PH-797804_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description PH-797804 perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the PH-797804_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.273645
ERRFI1 ERBB receptor feedback inhibitor 1 0.161778
ENO1 enolase 1, (alpha) 0.154914
IGFBP1 insulin-like growth factor binding protein 1 0.146528
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.138723
DSPP dentin sialophosphoprotein 0.137804
SVIL supervillin 0.113279
SAMD4A sterile alpha motif domain containing 4A 0.107674
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.103482
MT2A metallothionein 2A 0.0997349
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0945968
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0928791
ASPH aspartate beta-hydroxylase 0.0882601
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0869064
ATXN1 ataxin 1 0.0797172
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0770206
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0766064
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0763543
EXT1 exostosin glycosyltransferase 1 0.0694501
LDHA lactate dehydrogenase A 0.0613442
TIMP1 TIMP metallopeptidase inhibitor 1 0.0611691
FAM107B family with sequence similarity 107, member B 0.0597741
RPS12 ribosomal protein S12 0.0580881
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.056597
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0551252
FRMD5 FERM domain containing 5 0.0537277
EHBP1 EH domain binding protein 1 0.0524496
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0520967
PDLIM5 PDZ and LIM domain 5 0.0516577
PEG3 paternally expressed 3 0.0515571
TPT1 tumor protein, translationally-controlled 1 0.0504775
CCL20 chemokine (C-C motif) ligand 20 0.0497381
MACF1 microtubule-actin crosslinking factor 1 0.0489438
RPL37A ribosomal protein L37a 0.0484835
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0480306
MYH9 myosin, heavy chain 9, non-muscle 0.0465202
TMSB10 thymosin beta 10 0.0438638
RPS8 ribosomal protein S8 0.0401484
KYNU kynureninase 0.0400552
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0398177
FOXP1 forkhead box P1 0.0390804
SDC4 syndecan 4 0.0376559
LPP LIM domain containing preferred translocation partner in lipoma 0.0376364
RPL23 ribosomal protein L23 0.0352125
GRB10 growth factor receptor-bound protein 10 0.0347543
TF transferrin 0.0344277
RPS24 ribosomal protein S24 0.0336412
PGK1 phosphoglycerate kinase 1 0.0334782
RPL11 ribosomal protein L11 0.0333133
KDM3A lysine (K)-specific demethylase 3A 0.0332815
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0328101
CANX calnexin 0.0325632
KIAA1217 KIAA1217 0.032206
UBC ubiquitin C 0.031495
ZBTB20 zinc finger and BTB domain containing 20 0.0314372
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0312301
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0310198
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0303778
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0297267
NDRG1 N-myc downstream regulated 1 0.0293205
DST dystonin 0.0291074
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0290555
RAD51B RAD51 paralog B 0.0283434
GMDS GDP-mannose 4,6-dehydratase 0.0282065
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0281851
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0281106
MAML2 mastermind-like 2 (Drosophila) 0.0274912
B2M beta-2-microglobulin 0.0274644
RPS27A ribosomal protein S27a 0.0274488
NAP1L1 nucleosome assembly protein 1-like 1 0.0273668
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0273149
GCLC glutamate-cysteine ligase, catalytic subunit 0.0270527
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0269055
GK glycerol kinase 0.0268687
PLIN2 perilipin 2 0.0266007
TPM4 tropomyosin 4 0.0263536
MBNL2 muscleblind-like splicing regulator 2 0.0262891
JAK1 Janus kinase 1 0.0262253
SOD2 superoxide dismutase 2, mitochondrial 0.0260335
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0259983
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0258494
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0257513
FMNL2 formin-like 2 0.0257459
FN1 fibronectin 1 0.0255886
TCIM transcriptional and immune response regulator 0.0252985
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0251713
PLXDC2 plexin domain containing 2 0.0247984
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.024561
CTSB cathepsin B 0.0244395
MCL1 myeloid cell leukemia 1 0.0242433
RPS6 ribosomal protein S6 0.0241623
APLP2 amyloid beta (A4) precursor-like protein 2 0.0239715
AHNAK AHNAK nucleoprotein 0.0239228
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0238022
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0236146
RPL7 ribosomal protein L7 0.0235676
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0235519
RPS18 ribosomal protein S18 0.023465
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0234232
FLNB filamin B, beta 0.0230172

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.161391
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.105663
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0691831
