell division cycle 37-like 1 | 0.81 |
| MARK4 | MAP/microtubule affinity-regulating kinase 4 | 0.81 |
| RNF145 | ring finger protein 145 | 0.8 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.79 |
| SIRT3 | sirtuin 3 | 0.77 |
| MVK | mevalonate kinase | 0.76 |
| TMUB1 | transmembrane and ubiquitin-like domain containing 1 | 0.73 |
| TCP11L1 | t-complex 11, testis-specific-like 1 | 0.71 |
| MVD | mevalonate (diphospho) decarboxylase | 0.7 |
| FDPS | farnesyl diphosphate synthase | 0.7 |
| JAK2 | Janus kinase 2 | 0.69 |
| PLIN2 | perilipin 2 | 0.68 |
| FADS1 | fatty acid desaturase 1 | 0.66 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | 0.66 |
| COMMD5 | COMM domain containing 5 | 0.65 |
| MIS12 | MIS12 kinetochore complex component | 0.65 |
| LPIN1 | lipin 1 | 0.64 |
| LDLR | low density lipoprotein receptor | 0.63 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.61 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.6 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | 0.59 |
| KLHL22 | kelch-like family member 22 | 0.56 |
| ELOVL6 | ELOVL fatty acid elongase 6 | 0.56 |
| E2F1 | E2F transcription factor 1 | 0.56 |
| ATP6V0D1 | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 | 0.55 |
| SLC25A38 | solute carrier family 25, member 38 | 0.54 |
| TNIP2 | TNFAIP3 interacting protein 2 | 0.54 |
| GZF1 | GDNF-inducible zinc finger protein 1 | 0.54 |
| FGFR4 | fibroblast growth factor receptor 4 | 0.54 |
| ANTKMT | adenine nucleotide translocase lysine methyltransferase | 0.53 |
| TICAM1 | toll-like receptor adaptor molecule 1 | 0.53 |
| COPZ1 | coatomer protein complex, subunit zeta 1 | 0.52 |
| DNAH2 | dynein, axonemal, heavy chain 2 | 0.52 |
| HINT3 | histidine triad nucleotide binding protein 3 | 0.52 |
| PPARGC1B | peroxisome proliferator-activated receptor gamma, coactivator 1 beta | 0.51 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.51 |
| C7 | complement component 7 | 0.51 |
| TMEM97 | transmembrane protein 97 | 0.5 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | 0.5 |
| PANK3 | pantothenate kinase 3 | 0.49 |
| AP4S1 | adaptor-related protein complex 4, sigma 1 subunit | 0.48 |
| COPS4 | COP9 signalosome subunit 4 | 0.48 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.48 |
| SUPT7L | suppressor of Ty 7 (S. cerevisiae)-like | 0.48 |
| COMMD9 | COMM domain containing 9 | 0.47 |
| ANKRD22 | ankyrin repeat domain 22 | 0.47 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.47 |
| SYN2 | synapsin II | 0.45 |
| SYNE4 | spectrin repeat containing, nuclear envelope family member 4 | 0.45 |
| TMEM41B | transmembrane protein 41B | 0.45 |
| ACLY | ATP citrate lyase | 0.45 |
| TRMT2B | tRNA methyltransferase 2 homolog B (S. cerevisiae) | 0.45 |
| FBXW4 | F-box and WD repeat domain containing 4 | 0.45 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.44 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | 0.44 |
| BORCS5 | BLOC-1 related complex subunit 5 | 0.44 |
| REEP1 | receptor accessory protein 1 | 0.44 |
| SLC38A2 | solute carrier family 38, member 2 | 0.44 |
| EIF3K | eukaryotic translation initiation factor 3, subunit K | 0.43 |
| RNF185 | ring finger protein 185 | 0.43 |
| NDFIP1 | Nedd4 family interacting protein 1 | 0.43 |
