PH-797804_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description PH-797804 perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the PH-797804_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.207079
VIM vimentin 0.177314
TP63 tumor protein p63 0.153008
PSD3 pleckstrin and Sec7 domain containing 3 0.149891
DST dystonin 0.111201
RPS12 ribosomal protein S12 0.0949663
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0874453
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0858246
CD44 CD44 molecule (Indian blood group) 0.0821121
RPS8 ribosomal protein S8 0.0804066
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0787032
HLA-B major histocompatibility complex, class I, B 0.0780471
TMSB10 thymosin beta 10 0.0743345
RPL37A ribosomal protein L37a 0.0732648
RPL36 ribosomal protein L36 0.0723323
RPS19 ribosomal protein S19 0.0692239
TPT1 tumor protein, translationally-controlled 1 0.0631374
MT1E metallothionein 1E 0.0629004
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0617836
RPL31 ribosomal protein L31 0.0610034
RPS3 ribosomal protein S3 0.059415
RPL26 ribosomal protein L26 0.0578513
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0570778
CADM2 cell adhesion molecule 2 0.0546495
CAPRIN2 caprin family member 2 0.0540825
RPL35A ribosomal protein L35a 0.0540319
RPLP2 ribosomal protein, large, P2 0.0502673
RPL12 ribosomal protein L12 0.0493084
SP100 SP100 nuclear antigen 0.0492626
IFI6 interferon, alpha-inducible protein 6 0.0482312
RPLP1 ribosomal protein, large, P1 0.0481151
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0471782
ZDHHC14 zinc finger, DHHC-type containing 14 0.046581
RAD51B RAD51 paralog B 0.046194
RUNX1 runt-related transcription factor 1 0.0461401
TSC22D1 TSC22 domain family, member 1 0.0453697
RPL36A ribosomal protein L36a 0.0451587
PRELID2 PRELI domain containing 2 0.0441849
NPAS2 neuronal PAS domain protein 2 0.0441841
RPS6 ribosomal protein S6 0.0428943
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0424169
RPL37 ribosomal protein L37 0.0422954
DPYD dihydropyrimidine dehydrogenase 0.0417812
B2M beta-2-microglobulin 0.0412472
RPS17 ribosomal protein S17 0.040975
RPS25 ribosomal protein S25 0.0399507
WWTR1 WW domain containing transcription regulator 1 0.0399099
PDE10A phosphodiesterase 10A 0.039435
BCAR3 breast cancer anti-estrogen resistance 3 0.0391718
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0377618
HDAC9 histone deacetylase 9 0.0365783
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0362773
RPS27 ribosomal protein S27 0.0361209
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0356696
RPL19 ribosomal protein L19 0.0355605
RPS24 ribosomal protein S24 0.0346596
EHBP1 EH domain binding protein 1 0.0344915
RPL23 ribosomal protein L23 0.0337306
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0335385
PLSCR1 phospholipid scramblase 1 0.0335303
RNF213 ring finger protein 213 0.0333116
CSMD3 CUB and Sushi multiple domains 3 0.03328
ENO2 enolase 2 (gamma, neuronal) 0.0327464
RPL27 ribosomal protein L27 0.0327386
ANGPTL4 angiopoietin-like 4 0.0325809
WARS1 tryptophanyl-tRNA synthetase 1 0.0323509
FTL ferritin, light polypeptide 0.0320041
MACF1 microtubule-actin crosslinking factor 1 0.0319123
SMYD3 SET and MYND domain containing 3 0.0314221
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0313691
EXOC4 exocyst complex component 4 0.0304646
VCL vinculin 0.0300221
LPP LIM domain containing preferred translocation partner in lipoma 0.0298729
RIGI RNA sensor RIG-I 0.0296265
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0293696
RPS13 ribosomal protein S13 0.0293405
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.028931
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0277926
PTMA prothymosin, alpha 0.0276573
TRIM56 tripartite motif containing 56 0.027548
HLA-A major histocompatibility complex, class I, A 0.0270746
RPL35 ribosomal protein L35 0.0265239
RPS29 ribosomal protein S29 0.0260636
BIRC3 baculoviral IAP repeat containing 3 0.0258946
RPL18 ribosomal protein L18 0.0258873
SQSTM1 sequestosome 1 0.0258534
RPS14 ribosomal protein S14 0.0252988
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0251904
IFIH1 interferon induced with helicase C domain 1 0.0251569
EFNA5 ephrin-A5 0.0247805
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0246792
CFAP299 cilia and flagella associated protein 299 0.0246564
TNS3 tensin 3 0.0242946
RPL28 ribosomal protein L28 0.0242219
ADAM10 ADAM metallopeptidase domain 10 0.0237537
ZBTB38 zinc finger and BTB domain containing 38 0.0232078
DNER delta/notch-like EGF repeat containing 0.0231706
FMNL2 formin-like 2 0.0231181
RACK1 receptor for activated C kinase 1 0.0226717
RPL9 ribosomal protein L9 0.0224931

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.154234
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.141511
