PFSK-1 Gene Set

Dataset GDSC Cell Line Gene Expression Profiles
Category transcriptomics
Type cell line
Description disease: malignant primitive neuroectodermal tumor (Cell Line Ontology, CLO_0008425)
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Genes

344 genes with high or low expression in PFSK-1 relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.

high expression

Symbol Name Standardized Value
PTPN9 protein tyrosine phosphatase, non-receptor type 9 3.60177
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 3.60177
ETV4 ets variant 4 3.60177
POLE polymerase (DNA directed), epsilon, catalytic subunit 3.60177
DIO3 deiodinase, iodothyronine, type III 3.60177
HCRTR2 hypocretin (orexin) receptor 2 3.60177
CDH4 cadherin 4, type 1, R-cadherin (retinal) 3.59818
DLGAP2 discs, large (Drosophila) homolog-associated protein 2 3.58284
ADGRB1 adhesion G protein-coupled receptor B1 3.1573
EBF2 early B-cell factor 2 3.12788
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 3.09792
MCC mutated in colorectal cancers 3.04138
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 2.94808
ETV5 ets variant 5 2.86712
ICOSLG inducible T-cell co-stimulator ligand 2.77762
GPC6 glypican 6 2.76924
BAHD1 bromo adjacent homology domain containing 1 2.69532
GPR3 G protein-coupled receptor 3 2.63773
CRH corticotropin releasing hormone 2.56868
LCN1 lipocalin 1 2.56603
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 2.54385
ETV1 ets variant 1 2.53145
GK glycerol kinase 2.51099
CDC14B cell division cycle 14B 2.5057
MPC1 mitochondrial pyruvate carrier 1 2.47132
MRPS2 mitochondrial ribosomal protein S2 2.40649
ABHD17A abhydrolase domain containing 17A 2.38166
HDAC5 histone deacetylase 5 2.37124
STK32B serine/threonine kinase 32B 2.36139
TLL2 tolloid-like 2 2.36135
FAM64A family with sequence similarity 64, member A 2.35782
SPON2 spondin 2, extracellular matrix protein 2.35231
AP2A2 adaptor-related protein complex 2, alpha 2 subunit 2.31666
PECAM1 platelet/endothelial cell adhesion molecule 1 2.29515
EPHB3 EPH receptor B3 2.28309
HOXD12 homeobox D12 2.27891
UST uronyl-2-sulfotransferase 2.25086
CD177 CD177 molecule 2.24681
FAM57A family with sequence similarity 57, member A 2.22755
COLEC11 collectin sub-family member 11 2.2272
LHX2 LIM homeobox 2 2.19363
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 2.16591
CCNE1 cyclin E1 2.15703
CIC capicua transcriptional repressor 2.15373
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.13398
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 2.11365
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain 2.09685
VGF VGF nerve growth factor inducible 2.08037
UBA1 ubiquitin-like modifier activating enzyme 1 2.07633
ACVRL1 activin A receptor type II-like 1 2.06354
ACOX2 acyl-CoA oxidase 2, branched chain 2.04582
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 2.04498
CDC14A cell division cycle 14A 2.04405
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 2.01014
PXDN peroxidasin 2.00944
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 2.00646
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 1.99791
SCNN1B sodium channel, non voltage gated 1 beta subunit 1.98978
ACOX3 acyl-CoA oxidase 3, pristanoyl 1.98235
FLT4 fms-related tyrosine kinase 4 1.9778
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 1.97695
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 1.97602
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 1.96305
LRRTM4 leucine rich repeat transmembrane neuronal 4 1.95299
USP46 ubiquitin specific peptidase 46 1.94879
HIP1 huntingtin interacting protein 1 1.94808
PI4K2A phosphatidylinositol 4-kinase type 2 alpha 1.93052
MAP1S microtubule-associated protein 1S 1.93045
GPX3 glutathione peroxidase 3 1.92208
BPI bactericidal/permeability-increasing protein 1.90907
EML3 echinoderm microtubule associated protein like 3 1.90518
CREBL2 cAMP responsive element binding protein-like 2 1.89878
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 1.89759
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 1.88483
OBP2A odorant binding protein 2A 1.88026
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa 1.87627
COL5A3 collagen, type V, alpha 3 1.87083
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 1.86432
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 1.85113
ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E 1.84776
