PH-797804_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description PH-797804 perturbation in KATO III cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the PH-797804_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FGFR2 fibroblast growth factor receptor 2 0.112754
TMSB10 thymosin beta 10 0.103009
FTL ferritin, light polypeptide 0.0918115
B2M beta-2-microglobulin 0.0909904
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.090921
PTMA prothymosin, alpha 0.0782015
RPS3 ribosomal protein S3 0.0699502
TPT1 tumor protein, translationally-controlled 1 0.0667685
RPL23 ribosomal protein L23 0.0648063
RPS19 ribosomal protein S19 0.0626654
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0617711
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0608903
TMC5 transmembrane channel-like 5 0.0604354
RPLP1 ribosomal protein, large, P1 0.0597849
RPS6 ribosomal protein S6 0.0553961
RPS25 ribosomal protein S25 0.0511397
RPS8 ribosomal protein S8 0.0507945
EIF1 eukaryotic translation initiation factor 1 0.0499653
RPL35A ribosomal protein L35a 0.0493509
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0492747
RPS12 ribosomal protein S12 0.0492129
PGK1 phosphoglycerate kinase 1 0.048072
IFI27 interferon, alpha-inducible protein 27 0.0468569
S100P S100 calcium binding protein P 0.0467517
CALR calreticulin 0.0456194
RPL37A ribosomal protein L37a 0.0404253
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0396456
RPS17 ribosomal protein S17 0.0385111
MBNL2 muscleblind-like splicing regulator 2 0.0383362
S100A9 S100 calcium binding protein A9 0.038042
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0373073
KRT18 keratin 18, type I 0.0369448
NDRG1 N-myc downstream regulated 1 0.0368846
RPL19 ribosomal protein L19 0.0365043
SEPTIN9 septin 9 0.0358316
LMO7 LIM domain 7 0.0357487
AGR2 anterior gradient 2 0.0353761
AREG amphiregulin 0.0351406
IFI6 interferon, alpha-inducible protein 6 0.0350837
RPL18 ribosomal protein L18 0.0348236
HLA-A major histocompatibility complex, class I, A 0.0348023
GDA guanine deaminase 0.034254
BAIAP2L1 BAI1-associated protein 2-like 1 0.0341327
S100A6 S100 calcium binding protein A6 0.0338788
AKAP9 A kinase (PRKA) anchor protein 9 0.033702
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0334776
RPS27A ribosomal protein S27a 0.0329007
RPS21 ribosomal protein S21 0.0328823
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.031853
MYOF myoferlin 0.0315705
RPL26 ribosomal protein L26 0.0313269
ENO1 enolase 1, (alpha) 0.0293961
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0286427
RPS24 ribosomal protein S24 0.0286159
RPLP2 ribosomal protein, large, P2 0.0277392
LMNA lamin A/C 0.0276372
PKM pyruvate kinase, muscle 0.0275034
RPL12 ribosomal protein L12 0.0274239
RPS27 ribosomal protein S27 0.0272947
LCN2 lipocalin 2 0.0252456
ATF5 activating transcription factor 5 0.0251058
SEC61G Sec61 gamma subunit 0.0250467
AKAP13 A kinase (PRKA) anchor protein 13 0.0250269
DSPP dentin sialophosphoprotein 0.0247365
RPS29 ribosomal protein S29 0.0246969
MYH9 myosin, heavy chain 9, non-muscle 0.0245475
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0245384
RPS14 ribosomal protein S14 0.024444
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0242211
RPL36 ribosomal protein L36 0.024185
RPS16 ribosomal protein S16 0.0240237
RPL36A ribosomal protein L36a 0.0236438
LIMA1 LIM domain and actin binding 1 0.0231069
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0229707
NUPR1 nuclear protein, transcriptional regulator, 1 0.0229109
RPL7A ribosomal protein L7a 0.0226712
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0226547
AGR3 anterior gradient 3 0.0221428
RPL31 ribosomal protein L31 0.0219808
PDIA4 protein disulfide isomerase family A, member 4 0.0218684
TXNRD1 thioredoxin reductase 1 0.0217324
RPL28 ribosomal protein L28 0.0216169
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0216084
GSTP1 glutathione S-transferase pi 1 0.0215163
ASPH aspartate beta-hydroxylase 0.0214398
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0213026
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0211388
RPL9 ribosomal protein L9 0.0211283
EPCAM epithelial cell adhesion molecule 0.021108
EZR ezrin 0.0208497
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0206978
ANXA1 annexin A1 0.0205846
MYADM myeloid-associated differentiation marker 0.0202237
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0197338
SLC38A1 solute carrier family 38, member 1 0.0197127
CLDN4 claudin 4 0.0196211
ATXN1 ataxin 1 0.0193993
RPL7 ribosomal protein L7 0.0193783
S100A11 S100 calcium binding protein A11 0.019055
HLA-B major histocompatibility complex, class I, B 0.019018

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.0952729
RBM39 RNA binding motif protein 39 -0.0564813
CCNL1 cyclin L1 -0.0463805
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0432164
