PH-797804_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description PH-797804 perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the PH-797804_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.212915
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.15777
SMAD3 SMAD family member 3 0.131708
INTS6 integrator complex subunit 6 0.12469
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.120203
AKAP13 A kinase (PRKA) anchor protein 13 0.0854572
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0801938
EXT1 exostosin glycosyltransferase 1 0.079026
ANXA2 annexin A2 0.079022
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0728616
ASPH aspartate beta-hydroxylase 0.0721635
LCN2 lipocalin 2 0.0709323
ZSWIM6 zinc finger, SWIM-type containing 6 0.0680225
VCL vinculin 0.0657017
MYO1E myosin IE 0.0624275
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0614051
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0599268
BTBD9 BTB (POZ) domain containing 9 0.054712
AREG amphiregulin 0.053828
TPT1 tumor protein, translationally-controlled 1 0.0531281
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0524205
EFNB2 ephrin-B2 0.0503426
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0483987
LPP LIM domain containing preferred translocation partner in lipoma 0.0451156
PLSCR2 phospholipid scramblase 2 0.0443438
DSCAM Down syndrome cell adhesion molecule 0.0436341
FNDC3B fibronectin type III domain containing 3B 0.0430255
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0415361
MAP7 microtubule-associated protein 7 0.0407341
GMDS GDP-mannose 4,6-dehydratase 0.0404235
PKM pyruvate kinase, muscle 0.0402957
HKDC1 hexokinase domain containing 1 0.0389524
MCU mitochondrial calcium uniporter 0.0383312
TMC5 transmembrane channel-like 5 0.0382491
GCLC glutamate-cysteine ligase, catalytic subunit 0.0378542
KYNU kynureninase 0.037623
VMP1 vacuole membrane protein 1 0.037552
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0374222
C6ORF132 chromosome 6 open reading frame 132 0.0372257
B2M beta-2-microglobulin 0.0368139
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0366661
BAIAP2L1 BAI1-associated protein 2-like 1 0.0365842
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0364958
RNF213 ring finger protein 213 0.036284
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0360365
CATSPERB catsper channel auxiliary subunit beta 0.0358988
ANKRD10 ankyrin repeat domain 10 0.0356677
N4BP2L2 NEDD4 binding protein 2-like 2 0.0356283
ERBIN erbb2 interacting protein 0.034846
SERINC5 serine incorporator 5 0.0347878
MACC1 metastasis associated in colon cancer 1 0.0345166
SHB Src homology 2 domain containing adaptor protein B 0.0335684
TM4SF19 transmembrane 4 L six family member 19 0.0330159
ADAM10 ADAM metallopeptidase domain 10 0.0327387
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0325103
PADI1 peptidyl arginine deiminase, type I 0.0315196
PRKCA protein kinase C, alpha 0.0311714
CTNND1 catenin (cadherin-associated protein), delta 1 0.0309574
RAD51B RAD51 paralog B 0.0307779
MCL1 myeloid cell leukemia 1 0.0305872
EREG epiregulin 0.0304405
SP100 SP100 nuclear antigen 0.0302929
MCTP1 multiple C2 domains, transmembrane 1 0.0302744
ATXN1 ataxin 1 0.0301029
DIAPH1 diaphanous-related formin 1 0.0298333
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0297516
MBNL2 muscleblind-like splicing regulator 2 0.0293617
TJP1 tight junction protein 1 0.0292275
SPAG9 sperm associated antigen 9 0.0287314
ZBTB20 zinc finger and BTB domain containing 20 0.028567
SEPTIN9 septin 9 0.0284254
IFI6 interferon, alpha-inducible protein 6 0.0282633
TSC22D1 TSC22 domain family, member 1 0.02783
NABP1 nucleic acid binding protein 1 0.0277887
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0276561
YAP1 Yes-associated protein 1 0.0273038
RBM47 RNA binding motif protein 47 0.027198
LIMA1 LIM domain and actin binding 1 0.0268476
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0266742
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0265478
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0265349
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0260393
TRIM2 tripartite motif containing 2 0.025968
FTL ferritin, light polypeptide 0.0258361
PGK1 phosphoglycerate kinase 1 0.0257994
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0257311
SIK3 SIK family kinase 3 0.0256963
TUFT1 tuftelin 1 0.0256758
POU2F2 POU class 2 homeobox 2 0.0247909
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0246625
ENO1 enolase 1, (alpha) 0.0241792
PERP PERP, TP53 apoptosis effector 0.0238813
KIAA1217 KIAA1217 0.0234501
UBAP2 ubiquitin associated protein 2 0.0233727
CALR calreticulin 0.0233324
MT2A metallothionein 2A 0.0230726
MYO5B myosin VB 0.0230251
ZCCHC7 zinc finger, CCHC domain containing 7 0.0230169
SDC4 syndecan 4 0.0230087
UBE2H ubiquitin-conjugating enzyme E2H 0.0228904

decreased expression

Symbol Name Standardized Value
LYZ lysozyme -0.0570417
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0378718
