PGD Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description phosphogluconate dehydrogenase|6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015] (NCBI Entrez Gene Database, 5226)
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Genes

332 genes differentially expressed following the PGD gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
MOG myelin oligodendrocyte glycoprotein 3.03155
MYOM3 myomesin 3 3.03155
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 3.03155
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 3.03155
CNTN6 contactin 6 3.03155
MYO18B myosin XVIIIB 3.03155
SCNN1G sodium channel, non voltage gated 1 gamma subunit 3.03155
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 3.03155
BTNL9 butyrophilin-like 9 3.03155
S100Z S100 calcium binding protein Z 3.03155
STARD6 StAR-related lipid transfer (START) domain containing 6 3.03155
SUN3 Sad1 and UNC84 domain containing 3 3.03155
TNNI1 troponin I type 1 (skeletal, slow) 3.03155
NPBWR1 neuropeptides B/W receptor 1 3.03155
VTCN1 V-set domain containing T cell activation inhibitor 1 3.03155
RAB7B RAB7B, member RAS oncogene family 3.03155
RHOJ ras homolog family member J 3.03155
LRRC32 leucine rich repeat containing 32 3.03155
C1ORF146 chromosome 1 open reading frame 146 3.03155
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 3.03155
NAPSA napsin A aspartic peptidase 3.03155
OR52H1 olfactory receptor, family 52, subfamily H, member 1 3.03155
LOXL4 lysyl oxidase-like 4 3.03155
ZNF98 zinc finger protein 98 3.03155
LBHD1 LBH domain containing 1 3.03155
C9ORF152 chromosome 9 open reading frame 152 3.03155
GRXCR2 glutaredoxin, cysteine rich 2 2.98568
HORMAD2 HORMA domain containing 2 2.98568
RHOXF2B Rhox homeobox family, member 2B 2.98568
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 2.98568
FOXA1 forkhead box A1 2.98568
DNASE1L2 deoxyribonuclease I-like 2 2.98568
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 2.98568
NXPH3 neurexophilin 3 2.98568
LIPN lipase, family member N 2.98568
IGFL2 IGF-like family member 2 2.98568
TM4SF20 transmembrane 4 L six family member 20 2.98568
SH2D6 SH2 domain containing 6 2.98568
TRIM77 tripartite motif containing 77 2.98568
PTGFR prostaglandin F receptor (FP) 2.98568
NRROS negative regulator of reactive oxygen species 2.98568
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.98568
DRP2 dystrophin related protein 2 2.98568
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 2.98568
C2ORF80 chromosome 2 open reading frame 80 2.98568
MAGED4 melanoma antigen family D4 2.98568
ARSF arylsulfatase F 2.98568
MT1HL1 metallothionein 1H-like 1 2.98568
TUBB1 tubulin, beta 1 class VI 2.98568
PAX8 paired box 8 2.98568
PAX3 paired box 3 2.98568
DMRTC1B DMRT-like family C1B 2.98568
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 2.98568
LRG1 leucine-rich alpha-2-glycoprotein 1 2.98568
AHSG alpha-2-HS-glycoprotein 2.98568
ASB10 ankyrin repeat and SOCS box containing 10 2.98568
FNDC7 fibronectin type III domain containing 7 2.98568
HBZ hemoglobin, zeta 2.98568
CIMAP1B ciliary microtubule associated protein 1B 2.98568
BDKRB2 bradykinin receptor B2 2.98568
FOXC1 forkhead box C1 2.98568
MYPN myopalladin 2.98568
WNT16 wingless-type MMTV integration site family, member 16 2.98568
GATA2 GATA binding protein 2 2.98568
COX8C cytochrome c oxidase subunit VIIIC 2.98568
HAL histidine ammonia-lyase 2.98568
FRK fyn-related Src family tyrosine kinase 2.98568
OR2D3 olfactory receptor, family 2, subfamily D, member 3 2.98568
ACKR5 atypical chemokine receptor 5 2.98568
PROC protein C (inactivator of coagulation factors Va and VIIIa) 2.98568
PLCZ1 phospholipase C, zeta 1 2.98568
CFAP97D2 CFAP97 domain containing 2 2.98568
H3C13 H3 clustered histone 13 2.98568
LHFPL7 LHFPL tetraspan subfamily member 7 2.98568
CCN6 cellular communication network factor 6 2.98568
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 2.98568
HAO2 hydroxyacid oxidase 2 (long chain) 2.98568
ARX aristaless related homeobox 2.98568
GPX6 glutathione peroxidase 6 2.98568
AANAT aralkylamine N-acetyltransferase 2.98568
TARM1 T cell-interacting, activating receptor on myeloid cells 1 2.98568
