PF429242 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/23661637
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Genes

200 proteins with high or low expression in PF429242 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
NDFIP1 Nedd4 family interacting protein 1 2.34
TMEM59 transmembrane protein 59 1.52
NDFIP2 Nedd4 family interacting protein 2 1.51
NCOA4 nuclear receptor coactivator 4 1.49
ITM2C integral membrane protein 2C 1.46
CKM creatine kinase, muscle 1.34
LRP10 low density lipoprotein receptor-related protein 10 1.2
LAPTM4A lysosomal protein transmembrane 4 alpha 1.13
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 1.09
NBR1 neighbor of BRCA1 gene 1 1.07
TBX3 T-box 3 1.07
TTLL4 tubulin tyrosine ligase-like family member 4 1.04
RPL26 ribosomal protein L26 0.98
TACSTD2 tumor-associated calcium signal transducer 2 0.95
GINM1 glycoprotein integral membrane 1 0.94
CST6 cystatin E/M 0.93
RNF149 ring finger protein 149 0.92
TMEM160 transmembrane protein 160 0.91
PFN2 profilin 2 0.89
COL18A1 collagen, type XVIII, alpha 1 0.84
ITM2B integral membrane protein 2B 0.8
COL12A1 collagen, type XII, alpha 1 0.8
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.8
SASH1 SAM and SH3 domain containing 1 0.8
HAS3 hyaluronan synthase 3 0.76
TSPAN3 tetraspanin 3 0.73
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.73
IFNGR1 interferon gamma receptor 1 0.72
MAP1LC3B2 microtubule-associated protein 1 light chain 3 beta 2 0.71
SLC16A6 solute carrier family 16, member 6 0.71
PKM pyruvate kinase, muscle 0.71
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 0.71
SLC38A2 solute carrier family 38, member 2 0.7
LTBP3 latent transforming growth factor beta binding protein 3 0.7
SQSTM1 sequestosome 1 0.69
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.68
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.68
PDCD5 programmed cell death 5 0.68
RNF13 ring finger protein 13 0.67
RBM47 RNA binding motif protein 47 0.66
APOB apolipoprotein B 0.66
RNF130 ring finger protein 130 0.65
PPP1R3D protein phosphatase 1, regulatory subunit 3D 0.64
SDCBP syndecan binding protein (syntenin) 0.63
ZFP37 ZFP37 zinc finger protein 0.63
RPS23 ribosomal protein S23 0.6
HIST2H2BF histone cluster 2, H2bf 0.59
IFT22 intraflagellar transport 22 0.59
PDE9A phosphodiesterase 9A 0.58
IGFBP6 insulin-like growth factor binding protein 6 0.58
FGFR2 fibroblast growth factor receptor 2 0.57
SUSD1 sushi domain containing 1 0.57
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.57
CALCOCO2 calcium binding and coiled-coil domain 2 0.56
MPZL2 myelin protein zero-like 2 0.56
SLC49A4 solute carrier family 49 member 4 0.56
PTPRS protein tyrosine phosphatase, receptor type, S 0.54
SEPTIN4 septin 4 0.54
HIST2H2AB histone cluster 2, H2ab 0.54
BMERB1 bMERB domain containing 1 0.54
TMEM248 transmembrane protein 248 0.53
CDK10 cyclin-dependent kinase 10 0.52
PLCB4 phospholipase C, beta 4 0.52
RFLNB refilin B 0.52
HLA-B major histocompatibility complex, class I, B 0.52
RPL36AL ribosomal protein L36a-like 0.52
R3HDM2 R3H domain containing 2 0.52
F2RL1 coagulation factor II (thrombin) receptor-like 1 0.52
GTSF1 gametocyte specific factor 1 0.5
ACVR2A activin A receptor, type IIA 0.5
KLK7 kallikrein-related peptidase 7 0.49
SERINC3 serine incorporator 3 0.49
SNRPG small nuclear ribonucleoprotein polypeptide G 0.49
IFITM3 interferon induced transmembrane protein 3 0.49
SLC26A11 solute carrier family 26 (anion exchanger), member 11 0.49
MYRF myelin regulatory factor 0.48
NAP1L4 nucleosome assembly protein 1-like 4 0.47
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.47
SET SET nuclear proto-oncogene 0.46
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.46
TYK2 tyrosine kinase 2 0.46
TKT transketolase 0.45
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.45
RPL35A ribosomal protein L35a 0.45
LGALS1 lectin, galactoside-binding, soluble, 1 0.45
RYK receptor-like tyrosine kinase 0.45
JAGN1 jagunal homolog 1 (Drosophila) 0.45
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.45
FLNA filamin A, alpha 0.44
RARG retinoic acid receptor, gamma 0.44
AMACR alpha-methylacyl-CoA racemase 0.44
VMP1 vacuole membrane protein 1 0.44
VEZF1 vascular endothelial zinc finger 1 0.44
PARK7 parkinson protein 7 0.44
CD63 CD63 molecule 0.44
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 0.43
RPL31 ribosomal protein L31 0.43
CSTB cystatin B (stefin B) 0.43
NUCB1 nucleobindin 1 0.43
EIF3CL eukaryotic translation initiation factor 3, subunit C-like 0.43

