PH-797804_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description PH-797804 perturbation in HS-578T cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the PH-797804_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.246003
VIM vimentin 0.204161
MT2A metallothionein 2A 0.155919
TMSB10 thymosin beta 10 0.10465
TGFBI transforming growth factor, beta-induced, 68kDa 0.0922792
RPS8 ribosomal protein S8 0.0855403
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0849739
RPL35A ribosomal protein L35a 0.079291
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.077892
FTL ferritin, light polypeptide 0.074957
RPS6 ribosomal protein S6 0.0698648
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0692213
IER3 immediate early response 3 0.0641701
NDRG1 N-myc downstream regulated 1 0.0638163
LGALS1 lectin, galactoside-binding, soluble, 1 0.063028
S100A9 S100 calcium binding protein A9 0.0627218
TPT1 tumor protein, translationally-controlled 1 0.0578053
TPM4 tropomyosin 4 0.0555988
RPS3 ribosomal protein S3 0.054751
TIMP3 TIMP metallopeptidase inhibitor 3 0.0546946
B2M beta-2-microglobulin 0.0533967
IFI6 interferon, alpha-inducible protein 6 0.0527955
RPL37A ribosomal protein L37a 0.0527205
RPS12 ribosomal protein S12 0.0524549
EXT1 exostosin glycosyltransferase 1 0.0515378
RPS19 ribosomal protein S19 0.051525
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0510597
LOXL2 lysyl oxidase-like 2 0.050005
CALR calreticulin 0.0492792
EIF1 eukaryotic translation initiation factor 1 0.0488325
RPLP1 ribosomal protein, large, P1 0.0469615
HLA-B major histocompatibility complex, class I, B 0.0464005
PSD3 pleckstrin and Sec7 domain containing 3 0.0458854
RPL26 ribosomal protein L26 0.0435651
CD44 CD44 molecule (Indian blood group) 0.0434334
RPLP2 ribosomal protein, large, P2 0.0427812
RPL37 ribosomal protein L37 0.0385934
CAVIN1 caveolae associated protein 1 0.0383669
RPL36 ribosomal protein L36 0.0383455
RPL19 ribosomal protein L19 0.036555
RPS24 ribosomal protein S24 0.0360968
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.036064
RPL11 ribosomal protein L11 0.0351973
LDHA lactate dehydrogenase A 0.034993
COL1A2 collagen, type I, alpha 2 0.0348734
RPL30 ribosomal protein L30 0.0346286
RPL7 ribosomal protein L7 0.0343755
RPS13 ribosomal protein S13 0.0341663
FTH1 ferritin, heavy polypeptide 1 0.0340845
STC1 stanniocalcin 1 0.0335051
RPL23 ribosomal protein L23 0.0329845
RACK1 receptor for activated C kinase 1 0.0326486
IFITM3 interferon induced transmembrane protein 3 0.0323073
PTMA prothymosin, alpha 0.0322821
IGFBP7 insulin-like growth factor binding protein 7 0.0321312
RPL31 ribosomal protein L31 0.0313486
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0310723
RPS14 ribosomal protein S14 0.0303459
CXCL8 chemokine (C-X-C motif) ligand 8 0.0301566
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0301533
RPLP0 ribosomal protein, large, P0 0.0297971
RPL12 ribosomal protein L12 0.0296689
RRBP1 ribosome binding protein 1 0.0294828
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0291544
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0290848
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0289603
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0284196
RPL28 ribosomal protein L28 0.0280814
ASPH aspartate beta-hydroxylase 0.0275445
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.027374
RPL18 ribosomal protein L18 0.02736
TMSB4X thymosin beta 4, X-linked 0.0273571
RPS25 ribosomal protein S25 0.0272004
RPL5 ribosomal protein L5 0.0271172
RPL34 ribosomal protein L34 0.0260651
OSMR oncostatin M receptor 0.0258924
RPS16 ribosomal protein S16 0.0258704
RPL13A ribosomal protein L13a 0.0257079
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0250726
SP100 SP100 nuclear antigen 0.0250274
AKAP9 A kinase (PRKA) anchor protein 9 0.0249545
CDH13 cadherin 13 0.0249396
KPNB1 karyopherin (importin) beta 1 0.0247668
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0243991
ISG15 ISG15 ubiquitin-like modifier 0.0243343
RPS17 ribosomal protein S17 0.0243071
RPS21 ribosomal protein S21 0.0236565
HLA-A major histocompatibility complex, class I, A 0.0234957
RPL27 ribosomal protein L27 0.0234013
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0229569
ERRFI1 ERBB receptor feedback inhibitor 1 0.0229181
RPL9 ribosomal protein L9 0.0228309
RPS20 ribosomal protein S20 0.022503
STC2 stanniocalcin 2 0.0224628
ZBTB38 zinc finger and BTB domain containing 38 0.0221724
SEC61G Sec61 gamma subunit 0.021822
DLG1 discs, large homolog 1 (Drosophila) 0.0216207
ATF4 activating transcription factor 4 0.0214251
DDIT4 DNA-damage-inducible transcript 4 0.0212887
HM13 histocompatibility (minor) 13 0.0212672

decreased expression

Symbol Name Standardized Value
UBC ubiquitin C -0.0621152
COL1A1 collagen, type I, alpha 1 -0.0551323
CADM1 cell adhesion molecule 1 -0.038475
