PGAP1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description post-GPI attachment to proteins 1|PGAP1 catalyzes the inositol deacylation of glycosylphosphatidylinositol (GPI) at an early step in GPI biosynthesis. Inositol deacylation is essential for the generation of mature GPI capable of attachment to proteins (Tanaka et al., 2004 [PubMed 14734546]).[supplied by OMIM, Mar 2008] (NCBI Entrez Gene Database, 80055)
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Genes

313 genes differentially expressed following the PGAP1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 3.13476
MYO1A myosin IA 3.13476
HMX1 H6 family homeobox 1 3.13476
SPACA7 sperm acrosome associated 7 3.13476
C1QTNF8 C1q and tumor necrosis factor related protein 8 3.13476
EVPL envoplakin 3.13476
C12ORF43 chromosome 12 open reading frame 43 3.13476
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 3.13476
TSPO2 translocator protein 2 3.13476
CFAP45 cilia and flagella associated protein 45 3.13476
PRDM16 PR domain containing 16 3.13476
KLRF1 killer cell lectin-like receptor subfamily F, member 1 3.13476
ANKK1 ankyrin repeat and kinase domain containing 1 3.13476
DLL4 delta-like 4 (Drosophila) 3.13476
MUC20 mucin 20, cell surface associated 3.13476
TBATA thymus, brain and testes associated 3.13476
OXT oxytocin/neurophysin I prepropeptide 3.13476
IL2RB interleukin 2 receptor, beta 3.13476
ATOH7 atonal homolog 7 (Drosophila) 3.13476
EMCN endomucin 3.13476
VCX3A variable charge, X-linked 3A 3.13476
TUBA4B tubulin, alpha 4b 3.13476
MAGEC3 melanoma antigen family C3 3.13476
LPO lactoperoxidase 3.13476
MYOZ2 myozenin 2 3.13476
CSAG3 CSAG family, member 3 3.13476
ANGPTL7 angiopoietin-like 7 3.13476
TRAF3IP3 TRAF3 interacting protein 3 3.13476
HOXD10 homeobox D10 3.13476
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 3.13476
MOV10L1 Mov10 RISC complex RNA helicase like 1 3.13476
OPN5 opsin 5 3.13476
PCDHGA12 protocadherin gamma subfamily A, 12 3.13476
IL23R interleukin 23 receptor 3.13476
MASTL microtubule associated serine/threonine kinase-like 3.13476
SOST sclerostin 3.13476
ZC2HC1B zinc finger, C2HC-type containing 1B 3.13476
ABRA actin binding Rho activating protein 3.13476
OR6B1 olfactory receptor, family 6, subfamily B, member 1 3.13476
ADGRG1 adhesion G protein-coupled receptor G1 3.13476
ARRDC5 arrestin domain containing 5 3.13476
WDR87 WD repeat domain 87 3.13476
SLC26A4 solute carrier family 26 (anion exchanger), member 4 3.13476
PRICKLE4 prickle homolog 4 (Drosophila) 3.13476
SYCP1 synaptonemal complex protein 1 3.13476
TSGA13 testis specific, 13 3.13476
LBHD1 LBH domain containing 1 3.13476
PCDHB7 protocadherin beta 7 3.13476
SLC35G5 solute carrier family 35, member G5 3.13476
FAM167A family with sequence similarity 167, member A 3.13476
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 3.13476
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 3.13476
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 3.13476
RELL1 RELT-like 1 3.13476
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 3.13476
MYO7B myosin VIIB 3.13476
TXLNB taxilin beta 3.13476
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 3.13476
UCN urocortin 3.13476
NCF1 neutrophil cytosolic factor 1 3.13476
HDC histidine decarboxylase 3.13476
ULBP3 UL16 binding protein 3 3.13476
ANKRD34A ankyrin repeat domain 34A 3.13476
BIRC7 baculoviral IAP repeat containing 7 3.13476
CXCL2 chemokine (C-X-C motif) ligand 2 3.13476
TLR4 toll-like receptor 4 3.13476
NOTUM notum pectinacetylesterase homolog (Drosophila) 3.13476
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 3.13476
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 3.13476
GYPB glycophorin B (MNS blood group) 3.13476
MEOX1 mesenchyme homeobox 1 3.13476
RHOXF2 Rhox homeobox family, member 2 3.13476
UMOD uromodulin 3.13476