S100B S100 calcium binding protein B 2.98568
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 2.98568
ACTL10 actin-like 10 2.98568
OR2A1 olfactory receptor, family 2, subfamily A, member 1 2.98568
CPED1 cadherin-like and PC-esterase domain containing 1 2.98568
RAET1E retinoic acid early transcript 1E 2.98568
TAS2R5 taste receptor, type 2, member 5 2.98568
MLH1 mutL homolog 1 2.98568
SRL sarcalumenin 2.98568
SBK3 SH3 domain binding kinase family, member 3 2.98568
SIX3 SIX homeobox 3 2.98568
CCDC17 coiled-coil domain containing 17 2.98568
PTGDR2 prostaglandin D2 receptor 2 2.98568
OR7C1 olfactory receptor, family 7, subfamily C, member 1 2.98568
CCR4 chemokine (C-C motif) receptor 4 2.98568
KCNT1 potassium channel, sodium activated subfamily T, member 1 2.98568
SCN7A sodium channel, voltage gated, type VII alpha subunit 2.98568
MIA melanoma inhibitory activity 2.98568
GZMM granzyme M (lymphocyte met-ase 1) 2.98568
MSX1 msh homeobox 1 2.98568
SLC22A25 solute carrier family 22, member 25 2.98568
OR8D4 olfactory receptor, family 8, subfamily D, member 4 2.98568
ZSWIM3 zinc finger, SWIM-type containing 3 2.98568
HRH1 histamine receptor H1 2.98568
TEKT1 tektin 1 2.98568
BEST3 bestrophin 3 2.98568
MYF6 myogenic factor 6 (herculin) 2.98568
VAX2 ventral anterior homeobox 2 2.98568
APOH apolipoprotein H (beta-2-glycoprotein I) 2.98568
AMN amnion associated transmembrane protein 2.98568
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 2.98568
SMIM17 small integral membrane protein 17 2.98568
GFRAL GDNF family receptor alpha like 2.98568
SMYD1 SET and MYND domain containing 1 2.98568
ODF4 outer dense fiber of sperm tails 4 2.98568
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 2.98568
PLA2G12B phospholipase A2, group XIIB 2.98568
ANKRD33 ankyrin repeat domain 33 2.98568
RBSN rabenosyn, RAB effector 2.98568
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 2.98568
MAEL maelstrom spermatogenic transposon silencer 2.98568
PLGLB2 plasminogen-like B2 2.98568
C18ORF63 chromosome 18 open reading frame 63 2.98568
NXNL1 nucleoredoxin-like 1 2.98568
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 2.98568
MAB21L3 mab-21-like 3 (C. elegans) 2.98568
CLEC4E C-type lectin domain family 4, member E 2.98568
SCX scleraxis basic helix-loop-helix transcription factor 2.98568
CER1 cerberus 1, DAN family BMP antagonist 2.98568
KLHL41 kelch-like family member 41 2.98568
SLC22A24 solute carrier family 22, member 24 2.98568
NOX1 NADPH oxidase 1 2.98568
KLK11 kallikrein-related peptidase 11 2.98568
DPRX divergent-paired related homeobox 2.98568
TNN tenascin N 2.98568
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 2.98568
FBXO40 F-box protein 40 2.98568
CST4 cystatin S 2.98568
CLDN34 claudin 34 2.98568
ZNF843 zinc finger protein 843 2.98568
OCM oncomodulin 2.98568
PSORS1C1 psoriasis susceptibility 1 candidate 1 2.98568
CDCP2 CUB domain containing protein 2 2.98568
CFI complement factor I 2.98568
FOXG1 forkhead box G1 2.98568
ZNF648 zinc finger protein 648 2.98568
ASCL2 achaete-scute family bHLH transcription factor 2 2.98568
NEUROD4 neuronal differentiation 4 2.98568
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 2.98568
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 2.98568
CLEC2A C-type lectin domain family 2, member A 2.98568
SOST sclerostin 2.98568
RNASE6 ribonuclease, RNase A family, k6 2.98568
FAM161B family with sequence similarity 161, member B 2.98568
PDK4 pyruvate dehydrogenase kinase, isozyme 4 2.98568
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 2.98568
ITGAD integrin, alpha D 2.98568
BCL2A1 BCL2-related protein A1 2.98568
AIRE autoimmune regulator 2.98568
PFN4 profilin family, member 4 2.98568
ZPLD1 zona pellucida-like domain containing 1 2.98568
PADI1 peptidyl arginine deiminase, type I 2.98568
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 2.98568
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 2.98568
CHRM4 cholinergic receptor, muscarinic 4 2.98568
PRPH2 peripherin 2 (retinal degeneration, slow) 2.98568
DLX2 distal-less homeobox 2 2.98568
SYTL4 synaptotagmin-like 4 2.98568
LYZ lysozyme 2.98568