low expression

Symbol Name Standardized Value
SCAP SREBF chaperone -1.44
SCD stearoyl-CoA desaturase (delta-9-desaturase) -1.05
PLIN2 perilipin 2 -0.96
PIP prolactin-induced protein -0.87
LDLR low density lipoprotein receptor -0.87
FGFBP1 fibroblast growth factor binding protein 1 -0.83
CTSZ cathepsin Z -0.8
PCSK9 proprotein convertase subtilisin/kexin type 9 -0.76
IDI1 isopentenyl-diphosphate delta isomerase 1 -0.76
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.75
FURIN furin (paired basic amino acid cleaving enzyme) -0.72
SREBF2 sterol regulatory element binding transcription factor 2 -0.71
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 -0.7
CTSH cathepsin H -0.68
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.67
MSMO1 methylsterol monooxygenase 1 -0.63
FKTN fukutin -0.61
PAH phenylalanine hydroxylase -0.58
SAMD4A sterile alpha motif domain containing 4A -0.57
NEU1 sialidase 1 (lysosomal sialidase) -0.56
TMEM231 transmembrane protein 231 -0.55
JOSD1 Josephin domain containing 1 -0.54
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal -0.54
ZNF274 zinc finger protein 274 -0.53
LPIN1 lipin 1 -0.53
CLCN7 chloride channel, voltage-sensitive 7 -0.52
SREBF1 sterol regulatory element binding transcription factor 1 -0.51
METTL22 methyltransferase like 22 -0.5
FADS1 fatty acid desaturase 1 -0.5
RNF115 ring finger protein 115 -0.49
GLT8D1 glycosyltransferase 8 domain containing 1 -0.49
DDA1 DET1 and DDB1 associated 1 -0.47
MVK mevalonate kinase -0.47
QPCTL glutaminyl-peptide cyclotransferase-like -0.47
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.47
BBS4 Bardet-Biedl syndrome 4 -0.47
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 -0.46
DHCR24 24-dehydrocholesterol reductase -0.46
PPT1 palmitoyl-protein thioesterase 1 -0.44
BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3 -0.43
ROR1 receptor tyrosine kinase-like orphan receptor 1 -0.42
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.42
SC5D sterol-C5-desaturase -0.42
ACTN3 actinin, alpha 3 (gene/pseudogene) -0.41
LYST lysosomal trafficking regulator -0.41
HIST2H2AA3 histone cluster 2, H2aa3 -0.4
PIM1 Pim-1 proto-oncogene, serine/threonine kinase -0.4
SCPEP1 serine carboxypeptidase 1 -0.4
PYGM phosphorylase, glycogen, muscle -0.4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -0.39
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 -0.39
GLA galactosidase, alpha -0.39
DHCR7 7-dehydrocholesterol reductase -0.39
DCDC1 doublecortin domain containing 1 -0.39
BAHD1 bromo adjacent homology domain containing 1 -0.39
RPP25 ribonuclease P/MRP 25kDa subunit -0.39
CNEP1R1 CTD nuclear envelope phosphatase 1 regulatory subunit 1 -0.39
TRNP1 TMF1-regulated nuclear protein 1 -0.38
CAVIN2 caveolae associated protein 2 -0.38
ZNF250 zinc finger protein 250 -0.37
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 -0.37
CCND3 cyclin D3 -0.37
STC2 stanniocalcin 2 -0.36
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 -0.36
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) -0.36
FAM102B family with sequence similarity 102, member B -0.36
NPHP3 nephronophthisis 3 (adolescent) -0.35
CRPPA CDP-L-ribitol pyrophosphorylase A -0.35
NFE2L2 nuclear factor, erythroid 2-like 2 -0.35
DOCK11 dedicator of cytokinesis 11 -0.35
MVD mevalonate (diphospho) decarboxylase -0.35
NEB nebulin -0.35
PRCP prolylcarboxypeptidase (angiotensinase C) -0.35
C19ORF25 chromosome 19 open reading frame 25 -0.35
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit -0.35
CEP63 centrosomal protein 63kDa -0.34
SQLE squalene epoxidase -0.34
SCARA3 scavenger receptor class A, member 3 -0.34
PIGL phosphatidylinositol glycan anchor biosynthesis, class L -0.34
KLF3 Kruppel-like factor 3 (basic) -0.34
TSPAN9 tetraspanin 9 -0.33
ATF3 activating transcription factor 3 -0.33
EHD2 EH-domain containing 2 -0.33
PRMT6 protein arginine methyltransferase 6 -0.33
NAAA N-acylethanolamine acid amidase -0.33
ZNF304 zinc finger protein 304 -0.33
PXMP4 peroxisomal membrane protein 4, 24kDa -0.33
MED30 mediator complex subunit 30 -0.32
JUND jun D proto-oncogene -0.32
SERAC1 serine active site containing 1 -0.32
MCL1 myeloid cell leukemia 1 -0.31
ZNF286B zinc finger protein 286B -0.31
FUCA1 fucosidase, alpha-L- 1, tissue -0.31
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.31
PAQR7 progestin and adipoQ receptor family member VII -0.31
CDPF1 cysteine-rich, DPF motif domain containing 1 -0.31
NRIP1 nuclear receptor interacting protein 1 -0.31
FUCA2 fucosidase, alpha-L- 2, plasma -0.31
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) -0.31
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 -0.31