GJA10 gap junction protein, alpha 10, 62kDa 3.13476
IRF5 interferon regulatory factor 5 3.13476
TNC tenascin C 3.13476
IL31RA interleukin 31 receptor A 3.13476
RSPO1 R-spondin 1 3.13476
TAS2R1 taste receptor, type 2, member 1 3.13476
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 3.13476
CCDC185 coiled-coil domain containing 185 3.13476
C8B complement component 8, beta polypeptide 3.13476
FNDC11 fibronectin type III domain containing 11 3.13476
SLC22A24 solute carrier family 22, member 24 3.13476
TEKT2 tektin 2 (testicular) 3.13476
LOC107986837 uncharacterized LOC107986837 3.13476
WNT7B wingless-type MMTV integration site family, member 7B 3.13476
PCDHGA4 protocadherin gamma subfamily A, 4 3.13476
C2CD4A C2 calcium-dependent domain containing 4A 3.13476
DRD2 dopamine receptor D2 3.13476
FAM209A family with sequence similarity 209, member A 3.13476
CCDC27 coiled-coil domain containing 27 3.13476
TRIM55 tripartite motif containing 55 3.13476
TREH trehalase (brush-border membrane glycoprotein) 3.13476
SH2D4B SH2 domain containing 4B 3.13476
SPATA4 spermatogenesis associated 4 3.13476
HKDC1 hexokinase domain containing 1 3.13476
SPINK9 serine peptidase inhibitor, Kazal type 9 3.13476
SPEF1 sperm flagellar 1 3.13476
SMIM17 small integral membrane protein 17 3.13476
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 3.13476
ITGAD integrin, alpha D 3.13476
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 3.13476
MB myoglobin 3.13476
SFTA2 surfactant associated 2 3.13476
ETV3L ets variant 3-like 3.13476
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 3.13476
OPTC opticin 3.13476
FAIM2 Fas apoptotic inhibitory molecule 2 3.13476
CFAP276 cilia and flagella associated protein 276 3.13476
LDLRAD2 low density lipoprotein receptor class A domain containing 2 3.13476
SPEM2 SPEM family member 2 3.13476
TMPPE transmembrane protein with metallophosphoesterase domain 3.13476
NCR3 natural cytotoxicity triggering receptor 3 3.13476
PGR progesterone receptor 3.13476
CTSS cathepsin S 3.13476
GPR61 G protein-coupled receptor 61 3.13476
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 3.13476
SERINC4 serine incorporator 4 3.13476
PKDREJ polycystin (PKD) family receptor for egg jelly 3.13476
TGM7 transglutaminase 7 3.13476
ALOX5AP arachidonate 5-lipoxygenase-activating protein 3.13476
PROC protein C (inactivator of coagulation factors Va and VIIIa) 3.13476
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 3.13476
ACSM1 acyl-CoA synthetase medium-chain family member 1 3.13476
HSF4 heat shock transcription factor 4 3.13476
SCEL sciellin 3.13476
ERMN ermin, ERM-like protein 3.13476
DES desmin 3.13476
LPAR5 lysophosphatidic acid receptor 5 3.13476
FAM25A family with sequence similarity 25, member A 3.13476
TGM5 transglutaminase 5 3.13476
GRAP GRB2-related adaptor protein 3.13476
SLC51B solute carrier family 51, beta subunit 3.13476
CHAT choline O-acetyltransferase 3.13476
APOL3 apolipoprotein L, 3 3.13476
FGF17 fibroblast growth factor 17 3.13476
AMER3 APC membrane recruitment protein 3 3.13476
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 3.13476
MCHR2 melanin-concentrating hormone receptor 2 3.13476
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 3.13476
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 3.13476
CCDC198 coiled-coil domain containing 198 3.13476
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 3.13476
KLHL1 kelch-like family member 1 3.13476
TNR tenascin R 3.13476
EFCAB9 EF-hand calcium binding domain 9 3.13476
CST7 cystatin F (leukocystatin) 3.13476
CST4 cystatin S 3.13476
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 3.13476
ERICH6 glutamate-rich 6 3.13476
HAMP hepcidin antimicrobial peptide 3.13476
HGFAC HGF activator 3.13476
EBF2 early B-cell factor 2 3.13476
LRRC43 leucine rich repeat containing 43 3.13476
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 3.13476