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.074623
TXNRD1 thioredoxin reductase 1 -0.067837
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0549471
EEF2 eukaryotic translation elongation factor 2 -0.0475316
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0424844
WDR43 WD repeat domain 43 -0.0387142
GARS1 glycyl-tRNA synthetase 1 -0.0384323
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0383947
TM4SF1 transmembrane 4 L six family member 1 -0.0368832
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0343726
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0341162
UBC ubiquitin C -0.0338229
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0334102
CANX calnexin -0.0315428
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0304431
APP amyloid beta (A4) precursor protein -0.029686
KDM3A lysine (K)-specific demethylase 3A -0.0295578
EZR ezrin -0.0290828
RBM39 RNA binding motif protein 39 -0.0282508
MATR3 matrin 3 -0.026706
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0264865
TSC22D2 TSC22 domain family, member 2 -0.0260776
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0257971
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0254099
TFRC transferrin receptor -0.0253082
AHNAK AHNAK nucleoprotein -0.0249254
RLF rearranged L-myc fusion -0.0246899
ANXA1 annexin A1 -0.0246546
PUM2 pumilio RNA-binding family member 2 -0.0237842
NUP58 nucleoporin 58 -0.0235958
ACTG1 actin gamma 1 -0.0233463
WDR45B WD repeat domain 45B -0.0233087
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0230293
NOP58 NOP58 ribonucleoprotein -0.0225006
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0222946
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.022289
RTN4 reticulon 4 -0.0219367
NAMPT nicotinamide phosphoribosyltransferase -0.0218808
PDIA3 protein disulfide isomerase family A, member 3 -0.0214999
FOXJ3 forkhead box J3 -0.0214862
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0208886
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0205987
FUS FUS RNA binding protein -0.0204179
LOC112694756 uncharaterized LOC112694756 -0.0201589
SEPTIN7 septin 7 -0.0194749
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0191862
WAC WW domain containing adaptor with coiled-coil -0.0191831
NPR2 natriuretic peptide receptor 2 -0.0190561
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.018789
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0186082
CKAP5 cytoskeleton associated protein 5 -0.0183043
KCMF1 potassium channel modulatory factor 1 -0.0182479
TOP1 topoisomerase (DNA) I -0.0180488
ZFR zinc finger RNA binding protein -0.0180269
IARS1 isoleucyl-tRNA synthetase 1 -0.0179424
SBNO1 strawberry notch homolog 1 (Drosophila) -0.0178717
OLA1 Obg-like ATPase 1 -0.017575
TOP2A topoisomerase (DNA) II alpha 170kDa -0.017442
MARCHF6 membrane associated ring-CH-type finger 6 -0.0173918
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0172459
PRRC2C proline-rich coiled-coil 2C -0.0170929
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0170773
KMT2C lysine (K)-specific methyltransferase 2C -0.0170259
PUM1 pumilio RNA-binding family member 1 -0.0170081
PDIA6 protein disulfide isomerase family A, member 6 -0.01669
XPO1 exportin 1 -0.016628
CENPF centromere protein F, 350/400kDa -0.0165632
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0164958
ECT2 epithelial cell transforming 2 -0.0162667
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.0162654
GOLGA4 golgin A4 -0.0161129
CUL3 cullin 3 -0.0160509
ADAM9 ADAM metallopeptidase domain 9 -0.0160152
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0159837
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0159413
ADAM17 ADAM metallopeptidase domain 17 -0.0157364
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0156931
KIF5B kinesin family member 5B -0.015619
OGA O-GlcNAcase -0.0155544
STRN3 striatin, calmodulin binding protein 3 -0.0155286
EMP1 epithelial membrane protein 1 -0.0155282
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0155211
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0155
BRWD1 bromodomain and WD repeat domain containing 1 -0.0154073
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0154041
AHCTF1 AT hook containing transcription factor 1 -0.0153746
UBA2 ubiquitin-like modifier activating enzyme 2 -0.0153118
RBM27 RNA binding motif protein 27 -0.0153109
EIF3B eukaryotic translation initiation factor 3, subunit B -0.0152776
LMAN1 lectin, mannose-binding, 1 -0.0151936
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0151601
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0150583
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.014978
RBM25 RNA binding motif protein 25 -0.0149219
HOOK2 hook microtubule-tethering protein 2 -0.0148508
YBX3 Y box binding protein 3 -0.0148214
RNF145 ring finger protein 145 -0.0146546
POTEF POTE ankyrin domain family, member F -0.0146306