| CSNK1G2 | casein kinase 1, gamma 2 | 0.42 |
| TYMP | thymidine phosphorylase | 0.42 |
| ACY1 | aminoacylase 1 | 0.42 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | 0.42 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.42 |
| HAUS7 | HAUS augmin-like complex, subunit 7 | 0.41 |
| ABHD5 | abhydrolase domain containing 5 | 0.41 |
| MICA | MHC class I polypeptide-related sequence A | 0.4 |
| FRMPD3 | FERM and PDZ domain containing 3 | 0.4 |
| TREX1 | three prime repair exonuclease 1 | 0.4 |
| MARS2 | methionyl-tRNA synthetase 2, mitochondrial | 0.39 |
| DESI2 | desumoylating isopeptidase 2 | 0.39 |
| ECI1 | enoyl-CoA delta isomerase 1 | 0.39 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 | 0.39 |
| HMOX1 | heme oxygenase 1 | 0.39 |
| UXT | ubiquitously-expressed, prefoldin-like chaperone | 0.39 |
| NES | nestin | 0.39 |
| SAYSD1 | SAYSVFN motif domain containing 1 | 0.39 |
| ERG28 | ergosterol biosynthesis 28 homolog | 0.38 |
| SCARB1 | scavenger receptor class B, member 1 | 0.38 |
| APOE | apolipoprotein E | 0.38 |
| NCOA4 | nuclear receptor coactivator 4 | 0.38 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CKS2 | CDC28 protein kinase regulatory subunit 2 | -2.76 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | -2.53 |
| ENO1 | enolase 1, (alpha) | -2.11 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -1.75 |
| ZXDC | ZXD family zinc finger C | -1.74 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -1.71 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | -1.52 |
| H1-2 | H1.2 linker histone, cluster member | -1.49 |
| ZNRD1 | zinc ribbon domain containing 1 | -1.43 |
| ZNF689 | zinc finger protein 689 | -1.38 |
| DNAH12 | dynein, axonemal, heavy chain 12 | -1.33 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | -1.31 |
| COL6A3 | collagen, type VI, alpha 3 | -1.24 |
| COA4 | cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) | -1.22 |
| FZD7 | frizzled class receptor 7 | -1.21 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | -1.19 |
| JPT2 | Jupiter microtubule associated homolog 2 | -1.15 |
| MYH13 | myosin, heavy chain 13, skeletal muscle | -1.12 |
| PPIE | peptidylprolyl isomerase E (cyclophilin E) | -1.09 |
| COX19 | COX19 cytochrome c oxidase assembly factor | -1.08 |
| C1ORF52 | chromosome 1 open reading frame 52 | -1.07 |
| RPL37 | ribosomal protein L37 | -1.03 |
| NKAP | NFKB activating protein | -1.01 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | -0.99 |
| DERPC | DERPC proline and glycine rich nuclear protein | -0.97 |
| RPL29 | ribosomal protein L29 | -0.96 |
| FAU | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed | -0.92 |
| CNPY2 | canopy FGF signaling regulator 2 | -0.9 |
| ZNF503 | zinc finger protein 503 | -0.88 |
| TWSG1 | twisted gastrulation BMP signaling modulator 1 | -0.88 |
| SLC44A2 | solute carrier family 44 (choline transporter), member 2 | -0.86 |
| ZCCHC17 | zinc finger, CCHC domain containing 17 | -0.85 |
| PEBP1 | phosphatidylethanolamine binding protein 1 | -0.83 |
| ZNF362 | zinc finger protein 362 | -0.81 |
| ADIPOR1 | adiponectin receptor 1 | -0.8 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.8 |
| MAX | MYC associated factor X | -0.78 |