CLIC5 chloride intracellular channel 5 3.13476
CCDC9B coiled-coil domain containing 9B 3.13476
F2RL3 coagulation factor II (thrombin) receptor-like 3 3.13476
SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 3.01671
SPACA9 sperm acrosome associated 9 2.99718
SFXN3 sideroflexin 3 2.99718
TMEM171 transmembrane protein 171 2.99718
CASKIN1 CASK interacting protein 1 2.99534
ZNF57 zinc finger protein 57 2.91014
NDUFA12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 2.87548
SFRP4 secreted frizzled-related protein 4 2.86072
TTYH3 tweety family member 3 2.84235
LPAR1 lysophosphatidic acid receptor 1 2.77929
PGBD5 piggyBac transposable element derived 5 2.76348
EFNA2 ephrin-A2 2.74008
ZNF594 zinc finger protein 594 2.73794
DIPK1A divergent protein kinase domain 1A 2.59118
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 2.49866
KLHL13 kelch-like family member 13 2.49417
KCNIP2 Kv channel interacting protein 2 2.45554
BTD biotinidase 2.40429
PANK2 pantothenate kinase 2 2.39531
MCMBP minichromosome maintenance complex binding protein 2.39409
HIC1 hypermethylated in cancer 1 2.39323
CLCNKB chloride channel, voltage-sensitive Kb 2.37395
SGO2 shugoshin 2 2.37395
PCP4L1 Purkinje cell protein 4 like 1 2.37395
KIAA1217 KIAA1217 2.36166
GOLGA1 golgin A1 2.32736
RPL4 ribosomal protein L4 2.32049
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 2.31224
TBC1D28 TBC1 domain family, member 28 2.26652
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 2.25722
FTH1 ferritin, heavy polypeptide 1 2.23416
TCF25 transcription factor 25 (basic helix-loop-helix) 2.23148
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 2.22511
ORC2 origin recognition complex, subunit 2 2.22511
MOB4 MOB family member 4, phocein 2.2236
WDR37 WD repeat domain 37 2.20247
DACH1 dachshund family transcription factor 1 2.19672
BLTP1 bridge-like lipid transfer protein family member 1 2.1508
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 2.14116
NF2 neurofibromin 2 (merlin) 2.12711
IL13RA1 interleukin 13 receptor, alpha 1 2.12092
ZBTB6 zinc finger and BTB domain containing 6 2.1122
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2.09516
DENR density-regulated protein 2.08443
ZNF568 zinc finger protein 568 2.08156
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 2.07738
KAT6A K(lysine) acetyltransferase 6A 2.05785
ATXN3 ataxin 3 2.03905
PFDN6 prefoldin subunit 6 2.02779
NELFA negative elongation factor complex member A 2.00536
CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 2.00397

decreased expression

Symbol Name Standardized Value
IFT70B intraflagellar transport 70B -3.13476
FAM221B family with sequence similarity 221, member B -3.13476
OXTR oxytocin receptor -3.13476
FAM228A family with sequence similarity 228, member A -3.13476
LKAAEAR1 LKAAEAR motif containing 1 -3.13476
IRX3 iroquois homeobox 3 -3.13476
TNMD tenomodulin -3.13476
AMDHD1 amidohydrolase domain containing 1 -3.13476
SPTB spectrin, beta, erythrocytic -3.13476
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) -3.13476
ZNF575 zinc finger protein 575 -3.13476
RASAL3 RAS protein activator like 3 -3.13476
SPAAR small regulatory polypeptide of amino acid response -3.13476
PNMA8B PNMA family member 8B -3.13476
DARS2 aspartyl-tRNA synthetase 2, mitochondrial -3.13476
PCDHGA9 protocadherin gamma subfamily A, 9 -3.13476
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic -3.13476
GPR135 G protein-coupled receptor 135 -3.13476
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 -3.13476
ORC3 origin recognition complex, subunit 3 -3.13476
TMEM179 transmembrane protein 179 -3.13476
PLA2G4B phospholipase A2, group IVB (cytosolic) -3.13476
TUBA8 tubulin, alpha 8 -3.13476
IRGM immunity-related GTPase family, M -3.13476
ADRA2A adrenoceptor alpha 2A -3.13476
ZGLP1 zinc finger, GATA-like protein 1 -3.13476
