| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | PH-797804 perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the PH-797804_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.297202 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.189598 |
| NLGN1 | neuroligin 1 | 0.140103 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.132327 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0956262 |
| MMP12 | matrix metallopeptidase 12 | 0.0807955 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0801933 |
| TMEM41B | transmembrane protein 41B | 0.0793392 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.078467 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0716414 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0704762 |
| VMP1 | vacuole membrane protein 1 | 0.068409 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0675163 |
| DST | dystonin | 0.065482 |
| PCDH7 | protocadherin 7 | 0.0652438 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.064545 |
| YAP1 | Yes-associated protein 1 | 0.0643278 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0642122 |
| TMSB10 | thymosin beta 10 | 0.0641367 |
| ANXA1 | annexin A1 | 0.0625697 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0614692 |
| TENM3 | teneurin transmembrane protein 3 | 0.058566 |
| RPS3 | ribosomal protein S3 | 0.057281 |
| RRM2 | ribonucleotide reductase M2 | 0.0564353 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0526839 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | 0.0515538 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0509896 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0505424 |
| RPS12 | ribosomal protein S12 | 0.0497074 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0493738 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0491708 |
| EHBP1 | EH domain binding protein 1 | 0.0474849 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0471226 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0470691 |
| PDGFC | platelet derived growth factor C | 0.0465661 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0460126 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0451678 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.042964 |
| USP34 | ubiquitin specific peptidase 34 | 0.0423878 |
| AHNAK | AHNAK nucleoprotein | 0.0422588 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0411137 |
| JMJD1C | jumonji domain containing 1C | 0.0411127 |
| TXNRD1 | thioredoxin reductase 1 | 0.0411082 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0402171 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0399417 |
| NEBL | nebulette | 0.0390148 |
| RPLP1 | ribosomal protein, large, P1 | 0.0388935 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0385617 |
| PGK1 | phosphoglycerate kinase 1 | 0.0377039 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0374728 |
| MYL12B | myosin, light chain 12B, regulatory | 0.0374634 |
| ATP11A | ATPase, class VI, type 11A | 0.0370914 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0365551 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0346167 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0339006 |
| HMGA2 | high mobility group AT-hook 2 | 0.0338184 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0337966 |
| KLF6 | Kruppel-like factor 6 | 0.0336167 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0335943 |
| LDHA | lactate dehydrogenase A | 0.0333492 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0333284 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0331383 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0316314 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0314213 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0313282 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.0312826 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0312342 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0310881 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0309596 |
| PEG10 | paternally expressed 10 | 0.0308399 |
| SMYD3 | SET and MYND domain containing 3 | 0.0307779 |
| EDARADD | EDAR-associated death domain | 0.0306927 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0305842 |
| TPI1 | triosephosphate isomerase 1 | 0.0303253 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0301499 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.030084 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0299177 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0297658 |
| ADIPOR2 | adiponectin receptor 2 | 0.0296616 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0295999 |
| CELF2 | CUGBP, Elav-like family member 2 | 0.0293069 |
| NEGR1 | neuronal growth regulator 1 | 0.0292164 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0290711 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0282938 |
| MTAP | methylthioadenosine phosphorylase | 0.0281059 |
| WWOX | WW domain containing oxidoreductase | 0.0278793 |
| EXOC6B | exocyst complex component 6B | 0.0278652 |
| CLTC | clathrin, heavy chain (Hc) | 0.0278113 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0275823 |
| ASPH | aspartate beta-hydroxylase | 0.0272181 |
| RPL26 | ribosomal protein L26 | 0.0271891 |
| SQSTM1 | sequestosome 1 | 0.0270765 |
| RAD51B | RAD51 paralog B | 0.0268786 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0265351 |
| EXOC4 | exocyst complex component 4 | 0.026246 |
| TMEM123 | transmembrane protein 123 | 0.0261396 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0260995 |
| CEP192 | centrosomal protein 192kDa | 0.026057 |
| CALR | calreticulin | 0.0257696 |