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0359376
RAB7A RAB7A, member RAS oncogene family -0.0358711
BIRC6 baculoviral IAP repeat containing 6 -0.0343674
ZNF292 zinc finger protein 292 -0.0297492
USPL1 ubiquitin specific peptidase like 1 -0.0268738
PUM2 pumilio RNA-binding family member 2 -0.0262094
EWSR1 EWS RNA-binding protein 1 -0.0257291
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0255609
MAML2 mastermind-like 2 (Drosophila) -0.0253284
GPATCH8 G patch domain containing 8 -0.0248142
WDR43 WD repeat domain 43 -0.0246704
TRA2B transformer 2 beta homolog (Drosophila) -0.0244029
TRPS1 trichorhinophalangeal syndrome I -0.0243687
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha -0.0224394
PRPF3 pre-mRNA processing factor 3 -0.0224227
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0223148
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0221109
GMDS GDP-mannose 4,6-dehydratase -0.0219788
RLF rearranged L-myc fusion -0.0218461
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.021623
NOP58 NOP58 ribonucleoprotein -0.021481
RUNX1 runt-related transcription factor 1 -0.0212712
FOSL1 FOS-like antigen 1 -0.0209789
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0208852
RASAL2 RAS protein activator like 2 -0.0207257
PRPF8 pre-mRNA processing factor 8 -0.0200137
LSG1 large 60S subunit nuclear export GTPase 1 -0.0199127
IARS1 isoleucyl-tRNA synthetase 1 -0.0194123
NUP160 nucleoporin 160kDa -0.01928
VMP1 vacuole membrane protein 1 -0.0190978
WAC WW domain containing adaptor with coiled-coil -0.0188569
AQR aquarius intron-binding spliceosomal factor -0.0185381
ZFAND3 zinc finger, AN1-type domain 3 -0.0184989
TCF12 transcription factor 12 -0.0180506
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0176212
NIPBL Nipped-B homolog (Drosophila) -0.0175358
SETX senataxin -0.0173521
EIF2A eukaryotic translation initiation factor 2A, 65kDa -0.0173056
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0172011
CUL3 cullin 3 -0.01687
KDM6A lysine (K)-specific demethylase 6A -0.0167959
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -0.0165644
SETD5 SET domain containing 5 -0.0165218
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0164985
ANXA2 annexin A2 -0.0163567
RPTOR regulatory associated protein of MTOR, complex 1 -0.016286
FUS FUS RNA binding protein -0.0162473
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0161447
LARP4B La ribonucleoprotein domain family, member 4B -0.0160989
SCAF8 SR-related CTD-associated factor 8 -0.015713
PUM1 pumilio RNA-binding family member 1 -0.0155577
METTL16 methyltransferase like 16 -0.0151334
RBM25 RNA binding motif protein 25 -0.0149379
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0148054
UBQLN1 ubiquilin 1 -0.0147915
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 -0.0145971
EIF4B eukaryotic translation initiation factor 4B -0.0145172
NUP58 nucleoporin 58 -0.0145171
CSNK1A1 casein kinase 1, alpha 1 -0.0144182
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0143998
SENP5 SUMO1/sentrin specific peptidase 5 -0.0143124
PDIA3 protein disulfide isomerase family A, member 3 -0.0142695
MSMO1 methylsterol monooxygenase 1 -0.0142486
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0142359
AGFG1 ArfGAP with FG repeats 1 -0.0142293
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0140796
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0140492
PRPF6 pre-mRNA processing factor 6 -0.0140348
TFRC transferrin receptor -0.01402
KAT6A K(lysine) acetyltransferase 6A -0.0138747
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0138578
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.013838
RBM33 RNA binding motif protein 33 -0.0137245
RSRC2 arginine/serine-rich coiled-coil 2 -0.0137156
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.013706
ZNF148 zinc finger protein 148 -0.0136854
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0136316
SFPQ splicing factor proline/glutamine-rich -0.0136091
DIDO1 death inducer-obliterator 1 -0.013434
ACACA acetyl-CoA carboxylase alpha -0.0134188
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) -0.0133722
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0133214
USP15 ubiquitin specific peptidase 15 -0.0133099
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0132923
FAF1 Fas (TNFRSF6) associated factor 1 -0.013151
IRF1 interferon regulatory factor 1 -0.0131286
FOXJ3 forkhead box J3 -0.0131018
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0130589
KMT2E lysine (K)-specific methyltransferase 2E -0.0130274
ZNF207 zinc finger protein 207 -0.0130243
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 -0.0130007
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 -0.0129057
MED17 mediator complex subunit 17 -0.0128331
FAM133B family with sequence similarity 133, member B -0.0128126
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0128013
GTPBP4 GTP binding protein 4 -0.012765