PH-797804_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description PH-797804 perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the PH-797804_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.0810908
B2M beta-2-microglobulin 0.0645099
TMSB10 thymosin beta 10 0.0536403
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0490317
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0482411
RPS8 ribosomal protein S8 0.0475768
NDRG1 N-myc downstream regulated 1 0.0466405
RPLP1 ribosomal protein, large, P1 0.0451112
PTMA prothymosin, alpha 0.0443213
RPLP2 ribosomal protein, large, P2 0.042813
RPS3 ribosomal protein S3 0.0417301
RPS12 ribosomal protein S12 0.0415321
RPS6 ribosomal protein S6 0.0411246
RPS13 ribosomal protein S13 0.0376217
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.037577
MEF2A myocyte enhancer factor 2A 0.0371976
RPS19 ribosomal protein S19 0.0357191
FTL ferritin, light polypeptide 0.0342291
RPL37A ribosomal protein L37a 0.033587
PGK1 phosphoglycerate kinase 1 0.0319442
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0318781
RPS21 ribosomal protein S21 0.0315517
S100A6 S100 calcium binding protein A6 0.0308654
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0306443
AKAP9 A kinase (PRKA) anchor protein 9 0.0294472
KTN1 kinectin 1 (kinesin receptor) 0.0292953
ESYT2 extended synaptotagmin-like protein 2 0.0289242
CALR calreticulin 0.0288265
IFITM3 interferon induced transmembrane protein 3 0.0285616
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0284027
MBNL2 muscleblind-like splicing regulator 2 0.0279242
RPS25 ribosomal protein S25 0.0277663
RPL23 ribosomal protein L23 0.0277167
RPL12 ribosomal protein L12 0.0274953
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.0269668
DSTN destrin (actin depolymerizing factor) 0.0268529
TGM2 transglutaminase 2 0.0267621
S100A9 S100 calcium binding protein A9 0.0262763
RPS27 ribosomal protein S27 0.0260389
RPL31 ribosomal protein L31 0.0259244
TPT1 tumor protein, translationally-controlled 1 0.0240879
RACK1 receptor for activated C kinase 1 0.0238274
DUSP6 dual specificity phosphatase 6 0.0234844
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0234027
MBNL1 muscleblind-like splicing regulator 1 0.0233738
RPL36 ribosomal protein L36 0.0229731
CD44 CD44 molecule (Indian blood group) 0.0226527
GOLGA4 golgin A4 0.0226072
PKM pyruvate kinase, muscle 0.0225839
S100A2 S100 calcium binding protein A2 0.0225354
APLP2 amyloid beta (A4) precursor-like protein 2 0.0222992
KIAA1217 KIAA1217 0.0222507
IFITM1 interferon induced transmembrane protein 1 0.0220611
CLU clusterin 0.0220207
FNDC3B fibronectin type III domain containing 3B 0.0219982
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0216756
LDHA lactate dehydrogenase A 0.020907
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0205461
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0204349
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0203518
RPS14 ribosomal protein S14 0.0202974
RPS4X ribosomal protein S4, X-linked 0.0202413
MORF4L2 mortality factor 4 like 2 0.0202344
RPS17 ribosomal protein S17 0.0201634
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0200366
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0197172
ANGPTL4 angiopoietin-like 4 0.0197017
COG6 component of oligomeric golgi complex 6 0.0195568
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0195174
ACBD3 acyl-CoA binding domain containing 3 0.0194141
RPLP0 ribosomal protein, large, P0 0.0193724
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0193276
S100A10 S100 calcium binding protein A10 0.0192093
SERINC3 serine incorporator 3 0.0191992
POTEF POTE ankyrin domain family, member F 0.0191207
EIF1 eukaryotic translation initiation factor 1 0.018942
LGALS1 lectin, galactoside-binding, soluble, 1 0.018941
UBC ubiquitin C 0.0188749
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0184293
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0183486
UBE2B ubiquitin-conjugating enzyme E2B 0.0182759
LMNA lamin A/C 0.0181272
CYB5R3 cytochrome b5 reductase 3 0.0180358
LNPEP leucyl/cystinyl aminopeptidase 0.0179481
SEC61G Sec61 gamma subunit 0.0178119
NAP1L1 nucleosome assembly protein 1-like 1 0.017307
TTC3 tetratricopeptide repeat domain 3 0.0171923
ENO1 enolase 1, (alpha) 0.0171694
RPS24 ribosomal protein S24 0.0170707
RPS27A ribosomal protein S27a 0.0166517
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0164889
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0164836
SUCO SUN domain containing ossification factor 0.016266
HLA-B major histocompatibility complex, class I, B 0.0161704
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0160668
RPL11 ribosomal protein L11 0.016059
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0158327
MYADM myeloid-associated differentiation marker 0.0157747
MSN moesin 0.0157551
RPL7A ribosomal protein L7a 0.0156688

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.24257
TIMP3 TIMP metallopeptidase inhibitor 3 -0.22935
