| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/25265312 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in PF-8380 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PLEKHH2 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 | 2.21 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 1.74 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 1.36 |
| PKHD1 | polycystic kidney and hepatic disease 1 (autosomal recessive) | 0.95 |
| CEP57 | centrosomal protein 57kDa | 0.74 |
| ZBTB8A | zinc finger and BTB domain containing 8A | 0.6 |
| FSIP2 | fibrous sheath interacting protein 2 | 0.56 |
| TSPAN9 | tetraspanin 9 | 0.55 |
| MCRIP2 | MAPK regulated corepressor interacting protein 2 | 0.55 |
| METTL6 | methyltransferase like 6 | 0.55 |
| RGPD2 | RANBP2-like and GRIP domain containing 2 | 0.53 |
| RAD52 | RAD52 homolog (S. cerevisiae) | 0.51 |
| TMEM199 | transmembrane protein 199 | 0.51 |
| CCDC34 | coiled-coil domain containing 34 | 0.51 |
| KCTD17 | potassium channel tetramerization domain containing 17 | 0.48 |
| ZNF431 | zinc finger protein 431 | 0.46 |
| REX1BD | required for excision 1-B domain containing | 0.46 |
| ADCY10 | adenylate cyclase 10 (soluble) | 0.45 |
| SEMA6B | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B | 0.45 |
| FAN1 | FANCD2/FANCI-associated nuclease 1 | 0.44 |
| ZNF57 | zinc finger protein 57 | 0.44 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | 0.44 |
| WNT10B | wingless-type MMTV integration site family, member 10B | 0.44 |
| MFHAS1 | malignant fibrous histiocytoma amplified sequence 1 | 0.42 |
| ADM | adrenomedullin | 0.42 |
| SIKE1 | suppressor of IKBKE 1 | 0.41 |
| MIEN1 | migration and invasion enhancer 1 | 0.41 |
| ZBTB41 | zinc finger and BTB domain containing 41 | 0.4 |
| ZNF92 | zinc finger protein 92 | 0.39 |
| VPS37B | vacuolar protein sorting 37 homolog B (S. cerevisiae) | 0.39 |
| SH2D5 | SH2 domain containing 5 | 0.39 |
| DPY30 | dpy-30 homolog (C. elegans) | 0.39 |
| LRRC58 | leucine rich repeat containing 58 | 0.39 |
| WDR25 | WD repeat domain 25 | 0.39 |
| CSNK1G2 | casein kinase 1, gamma 2 | 0.39 |
| CR2 | complement component (3d/Epstein Barr virus) receptor 2 | 0.38 |
| MAGEA2 | melanoma antigen family A2 | 0.37 |
| AGAP2 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 | 0.37 |
| DPP8 | dipeptidyl-peptidase 8 | 0.37 |
| NCOR1 | nuclear receptor corepressor 1 | 0.37 |
| COA4 | cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) | 0.37 |
| NPHP4 | nephronophthisis 4 | 0.37 |
| BORA | bora, aurora kinase A activator | 0.36 |
| DCBLD1 | discoidin, CUB and LCCL domain containing 1 | 0.36 |
| LMOD1 | leiomodin 1 (smooth muscle) | 0.36 |
| CCDC90B | coiled-coil domain containing 90B | 0.36 |
| OSBPL7 | oxysterol binding protein-like 7 | 0.35 |
| ZNF780A | zinc finger protein 780A | 0.35 |
| ARSB | arylsulfatase B | 0.35 |
| PSRC1 | proline/serine-rich coiled-coil 1 | 0.35 |
| VDR | vitamin D (1,25- dihydroxyvitamin D3) receptor | 0.34 |
| ZSCAN21 | zinc finger and SCAN domain containing 21 | 0.34 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | 0.34 |
| IRX4 | iroquois homeobox 4 | 0.34 |
| MAP2K5 | mitogen-activated protein kinase kinase 5 | 0.34 |
| ITGB8 | integrin, beta 8 | 0.34 |
| FRRS1 | ferric-chelate reductase 1 | 0.34 |
| ATXN3 | ataxin 3 | 0.33 |
| SPNS1 | spinster homolog 1 (Drosophila) | 0.33 |
| BBS10 | Bardet-Biedl syndrome 10 | 0.32 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | 0.32 |
| CCDC77 | coiled-coil domain containing 77 | 0.32 |
| ZNF185 | zinc finger protein 185 (LIM domain) | 0.32 |
