PH-797804_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description PH-797804 perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the PH-797804_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 0.155169
PTMA prothymosin, alpha 0.145461
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.101413
TMSB10 thymosin beta 10 0.0947567
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0860315
RPS8 ribosomal protein S8 0.0849532
RPS12 ribosomal protein S12 0.0674727
RPS3 ribosomal protein S3 0.0648951
MT2A metallothionein 2A 0.0639535
RPL37A ribosomal protein L37a 0.0549289
RPLP2 ribosomal protein, large, P2 0.0540015
RPL31 ribosomal protein L31 0.0519165
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0502877
RPS6 ribosomal protein S6 0.0475363
RPLP1 ribosomal protein, large, P1 0.0470694
RPL26 ribosomal protein L26 0.0465731
CTBP2 C-terminal binding protein 2 0.0441558
RPS19 ribosomal protein S19 0.0415907
VIM vimentin 0.0414863
INTS6 integrator complex subunit 6 0.0385291
ENO1 enolase 1, (alpha) 0.0381658
RPLP0 ribosomal protein, large, P0 0.0380944
ASPH aspartate beta-hydroxylase 0.0361777
NDRG1 N-myc downstream regulated 1 0.0359105
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0357794
EGR1 early growth response 1 0.0330423
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0329281
RRM2 ribonucleotide reductase M2 0.0318256
B2M beta-2-microglobulin 0.0317726
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0313212
PKM pyruvate kinase, muscle 0.0311192
RPS13 ribosomal protein S13 0.0310633
RACK1 receptor for activated C kinase 1 0.030796
RPS24 ribosomal protein S24 0.0298377
RPL18 ribosomal protein L18 0.029825
HLA-B major histocompatibility complex, class I, B 0.029692
S100A9 S100 calcium binding protein A9 0.0290933
RPS17 ribosomal protein S17 0.0280151
RPL9 ribosomal protein L9 0.027848
RPL19 ribosomal protein L19 0.0272929
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0269058
RPL36 ribosomal protein L36 0.026575
RPS27A ribosomal protein S27a 0.0264017
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0263853
RPL30 ribosomal protein L30 0.0262291
ZSWIM6 zinc finger, SWIM-type containing 6 0.0260496
RPS14 ribosomal protein S14 0.0259406
PGK1 phosphoglycerate kinase 1 0.0258422
AKAP9 A kinase (PRKA) anchor protein 9 0.0257455
AEBP2 AE binding protein 2 0.0251377
RPL36A ribosomal protein L36a 0.0251209
MTDH metadherin 0.0251186
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0250769
MCL1 myeloid cell leukemia 1 0.0249038
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0246978
RPL35A ribosomal protein L35a 0.0246564
ISG15 ISG15 ubiquitin-like modifier 0.0246511
WWOX WW domain containing oxidoreductase 0.0244898
PLAUR plasminogen activator, urokinase receptor 0.0242991
SET SET nuclear proto-oncogene 0.0238283
RPL11 ribosomal protein L11 0.0236933
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0235974
EXT1 exostosin glycosyltransferase 1 0.0234192
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0232548
RPL35 ribosomal protein L35 0.0227229
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0225561
RPL23 ribosomal protein L23 0.0222988
HLA-A major histocompatibility complex, class I, A 0.0221942
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0220175
IFITM3 interferon induced transmembrane protein 3 0.0218486
AKAP12 A kinase (PRKA) anchor protein 12 0.0217073
SDC4 syndecan 4 0.0216949
RPL37 ribosomal protein L37 0.0214223
RPS21 ribosomal protein S21 0.0206851
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0206123
MACF1 microtubule-actin crosslinking factor 1 0.0201105
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0199681
RUNX1 runt-related transcription factor 1 0.0198562
LDHA lactate dehydrogenase A 0.0198413
RPS25 ribosomal protein S25 0.019732
TPM4 tropomyosin 4 0.0195138
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0193789
RAB6A RAB6A, member RAS oncogene family 0.0192585
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0192518
EIF5B eukaryotic translation initiation factor 5B 0.0191385
NAP1L1 nucleosome assembly protein 1-like 1 0.019122
LRRC23 leucine rich repeat containing 23 0.0190978
FNDC3B fibronectin type III domain containing 3B 0.0190839
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.019031
FTL ferritin, light polypeptide 0.0186274
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0186134
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0185005
MYH9 myosin, heavy chain 9, non-muscle 0.018496
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0183988
RPS5 ribosomal protein S5 0.0180902
RPS29 ribosomal protein S29 0.0178825
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0178239
RPL27A ribosomal protein L27a 0.0175637
RPL7A ribosomal protein L7a 0.0175049
EHBP1 EH domain binding protein 1 0.0171566

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.320164
LOC112694756 uncharaterized LOC112694756 -0.04251
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0421389
TXNRD1 thioredoxin reductase 1 -0.0377097
