PF4 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description platelet factor 4|This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014] (NCBI Entrez Gene Database, 5196)
External Link http://www.ncbi.nlm.nih.gov/gene/5196
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47 interacting proteins for PF4 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACTN1 actinin, alpha 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CCL5 chemokine (C-C motif) ligand 5
CSNK1A1 casein kinase 1, alpha 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR3 chemokine (C-X-C motif) receptor 3
F13A1 coagulation factor XIII, A1 polypeptide
FGF2 fibroblast growth factor 2 (basic)
FKBP1A FK506 binding protein 1A, 12kDa
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNG2 guanine nucleotide binding protein (G protein), gamma 2
GRK6 G protein-coupled receptor kinase 6
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
LDLR low density lipoprotein receptor
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K6 mitogen-activated protein kinase kinase 6
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MSN moesin
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NOS3 nitric oxide synthase 3 (endothelial cell)
PLEK pleckstrin
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCG protein kinase C, gamma
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PROCR protein C receptor, endothelial
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RDX radixin
SDC2 syndecan 2
SDPR serum deprivation response
SPHK1 sphingosine kinase 1
SRGN serglycin
THBD thrombomodulin
THBS1 thrombospondin 1
VCAN versican