NF1 neurofibromin 1 1.84323
PAQR3 progestin and adipoQ receptor family member III 1.84194
PAEP progestagen-associated endometrial protein 1.82399
PKNOX2 PBX/knotted 1 homeobox 2 1.82198
EHD3 EH-domain containing 3 1.82011
TNMD tenomodulin 1.81343
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 1.81276
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) 1.80276
ATXN7L1 ataxin 7-like 1 1.79631
NPFFR1 neuropeptide FF receptor 1 1.79552
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae) 1.79352
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 1.78965
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) 1.78853
GAS2 growth arrest-specific 2 1.78383
VCAN versican 1.78268
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 1.78224
GRIP1 glutamate receptor interacting protein 1 1.77314
IGF2 insulin-like growth factor 2 1.7625
MOSPD1 motile sperm domain containing 1 1.76167
TNPO1 transportin 1 1.76108
P3H3 prolyl 3-hydroxylase 3 1.75926
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa 1.75206
ZNF385D zinc finger protein 385D 1.74485
GLI3 GLI family zinc finger 3 1.74076
APOC3 apolipoprotein C-III 1.74064
AVP arginine vasopressin 1.73606
STK25 serine/threonine kinase 25 1.73368
HCRTR1 hypocretin (orexin) receptor 1 1.73178
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit 1.72909
SGSM3 small G protein signaling modulator 3 1.72434
ANGPT2 angiopoietin 2 1.72366
FGFR1 fibroblast growth factor receptor 1 1.71903
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 1.71178
CNGB1 cyclic nucleotide gated channel beta 1 1.70884
CCDC106 coiled-coil domain containing 106 1.70681
SORBS3 sorbin and SH3 domain containing 3 1.70529
MTMR2 myotubularin related protein 2 1.70328
MDFIC MyoD family inhibitor domain containing 1.70297
SOD1 superoxide dismutase 1, soluble 1.69538
ARL6IP4 ADP-ribosylation factor-like 6 interacting protein 4 1.68795
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 1.68345
POMC proopiomelanocortin 1.67744
GAMT guanidinoacetate N-methyltransferase 1.67389
GLP2R glucagon-like peptide 2 receptor 1.6666
CROCC ciliary rootlet coiled-coil, rootletin 1.6568
NCAM2 neural cell adhesion molecule 2 1.65486
PMM1 phosphomannomutase 1 1.6507
ATXN1 ataxin 1 1.64441
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 1.64113
DENND1A DENN/MADD domain containing 1A 1.63987
CREB3L1 cAMP responsive element binding protein 3-like 1 1.63878
FAM110D family with sequence similarity 110, member D 1.63626
ERF Ets2 repressor factor 1.63626
GANAB glucosidase, alpha; neutral AB 1.63306
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d 1.62337
RNF128 ring finger protein 128, E3 ubiquitin protein ligase 1.62324
GFRA1 GDNF family receptor alpha 1 1.62279
ITGA10 integrin, alpha 10 1.6215
NELL1 NEL-like 1 (chicken) 1.61776
MRPL28 mitochondrial ribosomal protein L28 1.61533
RBPJ recombination signal binding protein for immunoglobulin kappa J region 1.61464
RIC8A RIC8 guanine nucleotide exchange factor A 1.61291
CSN1S1 casein alpha s1 1.61099
EIF4E eukaryotic translation initiation factor 4E 1.60889
SEPT11 septin 11 1.60776
RPA1 replication protein A1, 70kDa 1.60557
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 1.60275
GPD1L glycerol-3-phosphate dehydrogenase 1-like 1.59557
CAMK1G calcium/calmodulin-dependent protein kinase IG 1.59399
TACC3 transforming, acidic coiled-coil containing protein 3 1.59208
HNRNPK heterogeneous nuclear ribonucleoprotein K 1.5843
OR2J3 olfactory receptor, family 2, subfamily J, member 3 1.58408
ANKRD55 ankyrin repeat domain 55 1.58403
ASTN1 astrotactin 1 1.58348
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 1.58231
ELP6 elongator acetyltransferase complex subunit 6 1.57633
GJA5 gap junction protein, alpha 5, 40kDa 1.57518
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 1.56422
ISLR immunoglobulin superfamily containing leucine-rich repeat 1.56268
BGN biglycan 1.55543
HRAS Harvey rat sarcoma viral oncogene homolog 1.55359
NPTX2 neuronal pentraxin II 1.55228
RELN reelin 1.54214
MAP2 microtubule-associated protein 2 1.542
EDNRA endothelin receptor type A 1.53666
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 1.53096
DMPK dystrophia myotonica-protein kinase 1.52898
ZNF460 zinc finger protein 460 1.52755
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 1.52345
FNBP1L formin binding protein 1-like 1.50891
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 1.5074