| LMO7 | LIM domain 7 | 0.0256225 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.184599 |
| WDR43 | WD repeat domain 43 | -0.0569699 |
| RPS23 | ribosomal protein S23 | -0.0455148 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0449233 |
| CCNL1 | cyclin L1 | -0.0333921 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0325289 |
| RPL35A | ribosomal protein L35a | -0.0309906 |
| RAB7A | RAB7A, member RAS oncogene family | -0.029225 |
| ACTG1 | actin gamma 1 | -0.0289866 |
| FTL | ferritin, light polypeptide | -0.0256841 |
| FOSL1 | FOS-like antigen 1 | -0.0239533 |
| HMGA1 | high mobility group AT-hook 1 | -0.0236889 |
| RPS29 | ribosomal protein S29 | -0.0220044 |
| RPS15 | ribosomal protein S15 | -0.021288 |
| PLK2 | polo-like kinase 2 | -0.0212686 |
| POTEF | POTE ankyrin domain family, member F | -0.0196251 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0193952 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0190122 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -0.0189009 |
| INTS6 | integrator complex subunit 6 | -0.0186147 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0183656 |
| RPS10 | ribosomal protein S10 | -0.0182527 |
| RPS26 | ribosomal protein S26 | -0.0180265 |
| HLA-A | major histocompatibility complex, class I, A | -0.0177135 |
| RPS11 | ribosomal protein S11 | -0.0171098 |
| PARD6B | par-6 family cell polarity regulator beta | -0.0165729 |
| AREG | amphiregulin | -0.0163181 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0162968 |
| RYK | receptor-like tyrosine kinase | -0.0161697 |
| RPL8 | ribosomal protein L8 | -0.0155339 |
| NAA15 | N(alpha)-acetyltransferase 15, NatA auxiliary subunit | -0.015245 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.015094 |
| SETD5 | SET domain containing 5 | -0.0149094 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.014626 |
| PER1 | period circadian clock 1 | -0.0143909 |
| FOXJ3 | forkhead box J3 | -0.0140073 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0138402 |
| GTPBP4 | GTP binding protein 4 | -0.013215 |
| WDR45B | WD repeat domain 45B | -0.0131558 |
| RPL21 | ribosomal protein L21 | -0.0125329 |
| PUM1 | pumilio RNA-binding family member 1 | -0.0124286 |
| NOP58 | NOP58 ribonucleoprotein | -0.0124226 |
| RLF | rearranged L-myc fusion | -0.0123279 |
| LDHB | lactate dehydrogenase B | -0.0122793 |
| RPL34 | ribosomal protein L34 | -0.0119636 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0119538 |
| RPS14 | ribosomal protein S14 | -0.0116346 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0115473 |
| USPL1 | ubiquitin specific peptidase like 1 | -0.0112791 |
| MED17 | mediator complex subunit 17 | -0.0109953 |
| EGR1 | early growth response 1 | -0.0108991 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0108711 |
| PPP4R2 | protein phosphatase 4, regulatory subunit 2 | -0.0108593 |
| HLA-B | major histocompatibility complex, class I, B | -0.0108147 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0107527 |
| GOLGB1 | golgin B1 | -0.0106858 |
| ATN1 | atrophin 1 | -0.0105584 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0103636 |
| RBM25 | RNA binding motif protein 25 | -0.0103598 |
| GOLGA4 | golgin A4 | -0.0103199 |
| RBM33 | RNA binding motif protein 33 | -0.0102847 |
| DDX18 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 | -0.0101608 |
| PPP4R3A | protein phosphatase 4 regulatory subunit 3A | -0.010133 |
| FRS2 | fibroblast growth factor receptor substrate 2 | -0.0101254 |
| PRPF3 | pre-mRNA processing factor 3 | -0.00998326 |
| PRELID1 | PRELI domain containing 1 | -0.00989662 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.00982517 |
| SCAF8 | SR-related CTD-associated factor 8 | -0.00975831 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.00974945 |
| TBCA | tubulin folding cofactor A | -0.00970295 |
| CDK2AP2 | cyclin-dependent kinase 2 associated protein 2 | -0.00961342 |
| RPIA | ribose 5-phosphate isomerase A | -0.00950083 |
| PRPF8 | pre-mRNA processing factor 8 | -0.00949589 |
| NFYA | nuclear transcription factor Y, alpha | -0.009492 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.00938874 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.00936738 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.00936494 |
| TIGAR | TP53 induced glycolysis regulatory phosphatase | -0.00936236 |
| AHCTF1 | AT hook containing transcription factor 1 | -0.00934652 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.00928668 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.00925602 |
| MDM4 | MDM4, p53 regulator | -0.00920276 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | -0.00859424 |
| EWSR1 | EWS RNA-binding protein 1 | -0.00857816 |
| BMPR1B | bone morphogenetic protein receptor, type IB | -0.00833844 |
| KCMF1 | potassium channel modulatory factor 1 | -0.00829646 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.00822938 |
| TAPBP | TAP binding protein (tapasin) | -0.00821257 |
| FASN | fatty acid synthase | -0.00814385 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.00812303 |
| LATS2 | large tumor suppressor kinase 2 | -0.00804232 |
| EPHA2 | EPH receptor A2 | -0.00803494 |
| ABCF1 | ATP-binding cassette, sub-family F (GCN20), member 1 | -0.00795531 |
| HBS1L | HBS1-like translational GTPase | -0.00794434 |
| WWC1 | WW and C2 domain containing 1 | -0.00785829 |
| ATG3 | autophagy related 3 | -0.00783085 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.00779167 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.00770737 |
| NDUFS8 | NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) | -0.00770698 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | -0.00769973 |