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 -3.13476
CER1 cerberus 1, DAN family BMP antagonist -3.13476
ALAS2 5'-aminolevulinate synthase 2 -3.13476
GSDMA gasdermin A -3.13476
NUTM1 NUT midline carcinoma, family member 1 -3.13476
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 -3.13476
RHOBTB2 Rho-related BTB domain containing 2 -3.13263
AR androgen receptor -3.11408
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 -3.02038
FKBP14 FK506 binding protein 14, 22 kDa -2.9976
CPNE1 copine I -2.78743
ZNF256 zinc finger protein 256 -2.78526
ADA2 adenosine deaminase 2 -2.78074
PAK1IP1 PAK1 interacting protein 1 -2.74008
STRN3 striatin, calmodulin binding protein 3 -2.73136
CACHD1 cache domain containing 1 -2.70381
FBXL22 F-box and leucine-rich repeat protein 22 -2.64906
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.62579
SYNJ2BP synaptojanin 2 binding protein -2.60767
SPEN spen family transcriptional repressor -2.57286
DZANK1 double zinc ribbon and ankyrin repeat domains 1 -2.54679
MEDAG mesenteric estrogen-dependent adipogenesis -2.53619
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -2.50409
ZDHHC15 zinc finger, DHHC-type containing 15 -2.49866
PLP1 proteolipid protein 1 -2.49675
CLPSL2 colipase-like 2 -2.49675
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -2.48084
FBXO2 F-box protein 2 -2.47223
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1 -2.4525
MAPKAP1 mitogen-activated protein kinase associated protein 1 -2.42232
PDGFD platelet derived growth factor D -2.42232
LAMB1 laminin, beta 1 -2.40716
UBE2M ubiquitin-conjugating enzyme E2M -2.39531
CASR calcium-sensing receptor -2.39409
YIPF4 Yip1 domain family, member 4 -2.39409
ACLY ATP citrate lyase -2.39323
GPR87 G protein-coupled receptor 87 -2.39323
CD83 CD83 molecule -2.39323
KDM5A lysine (K)-specific demethylase 5A -2.38743
MDH1B malate dehydrogenase 1B, NAD (soluble) -2.38589
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -2.38589
LIMS2 LIM and senescent cell antigen-like domains 2 -2.31399
MOK MOK protein kinase -2.31399
TIMP4 TIMP metallopeptidase inhibitor 4 -2.31399
IFI16 interferon, gamma-inducible protein 16 -2.31399
BMX BMX non-receptor tyrosine kinase -2.31399
ZEB1 zinc finger E-box binding homeobox 1 -2.31399
SPINT1 serine peptidase inhibitor, Kunitz type 1 -2.29627
DAZAP1 DAZ associated protein 1 -2.26652
GFM1 G elongation factor, mitochondrial 1 -2.23148
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -2.22511
PGAP1 post-GPI attachment to proteins 1 -2.22511
ALLC allantoicase -2.20555
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase -2.19672
AP4S1 adaptor-related protein complex 4, sigma 1 subunit -2.19516
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain -2.16194
RPP40 ribonuclease P/MRP 40kDa subunit -2.14935
LIN9 lin-9 DREAM MuvB core complex component -2.14702
GRB2 growth factor receptor-bound protein 2 -2.14084
SPMIP8 sperm microtubule inner protein 8 -2.12711
RHOV ras homolog family member V -2.12711
TRRAP transformation/transcription domain-associated protein -2.12464
AGBL5 ATP/GTP binding protein-like 5 -2.12464
FKBP1A FK506 binding protein 1A, 12kDa -2.11983
MCM4 minichromosome maintenance complex component 4 -2.07738
PSMG3 proteasome (prosome, macropain) assembly chaperone 3 -2.07738
PFDN1 prefoldin subunit 1 -2.07019
FER fer (fps/fes related) tyrosine kinase -2.06356
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 -2.0457
ZNF613 zinc finger protein 613 -2.04358
CAVIN4 caveolae associated protein 4 -2.04081
ACO2 aconitase 2, mitochondrial -2.01934
PEX1 peroxisomal biogenesis factor 1 -2.0153
ESYT3 extended synaptotagmin-like protein 3 -2.0153
SF3B2 splicing factor 3b, subunit 2, 145kDa -2.00655
BNIPL BCL2/adenovirus E1B 19kD interacting protein like -2.00578
ARHGAP26 Rho GTPase activating protein 26 -2.00578