CALM2 calmodulin 2 (phosphorylase kinase, delta) 1.50467
ZNF219 zinc finger protein 219 1.50296
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 1.5022
TMEM160 transmembrane protein 160 1.5017
MXD4 MAX dimerization protein 4 1.4945
HMGN3 high mobility group nucleosomal binding domain 3 1.49388
NHEJ1 nonhomologous end-joining factor 1 1.49174
LRP1B low density lipoprotein receptor-related protein 1B 1.4889
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa 1.48164
SAC3D1 SAC3 domain containing 1 1.47718
KCTD2 potassium channel tetramerization domain containing 2 1.47591
EMILIN1 elastin microfibril interfacer 1 1.47421
ZNF423 zinc finger protein 423 1.4739
ASL argininosuccinate lyase 1.47094
PCOLCE procollagen C-endopeptidase enhancer 1.47084
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) 1.47052
PDZD2 PDZ domain containing 2 1.46933
KIF13B kinesin family member 13B 1.46757
IDI1 isopentenyl-diphosphate delta isomerase 1 1.46626
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 1.46591
UNC13A unc-13 homolog A (C. elegans) 1.4659
CDH20 cadherin 20, type 2 1.46579
NPVF neuropeptide VF precursor 1.46563
CPZ carboxypeptidase Z 1.46509
ELOVL6 ELOVL fatty acid elongase 6 1.46405
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 1.46332
ANK1 ankyrin 1, erythrocytic 1.4619
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 1.45968
TRPM8 transient receptor potential cation channel, subfamily M, member 8 1.45817
CDX4 caudal type homeobox 4 1.45455
CHSY1 chondroitin sulfate synthase 1 1.45012
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 1.44493
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 1.44346
VEGFB vascular endothelial growth factor B 1.44312
TMED1 transmembrane emp24 protein transport domain containing 1 1.44132
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast) 1.44086
GRM7 glutamate receptor, metabotropic 7 1.43475
R3HCC1 R3H domain and coiled-coil containing 1 1.42454
OLFML2B olfactomedin-like 2B 1.42027
CSNK1G2 casein kinase 1, gamma 2 1.41857

low expression

Symbol Name Standardized Value
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -3.53725
HOXA2 homeobox A2 -3.50868
PRCP prolylcarboxypeptidase (angiotensinase C) -3.4845
IFT57 intraflagellar transport 57 -3.42907
HIST1H2BK histone cluster 1, H2bk -3.39703
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 -3.1987
CR1 complement component (3b/4b) receptor 1 (Knops blood group) -2.73795
PEX13 peroxisomal biogenesis factor 13 -2.68561
FAM63B family with sequence similarity 63, member B -2.66969
SPATA7 spermatogenesis associated 7 -2.55364
DAP death-associated protein -2.48552
FKBP14 FK506 binding protein 14, 22 kDa -2.47418
RNASEH2B ribonuclease H2, subunit B -2.38108
DKFZP586I1420 uncharacterized protein DKFZp586I1420 -2.30665
HK2 hexokinase 2 -2.30596
GSTM1 glutathione S-transferase mu 1 -2.30047
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -2.29582
H2BFS H2B histone family, member S (pseudogene) -2.27472
OSBPL3 oxysterol binding protein-like 3 -2.24321
WARS tryptophanyl-tRNA synthetase -2.24312
TSC22D3 TSC22 domain family, member 3 -2.22384
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 -2.2235
GSTM2 glutathione S-transferase mu 2 (muscle) -2.21819
ACP6 acid phosphatase 6, lysophosphatidic -2.1571
COBLL1 cordon-bleu WH2 repeat protein-like 1 -2.15279
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 -2.13931
KLHL2 kelch-like family member 2 -2.12225
RBKS ribokinase -2.12194
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 -2.11181
RAD50 RAD50 homolog (S. cerevisiae) -2.05971
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 -2.05005
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa -2.04389
TAGLN2 transgelin 2 -2.04189
CRYL1 crystallin, lambda 1 -2.0027
ACOT11 acyl-CoA thioesterase 11 -2.00044
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 -1.99825
KPNA4 karyopherin alpha 4 (importin alpha 3) -1.98892
DAAM1 dishevelled associated activator of morphogenesis 1 -1.97592
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -1.95982
FAIM Fas apoptotic inhibitory molecule -1.95025
GOLGA5 golgin A5 -1.94511
APEH acylaminoacyl-peptide hydrolase -1.93114
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 -1.89743
STXBP5L syntaxin binding protein 5-like -1.88981
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -1.8739
TPMT thiopurine S-methyltransferase -1.86687