SPHKAP SPHK1 interactor, AKAP domain containing 2.98568
TGM2 transglutaminase 2 2.98568
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 2.98568
IBSP integrin-binding sialoprotein 2.98568
SOSTDC1 sclerostin domain containing 1 2.98568
PAX5 paired box 5 2.87726
PCDHB4 protocadherin beta 4 2.8682
SFPQ splicing factor proline/glutamine-rich 2.83568
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 2.81055
MED12 mediator complex subunit 12 2.7576
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa 2.65475
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F 2.64935
GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 2.63844
PLSCR1 phospholipid scramblase 1 2.56142
CERS1 ceramide synthase 1 2.54486
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.53315
PGBD2 piggyBac transposable element derived 2 2.48642
LY96 lymphocyte antigen 96 2.4636
FMO1 flavin containing monooxygenase 1 2.4636
CPB2 carboxypeptidase B2 (plasma) 2.4636
KDM3A lysine (K)-specific demethylase 3A 2.42361
ETV3L ets variant 3-like 2.3681
NKTR natural killer cell triggering receptor 2.34558
GCA grancalcin, EF-hand calcium binding protein 2.34423
CTNS cystinosin, lysosomal cystine transporter 2.34192
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 2.32125
ZNF311 zinc finger protein 311 2.32125
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 2.31741
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3 2.31481
PPL periplakin 2.30228
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic 2.2996
RBBP5 retinoblastoma binding protein 5 2.28741
PTPN11 protein tyrosine phosphatase, non-receptor type 11 2.25381
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) 2.23361
MPPE1 metallophosphoesterase 1 2.22918
DRC11 dynein regulatory complex subunit 11 2.19323
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 2.16146
TLE5 TLE family member 5, transcriptional modulator 2.15995
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 2.14763
SARAF store-operated calcium entry-associated regulatory factor 2.13838
SUMO1 small ubiquitin-like modifier 1 2.13373
CENPI centromere protein I 2.11408
VASN vasorin 2.10533
MICU1 mitochondrial calcium uptake 1 2.10533
PERP PERP, TP53 apoptosis effector 2.10365
VWA5B1 von Willebrand factor A domain containing 5B1 2.10335
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) 2.10335
GSTO2 glutathione S-transferase omega 2 2.09692
MYO3A myosin IIIA 2.07902
NMI N-myc (and STAT) interactor 2.07862
TERT telomerase reverse transcriptase 2.07671
PTBP2 polypyrimidine tract binding protein 2 2.07615
ZNRF3 zinc and ring finger 3 2.07144
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 2.06491
ZNF430 zinc finger protein 430 2.06491
BCL7A B-cell CLL/lymphoma 7A 2.0603
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 2.04282
PBK PDZ binding kinase 2.04167
BBIP1 BBSome interacting protein 1 2.03922
DZIP1L DAZ interacting zinc finger protein 1-like 2.014

decreased expression

Symbol Name Standardized Value
TRPC3 transient receptor potential cation channel, subfamily C, member 3 -3.03155
TMEM74B transmembrane protein 74B -3.03155
TMC2 transmembrane channel-like 2 -2.98568
SLC25A45 solute carrier family 25, member 45 -2.98568
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like -2.98568
RFX1 regulatory factor X, 1 (influences HLA class II expression) -2.98568
RASL10A RAS-like, family 10, member A -2.98568
HEATR5B HEAT repeat containing 5B -2.98568
TSSK4 testis-specific serine kinase 4 -2.98568
OR2AG2 olfactory receptor, family 2, subfamily AG, member 2 -2.98568
ZNF791 zinc finger protein 791 -2.98568
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) -2.98568
SLC25A29 solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 -2.98568
TMEM151A transmembrane protein 151A -2.98568
ASCL5 achaete-scute family bHLH transcription factor 5 -2.98568
MYO16 myosin XVI -2.98568
GPRC5D G protein-coupled receptor, class C, group 5, member D -2.98568
CAMSAP3 calmodulin regulated spectrin-associated protein family, member 3 -2.98568
LCN15 lipocalin 15 -2.98568
TESK2 testis-specific kinase 2 -2.98568
HPX hemopexin -2.98568
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled -2.98568