ZMYND8 zinc finger, MYND-type containing 8 -0.0353128
TXNIP thioredoxin interacting protein -0.0347244
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.033944
USPL1 ubiquitin specific peptidase like 1 -0.0306028
MX1 MX dynamin-like GTPase 1 -0.0298296
RIGI RNA sensor RIG-I -0.029324
CCNL1 cyclin L1 -0.0285484
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0274004
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0260356
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0257722
NPSR1 neuropeptide S receptor 1 -0.02436
WDR43 WD repeat domain 43 -0.0239122
BCLAF1 BCL2-associated transcription factor 1 -0.0215143
XAF1 XIAP associated factor 1 -0.0205025
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0204489
PRPF3 pre-mRNA processing factor 3 -0.0203644
WDR45B WD repeat domain 45B -0.019465
HLA-B major histocompatibility complex, class I, B -0.0192767
NOP58 NOP58 ribonucleoprotein -0.0188029
RLF rearranged L-myc fusion -0.0179096
BRCA2 breast cancer 2, early onset -0.0178642
TFRC transferrin receptor -0.017778
HBS1L HBS1-like translational GTPase -0.0175121
RBM39 RNA binding motif protein 39 -0.0172826
NCOR1 nuclear receptor corepressor 1 -0.0172321
MKI67 marker of proliferation Ki-67 -0.0171529
NIPBL Nipped-B homolog (Drosophila) -0.0169306
HMGB1 high mobility group box 1 -0.0168994
MATR3 matrin 3 -0.0165564
DIAPH3 diaphanous-related formin 3 -0.0161977
PRPF8 pre-mRNA processing factor 8 -0.0161318
GNAS GNAS complex locus -0.0160794
ATP10B ATPase, class V, type 10B -0.0155863
PTMA prothymosin, alpha -0.0154795
MUC13 mucin 13, cell surface associated -0.0154383
ZNFX1 zinc finger, NFX1-type containing 1 -0.0152181
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0152001
RSRC2 arginine/serine-rich coiled-coil 2 -0.0151331
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) -0.0150004
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0147755
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0146901
TMEM87A transmembrane protein 87A -0.0146886
ITGA6 integrin, alpha 6 -0.014683
PUM2 pumilio RNA-binding family member 2 -0.0146595
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0146539
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic -0.0144647
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0142579
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0142504
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0139903
PDS5B PDS5 cohesin associated factor B -0.0138349
AQR aquarius intron-binding spliceosomal factor -0.0136934
LOC102724023 ES1 protein homolog, mitochondrial -0.0135328
PTEN phosphatase and tensin homolog -0.0133472
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -0.0131353
UBE3A ubiquitin protein ligase E3A -0.013115
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0128243
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0126798
NCOA7 nuclear receptor coactivator 7 -0.0125148
SPATA13 spermatogenesis associated 13 -0.012489
ITPKC inositol-trisphosphate 3-kinase C -0.0123802
PDIA3 protein disulfide isomerase family A, member 3 -0.0123653
ZDHHC20 zinc finger, DHHC-type containing 20 -0.0121693
KLF10 Kruppel-like factor 10 -0.0120383
DEK DEK proto-oncogene -0.0120135
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0117161
FAF2 Fas associated factor family member 2 -0.0117062
NUP160 nucleoporin 160kDa -0.0116792
PPP2R2D protein phosphatase 2, regulatory subunit B, delta -0.0116619
GRAMD2B GRAM domain containing 2B -0.0116496
XRN1 5'-3' exoribonuclease 1 -0.011539
LMTK2 lemur tyrosine kinase 2 -0.0115225
SMC4 structural maintenance of chromosomes 4 -0.0115169
MARCHF6 membrane associated ring-CH-type finger 6 -0.0114301
UBAC2 UBA domain containing 2 -0.0113271
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0113085
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0112625
TMEM62 transmembrane protein 62 -0.0111522
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0111473
STIL SCL/TAL1 interrupting locus -0.0111442
NUP58 nucleoporin 58 -0.010988
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0108947
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 -0.0107749
ZMYM2 zinc finger, MYM-type 2 -0.010762
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0107314
OASL 2'-5'-oligoadenylate synthetase-like -0.0107176
SMAP2 small ArfGAP2 -0.0107175
EIF3D eukaryotic translation initiation factor 3, subunit D -0.0106938
GLO1 glyoxalase I -0.010608
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.0105015
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0104822
ATAD2 ATPase family, AAA domain containing 2 -0.0104701
MAML2 mastermind-like 2 (Drosophila) -0.0104504
RREB1 ras responsive element binding protein 1 -0.0102223
NAMPT nicotinamide phosphoribosyltransferase -0.0102015
ADNP activity-dependent neuroprotector homeobox -0.0100892
FOXJ3 forkhead box J3 -0.0100517
LRPPRC leucine-rich pentatricopeptide repeat containing -0.00996969
TUBGCP3 tubulin, gamma complex associated protein 3 -0.00996737