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0327086
TRIO trio Rho guanine nucleotide exchange factor -0.0324592
PDE10A phosphodiesterase 10A -0.0320722
EEF2 eukaryotic translation elongation factor 2 -0.0294809
COL6A3 collagen, type VI, alpha 3 -0.0267713
COL7A1 collagen, type VII, alpha 1 -0.0264688
ATP13A3 ATPase type 13A3 -0.024993
CALU calumenin -0.0237073
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0224198
ARRDC3 arrestin domain containing 3 -0.0218507
MYH9 myosin, heavy chain 9, non-muscle -0.0215571
FNDC3B fibronectin type III domain containing 3B -0.0202844
TSC22D2 TSC22 domain family, member 2 -0.01933
FN1 fibronectin 1 -0.0192711
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0189372
COL4A1 collagen, type IV, alpha 1 -0.0172053
QKI QKI, KH domain containing, RNA binding -0.0169981
SFPQ splicing factor proline/glutamine-rich -0.0153885
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0153412
TFG TRK-fused gene -0.0151113
NOTCH2 notch 2 -0.0150973
TBC1D23 TBC1 domain family, member 23 -0.0149728
KDM3A lysine (K)-specific demethylase 3A -0.0149485
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0148591
JUN jun proto-oncogene -0.0144966
SHB Src homology 2 domain containing adaptor protein B -0.0141727
PCBP2 poly(rC) binding protein 2 -0.0140805
FLNA filamin A, alpha -0.0140167
CCNL1 cyclin L1 -0.0135961
FBN1 fibrillin 1 -0.0134257
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0132341
COL5A1 collagen, type V, alpha 1 -0.0131344
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.013129
HOOK2 hook microtubule-tethering protein 2 -0.0131148
FOSL1 FOS-like antigen 1 -0.0129535
SETD5 SET domain containing 5 -0.0127265
RBM39 RNA binding motif protein 39 -0.0125679
AHNAK AHNAK nucleoprotein -0.011959
ZFC3H1 zinc finger, C3H1-type containing -0.0118898
ADAM17 ADAM metallopeptidase domain 17 -0.0115282
KDM7A lysine (K)-specific demethylase 7A -0.0113601
GLS2 glutaminase 2 (liver, mitochondrial) -0.0112981
MATR3 matrin 3 -0.0112732
ABI3BP ABI family, member 3 (NESH) binding protein -0.0111563
ALKBH5 AlkB family member 5, RNA demethylase -0.0111346
SUCO SUN domain containing ossification factor -0.0110768
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0110143
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0108746
IARS1 isoleucyl-tRNA synthetase 1 -0.0107495
AHR aryl hydrocarbon receptor -0.0106892
TNIP1 TNFAIP3 interacting protein 1 -0.0106483
TOP2B topoisomerase (DNA) II beta 180kDa -0.0103584
THBS1 thrombospondin 1 -0.0102154
ECT2 epithelial cell transforming 2 -0.0101409
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0101388
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.010121
GSK3B glycogen synthase kinase 3 beta -0.0100843
HELZ helicase with zinc finger -0.0100724
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.010048
ADAM9 ADAM metallopeptidase domain 9 -0.0100059
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.00987974
ZNF292 zinc finger protein 292 -0.00972701
LTN1 listerin E3 ubiquitin protein ligase 1 -0.00971614
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme -0.00962296
CYLD cylindromatosis (turban tumor syndrome) -0.00945637
FOXJ3 forkhead box J3 -0.00941728
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.00940724
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0093694
EP400 E1A binding protein p400 -0.00927667
VEGFC vascular endothelial growth factor C -0.00924626
SBF2 SET binding factor 2 -0.00920642
THRAP3 thyroid hormone receptor associated protein 3 -0.00919762
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.00915121
HNRNPM heterogeneous nuclear ribonucleoprotein M -0.00909357
ICAM1 intercellular adhesion molecule 1 -0.00904904
CHD1 chromodomain helicase DNA binding protein 1 -0.00895267
IQGAP1 IQ motif containing GTPase activating protein 1 -0.00889878
PDIA3 protein disulfide isomerase family A, member 3 -0.00885853
FAT1 FAT atypical cadherin 1 -0.00880854
EMC1 ER membrane protein complex subunit 1 -0.00877345
RYBP RING1 and YY1 binding protein -0.0087511
SART1 squamous cell carcinoma antigen recognized by T cells -0.00871036
EIF4A1 eukaryotic translation initiation factor 4A1 -0.00869934
TMEM39A transmembrane protein 39A -0.00861439
IL6ST interleukin 6 signal transducer -0.00859396
CPEB2 cytoplasmic polyadenylation element binding protein 2 -0.00858731
SRPK2 SRSF protein kinase 2 -0.00857591
SPAG9 sperm associated antigen 9 -0.00857151
CCNT2 cyclin T2 -0.00855726
EPS8 epidermal growth factor receptor pathway substrate 8 -0.00853434
LENG8 leukocyte receptor cluster (LRC) member 8 -0.00850394
RYK receptor-like tyrosine kinase -0.00848705
UBP1 upstream binding protein 1 (LBP-1a) -0.00846696
TRIP12 thyroid hormone receptor interactor 12 -0.0084391
SMAD3 SMAD family member 3 -0.00842951
BRWD1 bromodomain and WD repeat domain containing 1 -0.00842557
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 -0.00841354