C3 complement component 3 -0.061759
EML4 echinoderm microtubule associated protein like 4 -0.0379031
PTPRM protein tyrosine phosphatase, receptor type, M -0.0317782
EGR1 early growth response 1 -0.0316165
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0280593
RBM25 RNA binding motif protein 25 -0.0272866
NKD1 naked cuticle homolog 1 (Drosophila) -0.0261996
DLC1 DLC1 Rho GTPase activating protein -0.0258677
FBF1 Fas (TNFRSF6) binding factor 1 -0.0258158
A2M alpha-2-macroglobulin -0.0187572
LYZ lysozyme -0.0187428
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.0180403
COBLL1 cordon-bleu WH2 repeat protein-like 1 -0.0175751
CCNL1 cyclin L1 -0.0173972
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0172862
FTH1 ferritin, heavy polypeptide 1 -0.0161319
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0154602
SLC38A2 solute carrier family 38, member 2 -0.0151718
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0151708
EEF2 eukaryotic translation elongation factor 2 -0.0149372
PTCHD4 patched domain containing 4 -0.0140242
SRRM1 serine/arginine repetitive matrix 1 -0.0133382
GNAS GNAS complex locus -0.0129451
CFB complement factor B -0.0128782
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0128559
MBNL3 muscleblind-like splicing regulator 3 -0.012828
FNBP4 formin binding protein 4 -0.0128026
VEGFA vascular endothelial growth factor A -0.0126795
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0125906
CYB5R3 cytochrome b5 reductase 3 -0.0125147
PTBP3 polypyrimidine tract binding protein 3 -0.0124447
GDF15 growth differentiation factor 15 -0.0124373
CHD6 chromodomain helicase DNA binding protein 6 -0.0123768
NRIP1 nuclear receptor interacting protein 1 -0.0123052
PRRC2B proline-rich coiled-coil 2B -0.0118988
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0117382
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -0.0115984
ACSS3 acyl-CoA synthetase short-chain family member 3 -0.0115885
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0115646
WTAP Wilms tumor 1 associated protein -0.011442
WDR43 WD repeat domain 43 -0.0114224
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0114068
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0110947
APOH apolipoprotein H (beta-2-glycoprotein I) -0.0110632
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0108733
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0106999
POU2F1 POU class 2 homeobox 1 -0.0103236
SYNJ2 synaptojanin 2 -0.0103055
ATP13A3 ATPase type 13A3 -0.0101047
TMEM51 transmembrane protein 51 -0.0099613
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.00990492
FCHSD2 FCH and double SH3 domains 2 -0.00981876
CDC7 cell division cycle 7 -0.00954916
CENPF centromere protein F, 350/400kDa -0.0094828
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 -0.0093414
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.00932046
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.00929906
ZFP36 ZFP36 ring finger protein -0.00929679
RNF145 ring finger protein 145 -0.00918596
PDS5B PDS5 cohesin associated factor B -0.0090653
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.00906156
DHFR dihydrofolate reductase -0.00905409
ACOX3 acyl-CoA oxidase 3, pristanoyl -0.00889675
ZNF207 zinc finger protein 207 -0.00876739
EPS8 epidermal growth factor receptor pathway substrate 8 -0.00868059
SMAD7 SMAD family member 7 -0.00862876
PPARG peroxisome proliferator-activated receptor gamma -0.008582
PTBP2 polypyrimidine tract binding protein 2 -0.0084556
PCBP2 poly(rC) binding protein 2 -0.00845309
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0084334
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0083843
RNF11 ring finger protein 11 -0.00834347
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.00825883
USP3 ubiquitin specific peptidase 3 -0.00824906
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -0.00823895
MATN3 matrilin 3 -0.00817416
LRP5 low density lipoprotein receptor-related protein 5 -0.00814894
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.00812794
PELI1 pellino E3 ubiquitin protein ligase 1 -0.00809506
WDFY3 WD repeat and FYVE domain containing 3 -0.00802269
TRAPPC10 trafficking protein particle complex 10 -0.0080219
RNF38 ring finger protein 38 -0.00794842
HIPK2 homeodomain interacting protein kinase 2 -0.0077596
ZDHHC20 zinc finger, DHHC-type containing 20 -0.00775226
MTUS1 microtubule associated tumor suppressor 1 -0.00773928
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0077337
LATS2 large tumor suppressor kinase 2 -0.00771729
YY1 YY1 transcription factor -0.00771376
BRWD1 bromodomain and WD repeat domain containing 1 -0.00770843
WNK2 WNK lysine deficient protein kinase 2 -0.00766109
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.00765363
ORM1 orosomucoid 1 -0.00762161
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -0.00761748
LARP4 La ribonucleoprotein domain family, member 4 -0.00761349
SESTD1 SEC14 and spectrin domains 1 -0.00752678
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.00751929
LCOR ligand dependent nuclear receptor corepressor -0.00742004