| PRICKLE3 | prickle homolog 3 (Drosophila) | -0.78 |
| OSTM1 | osteopetrosis associated transmembrane protein 1 | -0.78 |
| HIST2H2AA3 | histone cluster 2, H2aa3 | -0.77 |
| NDUFS6 | NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) | -0.77 |
| GLT8D1 | glycosyltransferase 8 domain containing 1 | -0.74 |
| ABCA12 | ATP-binding cassette, sub-family A (ABC1), member 12 | -0.73 |
| MT1F | metallothionein 1F | -0.73 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.73 |
| RNF126 | ring finger protein 126 | -0.72 |
| FKBP1A | FK506 binding protein 1A, 12kDa | -0.71 |
| SDHAF4 | succinate dehydrogenase complex assembly factor 4 | -0.71 |
| NKAPD1 | NKAP domain containing 1 | -0.71 |
| ZNF335 | zinc finger protein 335 | -0.7 |
| OTX1 | orthodenticle homeobox 1 | -0.68 |
| RPIA | ribose 5-phosphate isomerase A | -0.68 |
| NECTIN3 | nectin cell adhesion molecule 3 | -0.66 |
| PLPP3 | phospholipid phosphatase 3 | -0.66 |
| H1FX | H1 histone family, member X | -0.66 |
| H1-0 | H1.0 linker histone | -0.65 |
| PYGO2 | pygopus family PHD finger 2 | -0.65 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.65 |
| SYPL1 | synaptophysin-like 1 | -0.65 |
| MRPL34 | mitochondrial ribosomal protein L34 | -0.63 |
| RPS27A | ribosomal protein S27a | -0.63 |
| MT2A | metallothionein 2A | -0.62 |
| RPS26P11 | ribosomal protein S26 pseudogene 11 | -0.61 |
| ZNF696 | zinc finger protein 696 | -0.61 |
| RAD18 | RAD18 E3 ubiquitin protein ligase | -0.61 |
| LLPH | LLP homolog, long-term synaptic facilitation (Aplysia) | -0.61 |
| METAP2 | methionyl aminopeptidase 2 | -0.6 |
| RPL36AL | ribosomal protein L36a-like | -0.6 |
| RETREG1 | reticulophagy regulator 1 | -0.6 |
| SNRPC | small nuclear ribonucleoprotein polypeptide C | -0.6 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.6 |
| SRRM1 | serine/arginine repetitive matrix 1 | -0.59 |
| RPL22 | ribosomal protein L22 | -0.59 |
| XPC | xeroderma pigmentosum, complementation group C | -0.59 |
| COA5 | cytochrome c oxidase assembly factor 5 | -0.58 |
| PPP1R2 | protein phosphatase 1, regulatory (inhibitor) subunit 2 | -0.58 |
| LYAR | Ly1 antibody reactive | -0.58 |
| SF1 | splicing factor 1 | -0.57 |
| DNAH6 | dynein, axonemal, heavy chain 6 | -0.57 |
| KNOP1 | lysine-rich nucleolar protein 1 | -0.56 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.55 |
| PPP1R11 | protein phosphatase 1, regulatory (inhibitor) subunit 11 | -0.55 |
| NOP58 | NOP58 ribonucleoprotein | -0.54 |
| CKS1B | CDC28 protein kinase regulatory subunit 1B | -0.54 |
| H3-3A | H3.3 histone A | -0.54 |
| SH3RF2 | SH3 domain containing ring finger 2 | -0.54 |
| FN1 | fibronectin 1 | -0.54 |
| ESCO1 | establishment of sister chromatid cohesion N-acetyltransferase 1 | -0.54 |
| TAF3 | TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa | -0.53 |
| MAP3K21 | mitogen-activated protein kinase kinase kinase 21 | -0.53 |
| TBCA | tubulin folding cofactor A | -0.52 |
| MED19 | mediator complex subunit 19 | -0.52 |
| CD9 | CD9 molecule | -0.52 |
| CIR1 | corepressor interacting with RBPJ, 1 | -0.52 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.52 |
| MT1X | metallothionein 1X | -0.52 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.52 |
| CMC4 | C-x(9)-C motif containing 4 | -0.51 |