PALM2AKAP2 PALM2 and AKAP2 fusion -0.116434
RASAL2 RAS protein activator like 2 -0.102181
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.101238
BCAR3 breast cancer anti-estrogen resistance 3 -0.07303
DPYD dihydropyrimidine dehydrogenase -0.0728384
RBM39 RNA binding motif protein 39 -0.0592328
SULF1 sulfatase 1 -0.0576664
FLNB filamin B, beta -0.0576197
AHNAK AHNAK nucleoprotein -0.056015
SLC35F3 solute carrier family 35, member F3 -0.0549827
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0534808
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0483742
GRB10 growth factor receptor-bound protein 10 -0.0481404
ABI3BP ABI family, member 3 (NESH) binding protein -0.0458961
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0439048
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.043016
MTSS1 metastasis suppressor 1 -0.0428165
PDE4D phosphodiesterase 4D, cAMP-specific -0.0422919
PODXL podocalyxin-like -0.042079
MECOM MDS1 and EVI1 complex locus -0.0419065
PDLIM5 PDZ and LIM domain 5 -0.0411976
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0409876
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0399656
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.039627
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0394189
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0389841
ALCAM activated leukocyte cell adhesion molecule -0.0385687
CDK6 cyclin-dependent kinase 6 -0.0385403
RIGI RNA sensor RIG-I -0.0382569
ZNFX1 zinc finger, NFX1-type containing 1 -0.0363755
SULF2 sulfatase 2 -0.0362038
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0354927
FOSL1 FOS-like antigen 1 -0.0350708
PALLD palladin, cytoskeletal associated protein -0.0349185
ANO1 anoctamin 1, calcium activated chloride channel -0.0340089
WDR43 WD repeat domain 43 -0.0339072
PTK2 protein tyrosine kinase 2 -0.0337989
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0333693
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0331408
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0330836
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0330145
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0320427
ICE1 interactor of little elongation complex ELL subunit 1 -0.0318598
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0318572
ZEB1 zinc finger E-box binding homeobox 1 -0.0309887
RABGAP1L RAB GTPase activating protein 1-like -0.0304893
LAMC2 laminin, gamma 2 -0.030318
IARS1 isoleucyl-tRNA synthetase 1 -0.0301225
NRIP1 nuclear receptor interacting protein 1 -0.0295743
HSPG2 heparan sulfate proteoglycan 2 -0.0292844
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0292335
MPRIP myosin phosphatase Rho interacting protein -0.0290554
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0280018
BCL2L1 BCL2-like 1 -0.027845
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0276104
PSD3 pleckstrin and Sec7 domain containing 3 -0.0276015
SAMD9 sterile alpha motif domain containing 9 -0.0272835
NAV2 neuron navigator 2 -0.0272157
UTRN utrophin -0.026962
INTS6 integrator complex subunit 6 -0.0267154
APP amyloid beta (A4) precursor protein -0.0262172
ACTN4 actinin, alpha 4 -0.0258186
RAB7A RAB7A, member RAS oncogene family -0.0256547
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.024714
USPL1 ubiquitin specific peptidase like 1 -0.0238444
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0235989
SMYD3 SET and MYND domain containing 3 -0.022479
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0224771
TNS3 tensin 3 -0.0221233
EGFR epidermal growth factor receptor -0.0220409
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0219866
PRSS23 protease, serine, 23 -0.0217136
ZMYND8 zinc finger, MYND-type containing 8 -0.0212105
FAF1 Fas (TNFRSF6) associated factor 1 -0.0210686
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0209967
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 -0.0207834
RAI14 retinoic acid induced 14 -0.0205367
RLF rearranged L-myc fusion -0.0203783
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0202666
NIPBL Nipped-B homolog (Drosophila) -0.0201196
EWSR1 EWS RNA-binding protein 1 -0.0200883
DGKH diacylglycerol kinase, eta -0.0200136
CAPN2 calpain 2, (m/II) large subunit -0.019886
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0196739
PITPNB phosphatidylinositol transfer protein, beta -0.0196494
RCOR1 REST corepressor 1 -0.0195706
FOXJ3 forkhead box J3 -0.0195358
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0195066
PUM1 pumilio RNA-binding family member 1 -0.0194297
RND3 Rho family GTPase 3 -0.0194114
CDR2 cerebellar degeneration-related protein 2, 62kDa -0.019346
PRPF3 pre-mRNA processing factor 3 -0.0193291
FRMD6 FERM domain containing 6 -0.0192029
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.019175
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0191404
C4BPB complement component 4 binding protein, beta -0.0189563
LARP4B La ribonucleoprotein domain family, member 4B -0.0188647
NEK7 NIMA-related kinase 7 -0.018845