GFOD1 glucose-fructose oxidoreductase domain containing 1 -1.86621
CROT carnitine O-octanoyltransferase -1.84727
PLP2 proteolipid protein 2 (colonic epithelium-enriched) -1.83497
LRP5L low density lipoprotein receptor-related protein 5-like -1.82491
ZNF552 zinc finger protein 552 -1.81912
RGS19 regulator of G-protein signaling 19 -1.81177
CXADR coxsackie virus and adenovirus receptor -1.79042
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -1.78268
EFHC1 EF-hand domain (C-terminal) containing 1 -1.7556
ZDHHC4 zinc finger, DHHC-type containing 4 -1.74979
CCP110 centriolar coiled coil protein 110kDa -1.74822
TP53TG1 TP53 target 1 (non-protein coding) -1.74406
PRPF39 pre-mRNA processing factor 39 -1.74047
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 -1.73975
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -1.73341
PCDHGB5 protocadherin gamma subfamily B, 5 -1.72276
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 -1.72199
DNAH7 dynein, axonemal, heavy chain 7 -1.71688
FGF5 fibroblast growth factor 5 -1.71369
GADD45A growth arrest and DNA-damage-inducible, alpha -1.71279
HIST1H3H histone cluster 1, H3h -1.71248
GPR21 G protein-coupled receptor 21 -1.70533
HIST1H2BE histone cluster 1, H2be -1.70445
SUSD6 sushi domain containing 6 -1.69291
ISOC1 isochorismatase domain containing 1 -1.68397
IL7 interleukin 7 -1.68335
MFAP5 microfibrillar associated protein 5 -1.65466
ZBTB14 zinc finger and BTB domain containing 14 -1.65297
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 -1.64078
GCA grancalcin, EF-hand calcium binding protein -1.63938
PHKA1 phosphorylase kinase, alpha 1 (muscle) -1.63742
KLK5 kallikrein-related peptidase 5 -1.6355
LRRC8B leucine rich repeat containing 8 family, member B -1.62912
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -1.62733
TASP1 taspase, threonine aspartase, 1 -1.62696
SRP54 signal recognition particle 54kDa -1.62644
MPZ myelin protein zero -1.61142
EIF5A2 eukaryotic translation initiation factor 5A2 -1.60388
PARP8 poly (ADP-ribose) polymerase family, member 8 -1.6033
LOC157562 uncharacterized LOC157562 -1.60248
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog -1.59994
ZNF532 zinc finger protein 532 -1.58515
HIST1H4A histone cluster 1, H4a -1.58494
UBE2D1 ubiquitin-conjugating enzyme E2D 1 -1.57432
NPR2 natriuretic peptide receptor 2 -1.56965
TRIM14 tripartite motif containing 14 -1.56946
BTG3 BTG family, member 3 -1.56818
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -1.55947
GPALPP1 GPALPP motifs containing 1 -1.55314
FA2H fatty acid 2-hydroxylase -1.54815
GIMAP5 GTPase, IMAP family member 5 -1.54735
HAS2 hyaluronan synthase 2 -1.53959
IGFBP1 insulin-like growth factor binding protein 1 -1.53543
PELI1 pellino E3 ubiquitin protein ligase 1 -1.53409
GSTO1 glutathione S-transferase omega 1 -1.53334
GMPR2 guanosine monophosphate reductase 2 -1.53264
IL33R interleukin 33 receptor -1.53178
DHRS7 dehydrogenase/reductase (SDR family) member 7 -1.53063
HIST1H2BF histone cluster 1, H2bf -1.52416
MMP14 matrix metallopeptidase 14 (membrane-inserted) -1.52318
GOLGA8A golgin A8 family, member A -1.51733
GCLC glutamate-cysteine ligase, catalytic subunit -1.51068
EML4 echinoderm microtubule associated protein like 4 -1.50965
DENND3 DENN/MADD domain containing 3 -1.50928
UFM1 ubiquitin-fold modifier 1 -1.50921
OPHN1 oligophrenin 1 -1.5021
LIPA lipase A, lysosomal acid, cholesterol esterase -1.4998
FBXO34 F-box protein 34 -1.49605
HOXC6 homeobox C6 -1.49281
CEBPB CCAAT/enhancer binding protein (C/EBP), beta -1.48877
FRMD1 FERM domain containing 1 -1.48219
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 -1.47264
KLF4 Kruppel-like factor 4 (gut) -1.47233
PIGV phosphatidylinositol glycan anchor biosynthesis, class V -1.4666
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -1.45032
CYB561 cytochrome b561 -1.44691
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -1.44596
CEP70 centrosomal protein 70kDa -1.44476
SLC38A1 solute carrier family 38, member 1 -1.43692
MBNL2 muscleblind-like splicing regulator 2 -1.43533
ZNF507 zinc finger protein 507 -1.42611
PGM1 phosphoglucomutase 1 -1.42355
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -1.42026
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1 -1.4196
SRSF5 serine/arginine-rich splicing factor 5 -1.41831
HSPA1A heat shock 70kDa protein 1A -1.41731
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1 -1.41574