| FRK | fyn-related Src family tyrosine kinase | 0.32 |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 | 0.32 |
| ADPRH | ADP-ribosylarginine hydrolase | 0.31 |
| BAHCC1 | BAH domain and coiled-coil containing 1 | 0.31 |
| ZNF276 | zinc finger protein 276 | 0.31 |
| USP19 | ubiquitin specific peptidase 19 | 0.31 |
| NCOA4 | nuclear receptor coactivator 4 | 0.31 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.31 |
| MADD | MAP-kinase activating death domain | 0.31 |
| APBB1 | amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) | 0.3 |
| DNLZ | DNL-type zinc finger | 0.3 |
| RASSF7 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 | 0.3 |
| FCHO1 | FCH domain only 1 | 0.3 |
| MDM4 | MDM4, p53 regulator | 0.3 |
| RLIM | ring finger protein, LIM domain interacting | 0.29 |
| FGFR1OP2 | FGFR1 oncogene partner 2 | 0.29 |
| PCDHGA10 | protocadherin gamma subfamily A, 10 | 0.29 |
| VPS37C | vacuolar protein sorting 37 homolog C (S. cerevisiae) | 0.29 |
| ICOSLG | inducible T-cell co-stimulator ligand | 0.28 |
| HIST3H2BB | histone cluster 3, H2bb | 0.28 |
| E2F7 | E2F transcription factor 7 | 0.28 |
| CCDC115 | coiled-coil domain containing 115 | 0.28 |
| PITX2 | paired-like homeodomain 2 | 0.28 |
| NKAP | NFKB activating protein | 0.28 |
| USP33 | ubiquitin specific peptidase 33 | 0.28 |
| GATA2 | GATA binding protein 2 | 0.28 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.28 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.28 |
| DAP | death-associated protein | 0.28 |
| LENG9 | leukocyte receptor cluster (LRC) member 9 | 0.28 |
| MIGA2 | mitoguardin 2 | 0.27 |
| MYT1 | myelin transcription factor 1 | 0.27 |
| FBXL14 | F-box and leucine-rich repeat protein 14 | 0.27 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) | 0.27 |
| EVA1C | eva-1 homolog C (C. elegans) | 0.27 |
| ANKS6 | ankyrin repeat and sterile alpha motif domain containing 6 | 0.27 |
| Symbol | Name | Standardized Value |
|---|---|---|
| KLHL23 | kelch-like family member 23 | -1.77 |
| PIP | prolactin-induced protein | -1.22 |
| SPTBN5 | spectrin, beta, non-erythrocytic 5 | -1.15 |
| DIPK1B | divergent protein kinase domain 1B | -0.88 |
| EGR1 | early growth response 1 | -0.7 |
| TBC1D31 | TBC1 domain family, member 31 | -0.6 |
| METTL22 | methyltransferase like 22 | -0.6 |
| KIF26A | kinesin family member 26A | -0.59 |
| CTHRC1 | collagen triple helix repeat containing 1 | -0.58 |
| SNX19 | sorting nexin 19 | -0.57 |
| ARL14EPL | ADP-ribosylation factor-like 14 effector protein-like | -0.56 |
| DEPDC1 | DEP domain containing 1 | -0.51 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.51 |
| TSPAN5 | tetraspanin 5 | -0.49 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | -0.48 |
| JUN | jun proto-oncogene | -0.47 |
| PAQR4 | progestin and adipoQ receptor family member IV | -0.47 |
| RBKS | ribokinase | -0.45 |
| ATF3 | activating transcription factor 3 | -0.43 |
| FGGY | FGGY carbohydrate kinase domain containing | -0.43 |
| CAVIN2 | caveolae associated protein 2 | -0.42 |
| PLEKHA3 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 | -0.4 |
| LSM11 | LSM11, U7 small nuclear RNA associated | -0.39 |
| TMEM104 | transmembrane protein 104 | -0.38 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | -0.37 |
| SESN1 | sestrin 1 | -0.37 |
| ZBED4 | zinc finger, BED-type containing 4 | -0.36 |
| LYST | lysosomal trafficking regulator | -0.36 |
| ZNF317 | zinc finger protein 317 | -0.36 |
| TFAP4 | transcription factor AP-4 (activating enhancer binding protein 4) | -0.36 |
| PON3 | paraoxonase 3 | -0.36 |
| PGBD2 | piggyBac transposable element derived 2 | -0.35 |