EEF2 eukaryotic translation elongation factor 2 -0.0193133
PCBP2 poly(rC) binding protein 2 -0.0190051
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0188698
ARF4 ADP-ribosylation factor 4 -0.0183001
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0180888
KRT8 keratin 8, type II -0.0179343
TOR1AIP2 torsin A interacting protein 2 -0.0177928
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0177391
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0175415
WASF2 WAS protein family, member 2 -0.0167884
PRELID2 PRELI domain containing 2 -0.0165382
FTH1 ferritin, heavy polypeptide 1 -0.0163997
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0163911
POTEF POTE ankyrin domain family, member F -0.0155658
SPIDR scaffolding protein involved in DNA repair -0.0149912
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0143325
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.013819
PCM1 pericentriolar material 1 -0.0138152
UBC ubiquitin C -0.013723
CXADR coxsackie virus and adenovirus receptor -0.0133999
LCOR ligand dependent nuclear receptor corepressor -0.0133424
PDIA3 protein disulfide isomerase family A, member 3 -0.0132693
RB1CC1 RB1-inducible coiled-coil 1 -0.0132154
KIF5B kinesin family member 5B -0.013009
PHF21A PHD finger protein 21A -0.0130038
MKI67 marker of proliferation Ki-67 -0.0127187
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0126002
CANX calnexin -0.0125689
MSMO1 methylsterol monooxygenase 1 -0.0125585
SRSF11 serine/arginine-rich splicing factor 11 -0.012465
WDR26 WD repeat domain 26 -0.0123955
MATR3 matrin 3 -0.0121912
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0119811
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0119634
ARL5B ADP-ribosylation factor-like 5B -0.0119524
CDK19 cyclin-dependent kinase 19 -0.0118924
PNISR PNN-interacting serine/arginine-rich protein -0.0115727
PDZD8 PDZ domain containing 8 -0.0113786
ACBD3 acyl-CoA binding domain containing 3 -0.0113261
TMEM263 transmembrane protein 263 -0.0112638
JMJD1C jumonji domain containing 1C -0.0109835
SRRM1 serine/arginine repetitive matrix 1 -0.0108828
MIS18BP1 MIS18 binding protein 1 -0.0108225
ARCN1 archain 1 -0.0108108
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0107955
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0107309
MBNL2 muscleblind-like splicing regulator 2 -0.0106132
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0105964
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0105536
TM9SF3 transmembrane 9 superfamily member 3 -0.0105453
AKAP10 A kinase (PRKA) anchor protein 10 -0.0105116
PTBP3 polypyrimidine tract binding protein 3 -0.0104566
CKAP2 cytoskeleton associated protein 2 -0.0104377
USP32 ubiquitin specific peptidase 32 -0.0103257
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0103047
TOP2B topoisomerase (DNA) II beta 180kDa -0.0101348
FAF2 Fas associated factor family member 2 -0.0101041
CEP192 centrosomal protein 192kDa -0.0101026
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0100432
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0100052
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 -0.00997489
SUCO SUN domain containing ossification factor -0.00989881
LMAN1 lectin, mannose-binding, 1 -0.00988688
MASTL microtubule associated serine/threonine kinase-like -0.00980681
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma -0.00968158
GSK3B glycogen synthase kinase 3 beta -0.00964928
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 -0.00957903
MAP4 microtubule-associated protein 4 -0.00950054
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.00948311
FBXO21 F-box protein 21 -0.00945704
YY1 YY1 transcription factor -0.00941998
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0094064
USO1 USO1 vesicle transport factor -0.00939447
CFAP96 cilia and flagella associated protein 96 -0.00933829
ICAM1 intercellular adhesion molecule 1 -0.0092572
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.00913608
RPS15 ribosomal protein S15 -0.0091297
ZNF638 zinc finger protein 638 -0.00912458
ZDHHC20 zinc finger, DHHC-type containing 20 -0.00910065
ZBTB10 zinc finger and BTB domain containing 10 -0.0091006
U2SURP U2 snRNP-associated SURP domain containing -0.00907036
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.00904966
BABAM2 BRISC and BRCA1 A complex member 2 -0.00896159
FAT1 FAT atypical cadherin 1 -0.00891678
HMGN2 high mobility group nucleosomal binding domain 2 -0.00888147
IDI1 isopentenyl-diphosphate delta isomerase 1 -0.00885451
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.00870422
IARS1 isoleucyl-tRNA synthetase 1 -0.00867747
GOLGB1 golgin B1 -0.00858668
YEATS2 YEATS domain containing 2 -0.008566
SSB Sjogren syndrome antigen B (autoantigen La) -0.00856283
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 -0.00855828
NCKAP1 NCK-associated protein 1 -0.0085416
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 -0.00852437
POM121 POM121 transmembrane nucleoporin -0.00852169
ZNF652 zinc finger protein 652 -0.00851696