ASIC4 acid sensing (proton gated) ion channel family member 4 -2.98568
REP15 RAB15 effector protein -2.98568
CTSF cathepsin F -2.98568
SLAMF1 signaling lymphocytic activation molecule family member 1 -2.98568
CLDN14 claudin 14 -2.98568
KY kyphoscoliosis peptidase -2.98568
PGGHG protein-glucosylgalactosylhydroxylysine glucosidase -2.98568
TMEM278 transmembrane protein 278 -2.98568
UPK1B uroplakin 1B -2.98568
CFAP61 cilia and flagella associated protein 61 -2.98568
CRHR1 corticotropin releasing hormone receptor 1 -2.98568
UTS2B urotensin 2B -2.98568
TMPRSS4 transmembrane protease, serine 4 -2.98568
PDE1B phosphodiesterase 1B, calmodulin-dependent -2.98568
PGD phosphogluconate dehydrogenase -2.98568
SNX32 sorting nexin 32 -2.98568
PCDHGA4 protocadherin gamma subfamily A, 4 -2.98568
LDHAL6A lactate dehydrogenase A-like 6A -2.98568
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3 -2.98568
IGSF22 immunoglobulin superfamily, member 22 -2.96618
KLK8 kallikrein-related peptidase 8 -2.96618
RBM7 RNA binding motif protein 7 -2.91307
H3C6 H3 clustered histone 6 -2.8214
RSBN1L round spermatid basic protein 1-like -2.75857
CCDC90B coiled-coil domain containing 90B -2.74469
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 -2.72265
SGMS2 sphingomyelin synthase 2 -2.71268
ATF7IP activating transcription factor 7 interacting protein -2.66285
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) -2.6596
SH3RF3 SH3 domain containing ring finger 3 -2.5472
RMDN3 regulator of microtubule dynamics 3 -2.545
H2BC26 H2B clustered histone 26 -2.5061
CFAP221 cilia and flagella associated protein 221 -2.5061
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 -2.5061
DRD3 dopamine receptor D3 -2.5061
ELL3 elongation factor RNA polymerase II-like 3 -2.5061
CAPN1 calpain 1, (mu/I) large subunit -2.42924
LEKR1 leucine, glutamate and lysine rich 1 -2.42469
STK26 serine/threonine protein kinase 26 -2.42361
PIGB phosphatidylinositol glycan anchor biosynthesis, class B -2.42212
C8ORF34 chromosome 8 open reading frame 34 -2.42212
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.416
RELCH RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing -2.37789
AGAP6 ArfGAP with GTPase domain, ankyrin repeat and PH domain 6 -2.355
KIF20A kinesin family member 20A -2.3109
CD101 CD101 molecule -2.28741
LYG2 lysozyme G-like 2 -2.28068
NECAB1 N-terminal EF-hand calcium binding protein 1 -2.25381
TFB1M transcription factor B1, mitochondrial -2.25173
RABGGTA Rab geranylgeranyltransferase, alpha subunit -2.23972
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase -2.23238
FAM76A family with sequence similarity 76, member A -2.22918
CPT1B carnitine palmitoyltransferase 1B (muscle) -2.16146
ZNF8 zinc finger protein 8 -2.15993
BCO2 beta-carotene oxygenase 2 -2.14468
DDTL D-dopachrome tautomerase-like -2.14468
SHD Src homology 2 domain containing transforming protein D -2.14468
OGA O-GlcNAcase -2.14468
ZNF500 zinc finger protein 500 -2.13838
CAMK1D calcium/calmodulin-dependent protein kinase ID -2.13838
KATNA1 katanin p60 (ATPase containing) subunit A 1 -2.13687
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9 -2.13592
TANGO6 transport and golgi organization 6 homolog (Drosophila) -2.13373
COL6A1 collagen, type VI, alpha 1 -2.11408
RPRD1A regulation of nuclear pre-mRNA domain containing 1A -2.11408
DUS3L dihydrouridine synthase 3-like (S. cerevisiae) -2.07902
SPATS2L spermatogenesis associated, serine-rich 2-like -2.07144
PPIH peptidylprolyl isomerase H (cyclophilin H) -2.06491
MBNL1 muscleblind-like splicing regulator 1 -2.06164
CSDC2 cold shock domain containing C2, RNA binding -2.06087
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -2.06087
GJD3 gap junction protein, delta 3, 31.9kDa -2.06087
RNF157 ring finger protein 157 -2.06087
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 -2.05632
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 -2.05165
QTGAL queuosine-tRNA galactosyltransferase -2.03691
SNX16 sorting nexin 16 -2.02599
PHOSPHO2 phosphatase, orphan 2 -2.01758
CYB5R4 cytochrome b5 reductase 4 -2.01758
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -2.00287