| TTL | tubulin tyrosine ligase | -0.35 |
| DUSP4 | dual specificity phosphatase 4 | -0.35 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.35 |
| TNS4 | tensin 4 | -0.34 |
| CMTM4 | CKLF-like MARVEL transmembrane domain containing 4 | -0.34 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.34 |
| JAK3 | Janus kinase 3 | -0.34 |
| TTC30B | tetratricopeptide repeat domain 30B | -0.33 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.32 |
| NOTCH3 | notch 3 | -0.32 |
| ENO1 | enolase 1, (alpha) | -0.32 |
| LRFN3 | leucine rich repeat and fibronectin type III domain containing 3 | -0.32 |
| NRP1 | neuropilin 1 | -0.31 |
| USP43 | ubiquitin specific peptidase 43 | -0.31 |
| HOMEZ | homeobox and leucine zipper encoding | -0.31 |
| JRK | Jrk homolog (mouse) | -0.31 |
| N4BP3 | NEDD4 binding protein 3 | -0.3 |
| ZNF557 | zinc finger protein 557 | -0.3 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.3 |
| UPRT | uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) | -0.3 |
| DPY19L2 | dpy-19-like 2 (C. elegans) | -0.29 |
| HECA | headcase homolog (Drosophila) | -0.29 |
| SDHAF4 | succinate dehydrogenase complex assembly factor 4 | -0.29 |
| CERCAM | cerebral endothelial cell adhesion molecule | -0.29 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.29 |
| RHBDF1 | rhomboid 5 homolog 1 (Drosophila) | -0.29 |
| B4GALT2 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 | -0.29 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | -0.28 |
| HMOX2 | heme oxygenase 2 | -0.28 |
| PBLD | phenazine biosynthesis-like protein domain containing | -0.28 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -0.28 |
| PXMP4 | peroxisomal membrane protein 4, 24kDa | -0.28 |
| KIF27 | kinesin family member 27 | -0.28 |
| DUSP5 | dual specificity phosphatase 5 | -0.27 |
| APOB | apolipoprotein B | -0.27 |
| FAM110C | family with sequence similarity 110, member C | -0.27 |
| MAPK7 | mitogen-activated protein kinase 7 | -0.27 |
| KLHL9 | kelch-like family member 9 | -0.27 |
| PDGFA | platelet-derived growth factor alpha polypeptide | -0.27 |
| CACNB3 | calcium channel, voltage-dependent, beta 3 subunit | -0.27 |
| OLFM2 | olfactomedin 2 | -0.26 |
| FAM104A | family with sequence similarity 104, member A | -0.26 |
| SELENOF | selenoprotein F | -0.26 |
| TTLL5 | tubulin tyrosine ligase-like family member 5 | -0.26 |
| CLK4 | CDC-like kinase 4 | -0.25 |
| RAB19 | RAB19, member RAS oncogene family | -0.25 |
| MLX | MLX, MAX dimerization protein | -0.25 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | -0.25 |
| ANO10 | anoctamin 10 | -0.25 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | -0.25 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 | -0.25 |
| NEU3 | sialidase 3 (membrane sialidase) | -0.25 |
| SLC25A40 | solute carrier family 25, member 40 | -0.25 |
| HIPK1 | homeodomain interacting protein kinase 1 | -0.25 |
| NF1 | neurofibromin 1 | -0.25 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.25 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.25 |
| SAMD8 | sterile alpha motif domain containing 8 | -0.24 |
| GPANK1 | G patch domain and ankyrin repeats 1 | -0.24 |
| MFGE8 | milk fat globule-EGF factor 8 protein | -0.24 |
| SDC4 | syndecan 4 | -0.24 |
| SLC39A3 | solute carrier family 39 (zinc transporter), member 3 | -0.24 |
| DEDD | death effector domain containing | -0.24 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.24 |
| KIAA0513 | KIAA0513 | -0.24 |
| ATG4D | autophagy related 4D, cysteine peptidase | -0.24 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.24 |
